TRT Doses | How Often or NEVER? | All You Need with Dr. Rand McClain

In this video, Dr. Rand McClain sits down to talk to you about the pros and cons of dividing your TRT doses. There is debate on whether splitting up your TRT dose is beneficial or detrimental. Dr. Rand gives his insight and recommendation on whether or not to split up your does. Dr. Rand McClain was recently interviewed on The Mind Pump Podcast: Episode 1607
You can watch the full episode here: • 1607: How to Optimize ...
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Tags: TRT,Testosterone Replacement Therapy,Testosterone Therapy,Safety,Risks,Health Risks,Steroids,Anabolic Steroids,TRT Long Term Effects,TRT Side Effects,Side Effects of Injectable Testosterone,Injectable TRT Risks,TRT Therapy Health Benefits,Can TRT Help Cancer,TRT Benefits,Testosterone Replacement Therapy Benefits,Health Risks of TRT,Are There Long Term Effects of TRT,Are There Side Effects of Testosterone Replacement Therapy, How To Take TRT,How To Injects Testosterone, Oral Testosterone, Oral TRT, Injectable TRT, Injectable Testosterone, Testosterone Cream, The Best Way To Do TRT, TRT, Testosterone, Testosterone Replacement Therapy, Replacement Therapy, Ask The Doc, Dr, Dr Rand McClain, Hormone Dr, TRT Dr

[@Total_Body_Fitness_USA]

Dr. Rand states that all we have to do is give anastrozole if E2 increases due to once per week injections. So, let me state my experience as a medical professional in integrative functional medicine that specializes in TRT for the last 3 decades. The reason someone may feel better about 50% of the time when doing once per week injections vs every other day or more frequent injections is because of dosing. For example, you give someone 200mg of testosterone and you drive their total T through the roof, lower their SHBG which in turn drives up free T and E2. The patient feels great for a few days and then they do it all over again so they never really feel bad. This protocol may be okay for someone that is healthy and fairly young (not over 50) or so. However, in a patient that is older, you end up with super elevated DHT which can cause major problems with the prostate and significant hair loss, and even acne for some. You also end up with a significant increase in RBC count and hemoglobin/hematocrit levels. The idea is to mimic what the body naturally produces to avoid over conversion in the first place. If you don't feel as good doing more frequent injections it's because you need to either inject more testosterone per injection OR you have other hormones that are low such as DHEA-S and Pregnenolone. Check your SHBG and dose/inject accordingly. If SHBG is high and you are just starting out on TRT then you can dose high once per week and then taper off to EOD or even daily. If SHBG is low and free T is above the range, then you most definitely need to be dosing more frequently, especially if you are overweight or have some liver issues and have problems with conversion of too much T to E2 due to aromatization. Also, estrogen is protective, so knocking it down with AIs will cause your HDL to plummet, cholesterol to increase, along with joint and muscle aches. Another thing is that estrogen helps your body get rid of old blood cells which also helps to keep RBC count in range. Also, if you donate blood you will in turn crash your ferritin levels over time which then results in lower iron levels. This causes your body to release more erythropoietin which in turn increases RBCs. So, if you have elevated RBCs, hemoglobin, and hematocrit, the thing to do is check your ferritin and if lower than 30, supplement with Ferrochel. You can also sleep on grounded sheets which in turn decreases hematocrit and improves blood circulation by reducing RBC aggregation. Taking supplements like Nattokinase and Pycnogenol also work out great especially if you are prone to DVT and your RBC count is in the upper end of normal or out of range. A lot more to this, but just wanted to point out some things.

[@Vel_Plays_2.0]

Thank you

[@rayshoesmith]

Excellent information, thank you.

[@jason1040us]

Great info DOC! This is a really complicated thing no doubt, seems nobody has this thing nailed down, so many different scenarios with alot of people facing different genetic reactions in their body.

[@dansullivan1983]

Great info! My hematocrit it just above acceptable and been donating to keep it in check without hurting my iron to where it's too low but my TRT has been lowered for a few years now and still having this issue. They keep me in the 500-600 range which I hate but I can't be running around with motor oil in my veins. I have to try some of these suggestions.

[@gamevidz8763]

Should I take it once every other day once a day? Or every day?

[@RealMattKiefer]

Completely disagree, splitting dose 2x weekly, every 3.5 days I feel entirely better than a 1x a week massive blast of test that starts to waiver as the week winds down and I approach my next shot; Twice a week I feel way more “balanced” It also requires less AI use at least on my behalf.

[@dennistaekema9177]

Me too, My wife can tell right away when I am not splitting my dose. I have also way fewer Estrogen side effects.

[@brianweatherman1207]

Same same! I inject every 3 days and I'm already doing way better. In my experience doctors are worthless. Especially the ones that won't allow the patient to teach them something new.

[@heavyhitter2193]

Less AI use? lol you shouldn’t use any AI on TRT your screwing your health using that poison

[@nl3712]

@@heavyhitter2193 explain please? AI = aromatase inhibitors, right? I thought they reduced cancer risk and gyno

[@Slazbob]

Agreed…he’s incorrect by far. I’m every day dosing and zero sides after 3 months. Why do it his way and need an AI? I’m surprised at his advice, actually.

[@gameboyinc4694]

Definitely less bloat, less acne and feel better when pinning every 2-3 days

[@scotth5186]

What mg are you pinning every 2 to 3 days

[@andreluizpostigo848]

That’s what I do .. 100mg every 3 days

[@samiryan214]

@@andreluizpostigo848 thats would be 200mg a week !!!

[@_NOLA_-je6nd]

Same less acne for me when I pin twice a week

[@nathanhill8448]

A lot of guys say that by day 6 after injection they’re feeling down. Also, you skimmed over the biggest argument guys have, and that eliminating the need for an aromatase inhibitor.

