Von Willebrand Disease (VWD) Mnemonic

Von-Willebrand factor (vWF) comes from the meagakaryocytes (bone marrow) as well as the Weibel-Palade bodies (endothelial cells). Von Willebrand factor (vWF) helps the platelets adhere to the sub endothelial collagen via GP1b receptor on the platelet.
Von Willebrand disease (vWD) is the most common inherited bleeding disorder worldwide.
Primary hemostasis involves forming a platelet plug (thrombocytes) whereas secondary hemostasis involves making a fibrin thrombus (coagulation factors).
Ionized calcium helps blood coagulate.
We test for primary hemostasis via platelet count, bleeding time, and platelet aggregometry.
We test secondary Hemostasis via prothrombin time (PT), activated partial thromboplastin time (aPTT), and the old coagulation time (or clotting time, or thrombin time).
Von Willebrand Dusease (vWD) affects primary as well as secondary Hemostasis.
Hemolytic Uremic Syndrome (HUS), atypical Hemolytic Uremic Syndrome (aHUS), and Thrombotic Thrombocytopenic Syndrome (TTP).
Atypical hemolytic uremic syndrome (aHUS) is similar to thrombotic thrombocytopenic Purpura (TTP).
Typical Hemolytic Uremic Syndrome (HUS) is a triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure.
Thrombotic thrombocytopenic purpura (TTP) is a pentad of microangiopathic hemolytic anemia, thrombocytopenia, acute renal failure, fever, and neurological abnormalities.
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Bernard-Soulier Syndrome (BSS) is an autosomal recessive (AR) disorder characterized by a defective GP1b platelet receptor leading to a problematic platelet adhesion process (primary hemostasis).
Glanzmann Thrombasthenia (GT) is an autosomal recessive defect in the GPIIb/IIIa (GP2b/3a) receptor on the platelet which leads to defective platelet aggregation.
Ristocetin Cofactor Assay (RIPA) is usually abnormal in cases of Bernard-Soulier Syndrome (BSS).
Bleeding time is prolonged, platelets are big in size, but few in number (Macrothrombocytopenia).
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Platelet count is one of the lab tests used by a doctor or a hematologist to assess whether your platelet number is normal, low (thrombocytopenia) or high (thrombocytosis).
Bleeding 🩸 time (BT) is another test for platelet function.
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[@MedicosisPerfectionalis]

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[@micahperrymoreno]

Thank you doctor. Definitely this will help me in my upcoming exams.

[@MedicosisPerfectionalis]

Awesome 👏 Good luck 🍀 Thank you so much for watching

[@NuclearMedicine070]

Thank you so much for your videos!

[@iakns8125]

Thank you, love from Serbia💖

[@MedicosisPerfectionalis]

My pleasure 😇

[@dr.kaynatkhalid8243]

Thank you so much medicosis for such inspiring videos I actually also started a youtube channe named BIOLOGY HUB recently after seeing how you thoughtfully expalined everything you are like a mentore to me when it comes to teaching idon't have alot of equipment to generate videos like you but i am doi g things with what is available ❤❤👍👍 Thanks for being such an inspiration for me

[@MedicosisPerfectionalis]

You're welcome Good luck

[@binodmehta818]

You are awesome. Love from Nepal.

[@MedicosisPerfectionalis]

Thank you so much 😊

[@moh3999]

I like the mother she has a nice yellow hair 😍😍🥰🥰 Excellent as usual bro.👍👌

[@ravitejasamudrala4]

Hi my family history all members have Von Willebrand disease factor 8. We can take Covid-19 vaccine or not.lot of confusion please help me..

[@vineetaggarwal7942]

Great brother 👍

[@MedicosisPerfectionalis]

Thank you 🙏

[@rashatariq2529]

Thank you sir

[@MedicosisPerfectionalis]

My pleasure 😇

[@chanb.ms.alphafemale2275]

You have helpful information, however you are talking too fast for me until I am having difficulty following and understanding.

[@MedicosisPerfectionalis]

Thank you so much for your honest feedback! I appreciate it!

[@amirulhamudin]

Whoa. There are so many Big D.

[@AliAli-pi9lg]

I don't know, how to thank you

[@MedicosisPerfectionalis]

You’re very welcome 😊

[@eman-ne2ng]

tysm

[@MedicosisPerfectionalis]

My pleasure 😇

[@jacksparrow-wq1pb]

❤❤❤❤❤

[@MedicosisPerfectionalis]

Thank you!

[@meranayaipad7239]

❤❤❤

[@robertohvargas]

Von Willebrand factor is one of the most important issues in Covid 19. In the case of the disease explained on this video, the factor is underexpressed. I know this video attempt to simplify the subject in order to make it easy to understand (for an exam). But maybe, oversimplifying such an important subject, will make some students don't be aware enought, (when they become doctors), of a key factor to really understand what's going on, during the course of a disease. Great video anyway

[@MedicosisPerfectionalis]

Have you watched the video before this one, and the video after it. I have explained VWD and its different subtypes in great detail.

[@exolblink7611]

kzbin.info/www/bejne/emHEmXt8btSBj5I here you go ! He actually explained this disease in details in many videos

[@leonardhofstader814]

why every mnemonic has D in every disease? try something new bro :(

[@MedicosisPerfectionalis]

Fair enough, Dear!

[@freebornfloor1600]

@@MedicosisPerfectionalis hahah D for Dear! I love it hey, if it works, it works, and it Does work! ;)

[@MedicosisPerfectionalis]

Yup 👍