A novel treatment for Keratosis pilaris

Keratosis pilaris is a common condition that can affect up to 80% of adolescents. A variety of topical agents are usually used in its management. This includes urea and salicylic acid containing emollients. However, treatment is not always successful with these creams. In this video we will look at the use of a commonly used oral medication for acne, isotretinoin, and how this may be helpful in severe and resistant Keratosis pilaris. It is based on the article published recently in Clinical and Experimental Dermatology.
A. Kirchner and S. Hoyer, University of Illinois College of Medicine, Chicago, IL, USA; and Department of Dermatology, University of Illinois College of Medicine, Chicago, IL, USA.
Clinical and Experimental Dermatology (2022) 47, 619-621
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[@neillondon8709]

Good video😊 .. To the point.. No marketing and no beating round the bush..

[@DiscoverDermatology]

Thank you! Thats what we would like to provide. Pure evidence based research that has proven efficacy.

[@WhiteleafWorship]

Thanks for talk on a very common topic. Love the outdoor background ❤

[@DiscoverDermatology]

Thanks ma!

[@robertbach9085]

Useful tip, thank you!

[@DiscoverDermatology]

Glad it was helpful!

[@kavitachablani4968]

Thank you Sir for making this video for a very common condition. I have found your videos very helpful in my practice . Your information is simple , crisp , concise and supported by research. Thank you so much. Waiting for many more topics especially the common ones like frizzy hair , open pores , grey hair , ageing of hair etc

[@DiscoverDermatology]

Thank you for your kind words. I am glad you find the information in the channel helpful. Hopefully, it will provide everyone with scientific, practical, unbiased information. There is a previous video on grey hairs which I enclose kzbin.info/www/bejne/b3KTdYemlLZ4qZo

[@BegumMahmudaNur]

Very good source of information. My has been suffering...

[@DiscoverDermatology]

Thank you! A natural way of treating this condition. is to use oral Vitamin A as it can be a substitute for Isotretinoin. Her is a vide on it: kzbin.info/www/bejne/m3umpaawrKerb68

[@dulidp1]

Thank you

[@DiscoverDermatology]

Welcome Duli!

[@rajagopalsundaram2681]

Very good. topic nice explanation Thanking you Sir

[@DiscoverDermatology]

Thanks Rajagopal!

[@dr.krishnakumars2023]

useful for practice Dr

[@DiscoverDermatology]

Thanks a lot KK!

[@RohanYesudian]

Nice!

[@DiscoverDermatology]

Thanks Ro!

[@blobba5442]

I have this on my cheeks, and I'm looking on how to minimize or get of it. Thanks for the info!

[@DiscoverDermatology]

You are welcome. If Isotretinoin is difficult to get through the doctor, using Vitamin A may be an option. Here is a video on it: kzbin.info/www/bejne/m3umpaawrKerb68

[@dylbro4517]

Did you get rid of it? Did anything help?

[@graciev2973]

I've had this my whole life. the entire length of my arms to my wrists, my legs, and a tiny bit on my chest. I also will get tiiiny random hard spots that I can pick off. (not sure what those are but I wonder if they are more keratin) Thank you for this video. How would I go about asking my doctor to try this medication? I feel like they wont listen to me if I ask.

[@DiscoverDermatology]

Some dermatologists will be happy to use Isotretinoin for keratosis pillars. If they are unable to provide it, another option may be to use Vitamin A, which could be a natural supplement that mimics Isotretinoin to a certain extent. Here is a video on it. kzbin.info/www/bejne/m3umpaawrKerb68

[@NoPlaceLikeCheese]

I’ve used adapalene to great success. So this makes sense. The only problem is that it causes severe dryness. After trying other treatments (ammonium lactate, urea, salicylic acid) and finding them to be too irritating, I’m trying adapalene again, but slathering a moisturizer on top. I’m two weeks in and starting to see results.

[@DiscoverDermatology]

You are right. Topicals can sometimes irritate the skin. Another natural oral option is Vitamin A as it could sometimes be a substitute for isotretinoin. Here is a video on it kzbin.info/www/bejne/m3umpaawrKerb68

[@abhaysingh-mi2sp]

I have KP with brown bumps on my left upper arm and its spreading slowly.... Can this adapalene help me get rid of this?? Pls reply 🙏

[@NoPlaceLikeCheese]

@@abhaysingh-mi2sp Yes, adapalene worked for me. It took a few weeks for me to start to see results, but after two months, my arms were clear. So be patient! Also, moisturize! Adapalene can cause some nasty dryness so you need to also moisturize. CeraVe has been fantastic. It’s gentle, non-irritating, and not sticky.