[@krane15]

I suspect that these guys don't know enough to know what they feel. What is down? In the morning I feel more energized than I do in the evening. Is that a bad thing?

[@alexandershelbayeh3983]

It's okay to use a little bit of an AI. I think people over do it. I take one dose of .75 mg arimidex once a week on shot day which is 100mg test and my estrogen is perfect. No one on here is talking about the invasiveness of pinning all the time either

[@nathanhill8448]

@@alexandershelbayeh3983 really good point about pinning every day and adjusting the AI dose. Great input.

[@TheJ000ker]

I might suggest letting your blood pressure be your guide. If you’re injecting so much that your BP is high, (with BP meds). Lower your dose, split your dose or what ever it takes. After you adjust, try increasing as you go to build a protocol that works for you.

[@ronpaul9172]

Very happy to hear this. I was prescribed twice a week subQ. So far, I haven't felt a difference. I was diagnosed with a prolactinoma and have been running 81ng/dL for years without realizing it. :/ Hopefully the subq works over the next few days. If not, I may ask to switch to intramuscular and weekly instead of twice weekly.

[@antho22wateva]

Not really selling the idea of once a week injections is he. "Yeh we will just throw in more drugs to counteract estrogen". No thanks

[@qsdailydose8970]

I don’t want to take AI but still having issues on 24mg/wk idk if I should increase my dose or decrease my dose TT 1139 (250-1100) FT 273 (46-224) DHT 105 (12-65) TSH 2.13 (.4-4.5) E2 46 (

[@danh2310]

Exactly haha he must get commission on anastrazole

[@qsdailydose8970]

Dan H I’m not sure if I should increase or decrease my dose I’m on 24mg daily and still having issues I also take calcium d glucerate and dim here are recent labs: TT 1139 (250-1100) FT 273 (46-224) DHT 105 (12-65) TSH 2.13 (.4-4.5) E2 46 (

[@thesig301]

@@qsdailydose8970 24mg/w isn’t the normal dose usually 100-150/w

[@qsdailydose8970]

Elon I’m sorry I meant 24mg daily (168/wk) still having issues idk if I need more test or less

[@rmedina1886]

I've been on trt for 15 years. Started at 100mg once a week. For the past 10 years I've been pinning twice a week. I felt no difference, but my crit and hemoglobin went back to normal levels. My test ranges for 700 - 900. Please remember "free testosterone " is what matters. My free is in the 20's.

[@anasdaouk7096]

What is your weekly dose now?

[@gamevidz8763]

Should I take it once every other day once a day? Or every day?

[@gregmandriota6106]

Everyone should be "micro injecting" now and splitting the dose even Monday Wednesday Friday ⅓ of the dose each shot makes you feel amazing been doing this 20 years

[@CaneFu]

I have experienced exactly what this doctor is warning about and he is absolutely correct in my case. I cut my dose in half but started injecting it twice as often and here is what happened... 1) My libido went down 2) My morning erections ceased happening. 3) My SHBG went up 4) My free testosterone went down All of these things were negative consequences and so I returned to once a week 200mg dosing and everything improved again.

[@jeffreypetree7163]

Ya my doctor has me splitting the 200 mg a week but I'm not feeling it but it's only been month in to it . But I think I want to switch and do the full dose 1 time a week . I want full benefit of the testosterone , don't want to lose it's effectiveness by splitting it up . Mine Cost to much .

[@CaneFu]

@@jeffreypetree7163 Yeah, we're all different. As near as I can tell this might be the case.... 1) If you have high SHBG inject the full dose once a week to lower SHBG and increase free testosterone 2) If you have low SHBG then split the dose up into 2 or 3 smaller injections over the course of a week.

[@andres7196]

Same here going back to once

[@redefv]

I respect all opinions here. Personally, knowing the half life of a singular injection I like twice a week. Funny I do suffer from OCD too. I do right side Sunday and left side Wednesday.

[@chadpennington4594]

Actually, switching is good. I do glute one week, shoulders the next. twice a week as well.

[@dougdebaillon9862]

Simply put............it's different for everyone. Why do you think he said it helps 50% of the time? That means the other 50% works for them also. It's just a process that needs to be figured out for each individual. And saying that you don't need AI is BS. Some people can get away with not using them but others really need them. There is no one-size-fits-all when doing TRT.

[@johnmclaughlin4802]

Very interesting 👌

[@whitenoiseandrelaxation4051]

What's his thoughts on 1 pin every 3 months nibdo 1000mlg is the trt choice we have in the uk on the NHS

[@13Ambro]

I started off on once a week injections but then followed the new guidance and switched to twice a week, then every other day, every third day, even every day in an effort to keep hematocrit and estradiol under control. Guess what -nothing worked for that - I always wound up having to take an AI to bring down estrogen and my hematocrit always ran over 51. I recently switched back to once a week injections because I just felt better on it

[@mv2873]

You could possibly have sleep apnea.

[@clifton6919]

What is your dosage?

[@13Ambro]

@@clifton6919 I actually went back to a shot every 3 days - 40 mg Test E3d along with nandrolone for joints (dose varies from 40mg-120mg per week because I wave the dose every months). HCG 300 IUs along with Test shots. This keeps me in the upper 800s ng/dl Total and about 27 Free T. The reason why went back to splitting the dose was a few months ago I added 100-120 mg of nandrolone back to the protocol and I didn’t want to take ~200mg of total androgens (test plus nandrolone)in one shot

[@clifton6919]

@@13Ambro ah oke, thanks. Nandrolone destroys my libido, even at 50 mgs a week..

[@13Ambro]

@Dakine it would not help with joint pain directly - but the additional strength would be beneficial to joints if you work out. Nandrolone with TRT is amazing for joints.

