The Science of Looking Younger, Longer | Lifespan with Dr. David Sinclair #6

In Episode 6 of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante discuss cosmetic aging and how to improve skin, nails, and hair. They talk about why superficial aging occurs and how external signs of aging are often a reflection of biological age. The latest science behind various beautifying therapies is highlighted, including newer interventions like low-level laser therapy and platelet-rich plasma injections.
#DavidSinclair #Longevity #SkinCare
Thank you to our sponsors:
Athletic Greens - athleticgreens.com/sinclair
Levels - levels.link/sinclair
InsideTracker - insidetracker.com/sinclair
Our Patreon page:
/ davidsinclair
Lifespan book:
amzn.to/3sUqurT
Lifespan podcast website: www.lifespanpodcast.com
Dr. David Sinclair Social:
Instagram - / davidsinclairphd
Twitter - / davidasinclair
Facebook - / davidsinclairphd
Stay up to date with David's work to democratize biological age testing and insights: www.tallyhealth.com
Matthew LaPlante's Social:
Twitter - / mdlaplante
Timestamps:
00:00:00 Launching Episode Six: Combating Cosmetic Aging & Improving Skin, Nails & Hair
00:02:54 Estrogen, Progesterone, and Menopause
00:09:51 Thanking the Sponsors
00:12:57 The Pinch Test, Epidermal Thinning, and Foot Ulcers
00:18:29 Skin and Biological Aging
00:23:19 Cellular Senescence, Ultraviolet Light, and Skin Aging
00:28:15 Collagen, Keratin, and Skin Health
00:33:38 A Quick Aside about Nails
00:34:45 Autophagy and Retinoids
00:36:57 Resveratrol, NAD Boosters, and Hyaluronic Acid
00:41:44 Botox, Skin Peels, and Microneedling
00:43:28 No Duh Stuff: Sun Damage, Smoking, Alcohol, and Bad Food
00:45:42 Hair Loss and Hair Graying
00:49:45 Topical Treatments, Pills, and Dihydrotestosterone
00:55:19 Frickin Laser Beams: Low-level Laser Therapy
00:57:59 Platelet-rich Plasma (PRP) Injections
01:00:11 Hair Aging, Stress, and Gray Hair Reversal
01:06:11 Targeting Aging Upstream
01:07:37 Today’s Takeaways
01:09:25 Subscription and Support Options
Links:
Human faces and mortality predictions: bit.ly/3rA0tgd
Biological age prediction in human skin: bit.ly/3LdDZcO
Senescent cells and lifespan in mice: go.nature.com/3HFO9Rh
Nail growth and aging: bit.ly/34tnSYb
Autophagy is a major regulator of aging: bit.ly/3uHh2Jr
Hyaluronan and cancer resistance: go.nature.com/3HHoyHK
Topical tretinoin and hair growth: bit.ly/3GCF0rl
Dihydrotestosterone levels correlate with mortality: bit.ly/3GBFFJJ
Eunuchs are especially long-lived: bit.ly/3ukL1GU
Human hair greying is linked to life stress: bit.ly/3J5adVU
Grey hair reversal in mice: bit.ly/3Li9F0J
Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.
Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

[@FortniteKingClips]

David inspired me to go to college to study molecular biology and aim for a career in fighting aging because I heard of him from the podcast he did with Joe Rogan in 2019. Thanks David!

[@Byrzzaa]

Wish you all the best!

[@ci4396]

You should probably change your name on KZbin haha. Good luck 👍

[@koningsbruggen]

Nice, thanks for doing that king

[@StarBoyyX]

Thanks Andy same time tommorow ,don’t forget your shovel And packed lunch

[@frederickhofmann843]

that's great to hear Mr. Fortnite King!

[@JeffNixonComedy]

Black coffee and Sinclair podcast... the new Wednesday morning ritual

[@strictlyprivate6914]

Prof. Sinclair looks younger now than he did five years ago by well over 10 years. Fantastic!!! Resveratrol and NMN outstanding results

[@audiosmarts675]

28:22 Keratin & Collagen 34:50 Retinol and Retinoids 55:30 Low level laser therapy 58:15 Platelet rich plasma Gdf15 - Hair growth gene Tretinoin - Medication used to treat acne and sun-damaged skin

[@nikos4641]

its in the bloody bio mate we got a bunch of oldies on here or something

[@silverfox0079]

@@nikos4641 You are obviously so ignorant. Oldies? It seems from your comment that you will never make old bones!

[@arckocsog253]

Thank you!

[@Tmrajm]

@@silverfox0079 dsssssww n R No me bbvbbbbbb mo He

[@SoapMacLavish]

i appreciate u so much, im short on time but really wanted the vital info from this lol

[@Keira_IAM111]

People often tell me that I don't look my "age" (in my 50's). I pay attention to eating (organic, mostly vegetables) , exercise regularly, don't drink alcohol, don't smoke, take supplements and use organic skincare products. David Sinclair speaks volumes of truth for anti-aging in this video and appreciate his scientific logic.

