Basic Renal Function: Clearance and GFR

For tutoring on this topic, click here: lancemillerphd...

[@user-zc4cu6rz1d]

1:42 If the substance is reabsorbed and the urine conc. halved, why hasn’t the plasma conc. changed?

[@lavendershi7071]

This serie of videos really help me a lot with the calculation. Thank u very much!

[@xmax700]

This war amazing Thank you very much. perfect explain

[@vladbrad1389]

You're right it's a war it's an amazing war, and we're fighting it 💪

[@azadparray1659]

I have creatinine level between 1.1 to 1.25 from last three years now it is 1.23 Bp is 100/60 Sugar fasting below 100 No protein in urine USG is normal Is there any serious for my kidneys

[@LanceMillerPhD]

Your blood pressure and your fasting glucose are great, and the fact that you don’t have protein in the urine and are all positive signs and suggest your kidneys are healthy. Also, your serum creatinine is at the upper end for a male. That’s important to know that serum creatinine is only an estimate of glomerular filtration rate and can vary based on age, gender and muscle mass. as always, this does not replace advice from your physician.

[@antoniomunaretto9147]

i have a question. If the clearance of a substance that is only filtered and not reabsorbed or secreted is equal to the GFR, so 125ml/min. How is that in the first example you made the clearance is only 40?

[@LanceMillerPhD]

Hi, That's a great question. With the first example of clearance being 40 ml/min, I can see how you have a question and how it does not match with a clearance of 125 ml/min. In the first question where the clearance is 40 ml/min, this GFR is well below normal. I used these numbers to illustrate the role of filtration, reabsorption, and secretion on clearance (GFR) rather than illustrating a typical GFR. To get a clearance or GFR of 125 ml/min, we could use the following numbers: U = 100 mg/mL, V = 1 ml/min, and P = 0.8 mg/ml. This would give a GFR of 125 ml/min. I hope that helps clarify things and sorry for any confusion. Best, Dr. Miller

[@antoniomunaretto9147]

@@LanceMillerPhD okay now is clear, thank you very much for the clarification.

[@leticiamagalhaes3437]

The volumen of plasma needed to pass through the kidneys in a given amount of time un order to excrete a given quantily of substance in the Urine.

[@Ahmed_Abdulsattar7]

Amazing Thanks bro 🙏

[@مريم-ت9م]

Awesome

[@jamshedfbc]

Creatine filtered but not reabsorbed or secreted. Where would it go then?

[@LanceMillerPhD]

Creatinine is excreted in the urine.

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[@adityahs2]

do u prepare content from any one particular text books...? like berne and levy is what i follow..

[@mdabdulhafeezmalik45]

Beautyfully explained

[@leahbeechey2898]

Is clearance & eGFR the same thing?

[@CristianoRaashid77]

This was really helpful thank youuu!!!!

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Thank you that was helpful ❤

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[@paulafrengul9761]

Very clear and helpful thank you

[@ishaq542]

Thank you, sir!

[@LanceMillerPhD]

Very welcome!

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👍

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I am from Egypt, thank you very much for the valuable information and the interesting dynamic explanation. Thank you for your great efforts. Thank you

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[@TheSummerOf86]

Awesome, thanks! (maybe add 'RPF' and/or 'PAH' to the title)

[@matthewreddick9334]

Why would a less concentrated plasma yield a higher clearance? seems counterintuitive.

[@suhaibfarooq3343]

Simply because the plasma is less concentrated, more amount of it will be required to flow through the kidneys to excrete a given amount of solute.

[@ilovejesus9303]

Thank you so much for your time, this was helpful

[@ghassanauf8103]

PHD for this !!!!!

[@supunjayawardhana3695]

thank you

[@ranahanna160]

a question: if a substance is filtered, how come we have some of it left in the peritubular capillaries to secrete?

[@LanceMillerPhD]

That’s a great question. It’s because not all of the fluid and substances that pass through the glomerular capillaries is filtered.

[@rebornmmmmuch]

Thanks this really helps💘

[@ScholarIdeavideos]

Thanks

[@birdlynn417]

My blood test GFR was 86. Normal is 89 and over. Should I be concerned?

[@LanceMillerPhD]

That is good question and is best answered by your doctor. However, to get a better idea about one thinks about the GFR test, I recommend visiting the following link. www.kidney.org/atoz/content/gfr. The link provides more information about the test, relates values to renal function, and the role of additional tests, i.e., proteinuria, in making a proper diagnosis. In summary, a GFR of 86 suggests a mild loss of kidney function (e.g., your kidneys are 86% functional). However, you would have to have your GFR measured for about three months and measure the amount of protein in your urine to make an accurate assessment of renal function (see link). In addition, if your blood pressure is consistently elevated (i.e., >130/80 mm Hg) I would highly recommend you have this checked out sooner rather than later. I wish you well and hope that all turns out for the best.

[@howardrice2470]

This is all bs I been living for 40 years with less than 50 per cent filtration rate with no problems except doctors. Everybody is different. $$$$ is doctors goal! BS

[@fernandofrossard8612]

Helpful!

[@b.s.a.agamer7902]

Thank you

[@Duckguts1]

Thankyou for best illustrations dey hv saved my time and clear da concept 👍👍👍👍

[@yasasvihasanjana9792]

Thanks.... clearly explain

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Thanks a lot for this video💕

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Very much helpful . Thanks ♡

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THNX

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[@LanceMillerPhD]

Thanks. Glad to hear that.

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[@LanceMillerPhD]

Thanks!

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