intermolecular forces & drug-target binding

[@BabelMandebsky007]

Cool! Thank you! Are the mentioned bonding forces in effect for the binding of receptors of different sort?

[@ChemHelpASAP]

The forces are the same. In the end, the drug is binding to a protein, whether that protein is an enzyme or receptor. Drugs can bind other things (e.g., DNA), but protein targets are far more common.

[@wcyau1384]

Useful, support

[@ChemHelpASAP]

Thank you!

[@04shakhawathossain75]

Thank you Sir for this nice insightful presentation. A question arose in my mind that which atom can form the strongest H-bond? F, O or N? And why as such? 🤔

[@ChemHelpASAP]

The strongest hydrogen bond has a combination of hydrogen bonding and electrostatic attraction & would be between something like the O of a carboxylate anion and the H-N of a protonated amine. That might be around 4 kcal/mol. Most hydrogen bonds are more in the 2 kcal/mol range. Notice that I am avoiding hydrogen bonds with fluorine. They occur, but their relevance to drug binding seems to be low (or at least infrequently discussed). There is likely an x-ray crystallographer who has explored the topic somewhat.