[@ModelJames13]

It's all just randomly down to the individual (mostly). I do some of the things you do except I eat mostly meat and don't take any supplements and don't use organic skin products. Most people think I'm low 20's, even mistaken for a high schooler sometimes. I'm currently 40. They will never reverse aging, never. We can only try to hang on to our perceived youth as long as we can.

[@ryzikx]

@@ModelJames13 >they will never reverse aging i'll bet my entire life savings it will be possible within 20 years, and this is a conservative estimate from me. i wouldn't be surprised if it's here by 2030

[@mag4926]

@@ModelJames13 Unfortunately you didn't understand much.

[@lauradivittorio1014]

I also do more or less the same things, I'm Italian so I follow a Mediterranean diet with extra virgin olive oil as the main source of fat. I have been doing castor oil packs on my hair since I was twenty, I am now sixty-two and have no gray hair. The color you see in the photo is natural.

[@manshavivek]

@@lauradivittorio1014 pls can u explain the castor oil pack 🙏🏻

[@thatstheguy07]

David reminds me of that friend who got stoned for the very first time and when they talk they have this look/smirk on their face where they’re about to burst into laughter over absolutely nothing at any given moment 😄

[@QueenBeeDigital]

Yeah and then they start talking about condoms filled with walnuts 🤣🤣🤣

[@indiegold7153]

Here is why everyone should listen to D Sinclair...glowing white teeth, looking 30 at 50+, bone structure. BOOYAH!

[@daveoatway6126]

Great show. I have been using 1-Skin for a year and have noticed a difference in my skin. At 77 years old, my Pinch Test is very quick. I started taking NMN 3 years ago and noticed my hair getting brown again. This is increasing. Now I take 2 gm of NMN most days (i figure I am older and need all the help I can get) and walk 5-10 miles almost every day, with some HIIT. I'd be very interested in an update on Dr. Sinclair's father's journey. These shows are excellent - much better than many interviews with often clueless interviewers.

[@moeseneczko5553]

Which nmn do u take?

[@daveoatway6126]

@@moeseneczko5553 I take DoNOtAge pure NMN powder. I take two 1 gm doses in water or ccold coffee. I also take TMG as Dr. Sinclair does. Also DoNotAge

[@katarinaa351]

How do you get nmn

[@daveoatway6126]

@@katarinaa351 I mail order from DoNotAge from their website.

[@katarinaa351]

@@daveoatway6126 thanks!

[@siamsiraji3169]

Dr Sinclair has been an inspiration for me. I have heard of him back in 2018 for the first time, since then been following all of his work. Now, this year I will be graduating from the dept. of Biochemistry and Biotechnology. Currently, I am working on one of the sirtuins genes. All because of Dr Sinclair. You made this young boy dream big. I just turned 23 this year. Haha.. and I have decided to pursue this longevity field. Thank you wholeheartedly, Dr Siclair.

[@gregorie3752]

Soo lucky I’d love to work in that field but Biochem is no joke 😂

[@ladycolleenheller]

👏🏻👏🏻👏🏻

[@asada7972]

Facts

[@finlaynixon2531]

This comment made my day, your a sicko dude keep at it 🔥🔥

[@AnnTsungMD]

Happy for you!

[@drkaushikt6926]

As a doctor, this is one of the very few podcasts I genuinely look forward to

[@JeffNixonComedy]

Would be curious to know which other podcasts you find interesting or would reccomend. Cheers!

[@ralph1rodriguez]

Look into flat earth too

[@JeffNixonComedy]

@@ralph1rodriguez small potatoes...team triangle earth

[@ralph1rodriguez]

@@JeffNixonComedy I'd say it's a pretty big deal, given all the hit pieces, the "debunk" videos and websites, and disinformation dedicated against the true nature of our earth. All testable repeatable physics supports a flat earth and only concepts and theories support a twirling space ball.

[@willou901]

@@ralph1rodriguez hahahha

[@NicholasOdinson]

My new favorite podcast! Hope you keep it going after 8 episodes.

[@mr.roni0570]

Wow. It's becoming one of my favorite podcast series. I'm not gonna miss anyone. Keep up the good work and keep up educating us. Take love.

[@taismonteiro374]

Best podcast so far! Thank you so much, Dr. David Sinclair!

[@traceyleigh1111]

I love this podcast. I am almost 53 but feel 33. And apparently look more like 43. Vegetarian, yoga and meditation has been good so far but this is amazing information. I was a late parent. To know I have to power to live long enough to see grand kids grow up is amazing. Thank you both for all that you do. 🙏 And I love the humour. 🖖 😆 Aussie Gratitude being sent your way 🇭🇲

[@tealatata]

Wait till you hit 60 and your hormones are gone

[@mollypitcher9380]

@@tealatata true!!!

