Tysabri Vs Ocrevus. Which is Better?

Рет қаралды 4,840

Күн бұрын

Пікірлер: 96

@ryandahl1400 4 ай бұрын

Been on Ocrevus for 5 years, No relapses or MS progression and no infections. Im glad it is performing as well as other drugs.

@smrtolet 4 ай бұрын

On Ocrevus since 2020, no infections, no sideeffects, stationary MRI, no lesions, no brain volume loss. Had Covid twice, a little longer fever, 10ish+ days, but no other symptoms (respiratory and so on)

@HairSystemDIY 4 ай бұрын

Really interesting study. My wife is on Tysabri and has been pretty stable for 5 years

@cherylvl1036 4 ай бұрын

1:56 I’m not on either of these DMT’s but I always wondered why tysabri could cause PML. Thanks for explaining that it’s because lymphocytes are sequestered and aren’t surveilling the brain. Another great video!

@RyanMcHugh1984 4 ай бұрын

i was the first person under 18 to ever be prescribed Tysabri in the United States, as a 17 year old in 2007, by Dr. David Hojnacki. I would be honored to speak with you and am currently writing an autobiography. Please reach out to me, as I am in the process of applying for Ocrevus.

@roguestarz1034 4 ай бұрын

I would love a video on how close we are to Remyelination drugs

@DrBrandonBeaber 4 ай бұрын

I read an article about a novel remyelinating drug which I will do a video on soon. You may appreciate this video on clemastine: kzbin.info/www/bejne/imfTZphoiciFb7M

@Autumn-zt2dd 4 ай бұрын

Thank you!! This would be awesome!! I'm more interested in that than the drugs they push!!

@DrBrandonBeaber 4 ай бұрын

@@Autumn-zt2dd Well this could end up being another drug that "they" push.

@Autumn-zt2dd 4 ай бұрын

@@DrBrandonBeaber So True!!🤷‍♀️🙏

@ajperrin2293 4 ай бұрын

Thank you for the video! Perfect timing, I actually just got infused with ocrevus this afternoon. Been on it since 2017, love only having to think about my MS twice a year. Unfortunately I do get more infections than I ever did in the past but I am pleased with the lack of any relapses.

@DrBrandonBeaber 4 ай бұрын

Hopefully it continues to work well for you.

@roberture5903 4 ай бұрын

Thank you for the video Dr Brandon, I was on tysabri for 3 and 1/2 years before testing positive for the JC virus and now I am on kesimpta and I don't see much of a difference and I do love the convenience of doing a once a month injection at home rather than traveling to the clinic every 6 months for an infusion.

@klzeller 4 ай бұрын

Thank you for all your videos! I was diagnosed 2002. Ocrevus is my current DMT. I've been on 7 different types of treatments over the years. Ocrevus has been a miracle for me. I am JVC positive, secondary progressive. Hardly any infections.

@jimmyfox3328 4 ай бұрын

I've been on Ocrevus for 7 years, with almost know progression. Was diagnosed 9 years ago. Have PPMS. I also feel on any drug diet and the level of exercise you.can tolerate help Thanks for the video!

@jimmyfox3328 4 ай бұрын

I also have lost a brother and mom to complications of MS. I know that not everyone can afford good quality diets and not everyone are able to exercise like I have. Do what you can and we all hope for better treatments or a cure.

@Superiuzzy 4 ай бұрын

Thank you so much for your video! Do you think that the results with Kesimpta instead of Ocrevus would be the same?

@DrBrandonBeaber 4 ай бұрын

Most likely very similar.

@saharanights3518 4 ай бұрын

no, Kesimpta didnt do nothing at all, its a waste of time money and medicine @@DrBrandonBeaber

@carlacampillo8256 4 ай бұрын

Interesting!! Thanks for the video!

@DrBrandonBeaber 4 ай бұрын

@courtneytaylor1841 3 ай бұрын

Is it possible that there will ever be a once-a-year treatment?

