Will THIS Supplement Cocktail RESCUE YOUR Mitochondrial Health? | Dr. Tarnopolsky

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[@klecoxs2]

When you say take everything on an empty stomach does that include Arginine/Citrulline.

[@AriCat777]

Some Vitamin E is bad so what kind was used?

[@wildwoodskimberlynewworldd5282]

I tried to order this supplement filled everything out pressed check out no checkout all I got was an email and I don't even know if my cards been debited and it says, don't click the check out twice cuz you'll get multiple charges so what is going on here? I'm not a rich person I just can't be throwing 50 bucks all over the place

[@outlierz1796]

23:55 the actual cocktail is finally on screen

[@klecoxs2]

Thanks 😊

[@eeg0415]

TY. Appreciate it.

[@chipcook5346]

No one cares if 80% of the people in another state are obese. No one cares if 80% of the family next door are obese. I thank you for this. You saved me a lot of time.

[@Ban_Helmers]

Best coment on the whole thing.

[@2BWiley2]

Yes! Been looking to see reinforcement like this. What you call “cocktail” I call “entourage effect” - both referring to the multiplier effect of taking multiple different things in tandem to achieve a broader desired effect. I started mine 2 years ago, am 61 now (so started at 59). Results: 100% elimination of liver spots all over my skin from head to toe (I was a beach lifeguard in my teens and early 20’s, lifelong surfer, so massive skin damage), wrinkles 90% gone, all grey hairs returned to brown, mind is constantly “on fire” (abundant/overflowing cognitive energy), body fat dropped from 22% to steady 12% despite a relatively high caloric intake for my size (6’ tall, my baseline caloric consumption is around 2700 calories/day for maintenance), added about 12 pounds of muscle despite losing about 20lbs fat (I do lift 4-5 days a week and have a daily “muscle” stack as well), zero issues with blood sugar, blood pressure, etc., quit wanting alcohol so just stopped altogether 18 months ago, regular hikes with 1000’ elevation climb or more, etc. etc. Bottom line: I feel like I have 60 more years in front of me. I also keep separate, quite elaborate “cocktails” for Cognition, Muscle, Gut and Skin that all overlap a bit with my “Mitochondrial Cocktail” (obviously, healthy mitochondria are the foundation of everything else). Core elements of my mitochondrial health protocol consist of a mix of the following; (1) ATP/Energy: Creatine Monohydrate (1G per 10Kg body weight daily), Methylene Blue (12-24mg daily, 3 weeks on, one week off), (2) Antioxidant(s): NAC (1G per 10kg body weight daily), Glycine (2g per 10kg body weight daily), Ergothione (3mg per 10kg body weight daily), Astanxanthin (3mg per 10kg body weight daily), Curcumin (must have bioperrine, be liposomal and be nanotized to sub-100nm particle size to permeate cell walls), (3) Bypass; Ubiquinol form of CoQ10 (95% of CoQ10 products out there are Ubiquinone form, which are fine for younger people but which some research shows elderly populations cannot effectively convert into Ubiquinol - which is the active form of CoQ10 - why this isn’t common knowledge blows my mind), (4) “mitophogy cleanse”; 60 consecutive days of 1,000mg Urolithin A once per year, (5) essential daily vitamins (in particular magnesium, copper, zinc and selenium when contemplating mitochondrial impacts), D3, Omega 3’s and the “B’s” (I do higher doses, 100mg B3/Niacin, for vasodilation and NAD+ synthesis as well), fundamental to everything, etc., etc.. I could go on. Unfortunately, we will likely never find good “peer-reviewed” studies on such “cocktails” because the possible supplement permutations are endless and testing each permutation is prohibitively expensive. But I suspect one of the reasons “natural foods” have the beneficial effects they do HAS to be the “entourage effect” of all of the different beneficial molecules comprising those foods - the way these molecules combine and work together. Great topic.

[@Ban_Helmers]

So, synergy. But "the entourage effect" sounds cooler:) You really went the extra mile in describing your regimen!

[@gregkaufmann4502]

I have done a very similar regimen with good success. Dr. Fuhrman’s “nutritarian” approach was inspiring and most likely helped save me from heart complications

[@bebahojt]

I have been taking CoQ10 daily for over 20 years. I look a lot younger then my age of 72. It is a staple in my supplement regimen.

[@johnny9072]

That's good, but he mentions you need more than Coq10 [creatine, vitamin e, lipoic acid], add those...

