T cell subtypes | Th1, Th2, Treg, Th17 | Cytotoxic T cells | exhausted T cells

[@summatim]

0:01: T cell subtypes 1:10: T helper cells 4:20: T cell activation and differentiation 5:17: Th2 cells 5:53: Th17 cells 16:11: Cytotoxic vesicles lead to apoptosis 16:32: Activation of caspase 3 leads to apoptosis 17:40: Memory T cells play a role in immune response 21:05: Exhausted T cells are important for cancer 24:29: Negative core stimulation is a key mechanism to drive exhaustion

[@ganeshpatnaikdabiru1907]

Q

[@szilardmali2998]

Extremly useful video! It made many topics clearer for me! Thank you!

[@animatedbiologywitharpan]

Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.

[@Priyanka-dh7wu]

Hey!!!!!! Ur vedios are truly commendable A small request, plz start a proper series for exams like csir net, ur content and way of explanation is amazing It will surely reach heights.... Plz keep going!! 🌻

[@animatedbiologywitharpan]

please check out my playlists (www.youtube.com/@animatedbiologywitharpan/playlists) already there is unit-wise content for CSIR NET. for example Unit13 is named as biotechniques, Unit 5 is dev bio... so on. Definitely take a look. These videos are better than any existing institutes. share with friends

[@animatedbiologywitharpan]

For further queries Whtasapp us at [phone]

[@Priyanka-dh7wu]

@@animatedbiologywitharpan thank you so much

[@exciton007]

Thanks for all the videos. It would be helpful if there would be a cursor/pointer during the presentation. This would simplify the understanding.

[@animatedbiologywitharpan]

Thanks for your suggestion. We will incorporate this change in future videos

[@mariaochoa9387]

Very interesting 👌 thank you

[@animatedbiologywitharpan]

Please support my channel via super thanks. Super thanks option is present below any of my videos.

[@gayathriselvaraj5082]

Very useful sir thank you

[@animatedbiologywitharpan]

Please share my channel link with your friends and help me to reach big audiance. Don't forget to checkout immunology playlist kzbin.info/aero/PLKtiwIJ8Q7rq77W7r4cXPrbhi_VpLWw8c

[@animatedbiologywitharpan]

Please support our channel by using super thanks. Your 2$ donation would give us motivation to do more. Super thanks option is present below any of my videos, a heart sign with $ in it.

[@Viridian88]

Could we say that the scheme at 7.10 kinda represents a proof of the fact that cellular phenotype depends not only on genotype (which is supposed to be perfectly equal to the one of the mother cell by mitosis) but also on enviroment (in this case, mostly represented by local stimuli and cytokines relative concentrations)?

[@shreyakaushal8296]

Hey arpan sir can you plzzz make a video on interleukins in detail it will be very helpful Sirr plzz

[@animatedbiologywitharpan]

OK thanks for the suggestion, are you a med student ?

[@saptarshighosh3864]

Respected Sir, during Crohn's disease, the Pro-inflammatory cytokines should be more than Anti-inflammatory cytokines... Because the Treg cells are of less quantity than Th1 and Th17... but the seesaw is showing the opposite thing...

[@animatedbiologywitharpan]

The seesaw is bit confusing. I thought pro-inflammatory cytokines has higher weightage hence the seesaw will dip that side. May be I should have used arrows to explain this. Any way thanks for all the feedback. Seriously it will help me to improvise

[@kavitavats3581]

very good video

[@animatedbiologywitharpan]

Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.

[@il3mendo]

Is then th17 connected to autoimmune disease, th2 allergy response and th1 cancer ? Is the prolonged th17 expression connected with th1 ?

[@animatedbiologywitharpan]

Th17 is associated with auto immune disease and neurological disease like multiple sclerosis. also its role is important agains fungal infection. detailed video kzbin.info/www/bejne/nJSnp4OAps6qfpIsi=F8Z8lb7ptkJJlC6P

[@animatedbiologywitharpan]

multiple sclerosis kzbin.info/www/bejne/eavGmaxobK14fbMsi=J_DzzJlK_fzoJXiV

[@il3mendo]

@@animatedbiologywitharpan Usually autoimmune diseases will lead to neurological diseases, am I wrong ? Are autoimmune diseases associated just with the Mch 2 or mch1? If Mch 1 Is triggered by Mch 2 that means that the epigenetic is leading the pathology. Am I wrong ?

[@il3mendo]

@@animatedbiologywitharpan I have always been stuck on the dq2 (celiac disease). Could we say that Mch 2 is an Cd4 while Mch 1 is a Cd8 ? I know I am a pain in the ass

[@dr.shadmbbsdphmasco]

Yes ​@@il3mendo

[@srikantadash4603]

Can u please provide a link for ur video. T cell activation. I really in need of it. Please bhai send me

[@animatedbiologywitharpan]

kzbin.info/www/bejne/iJCcnYGFd96Dpqcsi=QfjDcfL98Nc1OTlg

[@rutikghagare4992]

Cytotoxic T cells also need to be activated by the APC to be functional because normal cell infected can`t give costimulatory signal please confirm once

[@animatedbiologywitharpan]

yes cytotoxic T cells needs to be activated as well.

[@djsaurabh007]

SIr at 9min 23 sec you say that IL4 activates TBET gene , shouldn't it activate GATA3 ?

[@animatedbiologywitharpan]

yup, it was a mistake it is GATA3

[@animatedbiologywitharpan]

I suggest you can refer to this article.www.sciencedirect.com/science/article/abs/pii/S1471490614000593

[@zembounsyhalard6222]

I wanna know that cytotoxic t cells are activated by infectious cell,Are their naive?😅

[@animatedbiologywitharpan]

Sure I will make a video on cytotoxic t cells in details

[@colly-5489]

what if someone has too much memory t cells?

[@animatedbiologywitharpan]

It generally does not happen. Technicaly there should be no problem

[@colly-5489]

i saw a laboratory report from a patient where the central memory T4, T8 are too high and the effektor memory RA T4, T8 too low.