[@mrmartinez4188]

The dock was saying, taking anastrozole and injecting once a week. How much anastrozole is recommended? Thanks

[@fishman80]

100mg every 6 days been good for me no issues love it

[@alexandershelbayeh3983]

Same bro. keeps me on point

[@albertsteptoe3710]

Any change in size are you not working out ?

[@MrMrBurnablunt]

Habe questions about what's ways or injection I can get to build more muscle and loos fat

[@robertmarshall531]

Unbelievable this is not what I have experienced whatsoever. I believe your advice is a danger to many men trying to feel normal again

[@Victordecross]

Yet the man works with all bodybuilders who 1. Look good 2. Feel good 3. Have healthy lives, kids, and dont get problems. While others self treat, and experience all the issues. This Docs advice is saving kids who pin for whatever reasons with never learning how the world works.

[@thomasjusinski7286]

I've been on TRT at 1 cc a week 200 mg, of testosterone cypionate for 9 years now. I do one shot a week and I feel great My sex drive is good I wake up at wood everyday and get wood for no reason sometimes four five six times a day or more. My energy levels are great and that's at 58 years young. But everybody's different but like I said one shot a week and I'm good, good luck to everyone and God bless you doctor.

[@xAzaar-]

do you take any aromatase inhibitors or estrogen blockers?

[@thomasjusinski7286]

@@xAzaar- I haven't needed any, I get my blood work every 3 months and it's been good thank God. Good luck

[@thomasjusinski7286]

​​​@@xAzaar- but I do have arimidex on hand, just in case. I have a really good doctor thank God. He will prescribe me whatever I need, as long as it's legal. I'm not talking about painkillers or anything stupid like that, but anything I need for my TRT , Happy New Year and God bless.

[@anasdaouk7096]

Why cypionate not enanthate? Cypionate got heavier ester

[@dilligaf2386]

I'm 55 don't have any problems sexualy but feel tied week pissed off sometimes my joints and muscles hurt. I'm thinking because I'm fine sexualy my testosterone levels are fine, but am I think correctly?

[@george9467]

First of all the dose and thus the frequency of pinning depends on the test and ester you are using. Its going to be different for enanthate and propionate. Test enanthate which is 250mg/ml (180mg actually, rest is the ester, ) will be totally different than test prop which could be lets say 100mg per ml (80mg actual test, rest 20 ester). So if you want around 120mg per week and you are using Enanthate then you ll split 1ml in about 3 equal doses (180/3=60) and use just 2 doses during the week. I dont really know what works best though. One shot with the whole dose or two split shots? I am really concerned about this issue. It appears that its better to split it because of the half life of the drug. Enanthate half life is 4.5 days, so i believe its better to shoot every 4 days so it goes up again and not every 10 days or even worst 14 days.

[@davedunn7759]

No doctor is going to factor in ester weight with dosing protocol. They ALL go by the label. I totally get where you’re going with this but it’s basically irrelevant. Imagine the confusion with room temperature IQ people trying to break down Sustanon actual weight then into multiple weekly doses 🤔👍🏻

[@jjmarcos]

@@davedunn7759 never knew this was a thing, could you explain the ester/test breakdown a little more? Am I not actually getting 250mg/ml of testosterone with cypionate or enanthate??

[@davedunn7759]

@@jjmarcos Enanthate and Cypionate at 250mg/ml will net approx 170-175mg of actual test. Propionate is higher at around 80mg/ml based on 100mg/ml. If you Google steroid ester weights you should get a chart showing the exact % for every ester.

[@jjmarcos]

@@davedunn7759 Thanks for the info. I'm wondering why this is never talked about in the bodybuilding forums though? If you wanted to do a 500mg/week cycle It seems like a pretty substantial deal if your 2cc's only contained 340mg of testosterone. Thats not a small difference! Every beginner guide always contains meticulous details about the whole process, I would think a huge detail like this would be included.

[@davedunn7759]

@@jjmarcos I guess the way to look at it is that every reference to “500mg per week” always means label weight not actual active ingredient weight. I’m sure this applies to all medications as well. It’s noteworthy though that testosterone suspension is actually 100mg/ml as water takes up no weight.

[@mikecara8181]

Clinics often use Anastrozole ….surprising you seemed in favor….Most docs who seem to know don’t think it’s good and in fact can be toxic. What do u think?

[@ephraim1995]

I'm doing test cyp every day micro administrations , feel the best this way I don't need any aromatase inhibitor

[@conroybent4586]

What dose are you doing

[@ephraim1995]

@@conroybent4586 200mg /week 28.5mg Ed

[@jayswanvguitar2570]

I take testosterone Cyp. Every 3 days 65mg is that ok it seems to be working well

[@gif24gt60]

Does dim or calcium d glucarate shuttle the estrogen to the favorable 2 hydroxy pathway versus the undesirable 16 hydroxy? I cannot find anyone or any website for the correct answer? Any thoughts?

[@Total_Body_Fitness_USA]

You should check it first to see if you have a problem with conversion to bad metabolites. I recommend the Dutch Test. However, to answer your question, there is a supplement I recommend and it's called EstroDim by Orthomolecular products. Taking a low dose of progesterone daily is also protective and if you have prostate issues like BPH you can use a cream applied to the perineal area nightly because it acts as a 5 alpha reductase blocker. I've been in the health field specializing in integrative functional medicine for nearly 3 decades. A lot to this, but hope that answers your question.

[@stevewilliams8275]

M

[@robwithrbk]

I don't know anyone that's had a negative result from 2x injections a week. I know several people that have had negative results from a single injections (sensitive nipples, sluggishness on days 5-7, etc).

[@7THxSIGN]

Tried numerous protocols. SubQ ED and EOD was without a doubt the worst. Twice a week IM is perfect, for me.

