AGING IS A SCIENCE: What To Eat & When To Eat To SLOW THE AGING Process | Matt Kaeberlein

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On Today's Episode:
You just want to look better, feel better, have bigger muscles, tighter skin, and a sexier body you can enjoy and be proud of. The information and narratives floating around on how to achieve that are all over the place, and understanding how to discern what the takeaway action is going to be for you to achieve results is really what you need.
Matt Kaeberlein, Director of the Biological Mechanisms of Healthy Aging Training Program, and founder and co-Director of the Dog Aging Project, is a biologist best known for his research on evolutionarily conserved mechanisms of aging.
When you’re doing your own research into what things you can be doing to optimize your health and lifespan, Matt warns that you’ll need to be careful of research studies with narratives that lean one-sided.
Some of the key ideas Matt and Tom discuss in this episode around anti-aging that will perk up your ears are:
Why Matt calls BS on “Reverse-Aging”
What the drug Rapamycin has the potential to do for long term health
What metrics should we be measuring for good health and anti-aging
With all the years of experience from Matt Kaeberlein as a biologist specializing in anti-aging, he confirms that exercise and nutrition are as effective as exogenous drugs such as Rapamycin.
Are we busy trying to create complicated solutions to anti-aging, longevity and health that plain old boring nutrition and exercise can take care of already?
Check out Matt Kaeberlein’s Dog Aging Project: dogagingproject.org/
QUOTES:
“We know things like rapamycin, [...] can reverse some of the functional declines that go along with aging.”
“I’m not so sure that exercise and nutrition are fundamentally different from rapamycin. Exercise hits the hallmarks of aging, it affects biological aging.”
Follow Matt Kaeberlein:
Website: kaeberlein.org/
Twitter: / mkaeberlein
Instagram: / dogagingproject

[@TomBilyeu]

WARNING: I will never ask for your contact info in the comments section, that is someone impersonating me!

[@DefyingOldAge]

Tom, i definitely have reversed my aging in a profound way

[@scottk1525]

You need to work on not interrupting your guest every 5 seconds.

[@TheAwsWorld]

@@scottk1525 the whole point of the podcast is to be informative, if the guest keeps talking to everyone like we’re scientist then we would not benefit from half the information, Tom’s interruptions have always been valid and beneficial.

[@scottk1525]

​@@TheAwsWorld " *if the guest keeps talking to everyone like we’re scientist then we would not benefit from half the information* " I'm not talking about Tom asking the guest to clarify some lingo, or to rephrase something. I'm talking about the other 95% of interruptions. Like when he'll cut the guest off to inject a personal story and then ask for insight about his own experience specifically. Or the guest will mention a factoid in passing, and Tom will halt the conversation to go off an a random exploration of that factoid that the guest really only mentioned to help support a point that Tom never let them get to. " *Tom’s interruptions have always been valid and beneficial* " No. They're often tangential. Almost always unnecessary, and certainly don't need to happen that very second. He could do what all *good* podcasters do and wait until the guest finishes what they're saying, or at least finishes their f*cking sentence, and then ask follow up questions. Instead, Tom rudely cuts the guest off mid sentence to ask questions that often take the conversation down tangential rabbit holes, rarely circling back to the topic that was interrupted. This isn't complicated. When you ask your quest a question, let them f*cking answer it.

[@BlackBoothSydney]

I miss the time stamps in your videos Tom!

[@CesarChavezPhotos]

- Avoid ultra-processed foods - Avoid being obese/overweight - Get your BMI down to a "normal range" - Avoid high levels of simple carbohydrates - complex carbohydrates in the form of vegetables are ok - A diet that's high in plant good quality plant-based calories typically is going to be pretty healthy - Whole foods diet is always good! BALANCE BETWEEN PERFORMANCE & LONGEVITY Optimal nutrition is going to be the main thing, so get you main building blocks (Amino acid profile) so you can build and maintain the muscle mass. As you get older , all-cause mortality is link to muscle mass...

[@froesesp]

and consuming most oils.

[@ja4907]

The importantst thing avoid too much stress

[@scottk1525]

I mean sure, that's the very short list of recommendations in this interview, but there's a ton more useful and interesting info about the state of aging research and various protocols and drugs. To simply chop this video into a bullet point list of diet tips kind of misses the point.

[@savednorwegian]

@@scottk1525 True. Its too limited. Stress is very important too

[@Impastanonymous]

Live in mentally healthy environment is the first thing to start

[@tuupiintia3028]

Tom just loves his own voice! In most interviews he's talking like 70% of the time, and constantly interrupting the guests! I don't know why the guests even bother trying to speak full sentences!

