TOP 5 Minoxidil + Finasteride Killers of The Future! Watch Them in 2025

[@letsgethair]

🧪 Join Get Hair Lab - The Science-Backed Shortcut to Hair Regrowth! letsgethair.com/lab

[@alexmaverick407]

We need something that blocks the androgen receptors in the the scalp. Not blocking the production of dht. If that happend is game over for hair loss. Something that attach to the androgen receptor so dht cannot plug into the scalp.

[@vinceslapchopper]

what if what you attach to the hair follicule receptor to block DHT blocks other important molecules as well? Like nutrients or other compounds playing a role in the health of your hair follicule? Whatever your approach is, you are going to create potential side effects. There are medications in this world that create far worse side effects than either 5-AR-inhibitors or minoxidil, it's just that people feel entitled to have 0 side effects for a medication that is just for cosmetic reasons. Which is a bit delusionnal if you ask me.

[@alexmaverick407]

​@@vinceslapchopper cosmetic ressons? U know how many peopple feel depressed for dealing with hair loss? If there was no aga peopple will be very happy. And yes u probably right. We dont know what could happend sideways. But we know dht is the enemy when it comes to hair loss. But its not the fault of dht itself. Is what it does in our hair cicles.

[@lightskin8878]

thats what RU 58841 does

[@trollzone1]

That’s what GT20029 does…Matt’s number 1 pick.

[@joshuaeisenberger4975]

Thats what RU-58841 and ketocanozol does. But i think the binding affiniti isnt good enough

[@kaisersoze851]

Your channel is gold, love it

[@letsgethair]

thanks man!

[@paytez]

The biggest problem is the lack of investors willing to invest money in hair loss research

[@Panagiotis1709]

why though? the demand is there. Whoever really solves this will drown in money.

[@richp6716]

​@@Panagiotis1709Exactly. Any company that declares they've cured hair loss or have a cream that makes your boobs bigger AND aren't the biggest richest company in the world are liars.

[@paytez]

@@Panagiotis1709 People and media are talking bad about finasteride. Now imagine an investor reads that stuff. In his mind those hair loss medicals are a threat that won‘t resist very long in the market and on top of that investing in this stuff will damage his reputation.

[@FueHairTransplant]

Great work

[@shubhamchakraborty7904]

They are bald investors for sure

[@radoslavantalik3936]

There are a few of these new releases every year and I've been following them for a good 15 years. There is great hope and only finasteride and minoxidil are still in the game even after 20 years, nothing will come of this, forget it

[@nikolastojanovic7440]

It’s amazing how many great things we could have in the hopefully near future. Say goodbye to AGA!

[@E924kb]

its taking too long! don't want to take finastride, maybe I will try minoxydil if my hair thinning gets worse. But the thought of using it for rest of life is not good news. Hopefully some new therapy with no side effects will come. Hope 4 the best!

[@samweirich5973]

Your hair is looking fantastic.

[@jorgedardon5487]

I'm on kx826 1% twice daily with no side effects. Just a very heavy shed. I truly believe this is a great fin alternative!!

[@harryg812]

Surely that costs a fortune

[@jorgedardon5487]

@@harryg812 It's not cheap. $130 a month. I'll take that over system wide hormone reduction.

[@fatalradius]

Finasteride and Dutasteride works super good already. But the percentage of men getting side effects has been growing while on the drugs. Would be nice for good alternatives.

[@ads94116]

no it isn't if it really grew it is because of nocebo effect and fear mongering like comment!

[@trollzone1]

Finasteride and Duta do not work for everyone. Fin does basically nothing for me and Dutasteride works a little better but caused me side effects after 2 years of usage.

[@Lucatellion]

​@@trollzone1how fin did nothing to you?

[@siemniak]

​@@Lucatellionfor me fin stopped hair loss with a slight regrow at the beginning but after around 4 years it got worse anyway and i was doing fin plus minoxidil plus nizoral.

[@GetLocklab]

The idea of studying moles on babies is pretty ingenious.

[@Malsouthsa]

Fernisteride and Minoxidil spray works like a dream. You just have to start it early. You can't expect to have massive hair loss already and then start the medication. Catch it early and understand what's going on. Go and see a dermatologist. They will inspect your head properly. That's what I did and my hair grew back in 4months and still doing well. Also use a good biotin shampoo, the way to tell if it's good is your finger nails will start to grow like crazy from washing your hair. If you stop fernisteride thought, you are likely to lose your hair growth in about 6months. So that's the downside

[@siemniak]

Bro it doesnt work for everybody and it doesn't work forever (for a lot of guys). I have started it a bit late had an amazing regrow, but after around 3 4 years it really was getting worse whatever i did.

[@moritzmoritz1314]

That's a very good presentation. All mecanisms of actions on one table. I am not sure if scalp muscle relaxation is actually scientifically proven, but without evidence against it, one possible way, what could be tried. Very good. I have heard that Ketoconazole is quite unheathy and causes liver damage. Do you also have studies for every entry? That would be interesting.