@jonm4501 4 ай бұрын

An idea for another video, AT what age should a person consider discontinuing taking Tysabri or Ocrevus? Are there other factors to consider other than age? I'm a 66 yr old male, EDSS 6.5, and I do wonder if the infection risk is worth taking either of these past age 70.

@DrBrandonBeaber 4 ай бұрын

This is a controversial topic. I may consider doing a video on it at some point.

@EvenSoItIsWell 4 ай бұрын

Excellent video Dr. Beaber. I haven’t taken either of these drugs, but would be open to changing if needed. I am curious too about the subcutaneous Ocrevus.

@DrBrandonBeaber 4 ай бұрын

It's EMA approved but not yet available in the united states.

@thres34 4 ай бұрын

Yes here in the UK - given in form of Jab in 10 minutes rather than 4 hours.

@EvenSoItIsWell 4 ай бұрын

@@thres34 that is fantastic!

@luis-villafana 2 ай бұрын

Hi Doctor Beaber. What do you think about alternate pathways of T-cell activation, such as dendritic cells and uric acid? Could there be some people with MS without direct B-cell related malfunctions?

@davidflewitt1671 4 ай бұрын

Thank you for your videos, I find them very informative. Could you maybe do a video on how Multiple Sclerosis causes bad fatigue and also if methotrexate is used to help slow down progression in MS, as I have psoriasis so maybe can help both conditions. I look forward to further videos

@DrBrandonBeaber 4 ай бұрын

Thanks for the suggestion. You may appreciate this video for people with MS and other autoimmune diseases: kzbin.info/www/bejne/gGbZo5-vZtKcj9E

@kjp13091 2 ай бұрын

Thanks so much for the informative video. I’ve been on Tysabri for about 3 years. No evidence of new disease activity. I sometimes get very intense brief episodes of a dizziness-like sensation since I’ve been on it. They’re pretty scary and I never had them before as a symptom from a flare up. Only began a few months after starting the drug. Curious to know if it could be related. Considering Ocrevus in the next year or so for pregnancy planning. Would love a video on DMTs/options for pregnancy planning.

@__Wanderer 4 ай бұрын

Interesting to see the differences! I've been wondering if I should switch to Ocrevus recently. Currently on vumerity/dmf and luckily stable over the last 2 years. I live in NL and they follow the escalation model. I wonder though if taking DMF (although stable) will be detrimental long term as there is a gap in effectiveness. I find it hard because although stable it perhaps gives me a false sense of security and isn't the best treatment. Perhaps instead of 1 relapse a year I have 1 in 5 years on DMF. With ocrevus though perhaps that changes to 1 in 10 years. What are your thoughts on these kinds of situations? (My Dr. didn't want to allow me to take ocrevus...)

@DrBrandonBeaber 4 ай бұрын

I can't comment on your specific situation, but my general opinion is that the benefit of higher efficacy disease modifying therapy outweighs the risk in most young people with relapsing MS. That being said, many people did well historically (and do well today) on lower efficacy treatments. There is always the possibility of deescalation (changing from a higher efficacy treatment to a lower efficacy treatment) later on.

@__Wanderer 4 ай бұрын

@@DrBrandonBeaber Thank you Dr. Brandon for your reply. I really appreciate and respect the time you take in your answers :) This is exactly my sentiment currently! It's frustrating wanting to take Ocrevus but having a system that doesn't allow it... or forces you to wait until you become worse. Will see if I can discuss this again with my neurologist at some point as it does bother me to know I am not doing everything I can to slow this down. Cheers and hope you have a great day :)

@laurarosanne 4 ай бұрын

Hi Wanderer, I am also in the NL (Sittard) and got Tysabri immediately. Because i had very active disease. It varies where you are treated….