[@moniryousefian8782]

Could you please share which brand of coq10 you're taking?! Appreciate it 🙏

[@Valreea]

@@moniryousefian8782 The narrator in the video said CoQ10 from Costco is as good as the supplement used in his study.

[@Needless2say]

The fat soluble form is best. I have bought the coq10 ubiquinol at costco (when its on sale) and had more energy. I did stop it however it contains soy and sorbitol. Sorbitol effects copper status and the copper transport enzyme ceruloplasmin (research Morley Robbins on yt) with taking high quality cod liver oil (for real vit. A -retinol ) I have healed my shoulder and back. I would like to find a coq10 that dosent have sorbitol and is affordable.

[@85nickelos]

​@@moniryousefian8782 Mecinalis is a good brand to use.

[@kevn99]

Pick up heavy weights for 1 hour 3-4 times weekly, consume healthy fats, protein and stay away from alcohol. I’ve got more including supplements but start here. 💪🏼.

[@RamMoneyman252]

Most of the “supplements” that actually help are found naturally in the things God already provided. Herbs, fruits, meats, etc.

[@stevec3526]

Also, adjust and appropriately level up the 8 major hormones will significantly help.

[@Needless2say]

​@RamMoneyman252 I agree especially the the foods that mankind hasn't transformed in to fake food yet, unlike geniticly modified, biologically engineered. I call that stuff "Phood".

[@kirstinstrand6292]

How old are you? Young, middle age. or over 65?

[@Needless2say]

Heavy metals down regulate the MTR-MTRR enzymes methyl B12 helps this as well as Betaine (trimethylglycine) through a different pathway keeping homocysteine from building up and downregulating the methionine cycle - and SAMe . Mold exposure down regulates the GSH enzyme preventing glutathione production. (See Dr Ben Lynch's videos for more info)

[@ArkadiProkopov]

Excellent presentation, precious information. Many thanks for your work!

[@alaneverett9767]

Dr Barry tan has been pointing out the difference between tocotrienols and tocopherol as far as Vitamin E goes. I wonder if the tocotrienols would be a better vitamin E to use...

[@arubaga]

I did some mitochondrial repair with berberine and Lauricidin.

[@Ardentic-mm]

Why pick berberine? Isn't it an alkaloid?

[@CJ-gu1gs]

What dose of berberine and laurucidin did upu take? How do you know that your mitochondrial health improved?

[@arubaga]

@@CJ-gu1gs See supplement label instructions. Exercise intolerance went away.

[@BarryBPruett]

Some of the most powerful mitochondrial protectors are methylene blue and very high dose melatonin like 1,000 mg. Have you tried these ????

[@D56t37-cu7ol]

methylene blue destroys nitric oxide. That's what Dr. Nathan Brian said in one of his videos.....

[@nadahere]

methylene blue is a toxin

[@eeg0415]

How to take 1,000mg melatonin. I've take 3mg if I can't sleep. Does melatonin come in powder form?

[@nadahere]

@@eeg0415 There are two types of Melatonin. One is produced when exposed to the sun and the other at night for sleep. It's probably the most powerful antioxidant but taking it at nigh may likely disregulate the circadian rhythm . Get more sun, movement, fix your circadian rhythm don't eat past 3 or 4 PM, sleep in total silence and dark without EM field emitters [electric devices] AND address your stress. Stress revs up the sympathetic fight-or-flight survival response and changes your chemistry. It's near impossible to sleep when the body is ready to run or fight. Sleep is where cleanup and repair happens without which you will be toast in short time. Almost happened to me.

[@macheadg5er]

@@D56t37-cu7ol he is wrong. MB works on a bell cure. It increases nitric oxide at low dose (10mg a day) it does nothing to nitric oxide at 60mg a day. It totally tanks nitric oxide at the 1 mg per pound dose . In fact most things in life work this way. Too little salt is bad too much is bad. etc...

[@billtrudell1636]

Great information. I've been making the point that supplements like these need to be used together in order to be effective. Studies that look at them individually usually don't get the true picture of their effectiveness. I was able to use a keto diet together with alpha-lipoic acid and acetyl-l-carnitine to restore feeling in my feet and coenzyme q10 I added which made amazing improvements in nerve health. I no longer have flat feet and chronic constipation and difficulty swallowing have cleared up. Brain fog which I had most of my life is gone it went away with acetyl-l-carnitine.

[@danbu76]

Danke!

[@DookeyRidr]

Interesting that Methylene Blue isn’t mentioned here… since it is one of the most mitochondrial-focused supplements in existence.

