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12.4 Grignard Reagents | Organic Chemistry

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Chad's Prep

Chad's Prep

Күн бұрын

Пікірлер: 56
@carlimendelow2569
@carlimendelow2569 4 ай бұрын
Fellow Pre-Med here...I HAVE to comment and say that I am in Orgo II because of YOU! You taught me how to think in Ochem, and even after practically failing my first Orgo 1 Exam I knew with your videos I would continue to get reps in and do better. Studying for the MCAT now too and totally believe your teaching has showed me what I need to know. Thank you for your content, kindness, and skillset. God Bless you!
@ChadsPrep
@ChadsPrep 4 ай бұрын
Thank you - Glad the channel is helping you out!
@neveenbotros3257
@neveenbotros3257 Жыл бұрын
I started enjoying chemistry because of you. Thank you!
@ChadsPrep
@ChadsPrep Жыл бұрын
You're welcome and Thank you!
@IsaacAdeniruju
@IsaacAdeniruju 11 ай бұрын
Your videos are AMAAAAAAAZING! God bless you dearly!
@ChadsPrep
@ChadsPrep 11 ай бұрын
Thaaaaaank you - same to you!
@EffigyOfficial
@EffigyOfficial 5 ай бұрын
Thanks a ton man, I've been forced to cram a lot of organic them and you've made it a lot easier than it would've been otherwise!
@ChadsPrep
@ChadsPrep 5 ай бұрын
Glad the channel is helping you - Happy Studying!
@princessphemorahsampsonedu101
@princessphemorahsampsonedu101 2 жыл бұрын
This made it easy for me to understand..so helpful😊
@ChadsPrep
@ChadsPrep 2 жыл бұрын
Excellent - glad to hear it!
@ilaydamumcuoglu8339
@ilaydamumcuoglu8339 Ай бұрын
amazing video! Is there a reason why THF is used for the synthesis of Grignard reagent
@target__iit
@target__iit 10 ай бұрын
hmm, this may seem like a silly question but what is the difference between a base and a nucleophile
@ChadsPrep
@ChadsPrep 10 ай бұрын
Not a silly question! The difference is really down to their action. Both bases and nucleophiles are electron rich species which donate electrons to electron deficient species. The definition of a Lewis base is an electron pair donor, so nucleophiles are Lewis bases which donate a pair of electrons to an electron deficient species, for example a carbon in C=O. The definition of a Bronsted Lowry base is 'accepting' i.e. forming a bond to a proton (H+) so the bases in these reaction pathways are Bronsted Lowry bases. So in organic reaction mechanisms we use the term 'Nucleophile' to describe a Lewis base, i.e. an electron rich species that attacks something other than hydrogen and 'Base' to describe an electron rich species that attacks hydrogen. I hope that is clear :)
@mayweerajit
@mayweerajit Ай бұрын
Your channel saved me from Orgo Exam2 (I have a blank knowledge on this thing), 😊😊😊 and today I have the 3rd exam 😍😍
@ChadsPrep
@ChadsPrep Ай бұрын
Happy Studying!
@BruceWayne-i2n
@BruceWayne-i2n Жыл бұрын
thanks for the video, it's great! just a quick question, isn't the H3O+ for all 3 of the reactions at 8:00 a type of protic solvent? Or does hydronium not really count as a solvent and something else is supplying it? Now that I'm checking again, I'm guessing the fact that it's sequential 1. and then 2. means that it can't take H+ from the H3O+ right?
@ChadsPrep
@ChadsPrep Жыл бұрын
Grignard reactions tend to use ether as a solvent. Protic solvents wouold protonate the Grignard and prevent the reaction from happening. For this reason H3O+ is added in the second step of these reaction (i.e. after the Grignard reagent has already reacted)
@nikitaliasiuk
@nikitaliasiuk 9 ай бұрын
would you consider covering organoboron or organoaluminum grignard reactions and synthesis of them?
@Groovy1965
@Groovy1965 2 ай бұрын
I took organic chemistry in 1985. I wish my professor framed this reaction like you did in your intro. It would have given the reaction some context and meaning to an otherwise rote class. I found the textbook more interesting than the professor. However, it was a long time ago
@ChadsPrep
@ChadsPrep 2 ай бұрын
