Which COVID Vaccine Booster is Best? Pfizer vs. Moderna vs. J. Johnson (Update 137)

Roger Seheult, MD of MedCram explains COVID 19 booster data on Moderna, Pfizer-BioNTech, and Johnson & Johnson and the efficacy of each coronavirus booster vs. full vaccination.
(This video was recorded on October 27, 2021)
TOPICS IN THIS VIDEO INCLUDE:
00:00 Which COVID-19 booster should I take?
00:15 Pre-print study looking at outcomes for original vaccines and randomized booster combinations in the United States
01:53 Side effects for various boosters given to patients with either J&J, Moderna, Pfizer original vaccines
05:46 Preliminary booster efficacy data: how well do IgG bind to SARS-CoV-2 spike proteins?
10:29 Preliminary data from Pfizer-BioNTech: Efficacy of a booster on top of fully vaccinated people in randomized, placebo-controlled trial
Roger Seheult, MD is the co-founder and lead professor at www.medcram.com/?Y...
He is Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine and an Associate Professor at the University of California, Riverside School of Medicine.
LINKS / REFERENCES:
Pfizer And BioNTech Announce Phase 3 Trial Data Showing High Efficacy Of A Booster Dose Of Their COVID-19 Vaccine (Pfizer) | www.pfizer.com/news/press-rel...
Heterologous SARS-CoV-2 Booster Vaccinations - Preliminary Report (medRxiv) | www.medrxiv.org/content/10.11...
All coronavirus updates are at MedCram.com (including more discussion on the COVID delta variant, vaccine passport, and more).
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Video Produced by Kyle Allred
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MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.
#COVID19 #SARSCoV2 #Coronavirus

[@brucegruetzmacher5891]

The best way to maintain your immunity is to be repeated exposed to virus. So throw away your masks and hug as many strangers as possible.

[@CindymeCindy]

The Pfizer shots and booster all nearly killed me. I lose 2 days of my life per shot, laying in bed with 101 fever and rapid shallow breathing, chills and odd stabbing pains in my abdomen and thighs. I get the massive swollen glands in my armpit and can’t raise my arm for days.

[@lolawhite3916]

For my healthy tripple vaxxed BF the first one was the last one: he passed away from a sudden heart attack a month after the booster.

[@jennaduvall2060]

When I got the first 2 doses of the pzifer vaccine, I had minor aches and pains, headache, and chills which went away within a few hours of getting the vaccine. However when I got the pzifer booster and flu shot, I was miserable, all of those side effects were so strong. Aches and pains, and headache was horrible and lasted for a couple of days for me. Never want to go through that again. Was horrible.

[@karenkaren3189]

I had Moderna shots. My booster was a half dose. I had very mild reactions to all three shots. However I felt the booster the most. I spent a day resting on the couch, drinking tea and napping. Mostly fatigue, some aches and chills. Felt 100% better the next day.

[@ld0022301]

Thanks for another great video Doctor. Amazed at the clarity and level of detail and presented in a way that folks with not too much scientific knowledge can understand.

[@mrsith1402]

The question everyone is asking is "if you get it after you are vaccinated does it negate the need for a booster jab?"

[@karahamil3657]

Amazing how you take a complicated subject and make it sooo easy to understand ... wish you were my chem. Bio .anatomy prof in college ...

[@jcasa12]

The fact that the moderna boost is full dose (100ug) in this study versus a half dose(50ug) which is the acutual dose people will receive. This almost invalidates the moderna boost graph results in this video, it is concerning because It is difficult to make a decision based on something that may be inaccuarate.

[@tomo9224]

You may very well have the only doctors handwriting that is understandable in the entire world. Thank you for all you do.

[@artieash6671]

Please explain the myocarditis risk for young men, specifically regarding boosters... if you can. With many thanks.

[@jamesmitchell6925]

Please talk about aspirating or drawing back when injecting the vaccine. If it’s injected into the bloodstream it increases your chance of myopericarditis. The deltoid is a muscle that needs a blood supply and therefore has blood vessels. Aspirate to vaccinate!

[@caleuxx9108]

Thank you for this. Looking forward to followup with new info in the future....!

[@70sladyalways25]

Excellent breakdown. Thank you for these informative videos.

[@HILARI333]

Thank you, Meccram !!! **** Could you Please make a video on the myocarditis & related risks with Moderna, and how 3 Nordic countries ( Sweden, Norway, and Finland) have suspended Moderna for people under 30 ( in Sweden for men AND women that age.)**** How safe is Moderna for women in their 40's and 50's? ( Concerned re: myocarditis, blood clots, etc.)....but I'd LIKE to get a Moderna booster, if safe enough ( I got J& J initially.) THANKS SO MUCH !!!