[@lumanliu8457]

But his is one of the host who asks the best questions. I recognize that often times the QnA is even more informative then when the guest prepared to talk.

[@SilverFan21k]

Hey Tom, its so cool that you find these topics interesting of Aging and Life Extension / Healthspan science. Thanks for having on Dr. Kaeberlein.

[@goldwhitedragon]

I love discussions like this that feed our frail egos and our narcissism.

[@jennykucher]

Super interesting to hear! Especially as a nutrition science student

[@AudreyLMcFarland]

Thank you for talking about Not all can do the same thing! I know I appreciate the fact that you (the discussion) is - We know, we do not know everything, and we know to "pay attention" to how you feel and what you eat.

[@jge123]

Key to aging is the stress others inflict on you.

[@ScrapPalletMan]

Listening to your podcasts is inspiring, educating and completely changing my outlook on life and eating. Thank you for literally turning back the clock on this 54-year-old body of mine.

[@conlawmeateater8792]

Right. This past year I've been obsessed with learning everything about anto aging.

[@scottk1525]

oh wow literally? you have a literal clock built into your body that was literally wound backward? wow. Are you a cyborg?

[@dzonthego]

I would just like someone promoting anti-aging theories, to actually look younger than their actual chronological age. So far, the only one who might fall into that category is Dr. David Sinclair.

[@veganandlovingit]

I think Bryan Johnson looks great.

[@dzonthego]

@@veganandlovingit He might be wrinkle free but he's only 45 and I truly think instead of looking great, he looks frightening. Hey...we all view things differently.

[@verrasimonsimon7876]

I fel the same way, they all look older, so obviously it doesn’t work

[@tamhlam]

Sinclair does not look healthy to me.

[@dzonthego]

@@tamhlam Curious as to why...specifically?

[@ememememememe7598]

Matt is a honest scientist

[@SilverFan21k]

Wow was this recent? Didnt know that you interviewed Matt Kaeberlein!

[@Cydinium]

Time to live forever boys

[@ramxehs1180]

What if don’t want to be a boy, what if I want to be a potato?

[@verrasimonsimon7876]

@@ramxehs1180 hilarious

[@charlesgreen7408]

Metformen has cut my craving for food, but when I decide to eat, it's enjoyable.

[@Tacheles8]

Funny to me when those "experts" look like zombies…. It’s kinda questionable

[@ConsciousFella]

I was thinking the same thing

[@CarolCarolDoddDodd]

I think it’s possibly because they have zero sun on their face and that is why they look like white sheets, but if they’re taking vitamin D to supplement that, does it counteract it??? Also, are we just not used to seeing somebody thin, which kind of accounts for the sunken eyes and somebody super pale?????? Just a thought but I came here to find this comment because he looks like death warmed over even though this might be a healthier look and we’re just not used to it because we grew up outdoors, farming, etc.

[@cryptonomous888]

Lol…same thoughts, why they don’t look young themselves?

[@dusk5956]

I mean to your point, they are zombies. They may live forever and they sure look like they have😂

[@scottk1525]

Who said he was an expert? Not him. He's just a scientist.

[@ligiasommers]

Super interesting 🙏🏻🌹✨🙏🏻

[@TheTibo13]

Timestamps?

[@kencarey3477]

Do the best you can and enjoy life!

[@aubigney]

being alive is a key cause of aging i think

[@scottk1525]

Holy shit Tom's tangential interruptions are dialed up to 13 in this one. Matt will literally say "I have a couple things to say about that," and half way through thing #1, Tom interrupts him with a question that derails the whole point Matt's trying to make.

[@alertbri]

1min 18secs in and yes, I see what you mean 🙄

[@jimdandy8996]

He always does this. Just like a child with impulse control problems.

[@gazlives]

he talks about himself too much. it's annoying

[@scottk1525]

@@gazlives Really though. Every interruption is a story about what he does or what he believes and why, as if this is a personal consultation or something.

[@blacina9036]

I had to stop watching. ...this is not new for Tom to interrupt but hopefully he will read these comments and tone it down....

[@peterd460]

Tom - I'd be curious if you get a chance to clarify on the caloric restriction. Matt said that rodents were restricted 60% vs what they would freely eat. Tom - I'm assuming your 25% reduction was a 25% calorie deficit which could in fact be a similar number. I can't imagine the rodents were losing weight all the time so it'd be curious to know what level of calorie deficit (if any) they were in.

