The Science of Looking Younger, Longer | Lifespan with Dr. David Sinclair #6

[@FortniteKingClips]

David inspired me to go to college to study molecular biology and aim for a career in fighting aging because I heard of him from the podcast he did with Joe Rogan in 2019. Thanks David!

[@Byrzzaa]

Wish you all the best!

[@ci4396]

You should probably change your name on KZbin haha. Good luck 👍

[@koningsbruggen]

Nice, thanks for doing that king

[@StarBoyyX]

Thanks Andy same time tommorow ,don’t forget your shovel And packed lunch

[@frederickhofmann843]

that's great to hear Mr. Fortnite King!

[@Keira_I_AM]

People often tell me that I don't look my "age" (in my 50's). I pay attention to eating (organic, mostly vegetables) , exercise regularly, don't drink alcohol, don't smoke, take supplements and use organic skincare products. David Sinclair speaks volumes of truth for anti-aging in this video and appreciate his scientific logic.

[@ModelJames13]

It's all just randomly down to the individual (mostly). I do some of the things you do except I eat mostly meat and don't take any supplements and don't use organic skin products. Most people think I'm low 20's, even mistaken for a high schooler sometimes. I'm currently 40. They will never reverse aging, never. We can only try to hang on to our perceived youth as long as we can.

[@ryzikx]

@@ModelJames13 >they will never reverse aging i'll bet my entire life savings it will be possible within 20 years, and this is a conservative estimate from me. i wouldn't be surprised if it's here by 2030

[@lauradivittorio1014]

I also do more or less the same things, I'm Italian so I follow a Mediterranean diet with extra virgin olive oil as the main source of fat. I have been doing castor oil packs on my hair since I was twenty, I am now sixty-two and have no gray hair. The color you see in the photo is natural.

[@manshavivek]

@@lauradivittorio1014 pls can u explain the castor oil pack 🙏🏻

[@avoiceforthevoiceless2068]

@@ModelJames13 LOL! Sounds like you may need someone to translate for you, or take a biology + science class.

[@audiosmarts675]

28:22 Keratin & Collagen 34:50 Retinol and Retinoids 55:30 Low level laser therapy 58:15 Platelet rich plasma Gdf15 - Hair growth gene Tretinoin - Medication used to treat acne and sun-damaged skin

[@nikos4641]

its in the bloody bio mate we got a bunch of oldies on here or something

[@silverfox0079]

@@nikos4641 You are obviously so ignorant. Oldies? It seems from your comment that you will never make old bones!

[@arckocsog253]

Thank you!

[@Cfhhvffgccc]

@@silverfox0079 dsssssww n R No me bbvbbbbbb mo He

[@SoapMacLavish]

i appreciate u so much, im short on time but really wanted the vital info from this lol

[@daveoatway6126]

Great show. I have been using 1-Skin for a year and have noticed a difference in my skin. At 77 years old, my Pinch Test is very quick. I started taking NMN 3 years ago and noticed my hair getting brown again. This is increasing. Now I take 2 gm of NMN most days (i figure I am older and need all the help I can get) and walk 5-10 miles almost every day, with some HIIT. I'd be very interested in an update on Dr. Sinclair's father's journey. These shows are excellent - much better than many interviews with often clueless interviewers.

[@moeseneczko5553]

Which nmn do u take?

[@daveoatway6126]

@@moeseneczko5553 I take DoNOtAge pure NMN powder. I take two 1 gm doses in water or ccold coffee. I also take TMG as Dr. Sinclair does. Also DoNotAge

[@katarinaa351]

How do you get nmn

[@daveoatway6126]

@@katarinaa351 I mail order from DoNotAge from their website.

[@katarinaa351]

@@daveoatway6126 thanks!

[@strictlyprivate6914]

Prof. Sinclair looks younger now than he did five years ago by well over 10 years. Fantastic!!! Resveratrol and NMN outstanding results

[@drkaushikt6926]

As a doctor, this is one of the very few podcasts I genuinely look forward to

[@JeffNixonComedy]

Would be curious to know which other podcasts you find interesting or would reccomend. Cheers!

[@ralph1rodriguez]

Look into flat earth too

[@JeffNixonComedy]

@@ralph1rodriguez small potatoes...team triangle earth

[@ralph1rodriguez]

@@JeffNixonComedy I'd say it's a pretty big deal, given all the hit pieces, the "debunk" videos and websites, and disinformation dedicated against the true nature of our earth. All testable repeatable physics supports a flat earth and only concepts and theories support a twirling space ball.