@__Wanderer 4 ай бұрын

@@laurarosanne In Utrecht for the treatment, I believe that NLs policy is still the escalation one from what I have understood. Were your symptoms severe? My optic neuritis has left me blind in my left eye (from my first relapse) so I thought that might qualify as active / severe onset :/ At least enough for ocrevus...

@laurarosanne 4 ай бұрын

Hi Wanderer, that sounds awful! Do you also speak dutch? I had a cervical spine lesion causing symptoms and many cerebral lesions. I guess it also depends on your doctor? Mine is young and modern, but I heard from an older professor who also does the escalation approach in the same center. Have you considered a second opinion? ErasMS centre is supposed to be good!

@1nsanetr 4 ай бұрын

What a great video! Thank you Dr. Beaber. Both are perfect drugs. My decision was Ocrevus because of its long-term safety.

@DrBrandonBeaber 4 ай бұрын

I hope it works well for you.

@1nsanetr 4 ай бұрын

@@DrBrandonBeaber Thank you.

@josephvered3991 4 ай бұрын

😊Hi from Israel thanks for this video it will help my daughter if it is good to switch from Tysabri to Ocrevus because of pyra now I am sure. she will not change her therapy but finally she will change her life style and I am sure she will be better God bless you❤

@DrBrandonBeaber 4 ай бұрын

@@josephvered3991 Thanks for the kind words.

@remage-c3d 3 ай бұрын

I am on Ocrevus but getting off due to colitis issues. However, being JCV+ I am concerned about going back to tysabri.... I was on it for 3 years before. The PML risk seems high at this point for me :(

@SasCooper-o7w 4 ай бұрын

I was diagnosed with RRMS in April 2023, I have 5/6 lesions on my brain, i've never been offered a spine MRI, i've had Optic neuritis twice, once in each eye, I tested positive for oligoclonal bands, I've never been offered any DMTs, would like to hear what your thoughts are on this?

@WilliamWallace-sc9cx 24 күн бұрын

Started with Copaxone, my doctor switch to Tysabri (stop it because of side effects) and now he recommends Ocrevus. But i'm scared about its side effects (infections, fatigue, feeling weak etc..) i'm totally lost..

@stonz42 4 ай бұрын

Thanks for the info Dr. Beaber. I began treatment on Tysabri as JC negative and became positive after only 5 months. I believe the initial test was a false negative because the results climbed steadily over my treatment (negative to moderate to positive). I opted for the 6 week interval for convenience and the possibility of JC, so I wasn't concerned at the time. However, my neuro recommended I switch to Ocrevus, which I later did without a problem, and I've been on it for 2 years now. I'm actually feeling better currently on Ocrevus than Tysabri, but it's possible that I needed more time on Tysabri for my body to heal. Some days I feel like I'm having PIRA, but thankfully the symptoms continue to subside and I bounce back. I also wish I wasn't so immunosuppressed, but unfortunately that's life with MS.

@DrBrandonBeaber 4 ай бұрын

This is one of the downsides of Tysabri. A significant number of people (like you) will end up switching due to JC virus antibody positivity.

@LabradorLady 4 ай бұрын

I’ve been taking Tysabri since 2011 and in the past year, I’ve just gone down and down and down… now my neurologist is shifting me onto a centre in Sheffield, UK for possible hsct… I still don’t know if there’s anything else on the table before I go down that route… my ms nurse asked if there was any mention of lemtrada…? Sadly nothing yet… I’ve been in a proper mess for over a year now and nobody seems to be getting on top of it!! Tysabri has been my wonder drug for such a long time and the disappointment is phenomenal and I’ve no explanation of what has happened!!!! 😮‍💨 a massive breakthrough..? But why?

@DrBrandonBeaber 4 ай бұрын

Sorry to hear this. Do you mean that you had relapses on tysabri or that you had slow progression (developed transition to secondary progressive MS)? Hopefully you find something which works for you going forward.