I'm glad you are enjoying the content!
@princeysuryan2561
@princeysuryan2561 3 ай бұрын
Could you please suggest some of your personal favorite chemistry books? I would appreciate your recommendations."
@princeysuryan2561
@princeysuryan2561 3 ай бұрын
You deserve millions of views and subscribers for all the valuable knowledge and hard work. 😊
@CaseyLada
@CaseyLada 11 ай бұрын
This is so helpful, thank you! Would we be able to use other agents besides H3O+ in the second step as an acid workup? Would H2O work?
@DaryaEsmaeilshirazi
@DaryaEsmaeilshirazi Жыл бұрын
you are literally the best THANK YOU!!!
@ChadsPrep
@ChadsPrep Жыл бұрын
You're welcome and Thank You!
@jaydenallegakoen9974
@jaydenallegakoen9974 2 жыл бұрын
Amazing video thank you so much
@ChadsPrep
@ChadsPrep 2 жыл бұрын
You're welcome - thank you!
@사랑첫-g5k
@사랑첫-g5k Жыл бұрын
thank you my techer,you very good❤❤❤
@ChadsPrep
@ChadsPrep Жыл бұрын
You're welcome and Thank You.
@mahla-nb4ki
@mahla-nb4ki 7 ай бұрын
can't LiAlH4 lead to a 3° alcohols?
@rohanpatel1864
@rohanpatel1864 3 жыл бұрын
Thank you!
@ChadsPrep
@ChadsPrep 3 жыл бұрын
You're welcome, Rohan!
@abdoulazizdabo9064
@abdoulazizdabo9064 Жыл бұрын
Thank you
@ChadsPrep
@ChadsPrep Жыл бұрын
You're welcome
@suraalsaeedi3822
@suraalsaeedi3822 3 жыл бұрын
thank you your way so clear
@ChadsPrep
@ChadsPrep 3 жыл бұрын
You’re welcome, Sura! 😊
@ryanalani1262
@ryanalani1262 3 жыл бұрын
Thank you! if there are two groups of aldehyde attached to the same reactant should we use Grignard twice? also what if the reactant were ester or O-CH3-CL or acid chloride?
@ChadsPrep
@ChadsPrep 3 жыл бұрын
Yes. If you have two aldehyde functional groups on a reactant then the reactant could react with 2 equivalents of the grignard. Esters, acid halides, and acid anhydrides can also react with two equivalents of a grignard too. I cover this in lesson 20.4: kzbin.info/www/bejne/lWKkhZSGgr-liLM Hope this helps!
@ryanalani1262
@ryanalani1262 3 жыл бұрын
@@ChadsPrep Thank you so much! I should watch that lesson before the exam yesterday :) The question was Ester carbonyl group attached to O-Ch3Cl I am not sure if O-Ch3Cl treated as leaving group or not?
@kehalyoucef2699
@kehalyoucef2699 Жыл бұрын
Thanks a lot
@ChadsPrep
@ChadsPrep Жыл бұрын
You're welcome.
@ramonaparicio6989
@ramonaparicio6989 Жыл бұрын
Thank you god
@ChadsPrep
@ChadsPrep Жыл бұрын
Happy Studying!
@gamewarden2813
@gamewarden2813 2 жыл бұрын
ty!
@ChadsPrep
@ChadsPrep 2 жыл бұрын
You're welcome!
@athenapaint
@athenapaint 3 жыл бұрын
Thank you! You've helped me get through all of my chemistry classes. Quick question: If the attachments are 2 ethyl groups and a benzine ring, would there still be a 3rd way to synthesize?
@ChadsPrep
@ChadsPrep 3 жыл бұрын
If any two of the groups were identical there would only be two ways to produce a tertiary alcohol beginning with a ketone. However, you will learn later in the semester that as long as two of the groups are identical you could actually start the synthesis with an ester and add excess grignard. So in this case if you started with a benzene ester (for example methyl benzoate) and then added two equivalents of an ethyl grignard (aka excess) you would get exactly the same product. This will be presented in lesson 20.4. Hope this helps!
@athenapaint
@athenapaint 3 жыл бұрын
@@ChadsPrep Whoa! I understand it now, super helpful. You are the G.O.A.T.
@ChadsPrep
@ChadsPrep 3 жыл бұрын
Thanks!
@KelvinPhiri750
@KelvinPhiri750 3 ай бұрын
Chad you are the best. your vedios are still useful todate ❤️⭕
@ChadsPrep
@ChadsPrep 3 ай бұрын
Thank you!
@KelvinPhiri750
@KelvinPhiri750 3 ай бұрын
@@ChadsPrep you are welcome Continue doing the great work❤️
@ChadsPrep
@ChadsPrep 3 ай бұрын
@@KelvinPhiri750
@dylan8951
@dylan8951 2 жыл бұрын
ur awesome!
@ChadsPrep
@ChadsPrep 2 жыл бұрын
Thank you!
@itswhoisme
@itswhoisme 7 ай бұрын
ofc our professor would want the grignard synthesis 🤡
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