[@willou901]

@@ralph1rodriguez hahahha

[@irenhollo662]

Dr. Sinclair, as a Hungarian admire your work! A proud Mother of a Harvard Student! Your podcaste is enjoyable... and easy to understand! Please keep it up! Thank you for your work!

[@indiegold7153]

Here is why everyone should listen to D Sinclair...glowing white teeth, looking 30 at 50+, bone structure. BOOYAH!

[@JeffNixonComedy]

Black coffee and Sinclair podcast... the new Wednesday morning ritual

[@ThisArdentLife]

Please do not shy away from talking about female concerns just because you aren't women. You don't have to have a uterus to understand the science of how they work! This approach runs the risk of leaving women in the dark. Please address our aging concerns equally. Thank you for the great info. I love your show!

[@siamsiraji3169]

Dr Sinclair has been an inspiration for me. I have heard of him back in 2018 for the first time, since then been following all of his work. Now, this year I will be graduating from the dept. of Biochemistry and Biotechnology. Currently, I am working on one of the sirtuins genes. All because of Dr Sinclair. You made this young boy dream big. I just turned 23 this year. Haha.. and I have decided to pursue this longevity field. Thank you wholeheartedly, Dr Siclair.

[@setme4ree]

Soo lucky I’d love to work in that field but Biochem is no joke 😂

[@ladycolleenheller]

👏🏻👏🏻👏🏻

[@asada7972]

Facts

[@finlaynixon2531]

This comment made my day, your a sicko dude keep at it 🔥🔥

[@AnnTsungMD]

Happy for you!

[@19Jetta]

I have been on NMN and resveratrol for a little over two weeks now...and it is working. I track my blood pressure and blood sugar most days. Both have stayed stubbornly high over the last few years, probably mostly due to the fact that I have gained weight in the last few years. I am working on the weight but so far I haven't lost...but my blood pressure and sugar are both down. This morning my bp was 118/83 and blood sugar was 98. This is the lowest these markers have been...years. I am excited to see my progress as I lose weight and continue to improve my diet. Thank you Dr Sinclair!

[@barbarafairbanks4578]

19 Jetta - very useful anecdotal information. Thanks for sharing👍

[@PinataOblongata]

Transient markers like these can't tell you if these compounds are "working". The only way we will ever know if they increase lifespan, which is what they are being used for, is if we can follow a large cohort of people both using and not using them, across many years, and compare the average life-span (or health biomarkers through end-of life years). If you are also altering your diet and exercise, you now have no idea which intervention is causing the drop in those numbers.

[@barbarafairbanks4578]

@@PinataOblongata Well, that said, e.g., 'following a large cohort of people' taking vs not taking NMN, for instance, thru their lifespan is an epidemiological pipedream... about as reliable as the 'transient markers' you are poo-pooing - even less so,more likely, bc one subject's evolving biomarkers vs a notoriously poorly tracked/controlled epidemiological 'study' of a large cohort (hundreds/thousands(?) couldn't really divulge all that much anyway (too many factors, including genetics), to obtain reliable data. I'd put my money on comparing my baseline biomarker data to a subsequent reading 6 wks later after making ONE change, i.e., adding in NMN OR resveratrol - or whatever - without making any other lifestyle/diet/supplement/environmental changes. Of course, if one is adding in a couple supplements and/or changing up their exercise routine or diet - their 'transient markers' are useless...that goes without saying, I agree. Though an improved biomarker profile cannot say much about lifespan, anyway. Possibly comparing a bio-age test before & after adding in something like NMN would give a better reading on how it's affecting our own life/healthspan?

[@PinataOblongata]

@@barbarafairbanks4578 You are mixing up epidemiology with actual long-term controlled intervention studies. Epidemiology just looks at data from people who were living their lives as normal and tries to find a signal in that. There is no true intervention and control arm. Yes, it would be difficult to corral enough participants and have them follow their regime faithfully, but until that happens we simply can't make grand claims that can't be supported. I wouldn't discount a change in your average biomarkers over a longer period of time (which would iron out the contribution of other variables), but in a week or so and as we agreed, adding in other variables muddying the waters, not useful.

