Which Neurotransmitter is the Most Stimulating? (Neurotransmitter Lore)

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That Chemist

That Chemist

Күн бұрын

Пікірлер: 650
@That_Chemist
@That_Chemist Жыл бұрын
Grab Atlas VPN for just $1.83/mo + 3 months extra before the SUMMER DEAL expires: get.atlasvpn.com/chemist 👈 #ad #atlasvpn
@nictibbetts
@nictibbetts Жыл бұрын
Dat neuronal chemical messaging system fuckin wit me brain chemistry n shit fu real homie got me thinkin thoughts n shit got my brain doin dat neuroplastic shit stretchin n growin.
@misterhat5823
@misterhat5823 Жыл бұрын
A VPN shill. Thumbs down.
@nictibbetts
@nictibbetts Жыл бұрын
@@misterhat5823 based
@junius71
@junius71 Жыл бұрын
From what I understand, MG isn't necessarily the absence of the the receptors as much as it is that the immunoglobulins are blocking Ach from reaching its target on the receptors which is why its usually treated with indirect parasympathomimetic which block Ach-esterase from breaking down Ach and increasing its concentration at the NMJ
@WhiteHazee
@WhiteHazee Жыл бұрын
I love it when you mix chemistry with pharma/biochemistry. But you can't put dopamine in C and put this vulgar norepinephrine in S 😢😢😢
@CompletelyNormal
@CompletelyNormal Жыл бұрын
Some of the other neurotransmitters not mentioned in this video get really weird. My favorite is endocannabinoids because they break all the rules. They were one of the last neurotransmitters to be discovered, and we still don't know everything they do, but the short version is that they work backwards. We only discovered them because someone realized, "Hey, weed clearly does something to your brain and it doesn't seem to be interacting with any of the neurotransmitter pathways that we already know about."
@gandalf8216
@gandalf8216 Жыл бұрын
I beg to differ, I consider the serotonin-dopamine pathways to the hippocampus and various areas of neurogenesis far more impactful, and novel. You know, how memories are formed and ultimately biased based upon emotional state and present focus/motivation. The endocannabinoid system is a simple regulatory system, not that different from GABA and glutamate, both able to be either inhibitory or stimulating depending on the site of the receptors. Serotonin systems (not a typo) are self-regulatory, due to stochastic distribution of receptor densities, which in turn regulates "direction" (or rather, the natural selector) of fresh neurons and their migration paths. I mean, the endocannabinoid system is pretty cool, because I have a weak spot for simple but effective systems, but the serotonin-dopamine pathways for memory formation and brain adaptability is too cool for anything to top off.
@profpuffofficial2
@profpuffofficial2 Жыл бұрын
@gandalf8216 wait till you discover metabolome-gut-mitochindrial-serotogenic systems and their interaction with the brain
@cyan_oxy6734
@cyan_oxy6734 Жыл бұрын
​@@gandalf8216I think serotonin should be left alone. Like seriously all these SSRI antidepressants are like kicking your TV to make it work again. Sometimes it works, sometimes you make it worse and sometimes the TV just dies. Just give me opium and koka leafs for depression like in the good old days. It surely can't be that hard. All these new psych meds are easily perscribed because they feel like shit. Just give me something that makes me feel good. People could freely buy opium in pharmacy for centuries but somehow in the last 100 years everything went to shit.
@AnthonyBolognese710
@AnthonyBolognese710 Жыл бұрын
@@cyan_oxy6734natural supplements like you mentioned, and deadlifts for depression. Seriously - lifting heavy weights [safely] really helps stave off depression.
@berrybee9242
@berrybee9242 Жыл бұрын
@@cyan_oxy6734 one of the dumbest takes ive seen all day
@travv88
@travv88 Жыл бұрын
14 minutes of dopamine explanation and then it is ranked C because cheese starts with C.
@unknownbandit6509
@unknownbandit6509 Жыл бұрын
i love how i get my dopamine and serotonin is a tiny hardworking walking chemical that carries a ball of neurotransmitters to my neurons. you go lil guys!