[@letsgethair]

@@moritzmoritz1314 ketoconazole shampoo won’t go systemic, so no worries about liver damage. Drinking beer regularly will cause more damage to the liver long term. Botox relaxes scalp muscle when injected. I have seen some nice improvements of this in studies and anecdotally with clients. But the results are bit permanent. Some individuals get used to Botox and are unable to see sustainable results. Scalp muscle tightening is likely a side effect of DHT harmful effects, rather than its cause.

[@moritzmoritz1314]

@@letsgethair Thank for the answer, i will consinder Ketoconazole. I have made a content analysis of the RU from china. The results were quite good and i have ordered new RU from china, because it is quite cheap. Do you think Pyrilutamide will be marketed? Because it is stronger than RU? CB 03 01 is as far as i know already proven by the FDA. But i don't think it is effective enough. I think the receptor is like a magnet and the value of efficacy only says something about how likly it is that DHT binds to the receptor. So RU should be a quite effective. I have also written with Gerald crochet, he did research on RU and can be found on KZbin by the name Antiandrogen1. The molecule structur of Pyrilutamide and RU is quite similiar, do you think, if Pyrilutamide will be marketed, RU will be legal as well or proven by the FDA? There are actually countries, where RU is legal, if the internet is a reliable source. What i am wondering about in the studies is, that Dustateride has less sideeffect than finasteride. I see there two possible reasons, either the studies of dustasteride are better, respectifly the methodology, or dustasteride as a larger molecule doesn't enter the blood-cerebral barrier in the way finasteride does. I have seen the videos from hair cafe from Kevin Mann. He denys the effects of Neurosteroids, but how do i know for sure. I take finasteride, but i don't know if it still works.

[@amirnouri6255]

Have you heard something about verteporfin

[@trollzone1]

Kx-826 has lowered my hair sheds a lot maybe by 90%. I don’t think it will regrow hair but it works better than finasteride for me! I’m using .5% twice a day. I’ve had no side effects

[@letsgethair]

Glad to hear. Getting it from the official supplier Koshine/Amazon?

[@trollzone1]

@@letsgethairKOSHINÉ. Zero side effect and I have a 960 testosterone level. Takes about 2 weeks for it to slow down shedding. So far has worked better than finasteride and dutasteride (for me).

[@uzumaki9899]

do you also use fin or only pyr

[@enigmatics69]

Glad to hear it's working for you! But I gotta say having to apply it twice a day in a shower is just really unmanageable and restricting of faily routine😶

[@trollzone1]

@@uzumaki9899here’s my routine: Minox the last 15 years and finasteride for the last 5 years. Fin has never stopped my hair sheds but did slow it down till recently. I had a terrible shed the last 12 months. Started KX-826 with those products and it minimized my sheds a lot. Between 70-90% less sheds. FYI 3 years ago I also used dutasteride which works a bit better than fin but it gave me side effects so I stopped it.

[@RealMagic1103]

Koshine kx826 gave me and many in the group mad side effects. started with headache and after 10 days heavy chest pains like I never had em on finasteride and libido completely to zero. I had mild sides on finasteride and kx826 was 10x that.

[@letsgethair]

looking for some engagement by overexaggerating?

[@ZukoTheShinigami]

​@@letsgethair How would you know he's exaggerating? I'm having varicoceles even with low dose topical finasteride. Is that an exaggeration?

[@boblully5053]

Bunk pyrilutamide

[@TheMaplestoryGuide]

Yeah koshine gave me headaches and testicular pain too. They seem to have abated with continuous use and 1x daily application rather than 2x. It is interesting none of the safety studies commented on the commonly reported side effect of headache. It makes me question if other side effects are possible.

[@RealMagic1103]

@@letsgethair no man I was in the group many people reported at least headache. why so unfriendly man? chill god damn just trying to inform people

[@Duplex39]

I hope these come soon, finasteride side effects hit me very hard and lingered for a long time. I would still suggest other people give it a go, but just keep an eye out for the side effects. Hoping the treatment comes before I decide to just give up and shave my hair off.

[@nazarionuti]

the truth is "statistically significant" doesn't mean much. It is way more important to have a high number of patients. Anything under 1000 "statistically significant" doesnt mean much.....

[@nazarionuti]

also another thought on the placebo effect: who are we to know whether these people when they go home take finasteride, or minoxidl? I mean imagine you find out you got the placebo, when you go back home how do you know you dont use finasteride

[@JayJayOkocha98]

can you fight hair loss ,with whatever it takes routine that doenst evolve fin.i cant take it

[@Banshee052]

Bro I just want to watch you and I learn english for you I am watching in Turkey thanks for your contect

[@letsgethair]

Great to hear! Tessekurler!

[@John-wl3hu]

Why can’t they just clone hair? They cloned a whole sheep 3 decades ago

[@ivana.3060]

Cancer and follicles created tend to stop growing hair after a few growth cycles.

