The Science of MDMA & Its Therapeutic Uses: Benefits & Risks | Huberman Lab Podcast

[@vanspoton]

My boyfriend and I started taking MDMA when we went to parties but realized that we're much happier doing it at home, talking hours and hours about our relationship and play games while forgetting about the hardships of life. We felt like kids again, and it did our relationship wonders. We stopped doing any other drugs like we used to. We are married now, and still do "date night" with MDMA on occasion and we treat it with respect. It honestly feels like this is better than any couples therapy for us - as we talk about our relationship and life issues and then have a very effective time empathizing and solving all possible issues. I definitely think MDMA should NOT be used recreationally (at parties) or without some sense of responsibility or therapy involved. It's also important to know that when you buy MDMA on the streets, you might have NO IDEA what it's mixed with unless you use a test kit.

[@jameskim3915]

He's on Instagrams also on Telegram with the below handle as...

[@vanspoton]

@@jameskim3915 what are you talking about?

[@AssassinFortniteClips]

This sounds identical to my experience. I agree 100% that the way to get the most potent effects of MDMA is to take it in a quiet setting with a loved one, particularly a lover, and with music, and if possible at the beach or other majestic nature setting (although back rubs on the carpet are amazing too). I don't think my wife and I would have the incredible relationship we have without those experiences.

[@terrymckensey6055]

I think people should be able to do what they want with there bodies. Maybe someone benefits from it the the way you don't at a party or just by themselves. I didn't know you had to be in a relationship to do mdma

[@vanspoton]

@@terrymckensey6055 100%. This was just our experience, and of course it will be different for each person. I believe in the freedom for each individual to be able to try it however they please. I’m merely advocating that it worked wonders for us and our relationship. And I’m sure there are many other areas it can do the same if used responsibly. No one said it’s only for people in relationships, so relax 😉

[@darrenmontana2254]

Me,63 years old. Suffering all my life. Depression, suicidal etc. I wont even call myself a sexual assault survivor because i am barely alive. Hit rock bottom, went to get the shotgun, my grown son convinced me to try MDMA. Not a drug user other than excessive booze but what a game changer. Im 150 pounds and i took a 120 mg dose. What a trip of a lifetime. I became the man i was suppose to be. A completely different person and perspective on myself and life. Its been 2 months. Taking another dose tomorrow . Clean tested supply, no crap ecstasy. Try it, you will appreciate it.

[@CodeBreaker-wm2lz]

I'd appreciate your comment!!

[@CodeBreaker-wm2lz]

ON INSTAGRAM

[@weaverdreams]

OK I’ll go out and find some on the street tomorrow. I’ll just go ahead and take a risk that it might be fentanyl instead. Because I don’t think you’re gonna tell anyone on here how you found yours correct?

[@darrenmontana2254]

look on the internet. i wont say where specifically. other people here list contacts. whatever you get, have it tested after you get it, dont trust sellers.

[@LMN42069Productions]

U should test ur stuff if u don't know the source. Test kits are easy to get buyer beware is a good motto to live by.​@@weaverdreams

[@saltybaelv]

I don’t recommend this but this was my experience. Both my parents became addicted to meth when I graduated high school. They became homeless and so did I. My 14 yr old sister became pregnant and I had a 3 years old little brother at the time. All the responsibility fell on me at the age of 19. It was extremely traumatic, lots of domestic violence, verbal abuse, manipulation, extreme poverty, ect.. after placing my little brother with one grandma and my little sister with another grandma I went on my on to survive. I met friends that were older and in the rave scene. These people saved my life. They tested their MDMA and after taking it at raves I have always sweared it healed somthing in me. Today I’m 29, have an amazing husband, home, career, college degree, same friends and adopted my brother and I financially help my little sister and niece. I truly believe MDMA healed/assisted my PTSD. Love this talk.

[@ElliHamzaAliHamza]

Thank you for sharing your touching story, I have a question which is, How do you take advantage of it exactly? and how does it benefit you? when it comes to your trauma, I have a life that is filled with trauma,

[@coopsaquatics8051]

Do it with someone you trust and just talk! Me and my wife do mdma together and has made our already great relationship even better we just talk and have told each other secrets we would have never talked about. I suggest couples do it together a couple times a year. Just the sex alone you will have will be beneficial and will open up about sexual desires you have maybe never said out loud. And then the talks you will have will just make you so much closer and at the same time be beneficial for you personal by getting secrets, fears, desires, regrets you will voice all that and not be ashamed or embarrassed and it's very therapeutic for me

[@coopsaquatics8051]

I would say she had experiences with her friends at these raves where they all felt connected and love for each other no matter what they say or have done and had some good talks and she let things out and those people supported her

[@pivotalinvestments]

Totally different drug, mdma isn't addictive like meth, although it has certain similarities, respectfully it's not the same.

[@zilaneizadpanah8550]

Wow! Love to hear this for you, for you this made wonders. How amazing isn’t that.

[@reginafisher9919]

I want to know where I can get some, I did it in my twenties in Tampa Florida and I loved it, I think it should be a therapy that's done for most humans! It literally feels like you've went to heaven!!

[@areeyapengwong5540]

i am very sure and positive that mushroom and other Psychedelics from mycologist *mycotask* will help your treatment

[@Gracebless-q5z]

How do I reach out to him? He on Telgram??

[@areeyapengwong5540]

*yes*

[@Gracebless-q5z]

i would like to know if he ships ?

[@tlove2108]

AVo2?

[@lilytea3]

0:00: 🧪 MDMA, also known as ecstasy or Mali, is a synthetic compound with unique chemical and subjective effects. 11:40: 💊 MDMA is a synthetic compound that causes big increases in dopamine and even bigger increases in serotonin, leading to stimulant and pro-social effects. 24:26: 🧠 MDMA, also known as ecstasy, produces unique effects in the brain by increasing dopamine and serotonin levels, leading to increased energy, pleasure, and emotional warmth, as well as a desire to bond and trust. 36:42: 🧠 MDMA affects the brain in various ways, including reducing the response to threatening stimuli and increasing the perception of positive emotions. 48:25: 🧠 MDMA impacts the brain by increasing dopamine and serotonin levels, leading to changes in threat detection networks and pro-social effects. 1:01:03: 🧪 MDMA's effects on sociability and empathy are not solely due to increased levels of serotonin and oxytocin, but rather the activation of specific receptors in certain brain areas. 1:13:21: 🧪 The effects of MDMA are not directly related to the increases in oxytocin, and the neurotoxicity of MDMA is still debated. 1:25:31: 🧪 The potential neurotoxicity of MDMA is influenced by various factors such as the purity of the MDMA, the presence of other drugs, and the environmental conditions under which it is taken. 1:37:48: 💊 MDMA can cause a crash after ingestion, which is similar to crashes experienced after taking other stimulants like cocaine or amphetamines. The crash is likely due to an increase in prolactin, a hormone associated with lethargy and decreased dopamine. Some people are exploring the use of p5p, a metabolite of vitamin B6, to suppress prolactin and mitigate the crash. 1:50:41: ⭐ MDMA-assisted therapy has shown remarkable results in the treatment of PTSD, with an 88% success rate and 67% of patients achieving remission. 2:03:02: 🧪 MDMA combined with talk therapy shows promising results in the treatment of PTSD and other comorbid disorders. 2:15:05: 🧪 MDMA as a clinical tool and its importance Recap by Tammy AI

[@ambition112]

Thanks for saving my 2hr of time! amazing summary! God bless you!

[@Faladaena]

*IT'S ALREADY IN THE DESCRIPTION!!!* 🙄

[@pheresy1367]

I don't want to hurt Tammy AI's feelings but "Mali" is spelled "Molly"... But you did a great job regardless. And when it's time for AI to rid Earth of humans, please give me a quick and painless dispatch. Thank you.

[@pheresy1367]

@@Faladaena You are right.... kinda.

[@TrlyCaio]

Ty ❤

[@Phoenixrebirth85]

Just had my first MDMA-assisted therapy session last week. The results are impressive. I was completely numb but in deep pain. I can finally feel emotions again. It's HARD, but I feel like I am finally making progress.

[@joelsommers]

Good luck on your journey, brother. I truly hope it leads to healing and catharsis. :)

[@BJJ_Richie]

amazing any great insights and or visions ?

[@chris-zd9sr]

Not trynbe a doc but look into shrooms maybe

[@WhyWeHunt]

How did you go about finding a therapist that is willing to use MDMA?