@andrewreisinger6860 4 ай бұрын

I was recently listening to a German author on the Joe Rogan podcast who had written a couple of books about drugs studied by German scientists during the Nazi regime. One of the books is titled "Tripped", about experiments done using LSD. This author stated that LSD has massive effects at reducing neuro inflammation in the brain. In fact, the original title of the book was titled "LSD for Mom", because of the positive effects of micro-dosing LSD by his mother, who was suffering from Alzheimer's. Do you think LSD could be a possible avenue of research as a treatment for people with MS? I realize all of the hurdles involving doing studies with illegal drugs. Have you ever heard of the anti neuro inflammatory effects of LSD?

@DrBrandonBeaber 4 ай бұрын

I have not actually heard of this to be honest. There is a review article I found about hallucinogens and immunomodulatory effects: www.ncbi.nlm.nih.gov/pmc/articles/PMC4500993/ There is a section on LSD with animal and basic science studies.

@themilkman7367 4 ай бұрын

The anti-inflammatory effects are probably, at least partly, through the Trk B pathway. I took low dose LSD during 2015 and 2016. I finally felt normal after many years of feeling "sick". I was finally diagnosed with RRMS in 2023.

@staceygriggs2587 4 ай бұрын

What about K2? I feel like MS is a liver problem. Like the liver is not able to process something and provide it to the body. What tests are done in this area? I had a dream where I was being told my husband's immune system needed to be strengthened.

@karentweed3504 4 ай бұрын

NEDA on Tysabri since Jan 2017, still JCV neg. Some disability improvement - getting more color vision backin left eye that has been ‘blind’ since ON in 2003. Been able to continue work FT.

@stupud818 4 ай бұрын

What is your opinion on the ocverus sub cutaneous delivery vs infusion?

@DrBrandonBeaber 4 ай бұрын

The subcutaneous dose of ocrevus achieves a similar degree of b-cell depletion and would likely be about equally effective in my opinion. Source: multiplesclerosisnewstoday.com/news-posts/2024/06/25/subcutaneous-ocrevus-approval-europe-forms-ms/

@laurarosanne 4 ай бұрын

Thank you for a very educational video Dr Beaber! I am on Tysabri since about 7 months. No progression, my symptoms actually improved a lot. Mild side effects such as fatigue for a few days after infusion and headache. After switching to a slower infusion rate (1,5 hours instead of 1) I do not get any more headaches. Happy with it and hope to stay on it for a long time. How about a video on research about myelin repair / cure for MS?

@DrBrandonBeaber 4 ай бұрын

I will do a video on a novel remyelinating agent shortly.

@AC-Milan1899 3 ай бұрын

I was on tysabri for a year snd it was good for me but because they found me positive on JC virus they said I'm at risk of developing PML and they put me on Ocrevus...but my MS symptoms worsen every year since then

@lemonpeelangelfish 4 ай бұрын

Excellent video- thank you Dr Beaber. I would have thought it was likely people stayed on Ocrelizumab as neurologists/pwMS may be reluctant to change to Natalizumab from an immune suppressant as it could increase the risk of PML? Be interesting to see a longer study comparison.

@DrBrandonBeaber 4 ай бұрын

You are right that people are more likely to change from tysabri to ocrevus than the other way around. However, for people who are JC virus antibody negative, the risk of PML is low even if they have previously received immunosuppressants. However, for people who have previously received immunosuppressants, the risk with a low titer JC virus antibody positive result is greater.

@luciece 4 ай бұрын

What about SC Natalizumab, is it still as effective as IV version considering they didn't even adjust the dose (meaning less drug gets in blood)? I'm currently on SC Ocrelizumab (former OCARINA study participant) and they did increase the dose quite a lot (600 to 920mg) to reach the same concentration.