[@joeblow1748]

Im 38 and mentaly feel like 90 😄

[@gp246]

Do you intermitant fast?

[@traceyleigh1111]

@@gp246 yes :)

[@QueenBeeDigital]

Regarding PRP, this is a very lovely treatment that can be done to rejuvenate the face as well, specifically when mixed with bio-stimulators like Sculptra aka Plasmasculpt ( shoutout to Dr. Rajani-also here on KZbin). But PRF is even better for hair, skin, and bodily rejuvenation. It’s also used in Dental surgeries. The Platelet rich Fibrin has a lot more growth factors and the results are so much better. I’ve had them both done locally. To get the Fibrin you simply spin the blood slower and for a shorter amount of time at the right angle. You then inject the fluid before it fully clots. Once you have a clot you can spread it across the face/scalp and micro needle it in. These treatments are A-MAZING for rejuvenation.

[@irenhollo662]

Dr. Sinclair, as a Hungarian admire your work! A proud Mother of a Harvard Student! Your podcaste is enjoyable... and easy to understand! Please keep it up! Thank you for your work!

[@xelaklement3367]

Thank you SO much for these podcasts. I look forward to them each week! You manage to be factual and informative while still keeping it interesting and even funny (had to laugh quite a few times) I was also wondering if anyone knew if these sponsors are also available in Europe or if there's something similar available on the old continent?

[@adbc8737]

You are helping so many people improve their health! Thank You! 🌀💚🌀

[@DocJaeBass]

Another hugely exciting podcast. I've turned off my movie channels and am rewatching this entire series and taking notes for my evening entertainment and education.Thank you.

[@lylan8737]

Thank you Dr David. i’m your biggest fan and i loved the life spam book that i reread it every once a while. I found your book calming and your voice is also calming. I love learning such great things from you and the best thing is that ur voice is healing

[@rumnas185]

This is my favorite channel on KZbin. I’m so thankful for your videos!

[@ashleywessel780]

Your personalities compliment and play off each other very nicely. Great conversation and info, thank you guys

[@simonfoo8684]

Thank you for sharing the sciences behind aging and possible pathways to reverse or slow down the process.

[@claudettesechler149]

Absolutely great! Loved learning about the product knowledge and thanks for breaking it all down!

[@ErickOberholtzer]

Thanks for the great content! I've read the book, but every podcast episode I take at least a few more little tidbits of new knowledge with me.

[@crazyfarmgirl606]

I am thankful for your podcast i am trying to soak up all the health and antiaging information i can. So that i can age well, both physically and mentally. I want to be an old person who can take care of themselves and have a full active life not requiring aid from others.

[@donahileti9282]

Thank you for your very interesting podcasts. I was delighted to hear that this episode will be on HRT and womens ageing. Sadly male boldness took central stage. Please please please present an episode dedicated to menopause. Most doctors are not trained in menopause and the whole world acts as though it does not exist…

[@ybigirl]

YES! There is next to no info on female BHRT which includes testosterone. Given the beautification effects of testosterone for both men and women, I was surprised to see this topic completely glossed over. :(

[@bt9124]

Menopause is Not Sexy and yet if the fact that it is also Great News is talked up, maybe it'd get more interest? I am SO glad that those mood-toppling hormones are finito.

[@bt9124]

@@LouiesLog Mine has never been without her hot flushes? She rather likes them. Brrrr-rr

[@ybigirl]

@@bt9124 For me peri-menopause was a nightmare. I went in search of a solution, being initially wary of HRT. But reading medical papers and evidence that BHRT provides benefits with respect to immune function, tissue strength, and not to mention brain health sent me in search of a CYCLIC hormone provider. (IMHO, those giving women static dosages are doing them a disservice, if not weakening the hormones' abilities to function as the body intended.) But, that doesn't mean it hasn't been challenging to figure out what is correct FOR ME. I agree with Dr. Sinclair that women (in their 25th year, or so) should have their hormones tested daily for a month. This would provide a detailed view as to appropriate dosing after the age of 35. I am one of those with the opinion that many issues of aging in women may be managed with earlier progesterone treatment, especially with respect to sleep cycles, tissue repair, and (moods) brain function.

[@HuyLe-up3mx]

@@ybigirl agreed. Check for progesterone deficiency in early 30s

[@ptyh27]

Dr. Sinclair looks really young for someone who is 52! I was watching his interview with Lewis Howes and it was really inspiring! I feel like it's something to do with our hormone change that age us as we get older

[@lauriegaudio4006]

This sounds amazing. I know this is a great calming and healthy practice for the mind and body which is especially needed since COVID.