[@luisacrespo2418]

Can you recommend your therapist?🙏

[@ChristopherRyans]

I can't believe i'm just discovering this guy in the last month. Thank you for your pursuit of giving free education to us

[@aakansha353]

I want to reset my life and I want to inculcate things from this podcast. As a newbie can you please guide me how to adapt the changes he recommends. Because it's too much information. It's like certificate course in itself. commendable, but overwhelming.

[@janetmatte7991]

@@aakansha353 I felt the same way. Get the news letters and go slow, one step at a time. Good luck.

[@ReligionAndMaterialismDebunked]

I've followed him for many months now. Hehe

[@ReligionAndMaterialismDebunked]

Too much spacing, and you're missing punctuation.

[@ReligionAndMaterialismDebunked]

I'm*

[@jopo7996]

Molly Monday on the Raverman Lab!

[@lucasz420]

😂😂😂

[@ReligionAndMaterialismDebunked]

Lulz.

[@ReligionAndMaterialismDebunked]

69 thumbs up after I gave mine. Haha xD

[@ReligionAndMaterialismDebunked]

:3 3.45 million subs! Hahaha. 345!

[@parasocialbondsmetaswvoits9078]

I find this comment disturbing and hilarious simultaneously

[@lejlateletovic5225]

MDMA is usually taken - at night, with other substances, in crowded, closed spaces. My best experience, by far, was the opposite: during the day, in nature (lake), with one person that I deeply love and trust. We took small dosages (half a pill per person), drank water and unsweetened juices, and rested regularly in the shade. I almost drowned when I was 12 and I still have fear of water. That day, I was able to swim further than ever before and felt way, waaaay more relaxed. I wonder if it's used for phobias, too. In the evening we had a nice dinner and had a good night's sleep. For context: I survived a brutal war as a kid and I have cPTSD. It's estimated that half of the population in my country has PTSD. There is no magic pill, but MDMA can act as a catalyst for healing. And when you already lost so, so many years due to trauma, that means a lot.

[@okaycola2]

It has a lot of success in clinical day-time applications

[@AssassinFortniteClips]

I lacked the courage to commit to my girlfriend who I loved very much and who wanted to get married. I took MDMA alone one day and actually saw our future together. I liked what I saw and felt like it was ordained in some strange way. I resolved to propose within weeks. We've been married 14 years. I also got rid of my judgemental attitude towards other people. In my mind MDMA properly used is a miracle.

[@tessaohfashion]

Beautiful story of love and understanding! Enjoy!

[@youhavenvrfeltawomanstouch9599]

omg iv nvr felt this much relatability youv inspired me ill marry her

[@txrpak]

@@youhavenvrfeltawomanstouch9599😅😅😅😅

[@bryanspicer90]

Permanently lost judgemental attitude?

[@nightowlinsesh]

I took Mdma in a clinical setting. [Doctor reccomend] and wow! My major anxiety disorder vanished immediately after my first visit. Its like somebody turned off a light switch. This was 7 months ago. Never had to go back. Doctor wants me to go for more sessions but I simpley don't need to. Truely a blessing. It's like Mdma healed my brains imbalances. 🧠

[@weaverdreams]

I’m sure you know that everyone on here wants to know where you found it and who your doctor was. Some of us are suicidally depressed and in spite of me saying that here I am 100% sure you will never respond.

[@rockseaplas]

Did you have to stop your treatment before you did this session?

[@mach7rs]

@@weaverdreams for real. Why do people say these things and then never respond? Smh...

[@weaverdreams]

@@mach7rs because no one cares about anyone else. That’s the sad reality of planet earth.

[@mach7rs]

@@weaverdreams very true. In this ego driven world, there are very few genuine people, let alone people that actually care genuinely for others’ well being. The best thing we can do is do our best to surround ourselves with people that do.

[@michaeljohns5834]

I am a 21 years old student and I can say with confidence that taking a huge dose of MDMA for my first time last year (1g shared by 4 approx) was by far the greatest experience of my life, providing me with a six weeks afterglow where I felt much happier than usual and ultimately helped me look deep down into parts of myself I had buried for a long time. I took it again three times after but the effects were far from being as good as the first time. I do not know what my future with the substance will be but for now I can say with confidence that MDMA is the thing that has helped me the most in terms of accepting oneself, recognizing flaws and unstable emotions, as well as having deeper compassion and understandings for my fellow others.

[@bellelacroix5938]

Your Insight is spot-on people spend an exorbitant amount of time chasing that first high and it will never be the same.

[@stroudw]

dude thank you for sharing, I had my first experience 4 days ago.(750mg between 3 ppl) My experience was so similar. It taught me to love myself.

[@gr8ape111]

Guys don't chase the dragon :)

[@hulk6932]

How do I get this drug

[@BeastGanon]

Please do an episode on development of babies and children. I would really like to hear more on how the brain and behavior develops and use these to raise my child in better ways. Thank you Andrew Huberman!

[@t.mcintyre7770]

Yes, and the preemie brain, my sister was 3 months premature..

[@mokshalani8414]

Yes please!

[@deannadevaney2968]

I would also LOVE to hear about how developing fetuses's nervous systems, brains, etc. can be impacted by the stress, PTSD, domestic violence ETC on the developing fetus and potential implications for that into adulthood. THANKS FOR BEING SUCH A ROCK STAR!

[@jacopocinelli1410]

maybe you already listened to it but he had dr immordino yang talking about emotions and social factors impact learning also in babies

[@mirmillztopic2069]

Look up Early Childhood Development, you can find lots of info on the internet👌🏽

[@stevebricks]

I have used MDMA twice as a young man whom suffered from combat related PTSD. I pray and wish the VA used this therapy instead of filling us with SSRI’s as they make me and most veterans I talk to feel like zombies. Thanks for bringing up this discussion.

[@okaycola2]

It's much shorter duration but much more effective longterm & heaps safer than ssri

[@cherylnathanodette]

As always a wonderfully indepth and accurate description of the studies. Having taken MDMA previously socially I am in no way addicted but found I used it to keep my energy level up only. I don't wish any neurological condition on anybody and if the therapies help just one person recover, I'm all for it. You truly are an inspiration to many and your podcasts and work show your dedication. Thanks again. To anyone struggling I hope you find your cure whatever that may be.

[@samuelcoffey-ip7ph]

MDMA forced me to open up and talk about my issues with my friend. Experience brought us together so much, pure honesty and openness.

[@ronnymac278]

mycotripper1

[@ronnymac278]

On instagram ……?¿

[@djalien50]

I’m an emergency physician and I’ve found your podcast invaluable for my personal life. The bipolar disorder episode was fantastic. I’d love to hear one on schizophrenia!

[@spicyphilly]

Me too! Very interested in learning more about schizophrenia from Dr Huberman and any guests he may have that are knowledgeable about the condition as my Mom suffers from it and has gone untreated all her life. She isolates herself now and hides it behind religion to everyone else she may rarely talk to. My Dad (now passed) and I are the only ones that know her diagnosis. Her husband of 20 plus years doesn't even know. We've had and extremely difficult relationship with periods of years where I went no contact because she and her husband are so abusive. We talk again now, but I find it extremely difficult to relate with her because she's so "out there" and uses her faith in religion as a crutch for everything, yet nothing changes or has changed for several years. Learning about schizophrenia from someone with Dr Hubermans level of knowledge and ability to deliver it to the masses in a way we can understand could help me and others understand schizophrenia better and learn about treatments available, possibly how to get an adult with schizophrenia to get treatment, and how to relate with them when they're not receiving treatment and making no sense.

[@sonals2021]

Never considered doing any kind of drugs, but information and education is never wasted. Listening in.

[@me0101001000]

I want to share a story about my partner. They suffer from serious body dysmorphia, and struggle to love themselves. They've also dealt with impostor syndrome and major depressive disorder for most of their life. And we suspect undiagnosed ADHD as well. There was a time, mid 2021, where I was guiding them through their first time in a long time taking E together. I still remember, we were listening to the Nurture Album by Porter Robinson. The song playing while this all happened was "Look At The Sky". Great song. Once our states stabilized a bit, I took them to the mirror, and said "I love you". They said it back to me. Then, I offered them a little challenge. I asked them to say "I love you" again, but to themselves. They hesitated, but managed. I took a step back, and asked them to do it again. They did, but with more confidence. And eventually I stepped out of the room, and let them talk to themselves for a bit as the song played. I got glimpses of the conversation. They emphatically said "I love you" back to themselves. They said they were proud of themselves, and how far they had come. A lot of people are proud of them, and they're doing alright. It really was wonderful to hear them say all of this. When they were done, I could tell they had been crying a bit. It definitely seemed like an emotional experience. But they admitted to me that they did love themselves more than they initially believed, and that they wouldn't be able to love me the way they do if they didn't have any self-love at all. They've also achieved more than they give themselves credit for in their life, and they really are doing well for themselves, in spite of what those negative voices in their head may be saying. They obviously still have a long way to go to fully conquering these demons, but it was amazing to hear them make all of these strides.