@That_Chemist
@That_Chemist Жыл бұрын
let those sacks of neurotransmitter MARCH
@0alalune0
@0alalune0 Жыл бұрын
If you want to learn more about them: kzbin.info/www/bejne/b4O4eX2eqNCKZpI
@dickartist
@dickartist Жыл бұрын
truly the molecular Sisyphus
@MoreTrenMoreMen69
@MoreTrenMoreMen69 Жыл бұрын
@@That_ChemistONWARDS TO VICTORY MY PRECIOUS NEURO HOMIES
@ujfujf422
@ujfujf422 Жыл бұрын
@@That_Chemist Do all neurotransmitters have them lil guys?
@kubas3816
@kubas3816 Жыл бұрын
As a med student, this video is rlly helpful. Never thought I'd see That Chemist go in this direction. Thank you
@That_Chemist
@That_Chemist Жыл бұрын
It’s because we wanna cover topics which are important, and our team has a fair amount of biochem expertise :)
@prapanthebachelorette6803
@prapanthebachelorette6803 Жыл бұрын
I’m glad you do something biochem stuff 😊
@feelinghealingfrequences7179
@feelinghealingfrequences7179 Жыл бұрын
never to late to drop out of med school and become a podiatrist and have a balanced work life
@mrpickles619
@mrpickles619 Жыл бұрын
You struck a great balance of discussing details of neurotransmitters while still being generally understandable to a non-chemist/non-biologist. I'd watch more videos talking about other neurotransmitters and/or talking more in depth about their functions. Also the S3RL x That Chemist crossover is as awesome as it was unexpected.
@That_Chemist
@That_Chemist Жыл бұрын
His music is great - Jole is a nice guy :)
@jva4120
@jva4120 Жыл бұрын
This man just summarized half a course of cellular physiology in roughly 14 minutes. Impressive.
@katoka143
@katoka143 Жыл бұрын
I'm hyped for when my chemistry studies at uni start in 2 months and I can finally understand your videos
@princepsregem4006
@princepsregem4006 10 ай бұрын
Serotonin is by far my favorite of the neurotransmitters. I absolutely love the special liquid colours it can make you see.
@colingeissler2540
@colingeissler2540 Жыл бұрын
wow so much effort has been taken into creating this video. The fact that there are these quick definitions/ extra context is provided is just so convenient, so I dont have to spend as much time looking things up myself. Thank you sir
@reformlabs1050
@reformlabs1050 Жыл бұрын
It took some effort but completely worth it! This is what I was hoping for exactly, to cater to the audiance that wants a more deeper understanding of stuff without going on Google to look it up.. I'm glad my inference was correct, thanks for the feed back :) David here, the guy who made the visuals for this video...
@Forehead_Fergus
@Forehead_Fergus Жыл бұрын
Babe wake up, thatchemist dropped a new video
@That_Chemist
@That_Chemist Жыл бұрын
sorry it took SO LONG :/
@jajastacha3796
@jajastacha3796 Жыл бұрын
Ok
@regulatorjohnson.
@regulatorjohnson. Жыл бұрын
Don't call me that...
@TrianglePants
@TrianglePants Жыл бұрын
yawn
@thomasrussell4674
@thomasrussell4674 Жыл бұрын
A tap on the shoulder from dopamine
@Linguae_Music
@Linguae_Music Жыл бұрын
DMT is the coolest neurotransmitter. In the visual cortex of laboratory mice, the proportional concentration of DMT compared to Serotonin, was found to be approximately 1:2 under normal conditions. :D (this is even more surprising given its short metabolic halflife of about 5 minutes.) That's why from now on, I will be referring to it as a neurotransmitter. I wish they would actually study it more. It has effects on neurogenesis, and neuron repair (at the very least by downstream activation of BDNF), and also plays a role in plasticity.
@ollie6133
@ollie6133 Жыл бұрын
For a chemical to get the status of being a neurotransmitter it must satisfy four conditions. 1: it's synthesized intracellularly. 2: it's stored intracellularly. 3: it's activated and then consequently 4: it's deactivated. I'm not saying DMT couldn't be a neurotransmitter, but an abundance of the stuff compared to serotonin isn't sufficient to say it is.