[@detectivehank1]

How exactly do you administer the alpha lipoic acid? It has a very short half life in the body, so 1 dose in the morning is pretty much entirely gone 8 hours later. Andy Cutler chelation method does it every 3 hours. Do you do it that much?

[@extrememiami]

R-ALA has more bioavailability try there.

[@DrAlexVasquezICHNFM]

Excellent work and thanks for presenting your data. Vitamin D dosage recommendation was too low.

[@carolinejohnson1249]

Then go outside and get some SUN

[@cajampa]

​@@carolinejohnson1249Not everyone live where there is Sun that gives vitamin D half of the year.

[@esvajcarac3527]

@@carolinejohnson1249 unless you happen to live in a place where the sun is too weak for Vit D production most of the time…

[@davidenglish7944]

Vitamin D 10,000 iu ♥️

[@thomasyoung1588]

What about PQQ for increased mitochondrial function?

[@cathyjennings5580]

Prednisone damages muscles & cartilage overtime.😢 a trouble maker.😢 😮 Interesting information Thanks! Insightful

[@johncroasdale2748]

I have metastasized ccancer and my energy is really low, is this something i can use to bolster my mitochondria?

[@monnoo8221]

take a look to this on YT: How Metabolic Therapy CHECKMATES Cancer. ...also Dr Seyfried about the same topic. Note that complete removal of sugar and carbs is likely very beneficial. Q10 and PQQ are probably indicated for your mitochondria, and importantly, it would not help cancer cells to grow faster.

[@johncroasdale2748]

Thanks for info

[@BarryBPruett]

Consider low deuterium water, high dose melatonin 1000-3000mg per day, fasting, fasting mimicking diet, very low sugar

[@johncroasdale2748]

@BarryBPruett Thanks for info. No sugar or carbs for 2.5 years. Deuterium water out of reach financially. I'm in South Africa with 22/1 exchange rate. Also on melatonin, but not as much as you suggest. What is a fasting mimicking diet?

[@BarryBPruett]

@johncroasdale2748 Do a search and it will come up...Walter Longo for FMD. The melatonin might be a long shot but is cheap and there are some very exciting anecdotal reports. Rustle Reiter , Ryker

[@susanc.2482]

Thank you so much! I like this low dosage cocktail. I can tailor my own, not expensive and feel safe👍👍💖💖

[@MonsieurLabbe]

Excellent information, thank you sir

[@friendcrow]

Have you considered adding TMG (trimethylglycine) to the mix instead of CLA? There seems to be some negative studies on CLA.

[@agustincabrera3551]

TMG works really good... At least for me it was a great discovery.

[@beesknees6970]

Creatine makes me dizzy. Can't figure it out. I'd like to see if Urolithin-A lives up to expectations.

[@StraitD2]

How does this connect with grounding if you have mitochondrial dysfunction and oxidative stress?

[@saliagassaliagas3575]

what about astaxanthin?

[@nancysmith-baker1813]

Thankyou , very interesting and good information .

[@aperson1181]

starts at 26:36

[@chipcook5346]

No one cares if 80% of the people in another state are obese. No one cares if 80% of the family next door are obese. Thanks for this. You saved me a lot of time.

[@AlexZaidi-e8w]

Personally I think it is a really bad idea to bump up NO, that stuff becomez super damaging when converted into reactive nitrogen species, or even just lest in the NO form, and will do what you are trying to prevent... It will clamp on to cytc and stop its function causing a back flow of electrons, or the RNS will assult the mito membrain oxidising the polys... I think on par with all this is that it reduces NAD to nadh driving reductive stress, again injibiting the mito.

[@robynhope219]

I am sick and tired hearing about supplements😢am already spending a small fortune on nutraceuticals and hi proteins. I'm a senior suffering with this god awful condition.😢 Worried about my brain, but feel no improvements.😢

[@Keithzzzzt]

Look up Dr Chris Palmer on youtube. " Brain energy " is his book. Go keto...never look back. Take high dose B1, omega 3's, a methylated b complex. " metabolic mind" on you tube is a great resource too. 4 weeks on a ketogenic diet will increase mitochondria by 400% in 4 weeks. Recent studies are curing bipolar and schitzophrenia in 12 weeks. Its all about rebooting the mitochondria. Supplements are pretty useless if you eat a high carb duet. Stem cells are actually suppressed when blood glucose in the brain is high. The brain loves ketones and in a low carb environment stem cells surge into the brain. THEN the supplements have a greater effect.