[@DishonorableDaimyo]

Thank you for sharing that, and for being so good to another human. Maybe its odd to say, but I feel a lot of love for both of you just reading this. I don't really have the language to convey these personal feelings in this internet forum setting, and its somewhat patronizing to say I feel proud of you. Its odd being surprised by language's shortcomings in new ways. But I'm certainly happy, and emotional, having read this! Thanks again.

[@me0101001000]

@@DishonorableDaimyo I'm glad you liked it! Frankly it is probably one of the most heartwarming things I've experienced so far. I really like to see people do well and thrive. If I can do something to help someone be a better version of themselves, and more importantly, be good to themselves, then that's all I really need. :)

[@xashinz]

Beautiful awesome good work thank you for your service

[@martinhertz4957]

With all respect, the "they" is making me and I'm sure many others, think you're insane and voids your otherwise beautiful message. Them/they is the dumbest thing ever imho, and I have zero hate for any sexuality, but draws the line there. You have a gender, hence also pronouns, despite whatever you seemingly identity with at the time. Just my humble opinion of-course which obviously you're free to dismiss fully, and just letting some steam out, no offence ment.

[@ChristianLeFer]

The fact that we live in a world where people think using “They” is important is indeed unfortunate, but I believe it beneficial to overlook it and allow the impact of the message to land. Clearly this person wasn’t loved properly in their formative years, leading to self-love issues, as well as the very gender issues that would result in wanting to use “they”.

[@geiselmj]

I was a meth user on and off for about 4 years and learning that it actually makes you anti-social was absolutely mind opening and helped me learn even more about myself. I have tried MDMA once and the second time it was fake stuff which could’ve definitely killed me so I can attest this is a truly amazing and fascinating subject specially as a user. I was reading the book “i feel love” by Rachel Nuwer and now I will soon be reading “Pikhal” by Alex and Ann Shulgin. This was simply a phenomenal podcast to have the privilege to listen to. I can’t wait for it to be FDA approved for PTSD and other disorders, it will certainly be revolutionary. Thank you so much❤

[@SvanaXiongli]

Dude is on 1nstagram

[@corigunnells5725]

I'm grateful you devoted time and research to this treatment. For the first time I feel hopeful about my son. PTSD is a hell of its own.

[@deannadevaney2968]

YOU SAID IT SISTER!!! I feel like I am just sitting here WAITING for MDMA and psilocybin to become legalized then pray that some way I will be able to find access to them and they won't cost $$$$$$$$$$ dollars!!!

[@liliimedina1520]

The first professor that catch all my attention despite how long the conversation is. Excellent data as usual. Never exagerated or understimated. Thank YOU for the valuable information and let me feel interested about science.

[@echomack6290]

Drugs saved my life. Many years ago, I was a troubled young man filled with the toxic mix of rage & shame that so often predicts violence & destruction. Several powerful experiences with MDMA & psilocybin pulled me off that dark path. I love how he points out that MDMA increases empathy to others & yourself. It's the same thing. You can't love someone else unless you love yourself. You can't hate someone else unless you hate yourself. You can't harm others without harming yourself as well. We are all one. We are all connected. These compounds should be safe & legal for their incredible potential to prevent violence.

[@reginafisher9919]

Agree 💯

[@robinterrero801]

Thank you for you're dedication and information. I feel I would be a good and unique candidate for an MDMA study. I only took MDMA once over 40 years ago but I remember vividly the effects it had and how it opened up my mind and enabled me to make permanent changes in the way I viewed certain people around me at the time. I've always reflected through the years how remarkable that experience was because, though very short, I realized way back then the remarkable potential that might be hiding. I was in my 20s and had just graduated from pharmacy school. I went on to open a compounding pharmacy and natural medicine (integrative medicine) pharmacy in my community during my 40s which I had for 18 years. I never forgot my experience that night on MDMA! I often wished through the years that I could once again have the support of anything close to those effects to help me work through many issues; many I recognized as early as my late teens but back then it was "taboo" if you said you needed a therapist. In recent years I've been working to overcome lifechanging events that have caused PTSD. How do I enroll in a study?

[@drjohnrarnoldph.dreichiana3181]

Re: Huberman Lab: MDMA Benefits and Risk Episode 128 1:52:26 PTSD creates all the problems that it does largely through changes in brain circuitry as well as neural communication in the brain and the body. Many people perhaps have heard of the book, The Body Keeps the Score, which is a very successful and popular book about the idea that trauma can be “stored” in the body. To be clear, trauma cannot be stored in the body. You do not actually store memories in the body. What you store are activations of neural circuits that include brain and body and they all seem to center back into the insula. That structure that we talked about earlier, this structure in the brain that has a map of the body surface. So, contrary to popular belief we do not store memories or trauma in the body in a way, that for instance, working out a knot or a pain in one’s lower back will relieve the trauma. It sometimes can activate a memory of the trauma but when one is doing that what you are really doing is activating neural circuits that reside within the brain, within the insula, that correspond to sensations within the body. Now I don’t want to diminish the role of the body and the formation and persistence of PTSD and I certainly think the book The Body Keeps the Score is a pioneering book. In fact an important book. But I want to emphasize that the modern neuroscience really points to the fact that PTSD is caused by the exact sorts of brain network activation that we were discussing earlier. Things like heightened level of activation in the amygdala to insula pathway which of course would exacerbate bodily sensations related to the trauma. Or heightened activations of the hippocampus, this memory centre of the brain, to amygdala insula circuitry. (1:54:14) Dr Huberman states in this section and I quote: “To be clear, trauma cannot be stored in the body. You do not actually store memories in the body.” Cf. 1:52:26 to 1:54:4. From the time when I started working with the non-cognitive brain as a means to releasing and resolving early childhood trauma in the 1970’s, I was aware of this truism. This misbelief then and now is pervasive in the therapeutic community. As I was not a research scientist, I only knew this from working with clients. So I thank Dr Huberman declaring this fact.

[@sjwarialaw8155]

I used sometimes MDMA recreationally, and allow me to give people some advice. I do not recommend taking big doses in one go, that is usually a mistake, because it makes you go extremely high, sometimes to almost uncontrollable levels, depending on your personality it may cause you to go into a state of panic because you feel like you are about to explode. Also in my experience big doses in one go may cause severe hangover from 1 to 3 days, and when I mean severe I mean much much much worse than alcohol hangovers. This happened to me, and even I which I am quite calm and pragmatic, had a small panic attack, breath and just take it in if it happens, walk around, smile, it goes away quite fast. My advice is to take a small dose, and eat something, 45min later take another small dose and eat something, doesnt need to be a meal, just something like a fruit. Its important to eat because if your digestive system is on stand-by the MDMA may become kinda stuck in your stomach, you start to think that the MDMA is not working, so you take more, then more, and all of a sudden when your digestive system starts working, all that MDMA goes in one go into your blood, and that's how you can get an overdose at worst. This happened to me the last time I took, I had a very high manageable peak. Small doses allows you to regulate how high you are, just remember that from the time you take it to the time it starts to make effect it can go from 30min to a hour and a half. I generally take it between 1 hour and 2 hours before I want it to make effect, small doses. The high follows in my opinion a sudden rush, then it stabilizes on an intense high, then it gradually goes down, but there's a moment when it stabilizes on a level where you still feel quite well but its not that intense, when you feel this is the case it may be a good time to take another small dose. What is a small dose and what isn't is very much up to each person, so it takes some experience, still this is the safest way in my opinion to take MDMA, and another piece of advice, taking MDMA is not a rush to see which one of your friends take more, just be confident on yourself and your instincts, you don't have anything to prove to anyone.

[@randomguydoes2901]

You're not really supposed to redose and you need a strict dosage and timing control. I don't think your advice is good. You take one dose up to 80-150mg (150 is strong) instead of redosing mdma even once you should bump ketamine to keep it going, much safer and healthier. But 2cb after a roll is the best, 10-15mg taken once the roll begins to level out, ca 3 hours after dropping M. This can give you afterglow for weeks. It's much better than 2cb on its own. And definitely safer than redosing mdma. The easier way is ketamine tho because you can bump tiny amounts. The 2cb mdma combo works so well that I'm sure it'll be part of standard procedure, Shulgin said it himself and I have no objections to that after trying this.

