Lithocholic Acid: A Gut Bacterial Metabolite That Extends Lifespan

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Papers referenced in the video:
Metagenomic and metabolomic remodeling in nonagenarians and centenarians and its association with genetic and socioeconomic factors
www.nature.com...
Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism
pubmed.ncbi.nl...
Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production
pubmed.ncbi.nl...
Alterations in xenobiotic metabolism in the long-lived Little mice
pubmed.ncbi.nl...
Bile Acids: A Communication Channel in the Gut-Brain Axis
pubmed.ncbi.nl...
Lithocholic acid significantly improves the survival of Drosophila melanogaster
pubmed.ncbi.nl...
Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians
pubmed.ncbi.nl...
Divergent effects of resistance and endurance exercise on plasma bile acids, FGF19, and FGF21 in humans
pubmed.ncbi.nl...
Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes
pubmed.ncbi.nl...
Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians
pubmed.ncbi.nl...