@thedarkroomlondon
@thedarkroomlondon 8 ай бұрын
For clarity, I presume you mean N,N-DMT in this case, as opposed to any of the common (4-PO, 4-HO, 5-MeO, 4-AcO) or uncommon analogs? IIRC there's some recent research that's found some quantities in human CSF, but the jury's out from what I've read as to if we can really call it an endogenous neurotransmitter... yet! "Biosynthesis and Extracellular Concentrations of N,N-dimethyltryptamine (DMT) in Mammalian Brain" 2019 makes for an interesting read, regardless.
@ericdaugherty5607
@ericdaugherty5607 Жыл бұрын
I would be stoked on a video pertaining to obscure neurotransmitters that are not commonly known about and the functions they have in the body!
@Jasonmakesvideo
@Jasonmakesvideo Жыл бұрын
There's a name for those and I've been trying to remember it for the past 3 days
@thefoxthatplaysgames1543
@thefoxthatplaysgames1543 Жыл бұрын
22:40 the AMPA receptors description is just the NMPA receptors description Great video
@morgan0
@morgan0 Жыл бұрын
it would be really cool if you did a video on the pathways from calories to energy for the cell, both for glucose and for ketones
@That_Chemist
@That_Chemist Жыл бұрын
Yeah we wanna do a video like this eventually
@nina-mill
@nina-mill Жыл бұрын
Jesus Christ... I just spent over three hours watching, pausing, digesting, and resuming a 30-minute KZbin video about six neurotransmitters. This was so dense, probably the most well compressed info-packed KZbin video I've ever watched. How did you do it! The writing, the editing, the animations, the research (that long ass list of references in the desc!)... and the humor sprinkled along the way💛 I couldn't be happier, I feel so immensely lucky to have this available to me- and for free? Incredible, incredible work from everybody involved, oh my goodness! Thank you all, from the bottom of my heart!Bless you!👏👏👏🙏❤️‍🔥🔥🔥💯
@That_Chemist
@That_Chemist Жыл бұрын
I'm glad you enjoyed it a lot! The best way to help the channel is to share the video with specific people who you think would enjoy it :) Have a _great_ day
@VirusGamingHDGaming
@VirusGamingHDGaming Жыл бұрын
0:36 little note here, neurons cannonically only release 1 NT. Some exceptions like motor neurons exist but 2 is usually the max. However, a neuron can accept different multiple neurons based on the receptors on its dendrites.
@shakogasteier6370
@shakogasteier6370 Жыл бұрын
No they Release all Kinds at any time, sometimes in a pulsating manner, or in a more steady Stream called Tonic. For example Tonic Inhibition via gaba IS very important in the brain. Tonic Inhibition IS modulated also via glia cells... and some antiepileptics decrease gaba decarboxylation...
@shakogasteier6370
@shakogasteier6370 Жыл бұрын
Sorry they increase glutamate decarboxylation, which increases gaba...
@derenjoy3r
@derenjoy3r Жыл бұрын
Damn, that start is pretty high quality. Good explanations!
@That_Chemist
@That_Chemist Жыл бұрын
I'm glad you like it :)
@AntimatterBeam8954
@AntimatterBeam8954 Жыл бұрын
Could my neuroanatomy lecturers at uni have been like this introduction, my lecturer sounded like he hadn't seen modern life before. And tier lists + learning = good PS - thank you for saying biology is complex. :)
@ShockedCaucasian
@ShockedCaucasian Жыл бұрын
This video was amazing! I learned so many nuances to things I thought I fully understood, and this just makes me want to pursue my biochemistry dreams even more haha. Thanks for the awesome 3d models of not only the neurotransmitters themselves but the receptors too! I had never known there are so many varieties of receptors for each neurotransmitter, Awesome content as always 😎
@adamantris2
@adamantris2 Жыл бұрын
that tiny music video at the end imitating the actual dopamine video by s3rl caught me offguard, love it
@nerfnerd10
@nerfnerd10 Жыл бұрын
Please continue this video series for every neurotransmitter!!
@penumbramine
@penumbramine Жыл бұрын
love the vid. I was curious if you would involve neuropeptides in the list such as dynorphins, enkephalins and endorphins. the opioid receptors gettin no love today.
@That_Chemist
@That_Chemist Жыл бұрын
if people are interested in the topic of neurotransmitters, we may consider making more ;) the best way to help is by sharing the video with people who you think would enjoy it!