[@DiscoverDermatology]

Adapalene cream is a retinoid cram and is one of the treatments used for KP. So it will help to reduce the appearance of KP but doubt if it will get rid of it completely. @@abhaysingh-mi2sp

[@samruddhiannasahebjadhav2784]

This is the one of the best video on kp I ever seen .....my kp getting more and more worst day by day ...I feel so bad when I see it even when people see it asks me a question what happened 😢 that time I don't have any ans plz sir help us make a more videos like this and where we get this istratinoin capsule ??

[@DiscoverDermatology]

Thank you for your kind words! Isotretinoin is usually prescribed only by dermatologists. If you prefer a natural alternative, you could try oral Vitamin A. Here is a video that I made on this topic. kzbin.info/www/bejne/m3umpaawrKerb68

[@samruddhiannasahebjadhav2784]

@@DiscoverDermatology thanks sir

[@user-yv6el6jb3d]

Hello doc , I have a kp all over my body and going under body laser just started I have kp on my face as well and also some bone issues can I take a cod liver oil to balance the keratin and u suggested isotretinoin how to use them and what to use for skin ? Could you pls suggest me what to use and how to use

[@DiscoverDermatology]

As mentioned in the video, ow dose Isotretinoin has been sued for extensive keratosis pillars. You could use the doses mentioned in the video, maybe starting at a low dose of about 20mg a day. There is no good literature on cod liver oil treatment for keratosis pillars.

[@shirishajanapareddy4234]

Sir, I had severe cystic acne after I stopped ocps which were given to me as I have PCOD. My doctor prescribed me isotretinoin which I took for almost a year. All the acne from my face were cleared but it had NO effect on the kp on my arms and other areas. If anything, it has spread even more. What do I do now? I also had a side effect of discoloration of my lips during the 10th month of isotretinoin which I was super scared of as it looked like vitiligo. After stopping isotretinoin the natural colour of my lips came back. Do I start applying topical gel over my arms or what?

[@DiscoverDermatology]

If there are side effects with Isotretinoin, topical retinoids are preferable for keratosis pilaris. 10% urea containing creams of lactic acid creams may also help. For the acne, metformin is an option of there is PCOS with acne. Here is a video on it m.kzbin.info/www/bejne/hqCxaKt6ga2lf7M

[@user-fg1zo2gm7t]

Dear Doctor, I have KP all over my body since my childhood. I would really appreciate your answer and i would be very grateful. I wanted to ask you to recommend me what dose of Isotretinoin should I consume. I am female, 20 years old (5.7 height and 55kg weight) . Thankfully, Maja

[@DiscoverDermatology]

As mentioned in the video, oral isotretinoin can be used in low doses for isotretinoin. A dose of about 20mg three times a week may be helpful as mentioned in the video. Vitamin A can be used as an alternative if isotretinoin is not available. Here is a video on it kzbin.info/www/bejne/m3umpaawrKerb68

[@vaaniudasi3821]

I have severe KP, was prescribed isotretinon for a month and a half, there was a significant improvement on the bumps, however no improvement on the pigmentation. Can chemical peels, lasers, micro blading help with that?

[@DiscoverDermatology]

They can, but topical agents could be tried first. Here is a video I did on facial pigmentation, but the treatments are applicable for any post inflammatory pigmentation so could be considered kzbin.info/www/bejne/pHSkemeGepVqac0

[@pragyamahajan1531]

Hi i also have kp on arms chest and buttocks i am taking isotretinoin medicine it’s been 5 days does this medicine really work pls reply

[@user-yg4mx2xx2m]

Sir does isotretinoin improve pigmentation associated with severe refractory KP ??

[@DiscoverDermatology]

Yes, it can help the pigmentation too. It takes a lot of time for pigmentation to resolve in dark skin though.

[@selinebrady9667]

How much mg of vitamin A or omega 3 or cod liver oil would you recommend a day

[@DiscoverDermatology]

The Vitamin A dose that is required is more than 10,000 to 50,000 IU a day. Here is a video on it kzbin.info/www/bejne/m3umpaawrKerb68 For fish oils, this video tells you what doses to use kzbin.info/www/bejne/hJmunJ9-qKZ2naM

[@Lemontartbabyfart]

Hi doctor thank you for your video. Unfortunately i have developed keratosis pilaris on my arms and legs severely 2 months after i stopped accuatne for ny acne. It has been 3 years now and it has not gone away. Do you have any ideas as to why i developed it after isotretinoin when i didnt have it before? Thank you.