[@Anna-rb6rg]

Precisely! I was also confused by the logical connections here. Especially given the fact that 1) rodents and humans eat more when they have nothing else to do, 2) rodents and humans eat more tasty and unhealthy food, so it's not clear which calories we are talking about, 3) the number of calories can be completely unrelated to increased hunger/autophagy/weight loss, etc.

[@mirandapillsbury7885]

I like how real he kept it. I just dont see us getting to a point where we can reverse aging....like EVER. And if we do it will probably be at least a century from now when all of us currently living will be gone.

[@fairuzastevenson9896]

Thank you

[@brianmaguire8254]

Genetically we can adapt as well to environmental stimuli

[@mukhanila9555]

Hello,"😊

[@gazlives]

seen this guy before on peter attia's podcast. he's so much more realistic (and accurate) than someone like david sinclair. i always get the bs vipe from sinclair, especially when he talks about caloric restriction and dietary stuff. in general he does that annoying hubris thing smart scientists fall into, advising on something that doesn't have he data to confirm it's a good idea for everyone.

[@scottk1525]

That's because Matt is in it for the science. Sinclair is in it for the money.

[@Anna-rb6rg]

it is always easier to remain conservative and say that nothing will work and there is little that can be changed. that not everything is so clear and hence that it is impossible to draw conclusions. such people inevitably seem smarter. but such way you won’t advance science much, and you won’t really motivate people for example, advice to eat less - obviously no one is in a cage with a lab assistant who feeds him, so most mentally healthy people will never reach the level of hurting themselves badly by cutting calories. not to mention that calories by themselves say little about nutrients and elements in food

[@piotrskutnik8472]

it's hard to listen to anyone who looks the Opposite of what he/ she tries to advise you on. but the shows must go on...

[@scottk1525]

He's not trying to "advise" people on anything. He's just a scientist reporting on the research. If you bothered to watch the interview, or any other with Matt, you'll notice that he is always hesitant and sometimes entirely opposed to making recommendations or giving advice. Usually he's 3 gallons of caveats and disclaimers in a 2 gallon bucket.

[@lukuma79]

I don't think at all that Brian Johnson looks Great!!! I can not believe how differently we see things!

[@alexperassolo3310]

8 to 20 burpees without push-ups with or without jump. 8 to 20 goblet squats. 8 to 20 romanian deadlifts. 2x times 10 to 20 180 degree jump. 8 to 20 push-ups or dumbell bench press. 8 to 20 back rows. 2x times 30 to 60 jumping jacks. 8 to 20 bicep curls. 8 to 20 shoulder presses. 2x times 90 situps

[@alexperassolo3310]

Situps - your choice

[@alexperassolo3310]

Mix and fucking match

[@jimdandy8996]

You forgot the ham sandwich.

[@marypierce4323]

What is delta 8 ?

[@stevepope6095]

Execise and constant movement during the day and evening is my secret , it has to be , at 55 my calcium plaque score is zero meaning 100 percent of men my age have plaque , and I feel and act younger , I bowl , bike , hike , lift heavy weights , bench 235 lbs , leg press 350 lbs , I believe the weights and my food choices have helped me the most, and adding Spin class again.

[@jimdandy8996]

Maybe the score is zero because you have soft plaque.

[@joeswartz8286]

Good for you. But 55 is very young. 👍

[@Anna-rb6rg]

the question is different - why do you have the strength and desire to move all day and evening ? so would like all people, but few can

[@mylesdent2214]

I've really tried, but simply cannot take the consistent interruptions anymore. Would just like to listen to the expert completing a point of interest. What a pity!

[@swilda123]

Thing to eat: blood Time to eat: midnight

[@Wendathena]

Vampire

[@Redflowers9]

Just a thought, vegan/vegetarian or keto/carnivore has a lower protein consumption than a typical "balanced" diet because you're combining not only the protein of animal foods but also that of plant foods. Grains or rice and legumes (which contain growth signalling amino acids on their own) can be combined to make a complete protein but if the person eating these plants also ate a lot of meat, their protein consumption is probably going to be much higher than someone who eats either just plants or just meat (or mostly) and this may be too much protein than what the body evolved for, our ancestors experienced a lot of scarcity, never full balanced diet with every nutrient available, so I wonder if that has something to do with people experiencing health benefits on either diet, because it restricts that protein or perhaps an overabundance of nutrients that maybe produce an opposite effect like too many MTOR growth signals? So perhaps vegetarian and keto allow people to eat as much as they like and reach satiety more easily without overdoing their protein?