@NewtonMD
@NewtonMD Жыл бұрын
Rat: gives up food for the sheer pleasure of *self stimulation*
@contomo5710
@contomo5710 Жыл бұрын
there was so much information packed into this video, ill have to get a little stimulated and watch it again before i can reuptake all that information into my neural pathways in a couple of minutes
@That_Chemist
@That_Chemist Жыл бұрын
I hope your signal transduction is affective :)
@zhon5311
@zhon5311 Жыл бұрын
love that you're having fun in these videos. thank you
@That_Chemist
@That_Chemist Жыл бұрын
I am having fun making them :-)
@eliasw8084
@eliasw8084 Жыл бұрын
Honestly one of the best channels I found in the past months. Sad to see that it not gets the attention it deserves. As much as it hurts to say, maybe more short form content would do a lot
@That_Chemist
@That_Chemist Жыл бұрын
short-form content isn't financially viable, now that being said, we are making them anyway now lol
@andrewz2854
@andrewz2854 Жыл бұрын
“I like to think of GTP as the Canadian dollar of the cell.” Perfect
@joranlefleur7942
@joranlefleur7942 Жыл бұрын
'Weeeelcome back, I'm that Chemist...' Such a great way to open your videos, love it. And the tier rankings of chemicals always crack me up!
@Some_Tomfoolery
@Some_Tomfoolery Жыл бұрын
Let’s goooooo, another video from thatchemist !!!🥳 This video is very stimulating, keep up the good work!
@That_Chemist
@That_Chemist Жыл бұрын
Thank you very much! Based and grimace-pilled
@Some_Tomfoolery
@Some_Tomfoolery Жыл бұрын
You are based :D
@turbovirgin_
@turbovirgin_ Жыл бұрын
People say that the human brain is essentially a very advanced computer. If this is true, then deciphering the mechanisms of the brain is like trying to make sense of spaghetti code written by insane hyperintelligent chimpanzees that have drafted, redrafted, overwritten, feature-creeped, and developed one after the other, for six thousand years. And the computer runs in Terraria.
@dororo2597
@dororo2597 Жыл бұрын
Cerrebelum
@Sniperboy5551
@Sniperboy5551 4 ай бұрын
That was the exact revelation I had when I used a certain 5-HT2A receptor agonist
@DubbyMoodz
@DubbyMoodz Жыл бұрын
Ever since I subscribed to Hamilton Morris I keep getting recommended these type of videos. Thank you Allmighty Algorithm for bringing me here, this video is incredibly concise for the amount of information it has.Alos, that quick humor works really well. :)
@That_Chemist
@That_Chemist Жыл бұрын
We also did a podcast together ;) kzbin.info/www/bejne/mqWqfqyBoa-bm7s
@0alalune0
@0alalune0 Жыл бұрын
I love how much explanation you added about these molecules' functions!
@chemdelic
@chemdelic Жыл бұрын
Editing is insane bro
@That_Chemist
@That_Chemist Жыл бұрын
thanks! David is a king
@GerinoMorn
@GerinoMorn Жыл бұрын
Learned helplessness is such an important topic, I think one of the most shocking I took out of my psych studies. I didn't graduate so I'm not gonna offer any advice to anyone, but do check it out, if you have.... troubled past.
@ciwous3759
@ciwous3759 Жыл бұрын
Be careful with the judgements you give, but don't get overcautious. It's good to share those thoughts.
@alextaylor4725
@alextaylor4725 6 ай бұрын
9:00 I fell in love with the way you say locomotion
@prufrock1977
@prufrock1977 Жыл бұрын
Love the ChubbyEmu reference 😂
@Celastrous
@Celastrous Жыл бұрын
Man this is amazing. When i asked for a high quality neutrotransmitter video, i didnt expect it to be this good!
@Rachel_Banner
@Rachel_Banner 8 ай бұрын
Just discovered your channel and am binging the videos, but I just had to let you know that the joy in your voice during the little singing bits in this one was especially wonderful. I couldn't help but smile! As someone who is not good at chemistry and wants to improve that, your explanations are fantastic and so engaging and funny. Thanks for all you do!
@PrestonThePianist
@PrestonThePianist Жыл бұрын
I guess me taking Biochemistry really paid off. This is such an amazing video covering so many hyper-complex concepts in amazing detail and clarity! Can't wait for the next video.
