TLR Signalling Pathway

Toll-like receptors (TLRs) play an essential role in the activation of innate immunity by recognizing molecules from pathogens like we have LPS from Gram negative Bacteria.
TLR signaling pathways arise from intracytoplasmic TIR domains, which are conserved among all TLRs and these TIR Domains are stimulated and activated by binding of Ligands towards the TLR proteins.
In this pathway we need the following Proteins :
1.Lipolysaccharide Binding Proteins.
2.CD-14
3.MD-2
4.TLR
5.MY D88
6.TIRAM
7.TRAM
8.TRAF
9.IRF.
10.NFKB
11.AP-1
12.IKK
and many other molecules .
From this pathway we get the transcription of Cytokines , Chemokines , Interferons .

[@user-py9re3hv2l]

i realllly hate this subject....but you simplfied it as much as possible,great job

[@muhammadzain-ul-abdeen7521]

Excellently explained, thank you❤️

[@kaulickmitra6898]

Fantastic explanation,Sir.

[@mitamajoomdar9390]

I need this video earlier 😭 but still happy 😊 finally got simplest way of tlr signaling pathway

[@michaeleisenberg7867]

Hello Shabir, Very nice animations with different colors and shapes. 👏👏👏

[@fatemehkolbadi6397]

Perfect explanation 👌

[@alannahhyland5758]

Very clearly explained, thank you very much!

[@hussainbiology]

Glad it was helpful!

[@alexei8468]

gracias!

[@muntazirhasan8494]

Bro excellent job. Totally impressive.

[@hussainbiology]

thanks for appreciation..Glad it helps....✌️

[@umerfarooqbiology7083]

very nice and great information

[@risharajkhowa5060]

what an explanation !🥰🥰🥰🥰

[@franciswalsh5469]

Very good, thank you

[@hussainbiology]

thanks for appreciation..Glad it helps....✌️

[@tonimartin6954]

Thank you!

[@hussainbiology]

You're welcome!

[@pikagirl..2420]

It was this easy!! Idk what my teachers taught me damn🤦‍♀️ they make things so complex..

[@uttamghosh503]

So easy to learn thank you sir

[@hussainbiology]

Keep watching

[@YanpingSoongNora]

How is TLR signaling shut off? If TLR signaling is overactivated, which diseases of the four types hypersensitivity reactions would such TLR hyperactivity be associated with?

[@gissie391]

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[@auqib_bhat]

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[@hussainbiology]

awaa.. Ahansa ✌️

[@auqib_bhat]

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[@hussainbiology]

@@auqib_bhat Shukriya boi.... InshaAllah jari rehga