[@Redflowers9]

@simone ambroise 1- yeah that's true but there were other factors involved, what we evolved to eat is still an important factor in deciding what is healthiest to eat 1- so just to be clear you're saying a balanced diet with everything in moderation is best?

[@gazlives]

@@simoneambroise6392 we don't know how long our ancestors lived (or could of lived) on ancestral diets. we have a few skeletons. we have skeletons showing very old humans too. we don't have much (or none) evidence showing if they died because of nutrition. we have a bit that they died of trauma. and we know many would have died way before old age merely because the conditions were so harsh (starvation, infections, blunt force trauma etc)

[@gazlives]

vegans can't get the right amino acid profile to be healthy unless they are very very serious with supplementation and know what they are doing. easy to get the right profile if you eat meat regularly because it's naturally occurs.

[@gazlives]

@@simoneambroise6392 we just don't know much at all. some would have fed well on large animals year round. pretty much everything is speculation on scant evidence. so yes we can't use them for perfect diet nor the imperfect diet.

[@Redflowers9]

​@simone ambroise Okay so quantity and quality of each kind of macronutrient and micronutrient? Yes but there are still certain examples of singular factors like trans fat, tobacco, alcohol, carcinogens... etc that can shorten lifespan. Protein activates MTOR which speeds up cell growth and likely the aging process and my point is that the protein content in plant foods eaten alongside protein content in animal products is overlooked and in most omnivorous diets and thus may be a lot more in total amino acid content which may be stimulating MTOR even more and this includes complete proteins like you have in meats that can also be formed by combining plant foods so this is a potential factor that may be causing problems by speeding up the aging process, and so you can see that vegan and carnivore diets rule out that factor as they limit net protein and amino acid content to either just plant foods or animal products. So most omnivorous diets may be sub-optimal for this reason and maybe we need to be better at measuring our net amino acid and protein content from all the foods we eat. For example: I'm having rice and beans for tea tonight (which make a complete protein/contain all amino acids (which activate MTOR)) so I'm going have the chicken (complete protein/contains all amino acids - which activate MTOR) in the fridge tomorrow with something else like spinach (vegetables with less amino acids because I want to keep my MTOR activation minimal) tomorrow night. This is not something that is talked about enough and so I think people can easily overdo this by eating much larger quantities of amino acids from both animal products and plant foods, than they can from just one or the other (like with vegan or carnivore). Simply put: total amino acid content maybe a factor that speeds up aging and it's much easier to over-eat amino acids by combining plant foods with animal products than just eating plant foods or just eating animal products on their own (vegan and carnivore diets).

[@jimdandy8996]

1:03:00 Uhhh, MRIs don't give off radiation guys.

[@TheAwsWorld]

Interesting regarding fasting, makes me wonder why do Muslims fast for a month every year, why is it not longer and not more often and if it has anything to do with improving health

[@yakncast7530]

@simone ambroise It's intermittent fasting. The length depends on what time of year it happens.

[@TheAwsWorld]

@simone ambroise I have tried it, and the portitions you can eat after fasting all day like that are very small, you feel full by basically having a glass of water and a few bites, and I have friends that fast that say the same so I am not sure that its as unhealthy as we think! My point is that its interesting that someone decided a 1000 years ago that fasting has benefits hence I ask the question to understand the root cause to come up with some rule, religious beliefs are often based on an observed benefit or at least a thought that its beneficial

[@GingerKral]

Nope raw vegan then vegan ruined me. Ive now gone carnivore for 90 days to reboot and I feel amazing!!! No struggles at all.

[@scottk1525]

Carnivore is for idiots that believe internet hype

[@biggy380]

My question would be, is there any birth defects in apes and if so at what rate? If there isn’t an overly obvious higher rate of birth Defects, then perhaps is it our environment/diets that are causing it, because our hormones are thrown off by these horrible foods most people are eating now? I wonder if the biggest factor in aging is actually toxicity. It seems to me that the foods and environment that we are in tends to have the biggest effect on aging. Even exercise can be linked to this too, because if you are exercising I believe it’s setting in processes that are actually removing toxins. Exercising helps to use up sugar that is essential removing it from our system. Also caloric restriction that seems to be a huge factor in anti aging, would mean you were taking in less toxins and would allow your body time to clear them out!