@That_Chemist
@That_Chemist Жыл бұрын
Glad you enjoyed it!
@fero_101
@fero_101 Жыл бұрын
Please make more neurotransmitter videos, your explaining of what they do and how they function is so good, its also really interesting content. Loved the video :).
@GerinoMorn
@GerinoMorn Жыл бұрын
Ah yes, noradrenaline. It turns out that when treated with serotonin/noradrenaline reuptake inhibitor my heart rate rises from my "normal" 36bpm to something more traditional xD
@markos.5539
@markos.5539 Жыл бұрын
bro this is probably the most amount of actual learning ive gotten in a while and you made a 30 min video of it. Props to you. Still have to pause a lot to even grasp wtf is going on. It is definitely interesting and i wish to know more.
@That_Chemist
@That_Chemist Жыл бұрын
I appreciate your kind words! It motivates the team to keep making videos :D
@claudelorrain-bouchard6941
@claudelorrain-bouchard6941 Жыл бұрын
6:59 new watching this video instead of eating breakfast... these videos are "self-stimulation"
@That_Chemist
@That_Chemist Жыл бұрын
You should eat breakfast, otherwise you will feel tired unless you are used to skipping breakfast, but most people should probably eat breakfast, so I’m Gonna be the first creator to tell you specifically to eat breakfast
@rietbergamber852
@rietbergamber852 Жыл бұрын
I have been studying psychology and neuroscience for 5 years and failed the learning and memory course 3 times. This video taught me more than that entire course ever did.
@That_Chemist
@That_Chemist Жыл бұрын
I’m happy to hear that it helped! It sounds like the prof for that course needs to work on communication
@rdallas81
@rdallas81 Жыл бұрын
​@@That_Chemistor- someone needs to study.
@salvadorbarbagarcia7907
@salvadorbarbagarcia7907 Жыл бұрын
this guy is nailing the design of his videos even further
@reallightfield5314
@reallightfield5314 Жыл бұрын
What I've learned from this is that apparently everything can cause Anxiety if your body is screwed up enough
@SuperCameronMan
@SuperCameronMan Жыл бұрын
I love these videos because you're like: *Complex and thorough explanation of dopamine*, followed by "Dopamine goes in C tier because cheese starts with 'c'."
@TOP.MUSICZ
@TOP.MUSICZ Жыл бұрын
This video's quality is stunning, keep it up and thanks for all the informations ;)
@That_Chemist
@That_Chemist Жыл бұрын
We're glad you like it :)!
@Drunk_scientist201
@Drunk_scientist201 Жыл бұрын
I love you and your videos especially those about biochemistry, I swear to god u directly hit a spot with your animations and explanations of the biochemistry. I could literally listen to a whole semester of biochemistry in a week if it was all videos of yours
@Clubcanthandleme13
@Clubcanthandleme13 Жыл бұрын
the chubbyemu bit got me, had to check if i was still watching a that chemist vid lol. great as always, as someone who's got an interest and chemistry, especially how things react with neurotransmitters and medication with the body as a whole, this video taught me a lot more than text books could in such a short time
@That_Chemist
@That_Chemist Жыл бұрын
I will share your kind words with the team :)
@loganwolv3393
@loganwolv3393 Жыл бұрын
I can confidently say that this video has decreased my GABA levels and increased my Dopamine, Serotonin, Acetylcholine, Noradrelanine, Serotonin and Dopamine levels all at once! Thank you.
@gboekenkruger1
@gboekenkruger1 Жыл бұрын
Thank you for the depth to each neurotransmitter. Most information videos are so basic, you covered a lot!
@TexadaIslandRocks
@TexadaIslandRocks Жыл бұрын
“Atlas acts like GABA” killed me during the ad 😂
@That_Chemist
@That_Chemist Жыл бұрын
They still haven’t paid me for the ad yet
@TexadaIslandRocks
@TexadaIslandRocks Жыл бұрын
@@That_Chemist ugh aww sorry man that sucks 😫
@NotreDanish
@NotreDanish Жыл бұрын
Well now I understand even better why I am taking the specific medication I just got prescribed. It’s an NDRI and it was recommended due to me having depressive mood swings and ADHD symptoms and now I understand even better why it works well for both parts.