[@Systemlord30]

Dr. Rand McClain I have a question, I’m on Jatenzo (237 mg twice daily) and my peaks are around 800-1000 ng/dL, (SHBG 20) and my troughs are usually around 300 ng/dL at 12 hours. My question is why do I feel the same all the time if my levels are dropping low?

[@TheGareth77]

You're lucky you aren't super sensitive. Jatenzo will give you benefits for days and days even if test levels dropped say you ran out of pills, you'll still feel OK for about 2-3 weeks. I've been there

[@Systemlord30]

@@TheGareth77 I recently stopped Jatenzo for two weeks, no huge crash and my HPTA fired back up after only one week. I confirmed it, LH 1.4, Total T @ 81. I went back on TRT. This is after 7 years on TRT with an 8 month break within those 7 years.

[@Majnun74]

Can I take natural supplements (Tongkat Ali/Fadogia Agrestis ) to offset the side effects of microdosing TRT?

[@JE-gy4ew]

Why on earth would anyone opt to take an ai instead of just dosing more frequently? When I started with TRT I did one weekly shot and my E2 went really high. By doing it twice a week I don't have that issue.

[@DeRock401]

Love how we got janitors at Applebees in the comments saying this DR doesn’t know what he’s talking about. This guy is literally a testosterone EXPERT lol.

[@chelious1973]

😂 I know. Hahahaaa

[@MaddenMagician]

Although I'm not a medical doctor I have multiple doctorates and have researched this more than this guy guaranteed my doctors are in research this guy is told what to do by companies that's how medical doctor works they're not real doctors did I conduct research or create new research in the field that's a PhD. If you want to try to avoid an aromatase inhibitor take it twice a week it's not a guarantee because it's patient sensitive but if you take it once a week you are definitely getting an AI PERIOD it's not rocket science but there's someone with your IQ I can see how this might be difficult and almost seemed like got you prehistoric brained people are so cute

[@soggybottomfarm2575]

So what if the guy that works at Applebee's has been on trt injections for 15yrs and has tried every which way of taking testosterone so NO that wouldn't give a reason to speak on his experiences. This is whats wrong with America's health care system now people take the words of Dr's as Golden when in all there really not good Dr's at all, or old and not up to date with latest protocols

[@albertsteptoe3710]

If I done 1ml or 200mg per week for 12 weeks and trained at gym would I develop a Good mucle and build ? ( in gym 5-6 day a week ) . Aslo will it ruin my normal sec drive as I’m taking this just for physique purposes ? .

[@NEWCHAPTER-gp2xf]

With proper dieting as well. Absolutely! I recommend if you're planning to be on it, you should stay on it.

[@michaelsteven8143]

I recently switched from once week injection to every other day injections, and it’s been fantastic for me actually, I would do once week injection and feel amazing again and the next day feel okay but not great and the next day feel like garbage so you can imagine how I felt on day 6-7 ( horrible). I’m still doing IM injections just because idc about sub Q TBH , rotating between deltoids, ventral glutes, regular glute area, and biceps if I have to and so far it’s been great, the only thing I’ve noticed is my estrogen levels have shot up significantly since switching to every other day, so I’ve gotten some arimidex and letrozole for that reason and I hate to have to take them cause they make you feel like straight garbage zombie mode when you’re on either, not taken together obviously .

[@vinny6967]

Do subq every morning, that's what I do now on trt way better than peaks and troughs as you get doing it longer in-between

[@northjapanfighters5211]

Because "microdosing" will give you a flat line free T..whitch is the opposite to what naturally the body works..now its aromatizing overtime.

[@HarleyBreakoutGuy]

what does this mean conversion to astrogen? is that like female hormone?

[@icon5892]

I do mon and thur shots. I tried once a week and i did notice my libido was higher with once a week shot.

[@vrsimulo1234]

Same,feel much better

[@gamevidz8763]

Should I take it once every other day once a day? Or every day?

[@stewartclark8760]

I've tried once a week and twice. Couldn't feel a difference. 150 mg test cyp shot on Monday morning then 3mg aromasin taken on the Tuesday.

[@krane15]

I suspect that some people do, and some don't. Its not unheard of for doctor to recommend splitting dosages of many medications for some patients where the full dose all at once is too much. With others, there's not need to do that.

[@gamevidz8763]

Should I take it once every other day once a day? Or every day?

[@derrickmoon3296]

150 is pretty high remember a 20 year old male produces roughly 26mg every 3 days naturally.

[@jasonerickson1033]

I take 200mg shot a week my blood test came back with my t level was 1003 I’m 46 years old is this to high I feel good but my dr. Thinks it’s to high I don’t think it is I take my shot once a week what do u recommend

[@midotvadventure504]

Did you lose weight and gain noticeable muscles? Are you on a diet and exercise? I mean doctors always go against the “longevity” treatments so consult your primary Dr and your TRT doctor about the confusion. Good luck friend

[@mattarndt4452]

1000 isn’t necessarily too high. Check your labs though.

[@MrMrBurnablunt]

Who do. You guys use for you trt or hg injection.. Im. Trying to find a legit place to help me lose fat and get bigger I'm starting my journey into bodybuilding and also know that I need testosterone replacement definitely I need a good place to either buy my testosterone and supplements or a doctor that will help me optimize all of these anyone having you suggestions on a good doctor or place to buy the supplements

[@lamrossmatthews]

I disagree, I have tried everything from weekly to daily and for me the best is 3 x week. I feel better on 3x a week than even 2 x a week .. however everyday i noticed no improvement

[@johndoe-ie1be]

Every other day... i can tell you with 100% honesty IT WORKS !

[@coldsmokepwrstroke]

Trt ten years now. I like enanthate 80mg twice a week. Once a week is fine but twice a week seems like everything is even more balanced. Every two weeks is too long. Over 200mg a week I start to get side effects.