[@Parallelpipefart]

​@@ivana.3060 what u mean cancer

[@MarkJones-si2bb]

When it says 16.8/hrs /cm2, is that new hair growth, or current hairs becoming thicker? And would that be a 10% improvement, 20% improvement? Thanks. . Other hair channels haven't mentioned this good news.

[@letsgethair]

New hair growth.

[@pierfrancescograziani]

My dermatologist prescribed finasteride gel 1% only twice a week to be rinsed off with shampoo 3 hours after application to avoid systemic absorption, do you think it could be a good dose and is it okay?

[@Dikshant360]

Take the pill instead

[@rgowlikar1]

Give it 3-4 months and assess, your dermatologist is being somewhat conservative which is smart.

[@trollzone1]

@@Dikshant360yup. Topical fin basically does nothing and can still go systemic due to the molecule’s size.

[@AliHamza-sv4ni]

@@trollzone1 you contradicted yourself in the same sentence . you said it does nothing but then also that it can go systemic lmao

[@TukangBotak]

Who is better Minoxidol or rogaine?

[@ErikvanderHeijden-g5s]

They are the same.

[@Nerdy_Aomeba]

Finasteride destroyed me. PFS is the worst! Glad they’re doing things to avoid the 5 alpha reductase and any androgen side of it

[@noonecares29]

How exactly finesteride destroyed you?

[@Nerdy_Aomeba]

@@noonecares29 exactly as the explanation I gave in my comment. Finasteride inhibits the 5-alpha reductase enzyme which inhibits DHT and causing androgen deficiencies. Androgen deficiencies causes issues even directly in the androgen receptors. Messing up androgens causes a cascade of others issues such as neurosteroidal and neurotransmitter deficiencies and imbalances which impair cognitive abilities and sexual as well. All in all your hormones go out of whack. It gets more complex than this as it affects multiple of other mechanisms and processes. It will mess you up pretty blandly in more than one way. For some people they’ll be fine but that is dose dependent and also the length of the cycle. It also depends on where you are hormonally. But a bad combination of these the end results will not be pretty… very nasty syndrome.

[@govindsingh-mc1km]

@@Nerdy_Aomeba so when did you stopped using it?

[@Pala4765467141]

feeling better after you quit?

[@Nerdy_Aomeba]

@@govindsingh-mc1km you get the side affects when it hits you. But when you quit you go through a crash where you feel horrible. For me personally I quit after around 9 days more or less. But that’s just me since I started getting the side affects on day 7. But I’ve seen other that may be on it for months and years and then it hits them. It depends on the person genetics and hormone and the way they metabolize. But for those that go with it for long periods of time I think it’s worse for them. Because when it hits them they continue to take it. Because they don’t think it’s the finasteride. So then they continue and continue and they get even worse sides like PTSD psychotic issues even suicide. All because they can’t correlate it being the finasteride since they’ve been in it for so long and they’ve been fine, that they think it’s something else. It’s really sad and horrible.

[@spamham1976]

Anyone consider the potential investment opportunities associated with Kintor? Is this a publicly traded company? Withh this drug be trademarked ? How can we capitalize on this potential hair treatment breakthrough?

[@deathnote7546]

What to do if 5AR inhibitors (both fin and dut) cause acne on my face? Big, painful and a lot. If I stop taking it then acne disappear, it's related to 5AR and hormones. Anyone have the same experience?

[@letsgethair]

Interesting observation. They are both known to decrease sebum production in the skin. Also Dutasteride inhibits the 5AR type 1,2 activity so I wonder why. I have no explaination besides this being maybe just a transient type of side effect in the short run until the sebaceous glands and 5ar expression balances out in your skin...if not, visit dermatologist

[@joshuaeisenberger4975]

im using topical fin and noticed an increase in pimples on my face/neck. I never had bad acne mostly pimples on chest and back in puperty. Now i have like 3-4 in the face/neck with clean chest and back. its not that much but i noticed it myself before reading youre comment and now im pretty sure it has something todo with the fin

[@Hojjiifp]

There are minimum profits in this treatment.

[@Fraghound]

I'm so alpha, my body doesn't even produce TGF Beta.

[@letsgethair]

Explain then, why is world's biggest alpha male Andrew T bald

[@Fraghound]

I was just kidding. I'm actually on finasteride for about two years now and I'm saving money for my first hair transplant. I will need your help next year in picking a good clinic in Europe.

[@joshboston2323]

@@letsgethair ---I don't see anderw tate as "the world's biggest alpha male". He is terribly insecure and you can see it in his video's where he is bragging away. Someone who is bragging always has an underlying insecurity.. anyway, great video and thanks for your effort as always Matt.

[@saerrusfata286]

Have you checked regenera active ? Its seems to be quite effective

[@letsgethair]

It has been around for many years. It is safe but not as effective tbh, I consulted many clients who had used it in the past