[@barbarafairbanks4578]

@Pinata Oblongata IIRC (w/o re- reading what I wrote previously), I never suggested adding in another factor in whatever timespan you've mentioned... a week?/a week or 2? (If this is what you're referring to as per what we 'agreed on',, i.e. a longer timespan, I'm unsure why you are mentioning again. Perhaps your re-agreeing, with this concept (of control). Can you please provide an example of the type of long-term 'controlled' study of a large demographic, traversing lifespan(s), (that I appear to have confused with epidemiological studies?)

[@gloria6396]

ITS REMARKABLE HOW DR SINCLAIR HAS STAYED SO POSITIVE AFTER ALL HE HAS GONE THROUGH TO ME THIS IS ONE OF HIS MOST HELPFUL MESSAGE

[@Rr17user]

What did he go through?

[@ElChuntyCabra]

He went through your mom

[@MakinItHappenn]

What did he go through bro?

[@QueenBeeDigital]

Regarding PRP, this is a very lovely treatment that can be done to rejuvenate the face as well, specifically when mixed with bio-stimulators like Sculptra aka Plasmasculpt ( shoutout to Dr. Rajani-also here on KZbin). But PRF is even better for hair, skin, and bodily rejuvenation. It’s also used in Dental surgeries. The Platelet rich Fibrin has a lot more growth factors and the results are so much better. I’ve had them both done locally. To get the Fibrin you simply spin the blood slower and for a shorter amount of time at the right angle. You then inject the fluid before it fully clots. Once you have a clot you can spread it across the face/scalp and micro needle it in. These treatments are A-MAZING for rejuvenation.

[@helenmcintosh9747]

hi Dr Sinclair been watching from Australia you have saved my life i could not walk i had so much damage to my bones i take Metformin i have some respertol i do everything intermitten fasting eat vegan now. i now am now so much fitter my specialist was amazed i needed double hip replacement in 6mths i dont need operation anymore i am back riding pushbike i am 66yrs i feel like 40s thank you so much x

[@ptyh27]

Dr. Sinclair looks really young for someone who is 52! I was watching his interview with Lewis Howes and it was really inspiring! I feel like it's something to do with our hormone change that age us as we get older

[@kellysober9352]

I have been following David’s work for about 2 yrs now. Thank you for addressing women. You do have women listening. It does seem like women get left out of the coversation, out of research and their health issues (like autoimmunity) don’t get money and attention. It does feel like wr are second class honestly.

[@jjbenjamin8488]

There is mountains of research on literally every aspect of the female body, what are you talking about? On this very app there are COUNTLESS channels dedicated to womens health. Get real

[@traceyleigh1111]

I love this podcast. I am almost 53 but feel 33. And apparently look more like 43. Vegetarian, yoga and meditation has been good so far but this is amazing information. I was a late parent. To know I have to power to live long enough to see grand kids grow up is amazing. Thank you both for all that you do. 🙏 And I love the humour. 🖖 😆 Aussie Gratitude being sent your way 🇭🇲

[@tealatata]

Wait till you hit 60 and your hormones are gone

[@mollypitcher9380]

@@tealatata true!!!

[@joeblow1748]

Im 38 and mentaly feel like 90 😄

[@gp246]

Do you intermitant fast?

[@traceyleigh1111]

@@gp246 yes :)

[@katherandefy]

David and Matthew are so generous with their time. Live long and prosper, guys. We’re listening and learning.

[@cluman1]

They are making money from this so it's not as altruistic as you may think.

[@addictedtochocolateandcoff9582]

@@cluman1 how are they making money?

[@MichaelVelvet]

Wish there was a “Love” button. I love this show and I love your work Dr. Sinclair. Much respect and love for this content.

[@LouiesLog]

You can send him your ear in the mail

[@beherenow8289]

@@LouiesLog David is on a vegetarian diet at the moment

[@oliviamiller8187]

NMN demonstrated multiple benefits such as fighting muscle degeneration in elderly men and women, aerobic capability, and increasing endurance. The results may vary from person to person. Personally, it has been my 3rd month of taking NMN by vitruvin, that's 500mg, and I love how it worked impressively. I wish many people would give a shot in taking NMN and start living a happy, balanced, and healthy life as they age!

[@rachelstark8002]

ouldn't agree more. NMN by Vitruvin so far caress more research, and it's proven to be assuredly effective unlike other popular brands coming out these days which actually do not make any difference.

[@slotjnke1]

Do you take a certain brand?