[@AboodCohen]

So glad I found this podcast early in life, very thankful for both of you!

[@johny16G]

Just found about you 3 days ago and saw everything on this channel! Can’t wait for more episodes to come.

[@kittymurrah7400]

Dr Sinclair, I have been following you for about 3 years. Your knowledge is so impressive and hopeful. I have learned so much!!! Thank you

[@jadezee6316]

what did you learn from this video? or tell me one thing you are going to do because you learned it here.....something that wasnt known before

[@cecipalacios1007]

As always a great conversation! Since I do not use gloves when I am around my kitchen I thought that doing the skin fold on my hands would not be a good indicator so I did it on my foot and the difference is day and night. This considering that Skin’s thickness is so much alike..

[@catsteinhilb2880]

Thank you!! For finally addressing women’s hormones, particularly Menopause!!!

[@simsammalinao1823]

Good conversation. Much thanks Dr. Sinclaire and Matthew.

[@kat-ij4po]

I’ve just discovered this channel and Dr. Sinclair- he is fantastic. As a woman about the same age as David, this episode is of intense interest to me, but it covers a LOT of ground in a very short span and I’m hoping there are subsequent podcasts that go into a lot more detail. Not sure what is being recommended here in terms of hormone replacement for post menopausal women and confused as to other actionable takeaways. Hoping they slow all of this down and elaborate in subsequent podcasts that I just haven’t listened to yet! From prior podcasts I’m really clear that NMM, Resveratrol, Quercetin are great to take in the morning with a bit of fat - I’m on it!

[@kapa0224]

LOVE!!!!!!!! your podcasts! Thank you so much please keep making them. I listen many times and tell friends who love this content too. Heather

[@jawadkarim6615]

Great! Great! Great! Greatest Scientist David Sinclair . I really appreciate your kind help...

[@juliak2591]

I enjoyed this talk very much. Dr. Sinclair is clear and thorough. The interviewer is excellent as well. I had all my questions answered. Thank you!

[@senseofwonder4734]

Thank you for these podacst videos! You are so amazingly generous to share this with the world.

[@johncarpenter8459]

Dear Dr. Sinclair and Mr LaPlante. First, thank you very much producing the Lifespan podcast. Second, I greatly encourage you to continue the show. The content is intellectually invigorating and practical. It is also hopeful. During a period marked by constant undesirable exogenous shocks, you have offered ways by which we can influence the trajectory of our personal health. I eagerly await season two. Best regards and thank you again, John

[@kellysober9352]

I have been following David’s work for about 2 yrs now. Thank you for addressing women. You do have women listening. It does seem like women get left out of the coversation, out of research and their health issues (like autoimmunity) don’t get money and attention. It does feel like wr are second class honestly.

[@jjbenjamin8488]

There is mountains of research on literally every aspect of the female body, what are you talking about? On this very app there are COUNTLESS channels dedicated to womens health. Get real

[@cmickie3296]

Fascinating. Thank you gentlemen, for sharing your experience with us.

[@zvezdacolman345]

Thank you David! Addicted to your podcasts. So informative, educational, practical, interesting, exciting. And super helpful! And lots of fun as well. Just great stuff!

[@AnnTsungMD]

Glad you like his podcast also. I really love his episodes

[@frenchmontana423]

okay great podcast and thanks for it. however it sucks that you guys never really got into exact detail of what you should and shouldn't eat / do for hair and skin? do we workout more? so we fast? do we go in saunas? do we take cold showers? and good too, do we eat or more greens? more eggs / biotin? do we eat less carbs and sugar? wish we got those answers.

[@courtneyderouen]

Agreed. That’s why I also watch Dr Eric Berg and also Dr Mandel here on YT.

[@Theodora937]

he has episodes on this

[@frenchmontana423]

@@Theodora937 which? which episodes?

[@SebastianNiemann]

All episodes are for me one of the best podcasts ever made. Thanks for all the amazing work!

[@mihaelagheorghiu38]

Sinclair doesn't show any trial, any statistics, no writen scientific proof. He talks too much, like a TV star, usually true scientists have doubts, and express themselves with extreme care. A Harvard professor is no guarantee for truth, as Harvard and other prominent universities proved to be very corrupted during the recent Covid pandemic. Sinclair continues the opinion of Ancel Keys about human nutrition, which is totally wrong. He is just an logoreic influencer.

[@bestrongandloveyourself2370]

I keep pinching my hand now 😄 Thank you for this very interesting and useful episode! 🥰🥰🥰 I will try to be more careful with my Tretinoin treatment, I didn’t know that in a long run it might have negative effects. I love your podcast!!! 💖💖💖

[@PandaA-cv3mm]

Thanks for this. My mom has used retin-a since she was about 25. She is over 70 now. No skin cancer or other crap…. Her skin rocks!Very incredible info. Lots of love ❤️

[@HeatherOdeh]

Agree. I have been using it 2-3 nights a week since mid 90's and although I am 57 I am often asked how I keep my skin so youthful. It is Retin A, Vitamin C and sunscreen. But I also eat well and exercise almost every day.