[@DiscoverDermatology]

Sometimes, medications can unmask previous dry and sensitive skin especially as keratosis pillars is associated with dryness of the skin. It is paradoxical that a medication can be used to treat a condition but can also cause it at times. It may be useful to moisturise the skin regularly. Following the principles of using the moisturisers mentioned in this video may be helpful kzbin.info/www/bejne/Z3W6opd3lN55g9E

[@gmm1668]

This also happened to me. Would you recommend doing a second course of accutane in this case? As it was previously suggested. Or can this be too risky and cause the condition to worsen? Thank you for your information.

[@gmm1668]

Also can vitamin A have the same worsening effect if taken instead of accutane?

[@martinpaulsulague4291]

Where i can buy the isotretinoin?

[@DiscoverDermatology]

Isotretinoin is a hospital based medication and only a dermatologist can prescribe it. An alternative option is the use of Vitamin A and I enclose a video that I did on this recently kzbin.info/www/bejne/m3umpaawrKerb68

[@jasminekhan5828]

I also have severe KP since 15 years nothing really works idk what to do

[@DiscoverDermatology]

As mentioned in the video. low dose isotretinoin is a good option for KP if other treatments have not worked. If you are unable to get hold of isotretinoin, oral Vitamin A can be considered too. Here is a video on it: kzbin.info/www/bejne/m3umpaawrKerb68

[@egoogle6462]

it is from liver toxic as well

[@DiscoverDermatology]

Excessively high doses can cause liver toxicity.

[@samruddhiannasahebjadhav2784]

Dup to kp black spots are also occur on my arm ,hand plz tells any solution for that dark spots

[@DiscoverDermatology]

Using topical retinoids may be helpful if KP is causing dark marks. It may be worthwhile confirming the diagnosis first as that is key to using the right treatment.

[@AS26173]

Isotretinoin doesn't help rather increases the severity of kp..at least that's what i experienced

[@DiscoverDermatology]

You are right, any medication can cause and aggravate a condition it is supposed to help. Not everyone will have a positive response.

[@tanyasharma9949]

Sir, can we have laser hair reduction for this less noticeable? Please do reply sir

[@DiscoverDermatology]

Lasers can help the redness but I think the hyperkeratosis (roughened skin) still requires a retinoid agent or topical agents that smoothen the skin. If isotretinoin is difficult to get, then oral Vitamin A is an option too. kzbin.info/www/bejne/m3umpaawrKerb68

[@pragyamahajan1531]

Hey i want to ask how long does it take for kp bumps to go if we take dose of isotretinoin everyday

[@DiscoverDermatology]

It takes about 2 to 3 months to work.

[@deeputhapa6049]

Does it comes back after discontinue of isotretinoin

[@DiscoverDermatology]

It can but hopefully the metformin can prevent its recurrence. Some dietary changes can also help prevent recurrences. Here is a video that I did on this topic kzbin.info/www/bejne/o53Mk6Wri9Cro7M

[@Bezawittt]

Hello sir! Except my face(only a little bit of kp on it) and neck, all my body is full of sever kp and dark pigmented from the kp. My KP is not here and there, it is full of my entire body! I've seen so many doctors, they all say it is too much. If it is not itchy leave it as it is. But how I live with it? It's so dark and pumped all over my body. It has been 12 years. I've never wear sleevless clothes or any skin shown clothes in this entire 12 years! Even if i'm living in hot wether conditioned area. It is like hell! What shall I do sir, please help???

[@DiscoverDermatology]

The oral isotretinoin mentioned in the vide is an option worth considering. An alternative treatment is oral Vitamin A. here is a video on it. kzbin.info/www/bejne/m3umpaawrKerb68

[@ryocu]

Same here 💔 I am more depressed now

[@Bezawittt]

@@DiscoverDermatology Thank you, sir!!! I will look for it!

[@Bezawittt]

@@ryocu Me too! But, we have to stay Strong! Keep fighting!

[@peskybird3092]

I had my blood tests recently and vitamin A is completely fine. What should i do

[@DiscoverDermatology]

Blood Vitamin A are usually normal in keratosis pillaris. Isotretinoin is worthwhile if keratosis pilaris has not responded to any other treatment.

[@Afroz-xh8hy]

I have had Keratosis Pilaris all over my body since my childhood. I have consumed Isotretinoin 20 mg for 1 week but It caused several side effects like dry mouth, muscle pain, back pain, headache, etc. So, what should I do now, please suggest to me doctor

[@DiscoverDermatology]

The side effects of isotretinoin is dose related. So lower doses may have lower side effects. Another option is to use Vitamin A as it mimics isotretinoin. Here is a video on it. kzbin.info/www/bejne/m3umpaawrKerb68 #Disclaimer# Please note that this video is for education purposes. It is not meant for personal advice as your own doctor/dermatologist will be the best person to answer specific queries.