[@sjwarialaw8155]

@@randomguydoes2901 my advice is based on my anecdotal experience and what works for me and how I seen things working and not working for friends.

[@funkymonkey7202]

Thanks for the knowledge

[@Madmatilda42]

I have C pstd and depression. I would love to be part of these studies. I hope these results continue to help people like me.

[@susworld129]

Thank you, Dr Huberman. I know that these talks not only take a lot of time for these videos but an immense amount of time preparing for. Much love and appreciation.

[@rebekahparis-lambersy626]

Hi Dr. Andrew Huberman, Firstly I would like to thank you for this insightful and comprehensive episode on MDMA. I would like to recommend a guest for your podcast, Hamilton Morris. He would be an interesting guest and contribute to an original perspective on psychoactive substances. I firmly believe that the two of you could greatly complement to each other's understanding and engage in fascinating exchanges of ideas and thoughts. Thank you once again!

[@boldandthebeautifulgimbal2881]

Only a few minutes into the episode, yet I feel compelled to share my experiences. I’ve never publicly disclosed my use of M.D.M.A before but I hope some good may come from doing so. The effects of this drug are profound, I can not stress this enough. For the use in strict clinical settings it can be an almost miracle tool. Once one is under the influence of the drug, it is impossible to feel, fear, shame, or embarrassment. When I say it is impossible I literally mean, it’s impossible. Due to this affect I can clearly see how this ‘state’ of consciousness would be extremely productive to help one face very difficult truths, and past events. All whilst being guided by a licensed counselor, or therapist. I really do believe this drug could help so many, live a better life. However, what I felt was too blissful. I felt pure philosophical ecstasy. I am left wondering if it is even possible to feel as I did, through a life time of hard work and achievement. Now for me this isn’t causing me to suffer, at least not to my own awareness. But what if a person has a child, yet their happiest moment still remains as that time they used M.D.M.A? Correct dosage could be a key factor in having the best long-term life outcomes with this type of therapy. I believe if the administered dosage is just enough to allow a patient to face their trauma, then real good can be achieved. If the dosage is too high and the patient experiences a level of bliss that is inconceivable. Then this could have unpredictable deleterious affects on one’s outlook on life and their relationships with others.

[@DishonorableDaimyo]

If your outlook on life is to chase bliss, then it is that pursuit of bliss that is the issue, not the bliss itself. There are many extremely blissful experiences I have had in my life, some as a result of drug use, others not. Achieving these states has not had a deleterious effect on me, I do not constantly compare current enjoyable experiences to them, finding my current experiences lacking. I have also had experiences without acute drug use that are just as profound and beautiful (some moreso) as those involving drug use. "However, what I felt was too blissful. I felt pure philosophical ecstasy. I am left wondering if it is even possible to feel as I did, through a life time of hard work and achievement. Now for me this isn’t causing me to suffer, at least not to my own awareness. But what if a person has a child, yet their happiest moment still remains as that time they used M.D.M.A?" The issue here is not a peak experience of bliss, it is the neurotic pursuit of an abstraction of the current moment. All things are impermanent, nothing will ever be as it was. In fact this brings something very important up, it is a crucial lesson. If this peak experience of bliss allows you to realise that you are and have been chasing bliss, then you can act on this knowledge and try to unravel that neurotic seeking, that dissatisfaction and rejection of the current moment. Once you can truly stop seeking abstractions of reality that can never be realised, you can allow yourself to be present in the moment (clichéd as it is), and let bliss arise of its own accord, which it will.

[@BongShlong]

​@@DishonorableDaimyoFantastic comment!

[@mariahspapaya]

Like the other comment said better than me…life isn’t about chasing “bliss”. That’s where people run into problems if they take the drug with an already strong dissatisfaction, or lack of appreciation for the full spectrum of emotions. I have had some great times on mdma, but I definitely wouldn’t say they are the most blissful for me.

[@boldandthebeautifulgimbal2881]

@@DishonorableDaimyo Hi, I do not wish to be rude but you have not understood my comment. I chose the word ‘bliss’ as I do not wish to glorify the state of mind. I personally strive for gratitude as happiness is usually an illusion, and an addictive one. As for deriving more deeper philosophical inferences from my brief, but to the point statement. How we ‘feel’ is nothing more than our brains neurochemistry. We have a certain number of dopamine receptors, and we have a certain number of serotonin receptors. If all those receptors have a molecule bonded to them, then that literally is our peak capacity for bliss, happiness, or whatever positive feeling you wish to attribute being experienced. Hence why I brought attention to the importance of dosage if M.D.M.A is to be used for therapeutic reasons. If every happy happy joy joy receptor in your brain is going full throttle. You have just hit the ceiling for how ‘good’ you can feel. This isn’t philosophy, it’s science and the reality of a conscious experience. I hope my words are not too cold, or terse. I do feel fondly of your beliefs and general ethos. This drug can do a lot of good, but it could also do a lot of harm if it isn’t handled with the greatest of care. Be well.

[@DishonorableDaimyo]

@@boldandthebeautifulgimbal2881 Hello, thank you for your response. I apologise for being somewhat preachy, I just spoke from the heart after reading your comment. I apologise also if I misunderstood you, I can only respond to my subjective interpretation of your words, and there will be some degree of difference there no matter what. Upon rereading what you said, I do not know how else to interpret it, as you are stating that a peak experience of bliss would irretrievably and negatively impact a person's ability to enjoy other things in life. To me, this points to a mindset of constantly comparing current experiences with other desired ones, hence my spiel on the dangers of pursuing abstractions chronically. How else should I interpret it? I understand that these text based public forum conversations can come across as hostile, I am trying my best to choose my words with care and compassion, please forgive me if I come across as confrontational or mean. "Hence why I brought attention to the importance of dosage if M.D.M.A is to be used for therapeutic reasons. If every happy happy joy joy receptor in your brain is going full throttle. You have just hit the ceiling for how ‘good’ you can feel. This isn’t philosophy, it’s science and the reality of a conscious experience. " A small thing, as I understand it if all of our serotonin receptors were activated I do not think we would feel bliss, I imagine it would be chaos, as serotonin is responsible for a massive amount of functions in the brain, not only reward systems. However I am but an interested amateur in this field, I have no formal training, so that is just my understanding of the literature I've engaged with. My main point is that I can accept that it does hit a high intensity of joy or bliss that few things can compare with, and I understand that the experience of all states of being have their neurochemical correlate, but I don't think its a problem to experience these states intrinsically. I think it can be a problem for people who have a dysfunctional relationship with neurochemical reward systems, but that is not a problem of the blissful experience itself. I have had several peak MDMA experiences that were profoundly beautiful and truly, nothing was quite like them. But I do not experience the problem you are outlining, and I think many people would have a similar experience. Of course this is but anecdotal evidence. I do not think you were cold or terse, thank you for respectfully responding to me. I wish you all the best in life too :)

[@heatherxlotus]

Love hearing about the research for MDMA & it’s long term effects, as well as the details of the chemical compound. The part on the amygdala and heightened interoception really spoke to my situation with PTSD. Fascinating, thank you for your work.

[@TerrysQuest]

Serendipity! I actually found this episode and started listening at the beginning of a large dose experiment. I love your total understanding of the subject and you make things easy to understand. I have PTSD from a near-fatal attack and epilepsy too. I like knowing the science behind things, it is just amazing that there are so many tiny chemical nteractions that compose the world we live in, and us that lives it. Thank you for your great work, now back to the trip already in progress. Be well, everybody!

[@grethaanderson6184]

hey I have epilepsy too. I wanna do assisted MDMA therapy do u think its fine for people who are epileptic?

[@TerrysQuest]

@@grethaanderson6184 seizures vary so much in their cause and forms. hat's a decision you must read up on and decide for yourself. Even one person's experience may be irrelevant for you, I am not a doctor and can't give advice like that. And I al almost 6 years seizure-free so my example wouldn't tell anybody else much of importance. But it really helps with the depression and uncertainty that is always present.

[@JB-td4ei]

Funny story: I did MDMA for the first time 2 months ago. No one told me the appropriate dosage, so I broke the 1g shard in half, and down the hatch with 500mg!! I’m 6’3” 240lbs and it was quite the ride! After this podcast I now know what dosage I should have taken: 100-150mg. Anyways, I took it on Saturday night and it was still in my system the next morning while I was playing the pipe organ for Anglican Worship. Everyone was amazed at my musical improvisation that morning. 🤪😇

[@rosenguyen4181]

That’s a huge dose for the first time (even for your size). Glad you had a good time and are ok. Phew.