[@kimdorcy5150]

@@HeatherOdeh Yesssss! exactly!!!

[@julius1972100]

New Subscriber from the Philippines🇵🇭🇵🇭🇵🇭🇵🇭 Thank you fir your informative and free knowledge you are sharing to mankind. More power to your channel

[@ferdinandgoglia3634]

I've never exercised in 50 years, and I've probably eaten less than 1kg of veggies in 4 decades. Started feeling a bit rough recently, so I am trying to improve my health starting this week, so wish me luck😁

[@aiculsunlight9713]

Thank you so much Dr. Sinclair and “lovely” co - host for sharing your knowledge. I have listened/watched/shared your podcast often. I just wanted to make sure I understood. If my nails are growing too fast … does it means that I am aging too fast, or the other way around ?

[@meganwolfe2185]

Please do not shy away from talking about female concerns just because you aren't women. You don't have to have a uterus to understand the science of how they work! This approach runs the risk of leaving women in the dark. Please address our aging concerns equally. Thank you for the great info. I love your show!

[@litildiva]

all the knowledge and health benefits aside this is just top quality podcasting! would love to see you both having guests and taking this even farther

[@katherandefy]

David and Matthew are so generous with their time. Live long and prosper, guys. We’re listening and learning.

[@cluman1]

They are making money from this so it's not as altruistic as you may think.

[@addictedtochocolateandcoff9582]

@@cluman1 how are they making money?

[@NMNAntiAge]

Great talk, thank you for your work as always!

[@Plumpers]

Using my red/infrared laser light while I watch this on my head and face. It's really helped me with my brain fog left over from having COVID a year ago

[@01maggie]

I started taking AGR1 green drink... recommended by David S. It's a huge difference in recovery of covid...plus NMN and Transreservatol!!

[@Ghost-zy1oc]

Bad diet can cause brain fog. Proper human diet is worth to try

[@QueenBeeDigital]

Hey! I was one of the females that commented on your last video about leaving us out. I wanted to say thank you for addressing some of the issues surrounding female hormones and menopause. 😌 You guys are awesome 👏 👏👏👏

[@audreyboyle52]

Not a particularly comprehensive or accurate reply though

[@monicap7941]

@@audreyboyle52 Very sketchy and inaccurate info to be honest. Didn't even address the importance of using body identical hormones.

[@dianaprice3227]

Would really like to hear about osteoporosis and lack/loss of estrogen playing a major role ... reverse/improve bone quality/increase with "diet & minerals" the body is lacking, to stimulate osteo-genius/osteo-blast? Presently the available drugs for bone loss shut down/slow-down the osteo-clast function; cleaning up old/dead bone is just as important in the osteo-clast : osteo-blast cycle, is it not? Also, is NMN a possible usage? i.e. Dr. Sinclair's interview with Shawn Stevenson. Dr. Sinclair, thank you for what you do!

[@gloria6396]

THE 2 OF U TOGETHER R WONDERFUL FOR ME 2 UNDERSTAND I WISH THIS WOULD GO LONGER THAN 8 PODCASTS

[@TheblondJane25]

Love David Sinclair explanation, the facts, his voice and appearance!

[@peterschmid9878]

He's had work done, you understand. Right?

[@bt9124]

The other chap's voice by contrast, grates rather. And that cap needs a string of onions, a French accent, a bicycle and a little handbag dog.

[@marleerobertson1221]

Dr. David, thank you for your work and willingness to share! I’m sure this doesn’t come with a quick, easy answer - do you have research pertaining to people dealing with issues like histamine intolerance/mast cell activation syndrome? I’ve wondered if some of the products you talk about would trigger reactions in these folks. Thanks again!

[@kayas.1782]

Fascinating episode as always, guys! I was wondering if there’s any information regarding these ‘plant stem cell serums’ that I’ve noticed popping up in the cosmetics sections? Any validity in those, and if yes, what would be the science behind them?

[@plantbasedathleterealtor6145]

I am grateful for all your podcasts 💫🙏🏻

[@delcamino1736]

I wish Huberman lab podcast was as funny as yours! Thank you so much! Both podcasts are life-changing for me!

[@commonomics]

PLEASE do an episode on fertility for both men and women. I’m suffering from recurrent miscarriages and I would love to have some literature interpreted into layman’s terms.

[@marlenegold280]

Even having suboptimal thyroid function affects fertility and risk of miscarriage. High insulin resistance can too. Weight that is too low or too high affects fertility; ‘weight’ as in body fat composition, not just weight in a scale.