[@mohamadrezasoltani9126]

What side effects? And are you lifting ? What about testicle ? Are they going small?

[@erock5010]

Cynthianate any good? What's the difference?

[@AmnesiaxBeats]

E TOWN CONCRETE 😤😤😤

[@brianm4108]

100mg every seven days and at peak I am at a 1200ng level. Feel fine through the week it all depends on the individual. I was at 105ng prior to TRT. Thank god for TC…

[@cristobal.palmero4919]

Only 100mg every week?

[@sdfds1973]

@@cristobal.palmero4919 with enanthate sure the peak

[@user-wq7dl8lu3t]

Can someone suggest or point me in the right direction in terms of how much I test I should be injecting as an athlete for enhanced athletic performance?

[@carsonholdren9019]

More info bro plzzzz

[@jonasmarkuslarsson]

Why use anastrozole with side effects instead of changing the frequency?

[@niltomega2978]

I use to inject every two weeks and went to once a week. I really could not tell the difference.

[@abdelbachirlegrand5163]

what do you take to thin the blood under TRT and at what dose ?

[@robwithrbk]

You take less T bud.

[@ChristiannTyler]

I’m prone to gyno so I’m wondering if more frequent doses could help? My doc doesn’t offer nolva.. even with an AI I feel the nips getting tender

[@Semaj.18272]

I’m the same honestly try once a week of sustanon And okay around with the dose

[@northjapanfighters5211]

Nope it wont..

[@michaelmontana0804]

Need a little thought here. Doc wants me to start at 160 a week. Seems a bit high to me. Total T 563, Free T 38.

[@johnnyfontenot2999]

My total T was at 188 and free was at 4 and they started me at 100 every 2 weeks.... Now I'm at 200 every 2 weeks, I'm not a Dr or a professional but your free test is really high and your total T looks pretty good to me so idk why they even gave you trt to be honest. I guess it depends on the Dr but that injection amount sounds high to me but good luck with everything. Get a 2nd opinion my man

[@SteelSlugProductions]

This is an easy fix. Just do it WZ/MW3 style. You can swap weapons from your loadout, but the swap doesn’t take effect until after you Rez or end of rounds.

[@MrGladiator241969]

I am on TRT from urologist he has me taking 200mgs of testosterone Cypionate ever 2 weeks. My levels went from 213 to 906 in 1 month. The issue I'm having is my anxiety is off the charts I believe it's from testosterone going up and down making my mind on a roller coaster. I think q times a week or 1 time a week is a better dosage for me but the doctor says that's to much well then how do I combat this issue?

[@bradleytik8885]

Bro that’s not cool. You need to air this out with your doc or change them. The benefits of your test being elevated are completely shadowed by poor mental health now. Hope it works out for you man.

[@adambernon6930]

You're having anxiety bc your test numbers are spiking then cascading down after a 14 day administration. I agree with this doc on most things but it is pretty much settled science that smaller doses administered more frequently can reduce side effects by keeping serum levels more stable. This is not an anedote or an opinion. It's what it is.

[@nickcazares2024]

I had a similar problem, I always took 200mgs once a week and always had mild anxiety and just thought it was normal but got worse overtime. I know split my dose to 3x week at 40mgs and notice a big change in anxiety and panic attacks. My numbers were actually better on the stable dosing obviously . But on 200mgs my levels were 2400 after day 1 of injection and day 7 test levels dropped to 900. So it’s quite a yo-yo of test levels on once a week injections. But less is more in my opinion and not one shoe fits all.

[@stephenpospahala2767]

I can only assume that this doctor likes to hear his own voice as he offered 1 piece of advice and then said he can’t explain why

[@duvalcapozzi5328]

How do I connect with Dr Rand. I

[@dansmith9724]

I can't tell the difference between once a week and multiple times a week. After several weeks the blood levels build up and become more consistent anyway.

[@gamevidz8763]

Should I take it once every other day once a day? Or every day?

[@dansmith9724]

@@gamevidz8763 for trt I'd start with once a week. That was the main reason why they used an ester to slow the release of testosterone, so there's less injections. If more frequent injections improve things then go for it.

[@WalletInvestUSA]

What dose are you guys taking per week ? I'm taking 160mg... 2 times a week. 80 Monday and 80 Friday

[@maodanz1672]

125 every 3.5 seems normal 169 lbs 60 yo 9% bf 3 workouts a week

[@mrofnocnon]

Very large dosage

[@WalletInvestUSA]

@@mrofnocnon I’m taking 100mg week now

[@mrofnocnon]

@@WalletInvestUSA I take 120 mg in 3 doses per week of 40 mg. I have tried several variations. Once a week does not feel quite right, neither does twice a week. Perhaps my dosage it too high or too low. Its a tricky business getting this right.

[@mrofnocnon]

@@WalletInvestUSA Yes me too. 50 mg split dose every 3.1/2 days.

[@bobdoyle5945]

anyone use hcg here? i hear you need to do it 2 a week.. i rather just do it once.. does it matter? say 1000 iu weekly as protocol with 100 mg cyp per week as trt

[@chadashton7029]

Or just split the dose and not have to shove more meds into your body. And there's a LOT of people that will say they had issues on 1x week and feel better on split doses.

[@AprilLovesDIY]

Well if it’s not about the numbers but instead symptoms. Swelling and fluid retention. And weight gain

[@The_Handsom_Italian]

Don't agree at all with crushing estrogen. We need healthy levels of estrogen so atleast twice a week to keep that at a healthy range

[@DDDD-of3hv]

T has had more negative than positive results for me. Peptides work better for me. Again this is me. I did feel better when i split them up. I think this is a personal thing as we react differently. I also used Depo-T and felt better on that one, but again still negative. my main negative was mood swings, hit me one day and we are brawling, i get that real :fight" mode instead of flight. i didn't like that. to me, the negatives outweighted the positives, but man, some of the positives were just so awesome, it scared me at time, talk about feeling 25+ years younger... NAD+ and MOTSC i feel do a little better for me, but again, to each his own

[@HarleyBreakoutGuy]

i am 57 and i take sustanon 250 once per month, could i go once per week?