[@nextgenmillen]

Hope Tom is following this, so he lives the longest he can. He provides so much value to the world, we can't afford to lose him!

[@jimdandy8996]

Oh please🤮

[@nextgenmillen]

@@jimdandy8996 It's true! His interviewing skills are better than anyone else's and that translates to getting more value for the viewers/listeners.

[@jimdandy8996]

@@nextgenmillen You mean how he can't sit still and stop himself from annoying his guests by interrupting them constantly all the time? Yeah, great skills. Its like a child with poor impulse control.

[@jadedk9916]

Portion sizes matter. Europeans have a smaller portion size than Americans. The Japanese have a smaller portion size than even Europeans. Life expectancy: Japan > Europe >> US If you are eating American portion sizes and switch to either European or Japanese portion sizes, then it's a calorie restriction. But once your stomach gets used to the smaller size, then it's not a calorie restriction. It's just the normal calorie intake.

[@mariskab.9106]

Yes it is shocking to sea the portion sizes in North America...we always order one and share it :) people eat too much in general we do not need as much food as we no longer do a lot of physical labour.

[@kali542]

I swear by estrogen replacement as a menopausal women. I am 57. I have 2 older sisters who do not replace hormones. The difference is unbelievable. They have mental health challenges, belly fat, muscle wasting, pre-diabetes, bone and tooth loss, cardiac issues etc etc. I have none of that and I have been on estrogen for 10 years.

[@jimdandy8996]

How long have you been identifying as a woman?

[@kali542]

@@jimdandy8996 lol 😂 that’s funny.

[@alicejwho]

It may not be purely because of the oestrogen. I'm 57 and a cyclist, and slim and healthy (though I did ping something in my back recently, which is annoying) and I have great teeth. My resting hr is in the low 40s and my max is in the mid 180s. I don't do hrt, simply because I didn't feel the need. I do RLT and have an earthing sheet on my bed. I eat healthily and do intermittent fasting, amongst other things. My sister is 53, has hrt and is overweight. But she doesn't have the interest in health and longevity, as I do, so her habits are very different.

[@alicejwho]

Don't get me wrong though. I do wonder if I could have been more super-amazing if I'd taken hrt 😊

[@kali542]

@@alicejwho actually is it MENOPAUSE TAYLOR on youtube. Not Barbi

[@smm24hpanel9]

❤😊

[@prestonmann1242]

See if you can Book Cynthia Kenyon who in now with Calico, part of Google.

[@polymathpark]

1:06:26 - "they c*m all over the place" xD

[@dinosemr8141]

💖❤️💖❤️🙏❤️💖❤️💖

[@user-pw9gc5eg6y]

Cause No.1: time.

[@Ryan.G.Spalding]

I think Peter Attia thinks 2-5 years for a full body scan of individuals over the age of 35 or 40.

[@MyDadaia]

All those talking about trading are all those scamers who looking dor easy money. Because the. Subject has nothing to with trading.

[@baqirparkinson411]

Kok nyelip di close the door ?

[@danielalindan9642]

I'm a simple man: I hear Tom starting to speak, I skip. You get 30 minutes of relatively quality info.

[@funnytv-1631]

Am just using anti aging creams and they work best for me

[@kpakaify]

Do you eat them?

[@veganandlovingit]

@@kpakaify I rub the creams all over my birth certificate

[@polymathpark]

@@kpakaify lol

[@MissInfinity]

Won't change your biological age

[@jimdandy8996]

@@kpakaify Puts them on her vajay-jay so it doesn't become like old leather.

[@peterpan420]

It's glyphosate that's killing (y'all)

[@CesarChavezPhotos]

24:37 Hallmark Of Aging: Accumulation of senescent cells DNA Damage Telomere Shortening Epigenetic changes Mitochondria dysfunction

[@jaetwo_931]

Wish these videos were a little shorter..even cut up maybe….

[@goldentaurusfinance9840]

I increased my fiber in my diet with a variety of beans and added a V8 fruit drinks (not splash) and cut fried foods. Been on it for about a month. Weighed 285 and dropped as low as 270 but Im floating 275. Cant wait to see results in the next month

[@mr_x1703]

you will live forever now lol

[@goldentaurusfinance9840]

@@mr_x1703 260 now lol

[@musicxmovement]

WHAT THE FUCK GOING ON WITH THE TIMESTAMPS TOM? This ain’t 2012…

[@musicxmovement]

Don’t be that guy…

[@nootahainen]

​@@musicxmovement 😂haha I was also trying to click the stamps open. Sometimes there's so much info that we already know, then skipping to the "point" first works better and then maybe listen the rest

[@traceler]

Technology is costly, but I don't have time to listen to the whole thing and like to skip like in Hubberman lab who post clear timeline for each topic or question, no forcing you to take the whole thing if you dont like it.