[@oldjdmtek488]

My question is the virus is changing and the change is in the spike proteins, this is why Delta was so bad as it was different from Alpha. Delta seems to run its course and now it’s other variants coming our way. So why get Alpha boosters for a virus that is no longer around.

[@JohnMChew]

I got the J&J vaccine and all I had was a sore arm for about 4 days. (no flu like symptoms) I'm very apprehensive about getting any of the boosters. (not opposed ,just apprehensive)

[@suwanatatnina]

Thank you Dr. Seheult for show this graph of us your study. I had mild headache and could not get out of the bed for a day with 2 dose of Moderna. This one make me feel better for the booster of Moderna or Pfizer.

[@windywednesday4166]

Great job! ...all the information I didn't know I need.

[@tonyv8925]

My wife and I took the Pfizer series for a number or reasons. #1- Pfizer started research on a vaccine earlier than other providers, #2- After the first dose, we experienced no adverse side effects. #3- After second dose, I had no side effects, wife experienced the normal headache plus nausea. So, we opted for the booster shot and experienced zero side effects...no headaches, no nausea. I am a high risk person so it was imperative that I get vaccinated. So far, no ill effects from the booster and it has been 3 weeks. That is my testimony at this point.

[@channel1_channel]

Vitamin D ....boost immunity every day. Mind your weight. Don't eat junk foods much. This is a start. Do this and the stats are in your favor.

[@LFTRnow]

Excellent. As always I can count on Medcram for unbiased quality (and statistical) info as well as analysis of those stats.

[@ssss-ch3fs]

Following and Definitely waiting for an update on this paper after it has been peer reviewed 🎉

[@maddogpham9815]

OK Thank you for the video. I loved the data and results of those boosters, but I will love it more if you can presenting the Moderna half dose booster data and result. I am very sure many commenters here are also wondering and have the same thought like I do.

[@diyeana]

This is another excellent breakdown that is very helpful in weighing risk versus benefit. Thank you!

[@sgroadie6367]

How would you extrapolate Moderna boost as a half dose?

[@ahavrilla9577]

It's been over a month - any update on the missing data? Also wondering if there is a new video or any results from using the actual Moderna booster dosage, instead of results using double the dosage.

[@uptick888]

What about aspirating the needle no one does it here in the United States? Ty

[@Geronimo122]

Great presentation-- thank you.

[@Mangzorz]

This is so helpful and informative! Thank you. I got the Pfizer vaccine and never had any side effects, but getting the booster, I'm not sure which to choose, so this helped me make an educated decision. Thanks!

[@olyav5819]

Thanks for the update. It helped me to make my decision on booster shot.

[@NancyJGH]

Dr. Seheult, thank you for enlightening all of us. 🙏 God's Blessings!

[@AashimGupta15]

Thank you so much as always. Was constantly refreshing KZbin and waiting for this. Much appreciated!

[@audreymott5879]

Greatly appreciate this information. Many thanks.

[@JAYZ999]

As always, well explained and you go into a good amount of detail

[@onlyonesky9611]

This is great information, thank you very much Dr.!

[@MikeAvilaMD]

It would be interesting to know how the data relating to the half dose moderna boost pans out

[@nicebluejay]

Thanks Roger!

[@angelaharris1112]

Thank you for this important info!!

[@navsofour2892]

Excellent video, exactly what i was loooking for to make my own decision.

[@felipeevangelistajr1164]

Thanks for the info. It really make us more knowledgeable in choosing which of which is best for us.

[@petershulick5270]

Nobody mention like the military does when you get shots you're required to do about twenty push-ups afterwards to work this medication into your arm muscles, and practice at before bed and the next morning as well, I'm surprised nobody said anything about that? I'm former military 12 years previously and this was a common practice and basic training

[@susan2043]

Sincere thanks for making this very valuable infornation available to everybody.

[@franceslock1662]

I had 2 x AZ because that was all that was available at the time. I followed with 2 x spaced full strength Moderna boosters. I am in perfect health and have never had COVID to my knowledge. The only significant reaction I had was the first AZ - that was a shocker. The first Moderna produced a mild reaction that lasted a week. I’m so grateful to be protected, take vit D and get sunlight every day. If you have a positive mindset about vaccines, you will bounce back and do exceptionally well.

