TWiV 1174: Clinical update with Dr. Daniel Griffin

[@DeannaPiercy]

Unfortunately, here in Red Oklahoma, very few HCWs stay home with any viral disease unless they are extremely ill. They go to work and do NOT wear masks, thus making the health care settings risky for those of us at high risk for severe disease. We have to practically beg doctors, nurses, phlebotomists, etc. to wear a mask and are "lucky" if they'll don a loose-fitting surgical mask. A friend of mine caught COVID while hospitalized for something else and ended up in the ICU for a week. That is unacceptable.

[@litsci1877]

Yep. That's why I do my level best to stay out of the hospital. Odds of getting much sicker there are excellent, and I'm too old now for that to be trivial. Dental appointments are first of the day and my dentist and hygienist will wear N95s if asked, but pre-vax, when I arranged with the dentist to test first, the office manager got wind of this and blew a gasket. Academic facility, too. Last thing she wanted was for her staff to test, because if they were sick they'd have to go home. I asked her if she was going to discipline her faculty dentist for voluntarily taking a medical test and told her that if the answer was yes she could come with me to the Dean to discuss it, and she backed off, but she was livid. This was in Iowa, another red state. Come to think of it, that office had a LC neuro victim, too, at the front desk. Woman sounded like she got hit in the head, kept telling the same story over and over. And coughing. Fabric mask. Kept complaining about the mask, too.

[@RiDankulous]

Makes me wonder how often it happens everywhere, where there might be some people were sick even in areas where it’s less acceptable. Might be wise to wear a mask going into a doctor’s office or hospital who knows at the very least it would be helping others prevent them from getting sick from our own illnesses.

[@russelljohn5175]

Thank you, Vincent and Daniel. N

[@HS-1828]

As a high risk person, I DO NOT feel safe in medical settings because no one masks ever! I will be masking for the rest of my life.

[@jenniferw1595]

Same here my friend. Two family members have died of COVID.

[@HS-1828]

@ everyone thinks I love masking. 🙄 No one could hate them more. Well, probably others like me. I can’t take Paxlovid, so Covid has ruined my life. As if a chronic lung disease wasn’t enough.

[@Idahomie]

A big thanks to the Drs for the update- Dr Griiffin especially since he has what has to be' very busy 'day job'.

[@litsci1877]

100%

[@mariea1431]

Thanks!

[@litsci1877]

Why treat covid differently from flu and RSV? Well, as far as I'm aware, flu and RSV don't cause brain damage, and it seems to be pretty common among people who get covid, even now. Another friend just had to give up part of her work after getting hit by it last summer, one in a long string. Just can't get her head back together. It's not like she didn't need to do the work. Again, please consider people who are not well-off men well-looked-after by loving families and staff people at work who're paid less well and have less behind them.

[@tonytyrrell7271]

Ignorant reply here. I wish I remembered the source but here goes anyway. Many illnesses result in decreased brain size. Possibly merely from inactivity. Covid may be unique but the lack of study in non covid illness does not make Covid special. I likely got some of that wrong but the spirit is in there.

[@sciencefliestothemoon2305]

Flu can cause encephalitis, so can RSV

[@jenniferw1595]

@@sciencefliestothemoon2305 Flu you get maybe once a year- Covid you can get every other month as we do t have any long term immunity. BIG DIFFERENCE.

[@jenniferw1595]

@@tonytyrrell7271 look up Danielle Beckman. She is a scientist who uses a high resolution microscope and shows the difference in brain tissue between flu and Covid. The damage is sobering.

[@cylon5741]

@@sciencefliestothemoon2305 Does the brain shrink after encephalitis resolution? If not, what is your point?

[@Bete-Bete-Bete]

Noone should be giving sickness to people at their place of employment. Vincent should stop pushing people to go in while sick! And yes, Covid is different because of long Covid.

[@TwoCatsInLondon]

Apparently RFK wants the FDA to revert approval for the Polio vaccine. I’m sure this information has reached you by now, but I imagine it must be especially upsetting for Dr Racaniello because he studied the polio virus to extensively.

[@inkpot9359]

He kind of wanted OPV to go away, since polio is a picornavirus,it replicated enterally and caused polio in reflex. So it's withdrawal was prevented by him.

[@TwoCatsInLondon]

@@inkpot9359 Yes, I must admit the comment was a bit reflexive on my part, but I also doubt RFK will instate a live attenuated vaccine instead.

[@marklemont3735]

I believe there is an injectable polio vaccine, but some countries do not have the staff or money for the injectable vaccine.

[@sciencefliestothemoon2305]

​@@TwoCatsInLondonSalk polio vaccine, injectable inactivated virus.