[@Afroz-xh8hy]

Thank you so much, doctor..😇

[@dylbro4517]

Did it help? Is your KP any better?

[@artisahu6135]

How to contact you sir??

[@DiscoverDermatology]

Hi, as this is social media, we cannot give personal advice to anyone. These are videos of general information that will hopefully be beneficial for all those who view it.

[@user-rn9ys4lz9j]

I don't feel much of an effect. Should I increase my intake?

[@DiscoverDermatology]

t usually needs to be taken for about 4 to 6 months to have an effect.

[@chanteldavidson4546]

Could we just take an over the counter vitamin A?

[@DiscoverDermatology]

Good question. Vitamin A in large doses can have a similar effect to Isotretinoin (Accutane). However it is likely to cause considerable dryness of the skin and lips and can also accumulate in the liver. Its a certainly an option if you do not have access to Isotretinoin. I will try to do a video on high dose Vitamin A in the future.

[@chanteldavidson4546]

@@DiscoverDermatology Would love that! I heard somewhere that KP can stem from a Vitamin A deficiency so I was curious when you mentioned Accutane.

[@DiscoverDermatology]

@@chanteldavidson4546 Vitamin A deficiency usually causes something called phyrnoderma, which looks similar to KP

[@harshagk835]

Sir use of tretinoin 0.05 will help?

[@DiscoverDermatology]

Yes but can. Sometimes, topical retinoids can irritate the skin though, hence the use of oral retinoids like isotretinoin.

[@harshagk835]

@@DiscoverDermatology okk sir

[@harshagk835]

​@@DiscoverDermatologysir bathing in warm water good for this condition?

[@DiscoverDermatology]

Excessively warm water is not good. Here are some general principles on how to use moisturisers on the skin kzbin.info/www/bejne/Z3W6opd3lN55g9E @@harshagk835

[@user-rn9ys4lz9j]

Do I have to continue taking it even if I am cured??

[@DiscoverDermatology]

Isotretinoin does not cure the condition, but may keep it settled for a few weeks if not a few months. Some use maintenance doses of once or twice a week too.

[@papajibolo]

sir,i am a doctor as well and having kp since 15 yrs i have lost confidence in my self. i am 85 kgs how should i proceed.. currently taking 20 mg for 2 months. suggest me further

[@DiscoverDermatology]

Most studies suggest that isotretinoin may need to be taken for about 4 to 6 months before a beneficial effect is noted.

[@papajibolo]

@@DiscoverDermatology ok will continue to take it then for the next 6 months. will update after that.

[@user-rn9ys4lz9j]

the more I take, the faster I will heal?

[@DiscoverDermatology]

Low doses are usually sufficient as high doses can cause side effects like very dry skin. Another natural substitute for isotretinoin is the use of oral vitamin A. Here is a video on it Even though it mentions about the treatment for acne, it can be used for other conditions like keratosis pillars as well. kzbin.info/www/bejne/m3umpaawrKerb68

[@user-rn9ys4lz9j]

@@DiscoverDermatology I heard that taking a lot of protein can prevent the side effect of isotretinoin. What do you think about this?

[@DiscoverDermatology]

@@user-rn9ys4lz9j I dont think there is any scientific proof for it.

[@green5103]

Doctor, when I was treating acne, I used isotretinoin, and I had these bumps all over my body. I don’t know why, and you mentioned in this video that the treatment is these pills. Please answer me, and you won’t ignore my comment because I really suffer and my wedding is near

[@DiscoverDermatology]

The dose may be important. High doses can worsen the situation whilst lower doses are usually more beneficial. Another option is to use Vitamin A and here is a video on it kzbin.info/www/bejne/m3umpaawrKerb68

[@green5103]

What exact daily dose do you recommend and what external care routine can I do with a vitamin A supplement ​@@DiscoverDermatology

[@abhaysingh-mi2sp]

Did u have keratoisis pilaris or any other condition?

[@DiscoverDermatology]

There is no precise dose for Vitamin A, as mentioned in the video. Just need to use a dose that is comfortable for the given person. @@green5103

[@sheelaboraluwegedara9150]

Can I use every night?

[@DiscoverDermatology]

Its a capsule that is usually taken with the biggest meal for 8 to 12 weeks

[@himbofication]

kp is horrible, i finally am reaching a physique i like through weight lifting just for kp to riddle my arms and completely lower my self esteem lol

[@DiscoverDermatology]

Sorry to hear of your skin problem. There are quite a few creams that could be used in keratosis pillars which your doctor could prescribe. Isotretinoin is more difficult to get as only dermatologists generally prescribe it. One option may be to use Vitamin A as it could be a substitute for isotretinoin. Here is a video on it kzbin.info/www/bejne/m3umpaawrKerb68