[@fazdoll]

Is there any known quantitative correlation between IgG biding antibody levels and effectiveness in real-world studies? These graphs show that J&J boosted with a second J&J is the _worst_ of the IgG antibody levels. And yet, J&J's research showed that giving a J&J booster two months after an initial J&J shot gave 94% (give or take) effectiveness against symptoms for the dominant Delta variant. So, while mix-and-match boosting gives great IgG levels, in practice it might be unnecessary overkill. Also, how do we know that the effectiveness of the Pfizer and Moderna boosters won't fade like the original shots did?

[@stephenfield4593]

This is good information and I appreciate the work. In my case you are recommending Moderna but this is with the full dose. Is there anyway of knowing how this data sill change with the half dose? ( I had Moderna originally) Otherwise it might be better for me to get Pfizer.

[@edwinjewell5359]

If this is A worldwide pandemic why whould you have multiple Companys with different vaccines instead of compiling data and going with what really has Best efficacy rates.

[@kittyfarkas]

Good info. Thank you. I took a 3rd dose Moderna in Aug as I'm immune compromised, and my paper says .50 dosage .Does not say micro grams..just .50 .I'm wondering if I was given half dose?

[@igelkott255]

I want to see the results of people who had COVID, then got fully vaccinated, then got boosted and compare to non-boosted.

[@negativeone4021]

I got covid. Had it pretty bad and now I am boosted with problems lasting months long.

[@CreepyRecordings]

I took AstraZeneca then three-four months after I took the Pfizer and now six months after I got the Moderna booster but this so far is the worst symptoms ever fever and headaches that won’t stop

[@jjstimpson1]

Excellent as usual

[@dalebabbitt6185]

Well presented, thank you!!!

[@rubywest5730]

Many 💉 people I know are ill after being injected. Those drug free, are fine. What's going on?

[@datapro007]

Excellent presentation, thank you.

[@pregapillay5326]

Many Thanks for a very clear summary of the value of booster doses - a retired physician

[@mjkcneely]

Question - if the J&J is an adenovirus vaccine and Pfizer, Moderna are mRNA vaccines, is there any benefit, such as, for example, a different type of immune response, that if mixed would theoretically give you broader immunity? Is this something that is measurable?

[@lw3269]

Got my Moderna booster a week before unknowingly spending time with family members who developed Covid a few days later. So far, so good. Was worth the chills and fatigue!

[@saeedawalimohammed1776]

Excellent explanation and very informative even for people who aren't scientists.

[@roma7923]

I got my first vacccine which is Moderna exact 7 days today, base on my experienced after first day of the shot l only felt sore half of my arm not the full arm, and then the next day it's totaly gone and felt nothing at all. My 2nd dose is on 27 this month. God Willing

[@MsTony1402]

This is all very interesting but here in the UK we don’t have a choice!

[@Bunkysworkshop]

Well I got the JnJ and I guess I’m going for the Moderna booster.

[@spyder000069]

I had my two pfizer shots in march '21. No issue with first one. Second one I had a headache that started 24 hours after shot and lasted for 6 hours. I never get head aches so I fairly confident this was a reaction to the shot. I was able to continue to my work day through it and felt better after napping. This morning I got the pfizer booster. No issues so far except a sore muscle at the injection site tonight. We will see if I get the headache tomorrow.

[@tonyv8925]

Thank you for the informative video, Sir.

[@deborahhebblethwaite1865]

Thanks Dr S🇨🇦

[@farzanehpaknia7968]

Thanks so much for the informative video!🙏🙏🙏🌷🌷🌷

[@tealatata]

it doesn’t make sense to me to mix and match the vaccines

[@Taconic66]

Had two doses of Moderna originally, pretty rough side effects on the second dose with headache and fatigue especially . Am definitely considering getting either of the other two for booster.

[@ratpatooti5080]

I can attest to the mild reaction having originally gotten Moderna and now having had the Pfizer booster. Thankfully, all I felt was a sore arm. I found it strange because I was totally floored by Moderna both times.

[@readg4fun]

Thanks for info; I agree about Moderna

[@reggieshark]

Yep i had 2 Modera and just got a phzer boost 💪

[@worldcitizeng6507]

I had the Pfizer vaccine in March/April, both times only with sore arm for 12 hours. I went to run my errands and then to bike at the gym 4 hours after my vaccination

[@shravanmehra3743]

Excellent. Any information with astra zeneca ?

[@arvinjaducana1892]

Nice xplaination doc..plss always update about vaccine

[@cyberblitz]

Curious, what is the name of the application you use for drawing when you're explaining things?

[@jimchallender4616]

Comforting information, Thanks

[@bme7491]

I've had the Pfizer vaccine and booster. Never had any side effect exclusive of soreness at the injection site (worse on the booster as the jab was aspirated). Makes me wonder if I generated any anti-bodies.