[@Logotic]

First of all, Marty Makary, nominated as head of the FDA, is an actual physician and in no way insane, whatever you may think of some of his positions. I'd expect him to push back hard on this. Secondly, Junior still has to be confirmed. Polio survivor Mitch McConnell doesn't seem to like him very much and could still scuttle his nomination, provided he's able to stay upright for a few more months.

[@WillNewcomb]

Two significant sections discussing polio and vaccines: 07:24 - 16:27 42:57 - 47:16

[@sleepydrJ]

Always an interesting show! Thank you so much for all your efforts at educating the public!

[@razerginn]

I currently have the flu, tested covid negative, got flu shot, got flu from spending 6 hours in an ER following motor vehicle collision. So far just a plugged nose and some mucus formed after 2 days of sore throat. Throat feeling better but its in my lungs currently.

[@francesschaefer]

Hope you get better soon hopefully the flu shot will help you from getting dangerously ill!

[@sciencefliestothemoon2305]

Did they tell which type? The vaccine covers A and B, but not C.

[@jenniferw1595]

Medical personnel should always be masked. 😷

[@RiDankulous]

I hope you get better from your illnesses and injuries

[@TheBiffsterLife]

Thanks

[@christopherlipowski397]

I hope JFKj will understand all the information that Daniel is presenting here. Good luck.

[@yolantadianow1584]

Now they going gave you all farma info and cov vax.....still on run. Is your choice now.

[@jdrissel]

I had raw milk once in my life. It was used to make hot chocolate. The cow in question was a championship cow from the King Ranch. I was about 13 at the time and I knew the risks. But I decided that the cow probably had better health care than I did, so I judged the risk acceptable. I didn't suffer any of the ill effects commonly linked to raw milk. But I did notice that the thickening if the mucus in my throat sinuses got worse than I usually got from milk. This lead me to wonder if heat altered whatever I was getting a low-level allergic reaction to when I drank milk. I mentioned this to my mother, who suggested I tests myself with scalded milk. Success, no reaction. So I quit drinking milk for the next 40 years. One day on a strange whim I decided to have some frosted flakes. It had been a favorite and it had been decades... The only milk available was ultra pastured lactose free milk. No reaction. I tried lactase drops with regular milk. Thick gunk again. So whatever it is, ultra pasteurization destroys it. I wonder if I will ever know what it is that I am allergic to...

[@bethchacon4924]

Milk protein?

[@jdrissel]

@@bethchacon4924 That's my guess

[@Bete-Bete-Bete]

@@bethchacon4924Do you believe ultra-pasteurized milk contains no milk protein? He said he had no reaction to it. How do you explain that?

[@Bete-Bete-Bete]

@@jdrisselMy guess is it’s bacteria because you did not react to scalded milk or ultra-pasteurized. Some bacteria survive pasteurization, often in very low numbers.

[@bethchacon4924]

@@Bete-Bete-Bete it could be denatured with the heat. There are blood tests for milk protein allergies. But good point

[@Idahomie]

This is another chapter of RFKjr's "As the worm turns"

[@cordannao]

Thank you, I've missed you all. Telecommunications are in a flux. Coralie from Australia Xxx

[@giovannadenissechiarellada3278]

Allways so interesting, thankyou for the update, eager to know about news in ID.

[@TomMitchellNiftyEgg]

Aha but you must also add zinc even ultra low lithium to make ivermectin work. [ sarcasism PRN ]

[@sbartdbarcelona44]

So informative. Thx you

[@JillKnapp]

Thank you, gentlemen!

[@WillNewcomb]

Thank you!!!

[@razerginn]

Are there any studies showing you dont need polio boosters?

[@AlbertMark-nb9zo]

Not really. What is known is that a complete series gives 99% effective protection for many years. Its recommended that adults get a single booster if traveling to areas with a high incidence of polio. Notice that's "adults", where protection may have waned over decades. Small doses of polio will have acted as natural boosters. Vince jokes of that many times during his research days and exposure.

[@sciencefliestothemoon2305]

​@@AlbertMark-nb9zoit is a bit dependent on the country's recommendations. The USA does a single booster. Most European countries do every 10 or 20 years, depending on the travel destination. Active outbreak areas may even require a booster within the last 12 months. Of course the data on this is meh, and the primary idea is, be safe than sorry.

[@leo2md786]

What does "high waste water activity mean"?

[@litsci1877]

lots of the virus found in sewage. It's a way of testing how much virus is circulating among the population without directly testing people.

[@marklemont3735]

Also flush your toilet with the lid down to prevent waste water virus from going airborne in a bathroom.

[@SuzanneTheme]

@@marklemont3735And getting on your toothbrush 😵‍💫

[@sciencefliestothemoon2305]

It means that higher levels of viral particles are found in the waste water. The particles are excreted by infected people.

[@marg716]

🎉🎉🎉Thank you

[@stormwalker321]

Thank you both , so much for your dedication,and all the information you share so freely, Deeply appreciate ..!Merry christmas to you and your families...🎄

[@danielasuncion9991]

So, is the polio germ replicating in those sewers?

