Vittorio Sebastiano | Epigenetic Reprogramming: The Path Ahead | @ Longevity Frontiers Workshop 2023

This video was recorded at Foresight's Longevity Frontiers Workshop 2023.
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Many longevity areas are still underexplored. Some were surfaced by our 2022 workshop, some are highlighted by the Longevity Prize, some are entirely new. This two-day event invites leading researchers, entrepreneurs, and funders to drive progress. Explore new opportunities, form lasting collaborations, and join us in driving cooperation toward shared long-term goals.Rapid keynotes are followed by working groups to curate opportunities for talent and funders, present at the workshop and beyond, to take on. Including mentorship hours, breakouts, and speaker & sponsor gathering.
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Vittorio Sebastiano, Stanford University: Epigenetic Reprogramming: The Path Ahead
med.stanford.edu/stemcell/ins...
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[@laurincarmichael9921]

What a wonderful presentation. Dr. Sebastiano is leading the field in optimizing iPSC generation and engineering for immunotolerance. I can't wait to read the future papers put out by his lab! 🧬🔬

[@CarolCarolDoddDodd]

We need way more information from this guy and bigger, clearer and closer slides. What was the name of the company that has this technology- turn? This is great information we just need a better video. Does he have a social media account or this company?

[@SirTenenbaum]

The company is called Turn Bio. Other companies researching epigenetic reprogramming include NewLimit, Altos Labs, Life Biosciences, and others.

[@andreeanovac1328]

Hi. I m very intérested in thid redearch. I can t help with money for the moment but i d loke to participate in the upcoming human trial

[@andreeanovac1328]

Is ist still posdible to apply or to register for the upcoming humzn trials especially the ones for dermatology ?

[@Montie-Adkins]

They need to hurry. I'm 51.

[@Jessica-kk1cz]

I’m 52. And completely agree. 😊 I have family near 80.

[@squamish4244]

They need to dispense with the overcautious approach and start trying out various approaches on humans. There will be no lack of volunteers. They already do all sorts of risky and damaging things in medicine, like prescribing 10 different psychiatric drugs to see what will work, despite the fact that these powerful drugs mess with your _brain._ I've been through 7 or 8 myself and the side effects...good lord. Why is that acceptable but trying various drugs out on old people isn't? People will do anything to avoid ending up crapping in a diaper and forgetting their own name. There's tons of low-hanging fruit that they could try today. And what's the worst that will happen to 80-year-old volunteers? They'll...die? I can't help but think that the medical community still has massive resistance to this stuff. The projections about how much elder care will cost in 20 years might change people's minds. You want a strong economy or not? At least the new companies seem determined to head into human trials as fast as possible. I think after 20 years of mouse trials, enough is enough for some of these approaches.

[@33Crazydude]

@@Jessica-kk1cz, I'm 45, the earlier the better

[@Jessica-kk1cz]

@@33Crazydude Indeed. If you’re from the U.S., talk to your Congressperson. What will stand in everyone’s way are three things. (1) Lack of sufficient funding for these labs for resources and scientists and computing power. NIH or ARPA-H should be funded to support this research in turn to make the science and technologies public -- not private for rich people. (2). FDA has got to stop pretending it’s 1950 with their “let’s do a 30 year study” trial processes. It’s 2023 - they need to approve using AI/ML models, and human cells in Petri dishes, and epigenetic clocks like Horvath, Inside Tracker, and others. Mice are useless models 80% if the time. (3). There needs to be Congressional support for funding rapid manufacture and distribution like they did for the COVID vaccine, and do it outside of corrupt big pharma. Make it a government program. And if you’re not from the U.S., tell your politicians the same. It does not matter which country is successful first. Because success in any area of the world should put pressure on governments globally to do the same. Therefore, everyone benefits. PS - also, bioelectricity research needs to be better funded. That will cure anyone with existing cancer, of any type. It’s the software of life. Watch Michael Levin out of Tufts University. There are podcasts on KZbin.

[@comradecapybara]

I'm 19, my parents are 48, My wish more than anything is to see aging treated in my, and hopefully their lifetimes. There's a long way to go so I won't get my hopes up but its nice to know its a possibility.