[@nml1930]

Thank you so much!!

[@catmom1322]

I've been researching to discover which booster is best. I was initially vaccinated with Pfizer, so now I think sticking with Pfizer is a promising idea . However, after my 2nd vaccine I had all the malaise, fatigue, & myalgias along with a pretty profound allergic reaction. The reaction at first was limited to the arm, with localized urticaria & pruritus, soon to follow with systemic reactions, mostly, again pruritus. What I can't find in the literature is that does that reaction prohibit me from taking the Pfizer booster? Thanks for this no-nonsense, succinct, & straight to the point video.

[@LFTRnow]

What I'm basically reading here is if you had been vaccinated by Moderna or Pfizer you can get a Moderna or Pfizer booster and your approximate rate and type of symptoms, as well as your improvement in efficacy against COVID, are roughly the same. It also shows (of course) that a booster is recommended no matter which of the 3 you originally had.

[@Arokhantos]

Here in Netherlands they decided not to give boosters yet except vunrable which appearntly does not include me even tho it previously did, now cases on the rise and im getting fed up.

[@BLACKLOTUS104]

As usual very good analysis and breakdown. Thank you. I live a country where we use Astra-Zeneca/Oxford. Is there any date about mixing with other vaccine as booster? Or why AZ not included in the study? Thank you.

[@dlloydy5356]

Thanks appreciate your clear explanation

[@allisonc7862]

So helpful, thank you!

[@lailapadovanibogari9038]

I had Pfizer. Second shot I had a severe reaction: sore arm, headache, high fever( 103.1) nausea. I was in bed for more than two days and I couldn’t even drink water. I just had the Pfizer booster two days ago: I still have fever(101.3), strong headache, nausea, lack of appetite, swollen lymph nodes in my armpit. My husband didn’t have any side effects. They told me that I have a very strong immune system.

[@pamelaneibuhr6959]

I’m sticking with my Moderna.

[@mxbraun0]

Thank you for this. This was super informative and easy to understand.

[@armindolopes2248]

thks for all...

[@scottcummings8602]

I would love to hear from those who originally got the J&J but are now either considering or have already gotten a booster from one of the others.... and if you had any side effects. thanks

[@madtical777]

thank you for the very extensive info. i came to your channel before i decided to get the moderna vaccine. i have a very good question, can you get some findings on if someone can still transmit / spread covid after receiving a booster shot?? and if yes what are the chances and severities. thanks for your excellent knowledge

[@cheryldias4269]

Will a longitudinal study have to be done to with the same test subjects using the same protocols to determine the efficacy of both B and T memory cells responses both qualitatively and quantitatively.

[@pac1fic055]

Happy to have have taken the Pfizer boost after getting the J&J. Felt a little hot the first night and a bit tired the next day (but went hiking anyway), and felt great afterwards.

[@James-hm9on]

what about aspiration before injection ?

[@zozzarogeorge6720]

Love this doctor

[@Epiceli169]

A better question to ask is how many boosters should you take

[@akkm6234]

Please share insights on kids 5-11 vaccine . Thanks

[@girlgeniusnyc272]

Thank you Dr Medcram and Team Medcram!

[@prettylittleravenna]

Anyone know which software he uses for writing parts of the video (yellow text on black background)?

[@ChrissieSM]

The booster is the same as the original first doses which were supposed to work for the original corona. Now that the virus has mutated several times, how can the booster fight the new variants?

[@SerafEnd]

That was an amazing explanation! Thank you so much for this.

[@hugomarquez3189]

This is the video I’ve been looking for all this time, I read the whole study and watched the CDC debating this, but I need more clarity on the Moderna booster, since they’re using half the dose of what they used for the study. I got the Moderna booster thinking it’d give me that 75x antibodies, but since it’s half, which is still more than Pfizer anyway, I’d love to see the numbers for the actual dose.

[@EMichaelBall]

Probably equal to a J&J boost of Pfizer or Moderna, with more side effects than J&J.

[@darkprince56]

I also got a reaction with the Moderna, though I just got the first dose. The injection site was very painful for ~3 days, about the area size of an orange and I got chills and fever for 2 days afterwards. 99.6 temp that night and 99.8 the next day.

[@littlevoice_11]

Please can you review the research on aspirating vaccines for covid

[@charlesward8196]

Does the severity of reaction have any relation to the level of protection? My second Shingrix shot kicked my ass for a week, but I did not have any significant reaction a week later to the 3rd Pfizer after two Pfizers.