[@hustlemami8732]

Hi there What condition? What are you on?

[@robynhope219]

@@hustlemami8732 Mito dysfunction...CoQ10, and other nutraceuticals, pres. Metformin and DHEA...I'm 70+and very fatigued ☹️

[@elijaherickson2000]

Check out Dr Jack Kruze he’s working with Robert F Kennedy Jr to fix mitochondrial health in the United States. My advise to anyone Is to get hours of direct sunlight every day and get yourself a red light panel. Stop looking at screens with blue light.

[@GnosticGuru]

Have you tried fasting?

[@outlierz1796]

I managed to fix severe mitochondrial dysfunction from mold exposure, with carnivore diet. Does that make sense following the same logic? I included dairy for calcium.

[@robynhope219]

Fixed? What symptoms did u have, and no longer have??

[@cathyjennings5580]

Is creatine safe for ckd, congested KIDNEYS HEALTH FUNCTIONS 😮???

[@cathyjennings5580]

Tooo THIN BODY ENERGY STRENGTH IS SUPER WEAKNESS/SHAKINES in legs. Helplessness disabled. Some fat on body increases stronger legs!!! 😊

[@KarsonsChannel]

So is arginine or cotrulline better?

[@westcoastswingmusic]

Thanks! 🎉

[@tadmarshall2739]

Is "beet root extract" another name for betaine (TMG, tri-methyl glycine)? What does "bid." mean? Divided doses?

[@autiemuse]

bi is two, as in latin = bi ped, bi cycle, etc. 2 times daily tid is 3x daily qid is 4x daily

[@matthewnicholson2699]

Would it be possible to get this from raw foods?

[@85nickelos]

No, betaine is more a compliment/substitute for folate. Beet root extract is different and supports nitric oxide.

[@davidjordan2011]

Correct regarding beet root extract. Raw beets and beet root extract contain large amounts of nitrate, one of the precursors the body can use to synthesize NO. (The other precursor is the amino acids arginine and citrulline, which are interconvertible.)

[@monnoo8221]

@@85nickelos f you don't understand physiology better keep quiet. You say "betaine is more a compliment/substitute for folate"... That's BS, completely.

[@Sleepdriver1984]

Agree, multi-supplementation is almost always the solution to most health issues

[@DobyDuke]

Eat a proper diet

[@Sleepdriver1984]

@@DobyDuke diet alone doesn't provide high dosage of molecules needed to make the difference, integrated biohacking is the answer to health's questions, we can and shall trick natural processes, not like Bryan Johnson does (since he doesn't enjoy life) but with the aim to live longer and look younger on the outside and the inside

[@cajampa]

​​​@@Sleepdriver1984Don't waste your time with the sceptics. You will never convince them. It is only them who are missing out. While we try it to optimize all aspects of ourselves and see the benefits for ourselves. It is really over their head, it is just to complicated for them. They haven't figured out that because we are doing all of this is what makes what we do easy. They have no clue how much potential we really have when you take our epigenetics as far as it can go.

[@Sleepdriver1984]

@@cajampa agree, thank you very much! We can do what's doable and affordable, since everyday life gets better and we can see them on the inside and the outside, too bad for who's not willing to improve his/her best version of themselves

[@cajampa]

@@Sleepdriver1984 Yeah, it is so frustrating to know the extent it is possible to improve oneself. And especially because we have done much of the work we are even more both aware and atuned to all others around us. Still thought, I have had to do my best to limit myself because I found it just leads to stress if i care to much. So I draw my line with the sceptics. Their personality and mind is not dynamics and open minded enough to delve deep into the type of introspection required to actually figure this out themselves. This is way they always demand sources for every little hint you give them. They don't realize that we have the power to do our own research and put 2 and 2 together. If you haven't done this yet. Take a plunge in to personality typism research and meta cognition. And you will find the reasons why they act like that. It makes it much easier to handle. And also to tailor our interactions to them on their level to get the best outcomes when we really want to help them.

[@ematise]

How all of these are influenced by diet and especially by glycation following a diet which includes carbohydrates.

[@Battery-kf4vu]

Does this supplement affect sleep? Especially coq10 takes 6 hours to be absorbed and has a half-life of 33h so it will remain high at bedtime.

[@monnoo8221]

slep is no induced by low mitochondrial energy. good energy levels are required for good sleep.

[@ronalifestrategies]

Thank you 🙏

[@dharma__3]

Wouldn't it then make sense to take vitamins E and C together on days that you don't exercise?