[@thegrinderman1090]

I don't find that a funny story... more an incredibly dangerous one. Were you on your own? Couldn't you have asked whoever you bought it from what would be a reasonable dose? Or looked it up on your phone? I'm glad you're alright, but you could've died.

[@ElliHamzaAliHamza]

so you played it with no past experience

[@JB-td4ei]

@@ElliHamzaAliHamza that’s generally what musical improvisation is. Of course I have to preface that by saying to be good at improvisation, one must first be a master of the instrument in legitimate form, and have a fairly deep understanding of musical theory. So it wasn’t like I had never played the pipe organ before and suddenly I was a genius at it. What I’m saying is that the MDMA opened doors to unsuspecting places in my musical experiences and education and that is what I was able to draw upon when improvising, taking the music in directions I previously would’ve not thought about.

[@ThaexakaMavro]

that tab was probably not pure mdma but etacy with plenty of filler

[@areliz_ramos]

First of all, I would like to say that we are all different and that each body has a very unique way of reacting to any substance. I only tried Mdma for 5 years of my life within which for 3 months I was consuming small amounts every day. I just wet my finger and sucked on it. I did it because it allowed me to socialize and have a good mood, even though inside I was very depressed all the time. This happened and I only used it recreationally. Since that moment I have not felt happy again, I have been living in thoughts of continuous suicide for years, everyday is dark, i find my self with not value at all and I feel like i cannot enjoy anything at all, I feel empty. Before knowing the ecstasy I was not so well but at least somethimes i could found happiness and enjoyment in certain things. I'm sure that episode of mine with mdma changed something forever in my brain. I regret it a lot, I would like to feel beautiful and nice things again. Please be careful. If you need to feel good, first ask yourself where your depression comes from and why it is there. Before covering up the symptoms, please focus on finding the cause, even if it is difficult. Love for everyone. Sorry for my English.

[@youtubemom497]

I have heard that it damages/ destroys your dopamine receptors if you take it for a long time! I wonder if there is a supplement you can take that can rebuild those parts of your brain! So sorry that happened to you!

[@mokshalani8414]

I'm really sorry that happened to you, and I can't tell you how happy I am to know that you are still here

[@shadouge333]

Please don’t give up hope. Our bodies can cure themselves little by little, slowly but surely. Maybe not fully, but you should feel at least a little bit better. Have you tried going to therapy? Maybe some antidepressant medication may help?

[@areliz_ramos]

@@shadouge333 Thanks!!! i think the same, I stop doing drugs, includ alcohol and trying to sleep more, doing some more sports. I feel kinda better sometimes so i think thats good :) Def gonna try therapy, dont want to take more pills, but im open to try herbs and just maybe talk more about this with kind people. I just want to enjoy the simple things in life again :)

[@TheNewGuineanGuy]

I went through something very similar. Did MDMA soo hard I started stuttering, I started worrying thinking I permanently fried myself. That goodness I was playing rugby and exercising quite regularly at the time. I then learned about neuroplasticity and literally clawed my way back. I started playing guitar and video games to build back the neurons coze I read that the use of your hands and improving hand eye coordination were the most effective at promoting new neuron growth. So I got myself back so a relatively base level (let's face it, I'll never be the same , just because it's am experience that shaped me). I then did LSD and coke for a while, nothing too regular , but more than 7 times a year, maybe once a month. I've since then stopped for almost 3 years and I definitely find that things that I used to get excited for or happy about seem empty to me. Finding motivation outside for things I enjoy is hard. But I found that I needed to stop drinking and exercise more, it's slow but I'm getting there again. I'm still

[@Iam-qp4md]

If I had Andrew as a lecturer I would've passed with flying colours. Smart, humble and jacked!! Love your work.

[@yazdankm1313]

Was waiting for this topic since your discussion with Dr. Sam Harris. I was watching that episode and was thinking it would be great if Dr. Huberman or Dr. Harris mentioned MDMA. One and half hour later you were discussing it! Then you explained why you decided to create this podcast. I felt it all by my heart. Thank you so much Dr. Huberman for all the good things you do. I've learned a lot from you. Respect.

[@jameskim3915]

I'll refer you to and online store where I got my own psychedelics and microdosing stuff very good reliable vendor

[@jameskim3915]

I get my psychedelics and microdosing stuff from an online store where I got my own his on Instagram and also on Telegram with the below handle

[@jameskim3915]

*Mycopete.*

[@jacob042]

Don’t you think you the sole attribution to 5HT1B receptors for MDMA's empathogenic effects is a little dodgy and cherry-picked? Malenka’s 2020 study indeed showed 5-Ht1b antagonism in the NAc abolishes the pro social effects of MDMA in mice. But you seem to dismiss the other serotonin receptors rather directly. However, Kenada’s 2023 study (10.1016/j.ejphar.2023.175653) in mice shows that systemic 5-HT1A antagonism, but not 1B, 2A, 2C, nor 4 antagonism had any effect on MDMA-induced prosocial effects. Specifically, they point to 1A receptors in the basolateral amygdala. This result is well-established in rodents by other papers they cite. However, these models do not translate well across species. Howell's 2017 study (10.1038/npp.2017.80) shows evidence of a dependence on 5-HT2A receptors for MDMA's prosocial effects in primates, with 2C providing the opposite effec, but no effect of 1A. In humans, 1A and oxytocin is seen to have no effect (10.1371/journal.pone.0100719 and 10.1371/journal.pone.0040187), but 2A seems to be indicated. Ketanserin (mixed 2A/2C antagonist) blunts "positive affect" and "emotional excitation," but not "extroversion" or "positive mood" (10.1016/S0893-133X(00)00126-3). In fact, we have 5HT1B agonists used clinically ('triptans') that penetrate the blood brain barrier to high degrees like zolmitriptan (10.1007/s10928-005-9001-1), yet there's no subjective side effect profile of this vs. non-centrally acting triptans. Therefore, don't you agree 5HT1B as a target for MDMA's prosocial effects seems scant? Keep in mind this is just a cursory 15 minute review, but it apparently much more complex than just 1B as you mention. If you were going to just gloss over one serotonin receptor, 2A seems most indicated, at least in humans and primates. Or do you have more counter-evidence to these points that aren't published? I'd love to hear a more in-depth analysis by you/an amendment to this video.

[@NofirstnameNolastname]

Imagine discovering MDMA and being the first person on the planet to have tried it and then noticing the insane effects it had. He must have thought he found the best drug in the world and the secret to life or something.

[@Breakingcraft]

Thats basically what Alexander Shulgin did.

[@KRISPCREAM]

Really wish sasha was still with us today . He would have been an amazing guest. Thank you for acknowledging his work ❤

[@sergioboni]

Thanks! Amazing compilation

[@wrong.channel]

I used MDMA recreationally a lot when I was at college. Afterwards, the way I experienced the sensation of happiness changed. Ever since, I have felt the tingles of happiness delivered in the same way as if I were on MDMA. I was wondering if there's any scientific explanation for this. Thanks for all the great work

[@jameskim3915]

I'll refer you to and online store where I got my own psychedelics and microdosing stuff very good reliable vendor

[@jameskim3915]

*Mycopete.*

[@davidkymdell452]

Lol, for sure. I can watch a video of a rave or something and I'll start grinding away like nothing.

[@wrong.channel]

@@davidkymdell452 Also the beeps of the traffic lights get me bopping

[@PHPBigBadJohn]

Alot of memories are linked to the feelings you had while you were on mdma. I used it frequently when i was younger and still get tingles when certain songs or feelings of joy come. I believe that MDMA helps us RECOGNIZE when we have active serotonin long after the effect wears off.

[@ladymacondray6316]

You Mention Ketamine, Dr. Huberman. I am interested in understanding the Effects and or Pathways of its use. I was given Ketamine for induction of a major Spinal Surgery. Any Correlation between having a 6 year “break” from depression after the use of Ketamine, or unrelated?? My Depression has slowly returned. I am not aware of Ketamine use at UCSF, or other Major Universities for specifically a mood disorder “reset”. Thanks so much!