@_kww_
@_kww_ Жыл бұрын
This is by far one of the most valuable and educational channels on this platform. Kepp up the amazing work 😊
@rilmar2137
@rilmar2137 Жыл бұрын
So many neurotransmitters to pick from and yet my brain just decided "no, thank you"
@That_Chemist
@That_Chemist Жыл бұрын
Sometimes you gotta help them get fixed
@hikarok4055
@hikarok4055 Жыл бұрын
Great video to explain the basic principle of how neurotransmitters work. Especially valuable for me and my friends (already shared), who just can't understand what I am talking about sometimes :^)
@That_Chemist
@That_Chemist Жыл бұрын
you are a legend for sharing it :)
@davidcora2751
@davidcora2751 Жыл бұрын
Thank you for a fascinating glimpse into the complexity of life!Very informative as to the basics which is somewhat within my grasp. Love the humor and the Zappa reference 😁😁.
@That_Chemist
@That_Chemist Жыл бұрын
Glad you enjoyed it!
@applenrd
@applenrd Жыл бұрын
bro is going from orgo memes and peer review comedy to an MCAT study channel
@AI.mposter
@AI.mposter Жыл бұрын
26:14 Nilered reference
@doommusic4738
@doommusic4738 Жыл бұрын
Super dopamine releasing video
@AnthonyBolognese710
@AnthonyBolognese710 Жыл бұрын
12:05 great video. There’s one additional aspect I believe should be mentioned about the dephosphorylation of the GTP. That phosphoryl group is transferred somewhere. Kinases add it to certain amino acids iirc so I’m wondering where it went in this demonstration. I’m guessing it was added elsewhere to the subunit that binds to GDP, or one of the other two as a signal to get into position. Phosphorylation events are part of the signal cascade too so I wasn’t sure if I missed it or it wasn’t covered in this part.
@That_Chemist
@That_Chemist Жыл бұрын
We didn’t cover it - one of the subunits is transiently phosphorylated so that it can carry out it’s function
@AnthonyBolognese710
@AnthonyBolognese710 Жыл бұрын
⁠@@That_Chemistthanks for confirming that. I wasn’t sure if I missed it. I knew it had to go somewhere.
@whitlermountain7198
@whitlermountain7198 Жыл бұрын
I love how much fun you have with this video
@thatguy431
@thatguy431 Жыл бұрын
bro, the editing and animations on this is amazing! nice work!
@That_Chemist
@That_Chemist Жыл бұрын
Thank you so much 😃 I will share your compliment with the team :)
@TheStefProff
@TheStefProff Жыл бұрын
wow, this channel is insane i love it. Great job, bro!
@That_Chemist
@That_Chemist Жыл бұрын
thanks :)
@AI.mposter
@AI.mposter Жыл бұрын
19:53 Chubbyemu reference?
@yari_dawg
@yari_dawg Жыл бұрын
ah i remember getting serotonin syndrome from taking a lot of cough syrup and drinking a lot of grapefruit juice, the lady on the phone said it was only mild but by fucking god it did not feel mild lmao
@kenhaze5230
@kenhaze5230 Жыл бұрын
I figured there'd be lots of memes and gloss, but this wasn't even a clinic on neutotransmission... It was a HOSPITAL on neutotransmission. Great job!
@oldskool1977
@oldskool1977 Жыл бұрын
In regards to dopamine: Methamphetamine is KING!!!
@andrewwheat8939
@andrewwheat8939 Жыл бұрын
we want more like this! you're amazing!
@That_Chemist
@That_Chemist Жыл бұрын
it's only possible with the amazing team we have :)
@wake6768
@wake6768 Жыл бұрын
Loved it! Please do more videos about neurotransmitters
@lunareclipse363
@lunareclipse363 Жыл бұрын
Finally, an interesting way to learn the things I missed by not going to neurochemistry lectures in uni and barely passing the course as a consequence!