[@EJfromNYC]

isnt the life span of sus like 7-12 days? I dont get why they would put you on anything longer than every 2 weeks? but everyone will tell you at least once a week. the rest will go even further and do twice a week, some every other day or micro dose every day.... so confusing. lol

[@HarleyBreakoutGuy]

@@EJfromNYC ahh i didn't know it's only 7 to 12 days, even the doctor said to me the 250mg is very low dosage. I am going to try every 2 weeks next. Thanks for the info.

[@HarleyBreakoutGuy]

@@EJfromNYC i dont use sus for muscle mass or gain, i use for sex drive.

[@alexsoules3760]

Just curious, if I still have testosterone but I inject a small amount, 80 mg in a week, does it shut me down?

[@rackpull772]

Yes

[@alexsoules3760]

@@rackpull772 Thanks Joe :)

[@JetMan35]

Yes

[@Victordecross]

Good stuff! But the reasoning behind splitting injections is most likely because people go heavy on coffee. Coffee releases dht, lowers shbg, stimulates cortisol and estrogen. (If you ever take 200mg of caffeine and a cup of black coffee the reason why you get 10x more boost from coffee is because it releases free T, lowers shbg, and increases DHT, Estrogen and Cortisol (often balanced by dht inhibitory stress effect). This creates far more adrenaline and estrogen. ) Then when you eat a meal and push everything inside of cells (from outside stimulus - neurotransmitters+hormones, to inside - production/effect), the body becomes slower from cortisol and sensitivity feedback loop and metabolism slows down. So not only you use up more Test from release in the blood, but now anything that is being released later in the week is not enough to keep the energy going. So replenishing more frequently gives few spikes rather than a big 1. And if you add sugar to coffee you release even more hormones, even more estrogen, which later turns into cortisol breaking down all T… Diet is a major factor. This Doc works with professionals alike, and may give his advice to different individuals, BASED on blood numbers

[@santiagogold446]

I went from 1 dose a week to 3.5 days to every other day. I spent a lot of time on all three. I like every other day. Dose had to go down from 200mg to 105. I keep a steady high normal level, which means less acne, and no need for an AI because levels are within range, and I still have the benefits

[@earlusmcdivett]

pinning every other day on testosterone is ridiculous and there is absolutely no science to backup your claim. It’s all in your head.

[@santiagogold446]

@@earlusmcdivett yea ok Dr Science. I have no acne anymore on this regimen. I’ve done multiple months of blood tests to dial in my protocol. My E2 is within normal range- 30. Total T is 810. Free T is mid twenties. SBG is low twenties. There’s your science champ. I don’t know where you’re coming from, but it ain’t from intelligent.

[@petercsigo3314]

@@santiagogold446 punk

[@rickterrance4981]

​@Santiago Gold you're saying you do 105 every other day or every other week?

[@TriggerTravels]

​@@rickterrance4981I think what he means is 105 per week instead of 200

[@warriorwarrior6999]

I take 1cc 200 mg every 7 days once per week injection. I have split it up into 1/2 cc 100mg injection on Tuesday and 1/2cc 100mg on Friday. There’s no difference. If anything I feel worse by splitting it up. 200 mg once a week injection is what works best for me. Besides test cypionate peak last 7 days and actually last up to 14 days but one injection every 14 days will have a roller coaster effect.

[@robwithrbk]

My numbers fall of a cliff after just 72hrs. On a single injection of 120mg, I peak above 1000 but my trough 4 or 5 days later is sometimes 300-400. When I do two injections a week, I'm always around 575-750 ng/dl peak and trough. I have plenty of friends on one shot a week and plenty on splitting doses 2x a week. You simply have to do what makes you feel better. My clinic doesn't chase numbers. They follow symptoms. I could probably be on a higher dose at another clinic, but I feel pretty good at my current dose, labs are down the middle every time.

[@CaneFu]

warrior6999 I experienced exactly what you did when I split my dose in half so I went back to injecting the full 200mg once per week and feel better. In particular when I split my dose my SHBG shot up and my free testosterone dropped so apparently some of us need that bigger dose taken all at once to get the full effect of it.

[@Semaj.18272]

He made sence when he said you only think you feel Better is because wen you object again you body’s natural haemostats goes up or along thise lines makes sence

[@elfazzz6640]

Will I lose my hair if I start on trt. Im 41yrs old and still have a good amount of hair.

[@derrickmoon3296]

Not if the dose isn't too high

[@edwinhermanson8842]

One injection per wk works just fine for me. And believe it or not 60 mgs per wk works good as well. Very good sex drive and fairly even. Good results at the gym too. As a small time older bodybuilder I am happy with the results I get from such a small dose which BTW is all can handle without having blood work go bad.

[@necessaryJustice_4all]

60mg or 60 units?

[@clifton6919]

@@necessaryJustice_4all testosterone dosage is in mg.

[@necessaryJustice_4all]

@@clifton6919 Sure. But in the community it's referred to as both. 👍

[@repliesoffcuzimright1679]

What is your total and free T with that low of a dose?

[@erock5010]

That's exactly what my doctor just recommended for me. 60 mg twice a week, even though I want to get bigger I'm going to drive this for a good while before I up the dosage

[@dump3deg6]

Maybe someone can answer this. I’ve been on 100mg weekly for a little over a month and haven’t felt anything in energy or libido or anything. My beginning test level was 54.5 (I’m 36, which is super low).. when should I expect to start feeling the benefits?