[@thatstheguy07]

David reminds me of that friend who got stoned for the very first time and when they talk they have this look/smirk on their face where they’re about to burst into laughter over absolutely nothing at any given moment 😄

[@QueenBeeDigital]

Yeah and then they start talking about condoms filled with walnuts 🤣🤣🤣

[@Plumpers]

Using my red/infrared laser light while I watch this on my head and face. It's really helped me with my brain fog left over from having COVID a year ago

[@01maggie]

I started taking AGR1 green drink... recommended by David S. It's a huge difference in recovery of covid...plus NMN and Transreservatol!!

[@Ghost-zy1oc]

Bad diet can cause brain fog. Proper human diet is worth to try

[@NicholasOdinson]

My new favorite podcast! Hope you keep it going after 8 episodes.

[@mcgragor1]

Cr. Brad Stanfield just posted another video saying Resveratrol does not work, I really think you should respond to this. Just reading the comments people are questioning Dr. Sinclair's integrity.

[@leadimentoobrien1221]

I am 58, no cavities, no fillings, my hair is very dark brown and lustrous, i don't and never had to dye my hair, my eyes are the age of a 30-40-year-old my doctor told me. I only have a few gray hairs, my fertility was high right up to 55! Not much for wrinkles. bones are good, skin is good, what I use is a face gadget that vibrates as it cleans. VIBRATION from what I read vibration is highly effective. The secret is I don't do cr*p to my body. no botox, none of that. Just grateful for what I got . As I am listening to this I had NO issues with menopause. My memory is sharp, I'm very active cuz I LIKE to be active. Perhaps because I'm IRISH I like to lift weights. That is a big tip. weight lifting. Bicycling works for me and going to the BEACH set me right. Bragg's Apple Cider Vinegar with Cinnamon is beneficial. OXALATES DID do something to my body. a while ago I made spinach, carrots, onion, celery soup with pasta elbows and used the water the veggies were cooked in for the soup broth. that I suspect created kidney stones. Unbeknownst to me especially spinach is high in OXALATES. Who knew eating right could do damage to your kidneys. please research OXALATES in your lab. With everyone drinking ALMOND MILK more people are going to damage their kidneys from drinking it. Almonds are high in oxalates. My skin pinch test went down in 2 sec. I use COCONUT CREAM for coffee etc.

[@incognitotorpedo42]

Oxalates are bad. Totally agree with you there. Too bad because baby spinach is so yummy, but it shouldn't be a staple. Anyway, you're lucky that you appear to have good genetics.

[@catherineblair550]

I love almond milk. But I was facing kidney issues also. It's the calcium they put in it. It's much to much. Make it yourself if you are going to drink it.

[@kittymurrah7400]

Dr Sinclair, I have been following you for about 3 years. Your knowledge is so impressive and hopeful. I have learned so much!!! Thank you

[@jadezee6316]

what did you learn from this video? or tell me one thing you are going to do because you learned it here.....something that wasnt known before

[@delphinekirkland1757]

My hand pinch test confirms my slow level of aging from using fasting protocols for 44 years with super-nutrition is effective. I'm 62 and my skin flexes back in one second! I've been very active and I really enjoy amazingly healthy diet. Genetics helps. I seldom tire and never get sick.

[@PandaA-cv3mm]

Thanks for this. My mom has used retin-a since she was about 25. She is over 70 now. No skin cancer or other crap…. Her skin rocks!Very incredible info. Lots of love ❤️

[@HeatherOdeh]

Agree. I have been using it 2-3 nights a week since mid 90's and although I am 57 I am often asked how I keep my skin so youthful. It is Retin A, Vitamin C and sunscreen. But I also eat well and exercise almost every day.

[@kimdorcy5150]

@@HeatherOdeh Yesssss! exactly!!!

[@jerumgamboa2717]

I have a son have a glaucoma on the left eye in his early age and when he turned 10yrs old and its affect the other eyes and i am still hopeful he can get back his sight with the science and technology today with expert same as you. I am seeing a light of the tunnel when i saw your podcast and i am hopeful you can help me Dr. David.

[@crazyfarmgirl606]

I am thankful for your podcast i am trying to soak up all the health and antiaging information i can. So that i can age well, both physically and mentally. I want to be an old person who can take care of themselves and have a full active life not requiring aid from others.

[@ferdinandgoglia3634]

I've never exercised in 50 years, and I've probably eaten less than 1kg of veggies in 4 decades. Started feeling a bit rough recently, so I am trying to improve my health starting this week, so wish me luck😁

[@EliasHossein799]

Great! Great! Great! Greatest Scientist David Sinclair . I really appreciate your kind help...