[@JeffCaplan313]

Eat more folate-containing foods (not folic acid).

[@janetstauffer9138]

So sorry to hear that. There are probably better people for infertility issues. I hope you find them. 😢💙

[@artamige]

Hi, I'm wondering do you eat dairy?

[@MichaelVelvet]

Wish there was a “Love” button. I love this show and I love your work Dr. Sinclair. Much respect and love for this content.

[@LouiesLog]

You can send him your ear in the mail

[@beherenow8289]

@@LouiesLog David is on a vegetarian diet at the moment

[@jewelleryaddict]

Thank you for including help for specifics on women's aging. So hard to find relevant info on it usually we are passed by as most studies in past did not include women because of our "difficult" hormones as we are usually told. Even if that's the problem women have more chronic illnesses and take most of the drugs made leaving us to play Russian roulette with whatever drugs we are given hoping they will work the same in us as a man. So bravo for including women's specific problems in you talks.

[@jeffreymckenzie3961]

Could listen to these guys all day

[@nina-xw6ku]

Thank you for address menopause.....would love a dedicated video on this topic from your perspective.

[@lisengel2498]

Interesting talk - I am 78 - and for some time I started eating 90 % whole food plants with Greens, beans, onions, mushrooms, nuts, seeds, berries and what I have observed is that my nails are getting stronger and that they grow faster 😊🍀💚🎶

[@barbarafairbanks4578]

Lis Engel...you are fortunate. Some of us don't have time to watch our nails grow🤣

[@gregorie3752]

What kind of beans and mushrooms

[@lukekennedy2410]

Cut out the beans and its perfect....unless your pressure cooking the lectins out of the beans your doomed contrary to how they make you feel

[@g.e.boroush5176]

@@lukekennedy2410 Cooking destroys/removes the lectins. In order to eat beans they must be thoroughly cooked. One cannot eat raw uncooked beans as they are hard as rocks. Once the beans are at a point they can be chewed and swallowed, the lectins are long gone. Moot point.

[@lisengel2498]

HahA I Think it takes a bit of Body awareness - to know whether your hair and nails are strong and grow fast and healthy 😊💜

[@mcgragor1]

Cr. Brad Stanfield just posted another video saying Resveratrol does not work, I really think you should respond to this. Just reading the comments people are questioning Dr. Sinclair's integrity.

[@sethflix]

I'M REEEEEEAAALLLLYY enjoying your podcast@ Thank YOU!

[@katiemiller2803]

Thank you for doing this podcast! Best one out there! Thank you for addressing women. We get left out a lot in the longevity podcasts and research.

[@audreyboyle52]

It would be great if a less male centric tone was adopted

[@heatherschramm]

Thank you for addressing the role of female hormones on aging.

[@audreyboyle52]

Pretty inadequate actually

[@moontiggsland]

Thank you for mentioning microneedling. I work with a similar technique with tattooing equipment to restructure scar tissue. The pain really depends on the area, depth and in women sometimes depending on what part of their menstrual circle they're at their pain threshold.

[@sfudge]

The menstrual pain threshold is no joke. I practice martial arts and find my pain threshold and cold tolerance absolutely plummets for a few days each month. Things that I normally don't even perceive as pain suddenly feel like catastrophic injuries 😂

[@sonnyecho9195]

What is the name of that process Ginny? Is there a yt channel that discusses this technique?

[@mystikrebel1089]

A very interesting and educational discussion totally worth the time

[@jerumgamboa2717]

I have a son have a glaucoma on the left eye in his early age and when he turned 10yrs old and its affect the other eyes and i am still hopeful he can get back his sight with the science and technology today with expert same as you. I am seeing a light of the tunnel when i saw your podcast and i am hopeful you can help me Dr. David.

[@aaliyahlee1265]

Thanks to Dr. Sinclair. I've always loved his videos. It's through him I learned about the benefits that NMN provides. Because with age comes with health issues. When you reach about 60, you often need major medical attention. But ever since I'm taking the vitruvin NMN supplement, it changed my life and the way I live everyday!

[@annewilliams9279]

Now I don't worry much about getting old and reach 60s and beyond, as we finally have supplements to depend on. I'm 45 and taking vitruvin NMN for almost a year now. I am grateful that I've known this at the early age, so getting 50s and beyond will not be a problem to me :)

[@aaliyahlee1265]

@@annewilliams9279 really good for you!

[@ca9878]

I'm glad they talk about menopause! So many women are going through this and all it's bad vicious side effect.

[@GDName]

I love this format between the two of you.

[@ableinternational3611]

As always packed with great info. Questions: 1. Are the topical cream such as Rogain and Retinol for men only or both? 2. About Hyaluronic Acid, is it effective to take it pill firms? 3. Couldn't find topical nicotinamide, but found nicotinic acid. The internet says nicotinic acid is niacin. Is it true? They do have topical nicotinamide? Which one is more effective? 4. Will it be helpful to take keratin pill for hair, nail and skin? Sorry for so many questions

[@meimei2630]

waiting for more episodes on this topic!