[@desireehoover6970]

Great information mahalo from Kauai

[@robynhope219]

You're making me homesick...the Garden Island is my fave. Aloha!

[@dankurth4232]

Methylene blue is lacking! MB is one of the most effective enhancers of mitochondrial function and mitochondrial health

[@codyeng9148]

That's an industrial dye. Peaters are insane

[@Battery-kf4vu]

I take MB, but there are 3-4 studies saying it may not be good for the nerves.

[@Viertelfranzose]

​@@Battery-kf4vumedical or Industrial MB is a big difference for health!!

[@Battery-kf4vu]

@@Viertelfranzose Whhat?? You think in studies they don't use pharmacological grade??

[@Viertelfranzose]

@@Battery-kf4vu No...of course not but MB is generally Safe if it is use first in little amounts and set how it feels and just for some peoples with special conditions it can be better not to use MB. Generally MB is safe if use Medical Quality. There are more Studys with MB and good reasons to try it. Specially with Infrared light together it's a booster. Too much MB can be bad..as many other things

[@joemolf3894]

You say every one on a high fat diet got fat! Then how is it the carnivore diet has a thinning affect on those doing carnivore? Sugar easily stores as fat carbs; animal fat doesn’t make you fat? Is this recent study. People who cut carbs lose weight pretty quickly.

[@stevec3526]

Testosterone Replacement Therapy will also assist with building muscle and burning off fat.

[@LYSS89]

And increase the risk of clotting

[@stevec3526]

@@LYSS89 Only if you overdose the testosterone replacement. Body builders typically overdose by a factor of ten.

[@robynhope219]

Doc put me on low dose of DHEA.

[@stevec3526]

@@robynhope219 That is good, but that is just one of the eight significant hormones.

[@robynhope219]

@@stevec3526 unfortunately, I don't have a money tree...can't afford one ☹️

[@stevec3526]

BMI is a ridiculous standard. The InBody device will electrically measures the amount of fat, water and muscle in a few minutes.

[@mjs28s]

Ok, and electrical impedance devices can be thrown off quite easily based on hydration levels, electrolyte levels, etc. BMI is not ridiculous at all. I wager that if you took 1,000 people off the streets at random, checked their BMI and real body fat percentages that they would be pretty closely tide together, on average. Yes there are those that are more muscled or work out often so they are muscular and are not fairly measured by the BMI standard, but the vast majority of people are. The number of people that BMI doesn't fairly apply to is probably 5%.

[@stevec3526]

@@mjs28s The InBody is remarkably accurate and consistent in its measurements.

[@jackcrognale417]

where can you buy trim 7

[@penguinlieo4723]

Don’t use it!

[@jackcrognale417]

Why

[@stephanygates6491]

"I won't go into that." 22:00 graph measuring "Fold Induction of mRNA". I wonder why not.

[@rossfiuzi3202]

Why is this significant??

[@fntime]

@@rossfiuzi3202 Because of Health?

[@jameslewis1605]

But does it really work or is it a placebo?

[@cajampa]

Try it and you can make your own conclusions. Or be a sceptic and miss out.

[@monnoo8221]

just watch it another 47 times.

[@johnrdunbar]

Redox Signaling Molecules are the foundation of cellular health. 8 drink them every day

[@intrinsicfactor5425]

_.......taking 200mg CoQ-10 with 20mg PQQ per day._

[@DobyDuke]

Prednisone is the worst

[@robynhope219]

DOES ONE EVER FULLY RECOVER FROM MITO DYSFUNCTION, or only improve? I never even improved, maybe bc i'm 70plus😢

[@monnoo8221]

you can completely recover. Yet, it took 30y to damage, and it won't be fixed in a few day or weeks. You need to target each and every context of energy metabolism at the same time, following a thorough plan based on full understanding

[@robynhope219]

@@monnoo8221 there is not even a test for mito dysfunction...self diagnosed thru a lot of reading. From adrenal fatigue to HPA axis dys to mito. Been thru hell.

[@robynhope219]

@@monnoo8221 oddly, I didn't have any symptoms before I turned 72.

[@fairchild1737]

I take THC 4 drops with coconut oil under my tongue at night.

[@mgyulai1417]

And where’s the methyline blue?

[@DobyDuke]

Eat a proper diet! Carnivore for the win!

[@johnnyvegas5681]

Prednisone...horrible drug to be on...for any person or animal.

[@joesphbegley3088]

Just stick to real food !

[@thatguy9051]

It's a business people, nothing more.