@AirwayBreathingChair
@AirwayBreathingChair Жыл бұрын
This brings back memories from the pharmacology classes I had to take for CRNA school. Would love to see a tier list of anesthetic drugs 🙂
@ashton4537
@ashton4537 Жыл бұрын
I literally have to comment on this video just to say how amazing the research for this is. The research you put together on mental health disorders and how different receptors are linked to them was not something I was expecting to find but as someone who used to take anti-depressants it was extremely interesting learning more about the different serotonin subtypes. I remember memorising the serotonin 5HT2C receptor when I was 14 as it is a common receptor site for SSRIS and it was something that intrigued me greatly. This video is incredible (especially as a highschool chem student), and I'd love to see more on the chemistry behind mental health disorders or even the endocannabinoid system in future :)
@That_Chemist
@That_Chemist Жыл бұрын
Our next big video is one on ADHD :)
@ashton4537
@ashton4537 Жыл бұрын
​@@That_Chemist Absolutely awesome.
@Guidus125
@Guidus125 Жыл бұрын
Superb comprehensive and easy to follow overview!
@sIippo
@sIippo Жыл бұрын
New favorite channel. Watched you a bit before but you really made a banger with this one. I love pharmacology and I love S3RL. Thank you. Thank you for putting 2 and 2 together and making an educational yet entertaining video. Never stop doing what you're doing!
@That_Chemist
@That_Chemist Жыл бұрын
Awesome, thank you!
@Joubes
@Joubes 9 ай бұрын
For anyone wondering, serotonin interaction with bowl control is why sometimes you have to take a dump when taking mushrooms
@Shinobubu
@Shinobubu Жыл бұрын
Brain uses so much ATP. And this is why Creatine can absolutely help with the brain's performance since it replenishes ATP faster.
@ryangribs
@ryangribs Жыл бұрын
Imagine being in evolutionary development for millions of years to place a crucial part in advanced biological function and getting placed as D tier
@Blue-Spirit
@Blue-Spirit Жыл бұрын
Thank you for breaking that banana in half. I saw a monkey do this once so i had to try it and i never stopped snapping banans. Ever since then, all my peers think i have too much dopamine. Some just cant handle the fact that primitive operations are SOMETIMES more optimal in comparison to culturally acceptable ones.
@Kresh42
@Kresh42 Жыл бұрын
25:15 Tony Soprano had a little-known third GABA receptor, the Gabagool receptor.
@DiamondFade
@DiamondFade 17 күн бұрын
i love it, i would like to see more pharmacology related content on your channel
@everythingexplained3226
@everythingexplained3226 Жыл бұрын
14:20 i could swear the consensus was receptor density increases with tolerance. thus more substance is required to reach desired effect. a person with tolerance has 50% more receptors. He thus needs 150% of substance to achieve the effect of a normal dose in a person without tolerance. edit: aparently it holds true for antagonists
@andreiloghin2522
@andreiloghin2522 Жыл бұрын
The only downside of this video is that it was posted a few months after I was studying the underlying mechanisms of all these neurotransmitters for my Pharmacology exam
@0xmmn
@0xmmn Жыл бұрын
I've never seen a youtube channel that goes this deep on any topic. thank you for doing this tho!
@abnormality00
@abnormality00 9 ай бұрын
my brain in the first part: haha he say giant chungus haha
@ColinTimmins
@ColinTimmins Жыл бұрын
Fantastic video. I had to slow it down by only 75% of the video speed and paused the video 50 times but I got there an hour or so later. But I learned a lot. Thanks! =]
@Doc_Vic
@Doc_Vic Жыл бұрын
Loved it. Make a part II !!!!
@kenbrady119
@kenbrady119 Жыл бұрын
That was rapid-fire biochemistry, pretty impressive for a fluorine chemist! One note: "vesicle" is spelled with just one 's'.
@That_Chemist
@That_Chemist Жыл бұрын
it's because we have a team of people now :D
@Jon-hh3gz
@Jon-hh3gz Жыл бұрын
Actually GABA is very very stimulating in its after effects. It helps repopulate glutamate in a region, is the leader in sleep quality and when it is achieved from maximum glutamate locally can make you super awake the next day. GABA is in a tier of its own.
@MusicExplorist
@MusicExplorist Жыл бұрын
Hearing you say "Acetylcholine" is causing my dopamine levels to increase.