[@RJC10101]

Matt looks similar to Michael Jackson!

[@DJSTOEK]

😷💕💕

[@carla.h2795]

Who would want to extend their lives having to restrict your daily calories to that extent!?

[@marie-louiseleroux828]

It is better to invest now,... You will never be younger than you are today and there will never be a perfect time to invest.. Due to compounding, which Einstein called the 8th wonder of the world, you can get rich slowly from investing if you do it from a young enough age.,

[@robertfransisco8503]

Please how can I get to Mr Michael Marcus?

[@robertfransisco8503]

Thank you for this. Will definitely reach out to him now. Thanks again

[@ameliamoore9783]

I’d be interested to know if they looked at affects on fertility caused by the decrease of senescent cells. And if they found that it’s best to start this treatment to the mice after the norm fertility window. Especially looking at this for the female mice. So much of the research looks at decreasing senescent activity. I haven’t heard Sinclair or any of the big names speak on this. You can’t abolish all senescent activity because they do play some role(s).

[@glenwilliams6107]

19min. im a Certified Health Educator, that guy has the Gift of Gab: 🎉 it can it can't?. it works for you, but there is no evidence it works for you? this study said this, that study said that? im not a psychologist, I wont diagnose, But I THINK..blah blah. Tom is trying hard to get a concrete answer out of him..Even making his own answer to his own question.. hmm..this is a hard one..in my opinion of course.

[@mirandapillsbury7885]

I wish there was a way to also look young again...I'm 29 now and I can notice very very slight signs of aging and it is tripping me out. I really hate it :(

[@MendyJanelle]

Plastic surgery!

[@sickickick]

​@@MendyJanelleyup, that's all it takes. paris hilton is in her 40s and looks 23. surgery, and wealth, will get you a long way.

[@mirandapillsbury7885]

@@MendyJanelle I don't want to go down that route. Plus it can make you look even weirder and older sometimes

[@thefoodproject7559]

Aging is inevitable. Even those that have all the money in the world to get procedures age!!! You just don't see it because everything is filtered today. There is no secret to living a healthy balanced life, because everyone's metabolic, genetics, lifestyle is different. Reasons why sometimes the healthiest ppl get cancer. You can wear all the sunscreen in the world and still get fine lines!!! The healthiest ppl studied do not stress about aging The way this generation does. Stop normalizing anti aging and see how less stressed you'll be and how better you'll live.

[@sickickick]

@@mirandapillsbury7885 sometimes. consider sunscreen every single day. i dont leave the house without it and i still look 15, no shit. the sun is a MAJOR cause of aging. i use oils, moisturizer, sunscreen, and retinol every day. when i say i will look young in my late 30s, i mean it. kids mistake me as a teen, because i never cosmetically aged past 20. SUNSCREEN SUNSCREEN SUNSCREEN! and retinol if you can afford it. but most importantly, sunscreen. never too late to use it. if you already look 30, well, sunscreen will make sure you stay looking 30 in your 40s. i swear by it.

[@javierbrokenleg]

The pass of time?

[@brianevans3530]

When we attain Self Knowledge and realize we are eternal, we worry less about aging and more about purifying and strengthening the mind in order to "shed this mortal coil" and be on our merry way.😂😂😂 The only thing more terrifying than death is realizing there is no death, and there are no others

[@Alykat736]

I never found that terrifying, I found it Freeing esp from humanities misunderstandings that tend to come from man’s religions.

[@brianevans3530]

@@Alykat736 imagine an infinite sentient being realizing it exists.

[@treycaldwell4118]

Yes we should all be obese with diabetes and hypertension such that a small minority isn't harmed by calorie restriction😂

[@morocha520]

First cause of aging is living

[@williamhenry3337]

Tom Bilyeu is worth 400 million dollars. ALL of the doctors doing podcasts are millionaires. I am on Social Security along with my best friend and his brother. His brother lives on a monthly check of $1,200. All of this information is great but maybe applies to 5 percent of the population. I am 74 years old and I have never had a blood test and don't have the money for one. I try to eat decent and get my protein from beans and eggs. FORGET $35 a pound grass feed beef. I do the $1.29 a bag dried beans.