[@recPokerFish]

you should be feeling it after a month ......your dose might be too low ...i started about 6 weeks ago at 200 mg a week ...im 58 and my overall test was 375 ng/dl when i started..i started injecting twice a week..honestly i started feeling the effects after 2 weeks..i am now injecting IM .30 mg every other day ..libido energy and body composition have all improved alot..not sure what numbers are now...will find out next week.

[@fitodaking16]

I was at 200mg every 2 weeks, then after 6 weeks, I switched to 100mg weekly. That didn't help at all. It made stuff worst. So now I'm at 150mg weekly and feel okay, better than before for sure. Depending on my blood work next week, It might switch to 200mg weekly.

[@bigbadbootydaddy616]

ive just taken 1.5 ml of test enthanate, planing on doing this every 7 days.. im looking to heal 9 broken ribs and gain a little muscle. Do you think i will need estrogen blockers at this amount?

[@robwithrbk]

Probably. That's like 300mg. That's a hefty dose and if you're not careful, you could have adverse symptoms or even gyno. It's been 3mo, how are your labs?

[@xanthromera]

This is insane advice.

[@krane15]

Because?

[@xanthromera]

@@krane15 I love this doctor, 99% of his advice is fantastic. There is really good reason to split TRT shots in to twice weekly. You have peak serum on day 2 and then by day 7 you can feel flat. I know this from myself, friends and papers I have read. Doing larger shots every 7 or 10 days will cause greater spikes in estrogen and may require you to take an AI like anastrozol which is talked about in the clip. Why add another chemical into your system? Do shots more frequently and remove the requirement for an AI and level off your hormone profile. I think these guys are concerned that patients will not adhere to injections twice weekly because it is not a pleasant experience. Once a week is easier for sure. I do shots every 4 days and don't notice any swings.

[@axiom4018]

Too much bro science out there.

[@krane15]

@@xanthromera Doctors will always be concerned with liability, which will always encroach on their ability to be totally candid with their patients.

[@adambernon6930]

@@krane15 He's right. He's relying an ancetodes and even admits that more frequent dosing schedule can potentially eliminate the need for an AI, which by the way has it's one toxitity and side effects. Keeping serum levels as stable as possible with a more frequent dosing schedule is always ideal. Necessary? No, but ideal 100%.

[@lsmithbsbll]

For me I figured out beyond a shadow of a doubt … my body doesn’t respond to pins less than .2 ml at once , regardless of the weekly dose or frequency

[@lsmithbsbll]

If I pinned .2 daily I would be on a huge cycle .. if I pinned .19 daily I’d be completely surpressed , if I pin .2 every 3rd day I feel great .. very strange

[@ScottDreyfus]

I just want twice a month not twice a week. The falloff is so drastic by the end of the month. I'm tired of this Rollercoaster. I'd like to just coast. Update going every 14 days now but flat out of gas by day 10. I want to close the window even if it means going down in dosage

[@mrofnocnon]

Try once a week.

[@ScottDreyfus]

@@mrofnocnon it’s been a year I’ve gone down to 120 mg split into two a week

[@mrofnocnon]

@@ScottDreyfus Almost the same as me, seems to work ok.

[@ScottDreyfus]

@@mrofnocnon it's been extremely stable for more than 6 months now always in the 900 to 1k range. It is keeping me going like a teenager out on the links. I did 321 loops around the golf course last year! Crazy to think I was 280+ just a couple years ago and was barely getting around.

[@bluehorseshoe5450]

Never take advice from a professional that can’t do shirt laundry 🧺

[@originalschmid]

#MorePlatesMoreDates

[@johnmoore1495]

Derek watching this video: “Like no dude, crying laughing face”

[@kevinm7523]

I can certainly imagine the sub cutaneous injection would absorb less reliably and less controlled simply from the lack of blood flow through fat tissue. The entire reason you inject directly into muscle to begin with

[@mrofnocnon]

The slower release from subQ lowers estrogen and hematocrit.

[@sethdezan9904]

It’s amazing how many answers don’t get answered in these videos. They just want to get us interested and take the money. All I ever wanted to know was how much and how often do I take HCG. But nope. That is way way way to hard of an answer to give. So you get people like me just winging it. Thank you doctors. “In the name of health” right lmao yeah ok.

[@Phil-bv4dh]

Frequency depends on your SHBG level

[@LastSanePerson]

I take a small dose daily and it’s way better. And the few people I know who changed from weekly to daily have said the same thing

[@axiom4018]

I don't have no libido on twice a week subq injections. My numbers are the same with IM so I'm puzzled what the issue is. My trough is around 800 and estradiol is in the 30s. Just can't understand why my libido is shit. Will going back to Im fix that?

[@TheRedding409]

Maybe dhea..pregnenolone..progress need to be looked at

[@Phil-bv4dh]

Once per week pushes down SHBG more. = More free, more DHT. The SHBG takes some time to be able to bind to test. Twice weekly gives it that extra time

[@alexandershelbayeh3983]

I see alot of people disagree which is fair but remember he's seen probably thousands of people. Personally I think it's in your head too. Chasing numbers. Testosterone isn't dopamine. That would make more sense to translate to how you feel so quickly.

[@rjthomasindyusa]

Soooo.... on one hand we have a guy who micro doses in an effort to mimic the natural production of testosterone and to try to avoid spikes in hormones so he can minimize the amount of drugs he puts in his body so the body can work a naturally as possible. On the other hand we have this doctor who states that pinning is an evasive procedure so he rather a guy pin once a week... causing potential spikes in the hormones and causing the patient to add other drugs to the protocol. What? I don't get it. Can someone help me on this?