[@irandiaz2895]

I always look forward to listening to his content. I would love to work with David Sinclair one day.

[@meloniedodaro2030]

Fantastic episode. I’m going to watch all of the others you have here on your channel. Question: Have you stopped posting new episodes or will you be sharing more again in the future? Thank you!

[@gloria6396]

ITS REMARKABLE HOW DR SINCLAIR HAS STAYED SO POSITIVE AFTER ALL HE HAS GONE THROUGH TO ME THIS IS ONE OF HIS MOST HELPFUL MESSAGE

[@Rr17user]

What did he go through?

[@ElChuntyCabra]

He went through your mom

[@MakinItHappenn]

What did he go through bro?

[@sonals2021]

I am glad that you mention women, quite important to note research where only men have been tested and how a particular drug or protocol may affect women.

[@teddyli4763]

Thank you to athletic greens for sponsoring this

[@tatyananikolovaaddictbouti9342]

This is the most helpful video i have ever seen...saved me a lot of wasted money on wrong things and procedures

[@19Jetta]

I have been on NMN and resveratrol for a little over two weeks now...and it is working. I track my blood pressure and blood sugar most days. Both have stayed stubbornly high over the last few years, probably mostly due to the fact that I have gained weight in the last few years. I am working on the weight but so far I haven't lost...but my blood pressure and sugar are both down. This morning my bp was 118/83 and blood sugar was 98. This is the lowest these markers have been...years. I am excited to see my progress as I lose weight and continue to improve my diet. Thank you Dr Sinclair!

[@barbarafairbanks4578]

19 Jetta - very useful anecdotal information. Thanks for sharing👍

[@PinataOblongata]

Transient markers like these can't tell you if these compounds are "working". The only way we will ever know if they increase lifespan, which is what they are being used for, is if we can follow a large cohort of people both using and not using them, across many years, and compare the average life-span (or health biomarkers through end-of life years). If you are also altering your diet and exercise, you now have no idea which intervention is causing the drop in those numbers.

[@barbarafairbanks4578]

@@PinataOblongata Well, that said, e.g., 'following a large cohort of people' taking vs not taking NMN, for instance, thru their lifespan is an epidemiological pipedream... about as reliable as the 'transient markers' you are poo-pooing - even less so,more likely, bc one subject's evolving biomarkers vs a notoriously poorly tracked/controlled epidemiological 'study' of a large cohort (hundreds/thousands(?) couldn't really divulge all that much anyway (too many factors, including genetics), to obtain reliable data. I'd put my money on comparing my baseline biomarker data to a subsequent reading 6 wks later after making ONE change, i.e., adding in NMN OR resveratrol - or whatever - without making any other lifestyle/diet/supplement/environmental changes. Of course, if one is adding in a couple supplements and/or changing up their exercise routine or diet - their 'transient markers' are useless...that goes without saying, I agree. Though an improved biomarker profile cannot say much about lifespan, anyway. Possibly comparing a bio-age test before & after adding in something like NMN would give a better reading on how it's affecting our own life/healthspan?

[@PinataOblongata]

@@barbarafairbanks4578 You are mixing up epidemiology with actual long-term controlled intervention studies. Epidemiology just looks at data from people who were living their lives as normal and tries to find a signal in that. There is no true intervention and control arm. Yes, it would be difficult to corral enough participants and have them follow their regime faithfully, but until that happens we simply can't make grand claims that can't be supported. I wouldn't discount a change in your average biomarkers over a longer period of time (which would iron out the contribution of other variables), but in a week or so and as we agreed, adding in other variables muddying the waters, not useful.

[@barbarafairbanks4578]

@Pinata Oblongata IIRC (w/o re- reading what I wrote previously), I never suggested adding in another factor in whatever timespan you've mentioned... a week?/a week or 2? (If this is what you're referring to as per what we 'agreed on',, i.e. a longer timespan, I'm unsure why you are mentioning again. Perhaps your re-agreeing, with this concept (of control). Can you please provide an example of the type of long-term 'controlled' study of a large demographic, traversing lifespan(s), (that I appear to have confused with epidemiological studies?)

[@oliviamiller8187]

NMN demonstrated multiple benefits such as fighting muscle degeneration in elderly men and women, aerobic capability, and increasing endurance. The results may vary from person to person. Personally, it has been my 3rd month of taking NMN by vitruvin, that's 500mg, and I love how it worked impressively. I wish many people would give a shot in taking NMN and start living a happy, balanced, and healthy life as they age!