[@colorme6536]

With the internet and all the social media is east to make money use tik tok to make money it’s not hard these days

[@tedschwartz2142]

DAVID SINCLAIR SAYS TO TAKE METFORMIN AND HE TAKES METFORMIN EVERY OTHER DAY ..

[@kathya1956]

if you are healthy weight and eat red meat for every meal 5 hr spaced apart, mtor is not an issue.

[@Michael-wy7om]

I smoked delta 8 and did gummy’s for two months and seriously looked 10 years older after, so there is some truth on aging faster. My own science experiment done to myself. You can take it or leave it but it was my experience 🧐🥸

[@Travelbythought]

I saw my parent age 10 years in two months when they went through a stressful period. I think we accumulate metabolic wastes and such and then one day, it is like the cells are full and it hits all at once. The smoking and gummy's probably put you over the top, but you were likely due soon and it would have just happened another way probably within a year or two.

[@colorme6536]

Tom stop interrupting your guests and stop talking so much , the guest is here to talk and u hardly let them

[@jonibusskohl8958]

You could of said this in less than 20 minutes....too long

[@oeaoo]

Objective way of thinking about life is utterly off.

[@cbtheInfamous]

😂 1:06:25 rare joke

[@veganandlovingit]

Poor fecking animals in labs. Do more human studies. I'd love to be monitored and get paid to fast.

[@rodiculous9464]

Oh no he suggested something other than darpa myocarditis shots can be used to treat covid, hope this guy is ready for a lifetime of shaming and cancelation

[@youwwaaaat7166]

Anti aging expert who looks old xD

[@scottk1525]

Who said he was an anti aging expert? Not even him. He's just a scientist. Calm down.

[@amg9163]

But, he's 90

[@geekspeak1066]

This culturally obsession with longevity needs to stop. Focus on what makes u a healthier human today and worry about the rest later.

[@heindattel3919]

First of all thanks for your efforts and the conversation. 🎶💫 @17:50: You are 100% wrong with your assumption that "we have zero odds of getting our complete needed muscle maintaining & building blocks with a vegan diet " with all due respect. Complete nonsense. I am plant based vegan (not a so called pudding vegan) for 10 years now and all my health problems disappeared completely and that as i side effect on top of my achieved mind clarity. I am lean and strong with a good amount of high endurance & power performing muscle mass on me. I look atleast 10-15 years younger then i am according to what i hear every day. So if you think that way than you definately not knowing enough about the true science of an accurate plant based diet or you did it most prolly completely wrong at some point in your life with what ever you tried there, resulting in this conclusion. Btw: I know from watching your very good episodes over the years, that you actualy are looking for a way to stay and feel young as long as possible. Well then let me tell you that your wrong conclusion is something you really need to address then for sure. You lost an important key Tom somewhere . Find it and use it correctly and you will get there. All the best 🍀💪

[@Anna-rb6rg]

1) you are biased in this matter because it is about your lifestyle 2) we do not have a second control you who would eat eggs, for example, to compare and draw conclusions 3) your isolated case does not allow drawing conclusions for 8 billion and does not refute research 4) 10 years is a decent amount of time, but not so huge that you can say with confidence that you are at the peak of your muscle mass and strength and will stay there 5) no one argues about the benefits of plant-based nutrition in comparison with the standard American diet, almost everything is better than this

[@arbur3058]

​@@Anna-rb6rg👏🏻👏🏻 amazing, well-said

[@arwendriel19]

Brian looks better because he probably had fillers & laser treatments to remove skin damage, tighten the skin & bring bang some facial structuer lost due to age-related bone loss.kzbin.infoCBMV8BXn5HI

[@bren.m7904]

I didn’t really learn anything

[@MegaMolly68]

Interesting info guys, but what would the poor do? Not everyone can pay for scans and tests and organic food. Bread, rice, beans, noodles can be cooked many ways and fill an empty belly. They also help make us fat. Without the poor, and the jobs we fill, the world would not turn.

[@scottk1525]

The poor will do what they have always done throughout history. Either: A: overcome the odds, ice skate uphill and make something of themselves or B: eek out a miserable life and die young

[@MegaMolly68]

@@scottk1525 HI Scott. The poor are often hard workers who have some reason for not making much money. Health, family, choices, misinformation, prejudice, no connections, responsibilities, evil people......... It's not for lack of trying to make something of themselves.