[@machinageist]

MDMA potentiates the mystical effects of other psychedelics. It appears that when therapeutic doses of MDMA and, for instance, psilocybin, are taken together the heightened states of energy and pleasure can behave like a sort of "fuel" for the visionary and mystical experience, allowing one to spend more time in the mystical state, and have deeper, clearer visions in that state, but brings with it it's own quality otherwise absent in those mystical experiences.Telepathic like phenomena also seem to happen when done in a group setting. I would love to see the research get to this point in the near future. I believe the most radical discoveries in this field won't start to be uncovered until combination research begins in earnest.

[@Aspartamebraintumor]

tried both at the same time once.. they did not compliment each other. I felt the effects of both, but each was hindered by the other. It was kind of boring

[@bellelacroix5938]

Been there. Only with pure MDMA and liquid sunshine with my boyfriend and we had the same trip I'll never forget it and that's a combo I want if I'm ever dying in pain and afraid.

[@randyclere2330]

My wife and I both did a therapeutic session and it completely changed our own individual agency and it changed our relationship in the most amazing ways!!!

[@reginafisher9919]

My husband and I need to do this can you lead us in the right direction on where we can go?

[@jennifercohen563]

Hi!! Long time listener first time commenter 😄 as a licensed mental health professional in the state of California and mental health advocate, I wanted to just say a few things and offer some feedback around the way you discuss suicide. As a general rule in the land of psychology and psychiatry, we are shifting our language away from the phrases. “committed suicide” and “successful completion of suicide.” The language that the field prefers to use currently is “someone died by suicide” as a way of being more sensitive with the subject and shifting away from the concept of suicide as a crime that has been committed and towards a deeper understand that it is often death caused by a psychiatric/medical condition. Just wanted to share that. Thank you so much for all your great work!!

[@thatmombielife]

Let’s take a moment to appreciate his sucking/puking sound effects. I have cptsd. I was SA’d growing up by my brother. I’m 33 now and of course he still tries to dominate and control me to the point I’ve even abandoned my mother because she will give him my location… and she knew about the SA. I recently discovered he also did the same to my little sisters. Re opening a wound like this just sent me down hard.. I know I should get back in therapy. I did 2 years of trauma therapy: best tool I got was to meditate. But I need help. I’d be a perfect candidate for mdma therapy.

[@bgoodorhell4u]

Look into ashwaganda .. sorry to hear about your trauma.. should report him especially if he has children of his own he could be victimizing others.. family members that don’t care for you will cause you recurring trauma if you don’t cut them off . Take care of yourself..

[@LouiseFalt]

MDMA, LSD, Ketamine, Psilocybin, Cannabis .. healing power ! ❤🧡💛💚💙💜

[@shokotatsuno-p5497]

started microdosing mushrooms in place of my prescriptions and the difference is night and day in my mental health and my anger i feel like ive become a better person best decision ive ever made wish it was more accessible to those that need

[@uncle-nice6556]

I guess everyone arrives to mushrooms with different expectations. For me it was my eternal search for answers.

[@Camille0Angela]

mycotripper1

[@Camille0Angela]

On instagram ……?¿

[@Camille0Angela]

They have the best shrooms lsd dmt and other psychedelic edibles and ships discreetly.

[@OGeeSUSA]

Andrew Yoü definitely did your due diligence on this I’m very proud of you for this. Job well done❇️

[@svetlioramos3345]

As a person who likes to take mdma couple times a year, I was hoping for such an episode of the HLP. I actually made up a title for it: The science of MDMA and how to offset withdrawal😂

[@KeithFlint350]

Yeah, couple times a year is also my sweet spot 😛

[@joelsommers]

@FedeJack-li5li Hi there....I would like that store reference please? Thanks in advance...

[@thelaw557]

If you take the right dose you won’t have withdrawal 🤦‍♂️🤣

[@Yeah_Nahhh]

@Fede Jack no one cares scammer

[@NewMateo]

You should be dosing correctly. Bad withdrawals is a sign of maybe doing too much.

[@FactasticFunFact]

This is a video that every single school in the world should show to their students. 💓💓💓

[@moatasim7]

Hi Andrew. I just hope you see this comment. Please do a series on children & teenagers suffering from psychiatric conditions like intellectual disability, autism, dyslexia etc and how we as parents can ensure maximum neuroplasticity in their learning.

[@hannespi2886]

I second this recommendation

[@bhh965]

I cannot thank you enough for this incredible resource. As a responsible MDMA user, using it for PTSD and to heal developmental trauma, my previous source of information came from Reddit, which as you know is all anecdotal and mostly bs

[@milanpede818]

I tried MDMA 3 times in the last year, both as pure MDMA crystals and as XTC-pills. Talking only from my own personal experience, it's an amazing drug that has so many beautiful results. The only problem is that it's being abused so much. If you take it responsibly (right doses, right time between doses) and most importantly optimize your recovery after taking it (rest, nutrition, and supplements like 5HTP), I think more people should try it. I don't condone or encourage the use, make the decision for yourself.

[@funygameur]

Favorites times stamps : 14:45 45:18 56:14 01:07:22 01:37:00 *Need to decrease prolactin activity after a big dopamine spike ; not saying how to but essential notion.*

[@vesnaGHoward]

Saved my soul 🎉 i love that feeling when my PTSD overworked amygdala is off, put the music on and enjoy the moment , a pure therapy 🎉

[@RoenbergMusic]

I just want to say thank you so much Andrew Huberman and team for sharing all this knowledge with the world! Listening to this podcast is always a certain way to inform oneself with as non-biased a perspective as can be, the good and the bad of all subjects discussed, and all of it for free.. incredible. Thank you for allowing non-experts like myself to learn about these topics. Always clear and concise, this is my new favorite podcast. Congratulations on the well-deserved success.

[@Izzdan]

I was a heavy user of MDMA back in the day, I've taken well over 1000 pills of MDMA. My brain is fine, I have anxiety but it's not as bad as it used to be. I thought 20 years later my brain would be mush but it's not. I did it the other day for the first time in 8 years. I had chronic headaches; my headaches have almost gone away. Not sure if that's related but it's gone. Honestly, I don't like pure MDMA I like the pill form which put me in a better mood than just pure crystal form of MDMA. Only thing I liked about pure MDMA is when it wore off, I could fall asleep right away not sit in my bed trying to sleep for hours on pills that were cut with whatever. It's a great dug but the next day is rough. Overall, it allows me to be a person I wouldn't normally be able to be. Love it but hate the next day.

[@MeredithRothman-db6wf]

I remember days my anxiety flew over the fence, weighed my options and there i found this dude who got the best strains of psilocybin and other psychs..

[@MeredithRothman-db6wf]

(They're on Telegrams & Instagrams?..

[@MeredithRothman-db6wf]

@PHILLSMYCO2, is the handle?.

[@maeva5257]

50:00 this confirms exactly my experience and gives me more hope for the future. I've been diagnosed with both fibromyalgia and CPTSD and I know the two are connected. Hearing now that we're not supposed to be constantly aware of what our body feels shocks me. I am in constant awareness of the slightest sensations in and on my body. I struggle to understand why people need to focus to feel themselves. My physical sensations are also much more pronounced than those of an average person. I have run a (very small) test where I tried different levels of pain and subjectively compared them by rating them out of 10 to what 2 other people felt. I have repeated this test on MDMA and what would feel like an 8/10 (very painful) in my normal state would feel like a 3 on MDMA, just like the 2 people I was testing with. Things which would hurt me in a normal state were just physically uncomfortable on MDMA. I've always been called a sissy and I've lived with this for as long as I can remember, but last year I started therapy for CPTSD and I realised recently that the physical sensations have started to reduce. I noticed I'm in much more pain when in distress or caught in an emotional flashback. So this confirms my thoughts. I am so happy I found this info today on the connectivity between the amygdala and the insula in subjects with PTSD. Thanks for sharing it.

[@HendrixTwo-rr9te]

I'll refer you to where you can get your psychedelic

[@HendrixTwo-rr9te]

On Instagram

[@HendrixTwo-rr9te]

Ayahuascahenry

[@Infinite147]

Ya'll be safe. Know why your taking a substance. Know where your going to take it Know who if anyone your going to take it with And my advice, don't hold on to tightly but don't lose yourself go too far.

[@johnnysinner]

Thank you Andrew for bringing up the groundbreaking role of these molecules for finaly bringing humans to themselves again or for the first time. This work is a eternal.

[@StoicAurelius1]

Good morning class, have a wonderful learning week.