[@rachelstark8002]

ouldn't agree more. NMN by Vitruvin so far caress more research, and it's proven to be assuredly effective unlike other popular brands coming out these days which actually do not make any difference.

[@slotjnke1]

Do you take a certain brand?

[@leadimentoobrien1221]

I am 58, no cavities, no fillings, my hair is very dark brown and lustrous, i don't and never had to dye my hair, my eyes are the age of a 30-40-year-old my doctor told me. I only have a few gray hairs, my fertility was high right up to 55! Not much for wrinkles. bones are good, skin is good, what I use is a face gadget that vibrates as it cleans. VIBRATION from what I read vibration is highly effective. The secret is I don't do cr*p to my body. no botox, none of that. Just grateful for what I got . As I am listening to this I had NO issues with menopause. My memory is sharp, I'm very active cuz I LIKE to be active. Perhaps because I'm IRISH I like to lift weights. That is a big tip. weight lifting. Bicycling works for me and going to the BEACH set me right. Bragg's Apple Cider Vinegar with Cinnamon is beneficial. OXALATES DID do something to my body. a while ago I made spinach, carrots, onion, celery soup with pasta elbows and used the water the veggies were cooked in for the soup broth. that I suspect created kidney stones. Unbeknownst to me especially spinach is high in OXALATES. Who knew eating right could do damage to your kidneys. please research OXALATES in your lab. With everyone drinking ALMOND MILK more people are going to damage their kidneys from drinking it. Almonds are high in oxalates. My skin pinch test went down in 2 sec. I use COCONUT CREAM for coffee etc.

[@incognitotorpedo42]

Oxalates are bad. Totally agree with you there. Too bad because baby spinach is so yummy, but it shouldn't be a staple. Anyway, you're lucky that you appear to have good genetics.

[@catherineblair550]

I love almond milk. But I was facing kidney issues also. It's the calcium they put in it. It's much to much. Make it yourself if you are going to drink it.

[@pontevedra660]

aaaahhh Doc, you are so sweetly great in your advertisements..... I trust you with my life, as you have led me, inspired me, through so many hurdles in my life.

[@natalieaxl804]

Thank you Dr, David 🙏

[@callofthedark]

Let’s Go… It’s time to upgrade, to elevate and to be better. 6th episode for the 6th week of 2022. What a way to begin a legendary start of my new year.. 🥰

[@tangulahook1805]

z

[@JayBird1993]

Great podcast! Thank you! I would love to see an episode on arthritis.

[@pawel2592]

It's a student offer 😂 you r DC go to the I'm o RTV footr free I got your you have t

[@helenmcintosh9747]

hi Dr Sinclair been watching from Australia you have saved my life i could not walk i had so much damage to my bones i take Metformin i have some respertol i do everything intermitten fasting eat vegan now. i now am now so much fitter my specialist was amazed i needed double hip replacement in 6mths i dont need operation anymore i am back riding pushbike i am 66yrs i feel like 40s thank you so much x

[@michellelouise8865]

Thank you so much. So helpful and interesting

[@inhocsignovinces8061]

Laser skin resurfacing, which wasn't mentioned, seems to be one of the best current anti-aging treatments out there, working both through hormesis (skin regrowth) and literally wiping out the below the surface senescent skin cells and cross-links (advanced glycation end products).

[@dollyproductions1]

Yes. i had this and it took 10 years off my face

[@barbarafairbanks4578]

In Hoc Signi Vinces - yes, I agree - found this 'anti-aging cosmetics' podcast to be sloppily presented with so many anti-aging procedures completely omitted, as to be laughable. Well-versed anti-aging YT Beauty Influencers are SO much more informative than this disappointing podcast :/

[@BadMannerKorea]

Depending on the treatment, it can damage fat. Which is a huge problem because as you get older fat naturally decreases around the eyes and other parts of your face. It’s really important to find somebody who knows what they’re doing and to get a less invasive laser, depending on your needs.

[@islakay]

@@BadMannerKorea the lasers can also leave burns

[@Mexicobeanpole]

Great video. Thank you so much. The thing I find confusing is the idea that thin and smaller people live longer. But, I’ve had both my Primary doctor and my Gyno tell me at 60, that I was getting too thin, and to “be careful”. They said that if you get really sick, being too thin can be bad, because your body has no fat stores to draw from, and also the increase of osteoporosis in older thin women. I’m 60, and thin, but not underweight thin.

[@michelles2299]

Because of bone density concerns if you get osteoporosis and break a hip it will shorten your life

[@miradohnal5112]

that's why the hormonal therapy can be greatly beneficial specially (and not just for thin skinny) for thin people to reduce osteoporosis risk and heart diseases. Something to look at even if you are 60years old.

[@annewilliams741]

Love the topic. Lots of info

[@autisticautumn7379]

Fascinating, the most interesting thing that I doubted was possible was the reversing greying hair amazing .