[@scottk1525]

@@MegaMolly68 " *The poor are often hard workers who have some reason for not making much money* " I don't know about "often." I think you're making broad generalizations based on personal experience. I think "the poor" are probably no more or less hard working than any other tax bracket. Also, I wouldn't confuse showing up to a job every day with "hard work." Even among people working the exact same job, you're likely to find a huge variety of work ethics, be it "poor" jobs or "rich" jobs alike. " *It's not for lack of trying to make something of themselves* " Sometimes it is. Sometimes it isn't. I understand the perils of being financially challenged. I've been there. And there are many reasons any given person might be struggling. But there is always a way out. Not saying it's easy. Just saying that nobody should ever resign themselves to being "poor," especially in 2023, when people can make six figures reviewing friggin video games on youtube for crying out loud, or seven figures selling chinese trinkets on amazon. I agree that there are many reasons somebody might be struggling financially, but I would argue that the vast majority of these reasons can be overcome in one way or another. Some people don't realize that if they put 1-2 hours a day into researching, learning, and trying different ways of making money online, that in a couple years they could be financially independent.

[@liz2959]

If you want to see what health and vibrancy look like, why don’t you invite someone like Lou Corona or Dan McDonald on to your show. Let’s see some people who are walking the talk, and actually radiate. Why not show people very natural ways to heath and vibrancy. While their methods are not necessarily easy to follow, the general population should be exposed to what true health actually looks like…

[@FJano12]

90 percent genetic the rest is environmental factors..

[@delaramwakefield3989]

I enjoy your videos but please allow speakers to talk more. You always interrupt and make it about you. Also Tom looks extremely unhealthy, and pale. IF does not seem to work for you. Please see a dr to make sure.

[@bdawnedon]

he looks like he has no blood

[@SzazaM077]

All these anti-aging gurus, specialist look tired, old and unhealthy themselves...not a good marketing! 🙈

[@LD-xl2qc]

Cura te ipsum

[@thehoteldeveloper]

I bet you could get most of the benefit of calorie restriction by doing carnivore and without all the suffering. I'd rather live 10 to 15 years less feeling awesome than spending the rest of my life being a miserable zombie.

[@scottk1525]

Carnivore is a stupid diet for morons that believe tiktok hype.

[@knockingseeker]

Even on a calorie defecit the longetivity benefits are wiped out on a high protein diet. The main benefits of calorie restriction come from mtor restriction.

[@scottk1525]

@@knockingseeker " *The main benefits of calorie restriction come from mtor restriction* " When was this established? I don't think it was.

[@knockingseeker]

@@scottk1525 the studies showed that mice fed calorie restricted diets but high in protein did not obtain the longetivity benefits. May be different in humans but it’s quite possible it applies.

[@scottk1525]

@@knockingseeker Were there multiple studies showing this? Or just one? In any case, we know that excessive protein can increase mortality risk, independently of caloric intake. So increasing protein during CR doesn't really tell us anything about CR itself. It'd be like saying "the main benefit to CR is a reduction in sugar, because CR restricted animals on a high sugar diet, don't live longer." Don't get me wrong, I think we can agree that excessive protein probably increases mortality. But I don't think he have enough evidence to conclude that protein restriction is the main mechanism of CR-induced longevity.

[@HeleneLouise]

Flying blind

[@mesalouis8976]

He looks old, though. Why hasn’t it worked for him?😒

[@apinto69]

😂

[@sufiblade]

He would've looked way older. He looks very energetic

[@rml4289]

Yeah I only pay attention if they look young, David Sinclair is the best to listen to, he actually looks younger than his age

[@randombrandon315]

How old is he tho? I mean if he’s 60 or older I think he’s doing a good job

[@ianjameshodges2999]

No ! He certainly DOESN'T LOOK OLD at all... So.good for his age..

[@savednorwegian]

*Mice arent people indeed* And the two arent looking too good in their face (yes they're fit).

[@polymathpark]

get Dr. Brad Stanfield on your podcast, he's raising money for a rapomycin study in humans

[@brainnutritionrevolution333]

These vids are highly agenda

[@Georgina9095]

Our government is putting so many families in difficult situations, you have helped me and my family so much, Mrs. Stacey Meredith, imagine investing $1,000 and receiving $10,200

[@user-tg6bc8qr6y]

I'd think caloric restriction percentage must account for the amount of brain activity. I'm just a regular know nothing dude, but yeah, 60% reduction in calorie will probably make my brain pretty slow and lazy