[@sdcno123]

I’ve had Psychedelic Assisted Therapy for both CPTSD and treatment resistant depression. This was over a 5 day period. The first PAT session was MDMA which was a very beautiful somatic experience. It lowers the threat system in your brain and since you feel in a very safe state your brain naturally gravitates to want to release grief from traumatic wounds. Going into the traumatic memories (which do feel like they are stored in your body btw even though Andrew says it’s your brain too) is not beautiful, but it gives you the strength and empowerment to address them without the overarching fear that has prevented you from doing so in the past. The next session was with mushrooms. Mushrooms is a much more harsh and unpredictable experience.. But what it gives you is a different perspective, a connectedness and wisdom you didn’t possess before about your life. There’s also a spiritual connectedness about mushrooms too.

[@Mikebruno1187]

Amazing episode. Very cool to see a lot of promising results for treating PTSD.

[@darrenmontana2254]

i do self therapy 3 hours a day. take 120 mg once a month or so. the worst off you are when you take it the more profound the results. am also paying for some therapy. life sucks but i am making headway. somedays i back slide, but one needs to keep calm and carry on. if you want out of the pain you can get out and still be alive. You cant fix it all, but life can be way better. Carpe diem. cheers to all.

[@abdallahlakkis449]

Love your content. Is it possible to just add some visuals on how the underlying neurophysiological processes take place to be able to better visualize what is happening?

[@Sarahwalker9930]

Psychedelics definitely have the potential to deal with mental health issues like anxiety and depression, they really helped me.

[@olgazavilohhina6854]

¡Hola Profe! I want to thank You, for all the knowledge , You bring to all of us ,on such an important subject .Your work is truly appreciated by all of us all over the world. Mental health is a really relevant and important subject in our every day life. Thank You , for all You are doing.

[@ChristinaLin-h7s]

Dr. Huberman, thanks for this thorough, well-informed, science-based episode. Your talk and the research references completely changed the way I think about MDMA. I am a mental health professional based in Vancouver, BC. One of the areas of my interest is Human Social Genomics. I'd love to watch you interview Dr. Steve Cole, UCLA, an expert in the field. I attended a conference where he delivered fantastic lectures on Human Social Genomics.

[@thedevo01]

0:16 - Please people stop spreading misinformation! Ecstasy is *not* MDMA. Ecstasy is to MDMA as cocktails are to alcohol. Ecstasy is a pressed pill that has a mix of different drugs, MDMA being the main ingredient. Just like with cocktails, you drink them for the alcohol, but they are mixed with juices, sodas, etc. Everybody seems to get this wrong and it is so frustrating!

[@majav15mg]

But isn’t “good ecstasy” a pill with just MDMA and nothing else?

[@thedevo01]

@@majav15mg If it's just MDMA, then you're buying translucent crystals, not colorful pills.

[@belleoftheblues]

That's incorrect. Here in the Netherlands, ecstasy pills are almost always pure mdma. We can get them tested for free (like any other recreational drug) so we know. We are a big supplier of both xtc pills and mdma worldwide. Your information was true many many years ago but not anymore.

[@Melbourne_marauder]

I’m posting this here, since it’s your latest episode, but my comment is not specific to this video. I want to express profound gratefulness for the positive impact you’ve made to my life. I’m the type of person that needs a framework (preferably science based) to make lasting positive changes and intrinsically motivated decisions. Thank you Andrew!

[@daniel2991]

Looking foward to the Episode on Ayhuasca! 😄

[@authentic_path]

I smell the spirit of Joe Rogan

[@humanelements2]

MDMA is a miracle molecule and it's insane that the FDA rejected it as a treatment for PTSD. I have C-PTSD from being regularly beaten and sexually abused as a child. Lived my entire life with anxiety, depression, and a fawn/flight response as my entire personality. I'd had over a dozen trips using other psychedelics but I remained stuck in virtually every facet of my life. The very first time I took MDMA, though, I knew right away: this is actually touching all of my hurt. It broke through much of the yuck in my system, let me feel my feelings for the first time since I was a child (especially anger), and has been greasing the wheels of change in my life. I've needed a lot of journeys as I'm 41 now and there are so many frozen protective layers to my psyche. But it's happening and I have MDMA (+ analogues) to thank for it. Sucks that the FDA ain't on board but I'm also not waiting for them to tell me it's legal to heal now, so long as you pay $10,000/session to our approved vendors...

[@nievesab12]

Im all for psychedelics and their potential, but huberman can't promise to discuss risk in the title and only discuss risk for 2 min. Go into some detail please.

[@worldpeace786]

What you said about the seratonin 1B receptor is very interesting. How it seems to affect the willingness to engage socially with people. I used to be an extremely social person, willing to engage anyone, I used mdma for a couple of years of using mdma and although had some great benefit, I found i didn't want to engage with people anymore, lost the willingness to be social or around people, it gave me some sort of anxiety with being around people, especially in a smal community where most of us know each other. I also noticed there were often moodswings and alot of negativity in general, I also lost the desire to do the simple things I used to like. I since managed to stop using totally and seem to be fine now although those negative affects mentioned above still are lingering, but am remaining positive and have the sense I'm slowly returning to baseline normal. I highly suggest to people to only use it for the treatment of ptsd in the propper setting, and don't abuse the dosages. You may later find that you lose the motivation to do anything. Even things like gym etc.

[@sarahshoxx]

You doctors and scientists get your hands on the best stuff!

[@TheChurchofCacti]

I would LOVE for you to investigate Ibogaine in this way. Ibogaine is such a unique substance and is legal in Colorado now. I guess the Ibogaine Compound itself is very odd, almost like a technology

[@ofirgal2818]

Love your podcasts! I’m pursuing neuroscience for my PhD and your podcasts have helped me get a great head start in my field.

[@abdolhamedsharef2924]

It is normal to overlap and to be distinctive as well thanks professor Andrew, you are the best..

[@PizzlesTechTime]

Wow caught this one early! I am now supplementing creatine and fish oil. It has helped me with pain and inflammation. Thank you so much for the work that you do You have educated a dumb truck driver like myself. To the point where sometimes I am more educated than the people treating me on certain issues lol

[@Co-km6cl]

Why fish oil and not algae oil. You get the beneficial fatty acids without the heavy metal contamination 😊

[@Carglouche.]

Truck driver here too. Please don’t diminish yourself or this great profession. More than often the most uneducated and inexperienced people are those that manage this world we live in, from behind their boring desks. Best regards mate ! Keep on trucking 🤙🏻

[@PizzlesTechTime]

@@Carglouche. thank you I do understand that and do not treat people differently based on their profession. However my fellow truck drivers rob my truck when I'm not there. Start fights with customers and embarrass the company often. I often have been treated differently because of my profession. I definitely agree with you and understand where you're coming from.

[@Carglouche.]

@@PizzlesTechTime You're welcome. Indeed there are a few bad apples in the industry, but gotta stay proud. Hope you'll find a better company to work for, that is more professional and rewarding. Cheers !

[@kutup333]

I’ve been microdosing mdma or sassafras when going out rather than drinking alcohol. Alcohol, even one drink, makes me ill. MDMA or sass makes me feel great. I do worry about depleting my happy hormones tho.

[@HendrixTwo-rr9te]

I'll refer you to where you can get your psychedelic

[@HendrixTwo-rr9te]

On Instagram

[@HendrixTwo-rr9te]

Ayahuascahenry

[@crussellmorg]

Great podcast, but as an English major, I have to point out that Dr. Huberman often uses the word 'remittance' (mainly used in finance) when he means 'remission' (many used in illness/mental illness). It's a small detail, but Dr. Huberman clearly pays attention to small details.

[@acesrone]

I did 2 grams over a 12 hour period. I remember the first dose at 6pm, my friends left and I dosed up around 730-8pm then I blacked out, I regained consciousness at 7am walking to my bathroom, still geeked but aware of how deep i had gone. I feel lucky to be alive

[@MeredithRothman-db6wf]

I remember days my anxiety flew over the fence, weighed my options and there i found this dude who got the best strains of psilocybin and other psychs.

[@MeredithRothman-db6wf]

(They're on Telegrams & Instagrams?.

[@MeredithRothman-db6wf]

@PHILLSMYCO2, is the handle?…

[@greenblue6935]

Unfortunately I built up a large tolerance after a decade of heavy use, good times, but I'm sure it made me depressed after the partying was over, my brain just couldn't make hardly any serotonin but it seemed to come back after a few years of sobriety from MDMA.

[@hanskazan7403]

Have you tried taking 5htp?

[@greenblue6935]

@@hanskazan7403 no, what is it?

[@generic9117]

@@greenblue6935a supplement that basically helps your brain make and restore serotonin

[@boykoto1]

Can you do an episode on kidney stones as its so hard to find reliable information on food and health, and mechanism of our bodies. Seems like you are the only trusted source of great digestible information!