@MySuperhappyfuntime
@MySuperhappyfuntime Жыл бұрын
Lazy Sunday with a new That Chemist video 😊
@varungoculdas4181
@varungoculdas4181 Жыл бұрын
Love to see the chubbyemu reference
@matt566
@matt566 Жыл бұрын
something i legit dont understand about human bio is like how in the world is neurotransmission so insanely fast? like the diagrams make it seem like the synapse vesicles move to edge then release then the receptors receive then it decides if thats gonna continue. like okay fast transport is like mm per day okay… but you touch something and you feel it cia registering in brain in literally 50ms??? how does the math work out here?
@Exergonick
@Exergonick Жыл бұрын
So that's a good point, there is a pool of vesicles ready for release and it kind of rotates them in and out kind of like an airport, theres always something on standby. My explanation was more focused on how they show up in the first place not how they are released, but effectively there is a voltage gradient that runs down and triggers them faster than any protein process.
@kinexkid
@kinexkid Жыл бұрын
Back when I was in college, one of my friends found a super old medical bottle from probably the 50s or 60s with pure dopamine in powder form in it. I have no idea what he did with it, but I'm sure it was all decomposed by then
@That_Chemist
@That_Chemist Жыл бұрын
even then, it shouldn't cross the blood brain barrier - catechols like dopamine are usually pretty reactive tho, so maybe it all decomposed
@ogonbio8145
@ogonbio8145 Жыл бұрын
I imagine a scene of some withered, depressed, student cleaning a dark, shelf - lined room. They are dragging a half full garbage bag with their left hand, as they walk along the length of each long shelf, grabbing every dusty glass bottle and haphazardly tossing it into the garbage bag with their right hand. As they near the end of a row they feel the need to stop and inspect one of the bottles, so they pivot a bottle as to make the label face them and as they do so the room is illuminated, it reads “DOPAMINE”. Being a smart boy the student realizes this bottle contains the answer to all of his mental problems and immediately starts dumping the contents of the bottle into his mouth, chewing and swallowing the powder. It tastes good so they crack open another bottle, finishing it just as fast. Suddenly the student starts to feel unwell and passes out, smacking the back of their head on the floor. The combination of pure dopamine and brain damage from the floor incident creates the perfect storm inside of the students brain for something extraordinary to happen. When they awake they are on top of a skyscraper in New York City, they feel a sense of strength and power never before known to humanity. The Student stands up and looks at the sky line, he feels as though he has a responsibility to protect the citizens of NYC as he does so. Looking out at the skyline overwhelms him with so much emotion that he channels it all into his new found ability to fly through the air like an eagle. While flying through the air the student witnesses a catalytic converter theft in progress, this causes such an intense wave of emotion they are able to channel it into a laser beam coming straight out of their heart to disintegrate the criminal and perfectly repair the damage done to the citizens exhaust via welding from some of the deflected beams. A crowd gathers around the scene, trying to understand what had just happened. “Was that the US military?” “No, I think it was an alien” Then, an old man steps into the centre of the crowd, looks off in the direction that the hero flew, takes off his sunglasses and says “That, was DopaMan.”.
@SailorGalaxia
@SailorGalaxia Жыл бұрын
@@ogonbio8145 A story for the ages.
@contomo5710
@contomo5710 Жыл бұрын
@@That_Chemist maybe dopamine is the next taste..... first glutamate -> umami, now dopamine -> ?happy taste?
@darthmaul197
@darthmaul197 Жыл бұрын
@@ogonbio8145bruh I’m now using this as a copypasta
@YesterdayvolligausderWel-oe4pd
@YesterdayvolligausderWel-oe4pd Жыл бұрын
Adrenaline of course is the most stimulating, but dopamine will always be my favorite 😂
@isaaccoffman2070
@isaaccoffman2070 Жыл бұрын
You were talking about cheese and I swear I just heard you say it releases Queso-Morphine
@VK2GPU
@VK2GPU Жыл бұрын
Love a good queso-morphine with corn chips!
@granta5009
@granta5009 Жыл бұрын
9:30 and d12 is Eminem’s forgotten band
@euchiron
@euchiron Жыл бұрын
The Enterochromaffin Man? Who lives on Duodenum Lane? Squirrel moment: I loved hearing especially about norepinephrine and serotonin because I take Effexor/venlafaxine, which inhibits reuptake of these two. Love this stuff!
@vladthe_cat
@vladthe_cat Жыл бұрын
Its funny how the brain is learning how it works lol
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