[@dlindo8892]

Yeah, subq doesn’t work for most guys. Eod shallow IM would work. Still overkill though.

[@qsdailydose8970]

But how much daily or eod?

[@dlindo8892]

@@qsdailydose8970 15-20 daily and 30-35 eod. There will be some rare cases outside of this range. Lower or higher.

[@qsdailydose8970]

DL Indo ok Thanku DL so basically I should lower my daily dose

[@qsdailydose8970]

DL Indo wish I knew my exact optimal dose without trying every dose

[@dlindo8892]

@@qsdailydose8970 What is your daily dose?

[@johnthebaptized27]

So I’m being treated by a male clinic the past 2 months. I get injections every week in the glute. I started out at 404 for test level then after 1 month it increased to 475. They increased my dose of testosterone after one month thinking that would help. On my second month lab the results came back at 407. I’ve been eating much healthier during this time, exercising 6 days a week, I log food and exercises daily. I’ve been loosing fat and gaining muscle but test levels haven’t been rising. I also am taking Ipamorelin cjc . Wondering if I’m seeing benefits more from peptide treatment and why TRT isn’t rising my levels.

[@samuelbatth4317]

You are using fake test

[@fernando_tasaico]

How much testosterone are you applied? A bit weird

[@johnthebaptized27]

So after two months, the third month I went to two shots split each week at 80 dosage shot and my levels went to 798 now.

[@robwithrbk]

@@johnthebaptized27 If you were doing 1 shot a week and new on TRT, your trough (days 6 and 7) can be very low and almost back to baseline. When you're new to TRT your clinic should be measuring peak (24-36hrs post injection) and trough (6-7 post injection) to see how you're tracking. Lastly, T levels vary heavily by how you work out, sleep, eat, etc. If you're on Day 7 and due for a shot, new to TRT, had a hard workout the day before and didn't sleep well, your numbers could be shit. Over time as you build residual T, days 5-7 you will have a higher baseline. But in the beginning you won't. So the days you get labs is critical.

[@milesk7465]

Stop repeating this video… we get it

[@Man-u-flex]

He’s the only guy or doctor on KZbin who says once a week is better. Wtf

[@coly0226]

More on this info please

[@Pacopaco888]

If your chasing perfect bloodwork frequency is better If your chasing the highest highs, less frequent higher dose is better Create a log and write down how you feel each day, then you will know your frequency

[@mikep3322]

1x per week vs 2x per week I feel the same

[@mooooooooooomooooooooooomo6829]

Yes 1 per week is great

[@mikegeorge991]

So,,,,,Once a week??? Or probably best to do twice a week?? Does anyone really know🤷‍♂️

[@Curtisitruc1982]

Love the dock. Disagree with once per week. More frequent the better

[@coreyparsons4030]

So micro dosing over a week in the right amounts divided isn’t as a effective as once a week dose? Do the results not vary based how you as a man metabolize and adapt to the TRT?

[@MindPumpTV]

There is always going to be individual variance, if you are interested in learning more check out our free hormone forum! facebook.com/groups/290271632470761

[@alexandershelbayeh3983]

Using an AI doesn't he doesn't mean blast it. If you were to take 100mg once a week 1mg of arimidex the day after the shot should do you fine

[@andres7196]

Went from once a week to twice and don’t feel as great honestly I even broke out idk

[@Ryno11090]

I feel worse aswell ! I was once per week and started 3 times per week and then even tried daily . I have always felt best once per week

[@13Ambro]

Curious if anyone is taking TRT with other compounds like nandrolone and if you do it all in one shot / day per week? There is something to be said for a high normal dose at once for medications. Similar to how it’s better to take 800mg of Ibuprofen at one time if you have an acute injury rather than 200 mg 4x per day.

[@PointlessPerspective]

I accidentally pinned 2.5ml of sus 250 and .5ml of deca deconate 250. Am I going to die? 😂🤣

[@thomasjones3508]

This makes me question his other advice.

[@mikecara3271]

Hell yeh I feel better with 2 or 3x a week

[@HikeRx]

The problem with having testosterone spikes is that it causes erythrocytosis in many patients

[@midotvadventure504]

So for patients having elevated red blood cells does that mean they won’t need vitamin B12? Good way to reduce that is to donate blood regularly I believe? What do you suggest? Thank you

[@robwithrbk]

@@midotvadventure504 If you're having to donate blood to regulate your red blood cell count, your dose is too high. I still donate blood, but it's not because of my red blood cell count.

[@detroitdiesel2983]

Terrible protocol. 2x per week and dump the AI.

[@commentscopyrightattorney5543]

I agree twice a week is best to maintain stable levels but man how does one decide which site to inject? Wouldn't the glute be sore? 😂😂

[@detroitdiesel2983]

@@commentscopyrightattorney5543 no. Alternate sides when injecting. Very large muscle so it can handle a small amount of oil very easily.

[@qsdailydose8970]

I inject daily but still having issues atv24mg daily idk if I should increase my dose or decrease my dose TT 1139 (250-1100) FT 273 (46-224) DHT 105 (12-65) TSH 2.13 (.4-4.5) E2 46 (

[@kimsinghrai]

@@commentscopyrightattorney5543 I have been using delts with a 5/8 inch 25 gauge needle, almost painless

[@sniper1444]

Please Explain. I have been having ED problems since starting trt. Do my estradiol levels aren't very high doc suggested an AI. It seems most doctors do. But when I look at KZbin and forums people that aren't doctors say ditch it. I take .8 ml once a week. 1381 test, 40 estradiol. Told the doctor again today about the Ed and again suggested an AI rather than lowering the dose. Any and all feedback much appreciated! Thank you!

[@murhalsimsir9119]

SubQ dropped my SHBG a lot

[@ricolaw2571]

ahh yes mind pump where you can see the insurance liability in their advice