@DrBrandonBeaber 4 ай бұрын

Subcutaneous Tysabri leads to 55% lower blood levels compared to the standard intravenous dose which could be a problem for people with high body weight or those using extended interval dosing. Source: pubmed.ncbi.nlm.nih.gov/36639226/

@luciece 4 ай бұрын

@DrBrandonBeaber yes I've seen this study. But is this really a problem in terms of efficacy.

@donnabolt5847 4 ай бұрын

@DrBrandonBeaber this makes me sad. I was patiently waiting to be able to do injections st home. I'm not risking that with aggressive ms . I will just shift my mindset thst st least I'm still getting care. Thanks for sharing the study. Seriously thank you!!

@olgsi 4 ай бұрын

Do you have any thoughts on new potential remyelination drug PIPE-307? Thank you for your videos.

@DrBrandonBeaber 4 ай бұрын

I'm very interested in this and will do a video on it shortly.

@olgsi 4 ай бұрын

@@DrBrandonBeaber thank you!

@saharanights3518 4 ай бұрын

i follow you since long time, but my son has very diffrent case that his doctor gave up on him unfortunately calling it a complicated case! actually i saw the doctor himself is complicated lazy doctor that he even didnt bother to do any office test till i asked him, or to prescribe any medicine till i asked him!! iam serious, he just the wrong man in the wrong pkace.. anyways he advice to give Kesimpta to my son, and he got worse and worse.. and when i tell him what happening.. he keep saying just wait.. we waited 7months on this medicine and now my son hardly can walk with very bad balance and bad tremor on his right arm. can any one advice pls. ? we just stopped all medication.. we only give vitamins and good nutrition.. even though he hate green leafy vegetables,he eats mostly keto.. but still very very slow recovery🥺🥺😢😢any advice, my heart is broke.. i went to German clinic, he advice to try Ocroves, but we lost faith on medicine.

@MrMikk532 4 ай бұрын

Something to remember is both kisempta and ocrevus are DMTs that prevent FUTURE disease and stop it from getting worse. It can't fix damage that has already been done. That being said, my experience is that after a big relapse, it takes time to improve. Ill just never get back to my old 100%. There are medications and lifestyle things that can help manage symptoms, but hopefully this new german doctor can provide new eyes! Good luck to your son!

@saharanights3518 4 ай бұрын

@@MrMikk532 thanks for yr answer, i am aware that Kesimpta doesnt fix what had happened, all the above happened to my son while taking this medicine. then he started giving my son upon my request, after i did a lot of research "coz his doctor never suggest anything" i asked for Ampyra for walking and Gababantine for tremor. and both made him more worse. he was walking like very drunk person.. so we stopped everything after 10 Kesimpta injections. and his balance a. little better than before like 3%. even PT didnt work, he did physical therapy for 6 months 3 times a week. and he used to get very tired till next session! something is wrong and no body seems to help..i wish if any one suggest a good trusted doctor.🙌. am only praying.

@frankiekirk6494 4 ай бұрын

I havnt had an attack In 4 years on ocrevus, rebif was terrible. I had lapse after lapse on it

@karindella 17 күн бұрын

What about herpes simplex encephalitis? I met someone that had that while on Tysabri. They had a very fever with hallucinations. There is a treatment but it had to be administered Valcyclovir within 48 hours She had some permanent brain damage and memory loss.

@alexandraluke2029 4 ай бұрын

I’ve been on Tysabri since I was diagnosed- and I was diagnosed early. In 5 years no relapses and no progression. Even after 2 pregnancies

@DrBrandonBeaber 4 ай бұрын

Nice.

@rajeshbarik6980 4 ай бұрын

Is MS transmitted through sex?

@DrBrandonBeaber 4 ай бұрын

No. There are excellent studies on spouses of people with MS, and they are not at increased risk.

@rajeshbarik6980 4 ай бұрын

@@DrBrandonBeaber I live in india .and i am talking Rituximab IV . I have diagnosed in RRMS (poms) at the age of 13 .Now I am 24 .I have no symptom .No disability.Just leading a normal life. an I in benign ms?