[@AlbertMark-nb9zo]

Polio is a virus. It requires a human host. Sewer testing just tests the people who have the virus replicate and pass through the gut. Of those people, I believe the stats is 1 in 250 to 500 will get paralytic disease of some sort if no immunity exists. Of the ones with paralytic disease 5-10% will die. It travels via fecal transmission and oral ingestion which is not as uncommon as you would like to think, especially among children.

[@dcaudwell]

Depends if there are any hosts down there (;

[@danielasuncion9991]

@dcaudwell What about rats?

[@sciencefliestothemoon2305]

​@@danielasuncion9991human specific. Also, Vincent has a whole series on virology, please watch.

[@traianliviudanciu8665]

Did we know at what tissue temperature did SARS COV2 better replicate ? Because If replicate better at low tissue temperature,must avoid antipiretics (ibuprofen ,Tylenol...)If SARS COV2 infection occur.

[@sciencefliestothemoon2305]

Dude aren't you posting this every episode? Get some google and you will find the answer. A hint, it is not 42.

[@traianliviudanciu8665]

@sciencefliestothemoon2305 at TWiV 659 at min29 german virologist Christian Drosten indicate that SARS COV2 better replicate at very low tissue temperature

[@sciencefliestothemoon2305]

@traianliviudanciu8665 yes 31 degrees. That does not make using tylenol a smart idea when your body needs to fight an infection. Besides you can't use antipyretics to drop the core temperature that low. At such a core temperature the heart stops

[@traianliviudanciu8665]

@sciencefliestothemoon2305 theoretically fever mitigate SARS COV2 infection Avoiding use of antipiretics If SARS COV2 infection occur can mitigate SARS COV2 infection

[@christopherlipowski397]

My wife left you $100 in cash at the Incubator. You were not there. Did you get it and if so, perhaps a thank you would be appreciated?

[@tonytyrrell7271]

People are terrible at understanding risk. Everything carries a risk. Raw milk, regular milk, OPV, IPV, aspirin, kale… People avoid odd things and then drive across town with the car ride being by far the greatest risk of the day.

[@DonedHiga]

26:08 I hear crickets chirping

[@littlebrownbird8020]

I'm not sure what you mean. He was talking about study looking at outcomes of mRNA vaccines versus the Novavax vaccine.

[@gribbler1695]

Squeaky chair perhaps.

[@MNP208]

That ivermectin one! 🤣🤣🤣🤣🤣

[@hunahpuyamamoto3964]

I wouldn’t prejudice RFK until he’s on the job. He has a large bureaucracy to learn about much less adjust policy. Surely there’s a good supply of competent apolitical knowledgeable people at his disposal to seek advice right?? If not then it’s far worse than I ever imagined.

[@elle26426]

I would say it will indeed be worse! He is nothing but a conspiracy driven nut job! I HOPE I am proven wrong. But this government is nothing more than a 🎪 full of 🤡 🤡🤡

[@RiDankulous]

The bureaucracy will be happy to tell him when he legally cannot do😂

[@cylon5741]

Ivermectin: A Multifaceted Drug With a Potential Beyond Anti-parasitic Therapy "...The role of ivermectin as an anti-inflammatory agent has only recently been understood. This is an integral part of its use as an antihelminthic agent. Ivermectin is now known to play an immunomodulatory role that suppresses inflammatory responses in humans .."

[@laurier3348]

Professors need more vax to become great again. Nice.

[@marklemont3735]

Please explain.

[@garthdryland]

First 😅

[@danielasuncion9991]

Yes, it certainly seems that way. 😎

[@SPCEMN3]

What's with Vincent's Dumb and Dumber haircut? It's getting worse and worse. He's cooler than that. Go to a professional, Vincent! Let them take care of you. You are an expert on virology, not style. Expertise takes work and talent. You didn't study style the way you did viruses. Being smart means knowing when you don't know.

[@litsci1877]

A little uncalled for. My dad has the same haircut, Vincent.

[@christinaduffy6618]

Why are you here. Hush

[@francesschaefer]

@@christinaduffy6618 agree

[@Jablicek]

The way someone looks is irrelevant. Substance over style.

[@marthabeck3981]

Why are you making such a stupid comment?

[@CONTACTLIGHTTOMMY]

Dan is so gaunt. What gives? Just aging?

[@jenniferwinsor7740]

I’ve been wondering the same thing.

[@HS-1828]

Maybe dieting.

[@sciencefliestothemoon2305]

He is ID, they are gaunt by design. Too many books not enough calories.

[@geonerd]

I'm pretty sure he's got something eating on him.

[@cky5573]

I was wondering the same thing. Hope he’s okay

[@atulmathur84]

Thanks!