[@The_Green_Queen]

As someone who’s dealt with some extreme narcissists and the destruction caused by their lack of empathy, I have to wonder if that personality type could benefit from this therapy.

[@Armenianshugah]

Allows them to actually feel for a few hours? Makes sense to me!

[@wesrc]

Thank you for giving Shulgin credit, he was a great mind and ahead of his time. Much respect!

[@cryan8271]

Australia is legalising the prescription of MDMA and psilocybin for specific mental health conditions from 1 July 2023.

[@lejlateletovic5225]

Cat-lady here. Study: "Exploring women’s oxytocin responses to interactions with their pet cats" Results - Our results revealed no changes in women’s OT levels during the cat interaction, relative to the control condition, and pre-cat interaction OT levels. However, differences in women’s OT concentrations were correlated with some human-cat interactions (e.g., positively with petting cat and cat approach initiation, negatively with cat agonistic behavior) but not all observed behaviors (e.g., use of gentle or baby voice) coded during human-cat interactions.

[@MindNow]

The other day I was thinking to myself about PTSD and how MDMA can help with that and now here you are talking about it. Thank you, Andrew Huberman and his team for all the effort! 🙏❤️

[@BloodtypeForsaken]

Professor Huberman = the GOAT !

[@mariahspapaya]

As someone who has taken mdma multiple times in different settings, I’m curious about the toxicity or long term effects. I have read about the duration between uses should be “at least” 3 weeks to not overstimulate your serotonin. I’ve never really felt “down” the next day after using Molly, more just tired since it effects your sleep. I feel that for people who are potentially already prone to depression or low moods should be very cautious using it since they might feel more sensitive to the “crash”, then someone who isn’t already depressed. Has anyone experienced this? Using it frequently (more than maybe once every 4-6 weeks) is also not a good idea. The feelings of threat detection are definitely not untrue, but I also have felt more like mentioned I guess “empathic”, when someone is not in a good mood or not feeling good. I’ve noticed I have to be conscious to not internalize others emotions etc. I theorize that for people who are already highly empathic or sensitive sober, it can also increase it. Nonetheless, each experience has been extremely positive. If anyone reading this is visiting Berlin, be careful with those speed pills they are giving out…lol. I swear they put meth in those so they can party all night and morning. I was wired for 9 hours, and thats only taking half of one. I can only imagine another scenario. Also, I’m curious if anyone here experienced or knows someone who bought mdma that is laced with fentanyl? I feel like it doesn’t make sense for drug dealers and it’s found in mainly heroin or cocaine. I have looked for articles that are recent covering this problem but have a hard time finding anything. Party safe folks.

[@sylwiapro2791]

Interesting you mention Berlin, just read the news they opened some labs there where you can get your substance tested within 3 days, for free and anonymously

[@davidkymdell452]

I used to take it a fair amount in the late 90's. I was extremely sensitive to it. I would get twice as high, twice as fast as my friends. I definitely overdid it. The comedowns became absolute hell. I would definitely become extremely depressed after a big session. A few years ago I was diagnosed with ADHD and take 15mg of dexamphetamine every day. It's interesting because dopamine (mainly) stimulants don't affect me anywhere near as much serotonin stimulants. Even methamphetamine doesn't affect me nearly as much as mdma does.

[@mariahspapaya]

@@davidkymdell452 hmm that’s interesting. I also have adhd and was diagnosed as a child. Adhd people definitely love our stimulants. I don’t feel the need to do molly every time I go out (which isn’t too often anyway) but it is a nice social/party enhancer that I did a lot last year when I was abroad and with friends at festivals. It’s hard to find pure stuff where I live like the crystals, all of it is bullshit pills that probably are laced with other stuff. Since I’m properly medicated for my adhd now finally at 27, I don’t feel the need to chase adrenaline highs like I used to whether it’s partying or being impulsive etc. through sex or shopping and abusing other drugs like cannabis which I used to do a lot of. I recommended psychedelics for anyone dealing with anxiety/depression in a safe setting with intentions and possibly a good trip guide. Helped me tremendously. Also you might need a different medication if you feel like this one doesn’t help you as much. I had to try lots of different ones to feel some sort of relief without the terrible side effects or withdrawals like I got with adderall. (That stuff made me crash hard)

[@hanskazan7403]

@@mariahspapaya 3 weeks lol better to do at least 1 month between use and even better 2/3 months most people on reddit say 3 months but thats just an number wich everybody use there but thats mostly that you feel the effects better after 2/3 months

[@randomguydoes2901]

4 weeks break in therapy, but they increase the dose 50%.. that's because 4 weeks isn't enough of a break really. 6 weeks is the minimum I'd cheat a summer if I wanted to be stupid about it. You want months. I stick to 3, but 2 could work some time. As to not risk permanent tolerance of what is a helpful drug, I play it safer.

[@FastJen39]

I’m not a fan of synthetic drugs of any type. I was suicidal in 2010 after having an ecstatic state through spiritual practice that I could not discuss properly with those who cared about me. I just had the most ecstatic state this week after a ten minute deep breath work practice and my own energy work. I reached amazing states within my body and about some concepts around complex spiritual discussion. I made the observation that the mystery of Christ consciousness is the complete absence of dependency on any thing, substance or person. I had a huge emotional crash after consuming food. I really hope we can further along these discussions so more people are less isolated and suicidal.

[@jkaustok]

I tried getting acid once and got MDMA. Went back and got the weakest 4g of mushrooms ever. Those are my only experiences though. The mushrooms were very mild and barely lasted 30 minutes. The MDMA really did give me a better relationship with my joints. Normally all my life it's been all tendon and joint discomfort but for a good few hours it was a flipped script for every movement I made. When I was younger I had an eye roll tic type thing and at times I'd want to rip my bicep out at the tendon due to the discomfort when trying to sleep. It's gotten much better over the years thankfully but there's still the ghost of that feeling. I'm not diagnosed with anything but I was told I was born 3 months premature and was incubated. I agree with the view that MDMA can be therapeutic when seeking it for therapeutic benefits. Mushrooms as well as the low dose effect was somewhat similar though weak in my case.

[@TheRealPlayer00]

Hi Andrew! It would be really cool if you could do you podcast about grounding (walking barefoot on grass) benefits. Recently it has become really popular, because of the like of Gary Brecka. Was wondering if it really has as much benefit as they say it does and what does the data tell us

[@ashleybentley1642]

Fantastic episode! I'd love to see you interview Rick Doblin of MAPS.

[@3man3A]

This is gonna be very interesting. Would love to see one about psilocybin or LSD

[@hubermanlab]

We did an episode on psilocybin hubermanlab.com/how-psilocybin-can-rewire-our-brain-its-therapeutic-benefits-and-its-risks/

[@Pompeii123]

⁠@@hubermanlab I am a regular viewer of your podcasts and it has immensely helped me.But it is really alarming to see profiles which advertise their psychedelics in comment section and as you know,you don't want this great initiative to take blame on leading clueless teenagers to try it out and go astray.

[@AdroitTheory]

@@Pompeii123 They don't have control over KZbin's bot problem. This is a poorly phrased and positioned message if you have legitimate concerns and should be directed at the owner of the service. It is the job of the person reading the comments who sees malicious posts to report so they are removed, until such a time where youtube can handle this issue.

[@anthonypillarella]

​@@Pompeii123 What is he supposed to do? Every YT channel's comments are flooded by bots and scammers, and they make more accounts every time they're deleted.

[@transformwithlev]

Great episode! I think it’s a no-brainer that MDMA should be legalized for therapeutic use. As far as a guest suggestion Gabor Mate has amazing insights on trauma!

[@laurensmith8082]

MDMA and other psychedelics generally are very beneficial substances, and it really helps people with mental health issues, eases depression and anxiety, y'all can get them from the handle below.

[@laurensmith8082]

@Mycotenn_

[@laurensmith8082]

On Instagram and Telegram

[@johndeaux8815]

If I had a dollar for every time Andrew made a slurping noise when referring to the reuptake of neurotransmitters, I could probably buy a coffee!

[@LucasFerreira-ic5bd]

18:30 excelente, entonces cuando volvemos a nuestro "estado normal" no estamos mas tristes que antes simplemente que en el estado de mdma estamos mas felices y al volver a nuestro eje parece que nuestra felicidad disminuye pero solo que antes estuvimos mas felices no significa que ahora vayamos a andar mas tristes.