[@sonals2021]

I am glad that you mention women, quite important to note research where only men have been tested and how a particular drug or protocol may affect women.

[@crowdancer5]

Stopped at 43 minutes to make this statement....I am female at 78 years of age....they took my ovaries about 22 years ago and have been on HRT since....believe me, I have not noticed looking younger...(than what?) but when some doc thinks I am on too high a doseand tries to cut back on them, I go into a total tailspin....physically and menially......I must wonder however, any of the topicals you are speaking of, for someone my age seem silly....I am not hearing you speak of anything other than facial creams....skin is not just on face and neck and I doubt any of us are going to be spending the money on facial cream all over the body to make for healthier skin! I understand this is dealing with "looking younger" but a makeup artist can do that....cmon, give us elders something to really chew on! Nowhere in any of the discussions have I heard mentions of the fact that elders lose much of their ability to properly digest nutrients and thus the body not having the raw material to build healthy bodys...skin and all. The studies are nteresting but can we get down to the nitty gritty here and speak to those of us who are already what society calls old. You so often do speak of male...and in the age bracket of mid life....50s or so....lets reach the elders too! Both male and female!

[@crh251]

Are you on synthetic hormones or bioidentical hormones?

[@vickybiagini8623]

Hes got nothing, and now hes talking about skin cream. Before it was the Science is mindblowing.

[@crowdancer5]

@@crh251 bio

[@crowdancer5]

I have to pay for them myself...insurances or medicare wont.......so many doctors wont and dont know how to prescribe them so it also costs for me to find someone who can and will. I wont be without them tho!

[@ela7145367030]

A Beverly Hills dermatologist said the cheapest and most effective skin lotion is olive oil. The dirtier the more nutrients. The skin absorbs small amount in 15 or so minutes. Wipe off the excess. Repeat after after showers or before bed. Sinclair is mostly talking about the biological science.

[@frenchmontana423]

okay great podcast and thanks for it. however it sucks that you guys never really got into exact detail of what you should and shouldn't eat / do for hair and skin? do we workout more? so we fast? do we go in saunas? do we take cold showers? and good too, do we eat or more greens? more eggs / biotin? do we eat less carbs and sugar? wish we got those answers.

[@courtneyderouen]

Agreed. That’s why I also watch Dr Eric Berg and also Dr Mandel here on YT.

[@Theodora937]

he has episodes on this

[@frenchmontana423]

@@Theodora937 which? which episodes?

[@catsteinhilb2880]

Thank you!! For finally addressing women’s hormones, particularly Menopause!!!

[@EMB-tl6mi]

Thank you for addressing this for women. I'm in estrogen, testosterone and progesterone and I feel great, lost some body fat and my mood improved drastically; but this is something my MD or OBGYN don't want to treat. I'm doing it outside my network and it's very expensive.

[@Alykat736]

I’m just curious your age? My in-laws do all 3 hormones too and started it in there 70’s

[@EMB-tl6mi]

@@Alykat736 I'm 49, I had a hysterectomy, I should've started earlier.

[@Adhara740]

I’m so glad you took the initiative to get the care you should be entitled to!

[@Adhara740]

@@Alykat736 there is a 10 year window post menopause to introduce estrogen into your body again. Anything past that doesn’t benefit any longer it’s been too long.

[@LisaAnne107]

@@Adhara740 I heard Dr. Taylor (Menopause Taylor on KZbin) discuss the 10 year window in a recent video and she said that in some cases women can begin estrogen replacement more than 10 years after menopause. Beginning estrogen replacement is dependent on how healthy a woman is, not just length of time since menopause.

[@Goatcheesemightyfine]

Thank you for addressing the role of female hormones on aging.

[@audreyboyle52]

Pretty inadequate actually

[@hamirmahal]

To clarify, at 52:32, the quantity 9.8 to 15.8 nanomoles per liter is the optimal level for testosterone, and not dihydrotestosterone (DHT), correct? The study linked in the description says, "Testosterone (T) levels decline with age and lower T has been associated with increased mortality in aging men. However, the associations of its metabolites, dihydrotestosterone (DHT) and estradiol (E2), with mortality are poorly defined." The only reference to "9.8 to 15.8" on the page says, "Instead, an optimal range of circulating total T corresponding to a range of 9.8 to 15.8 nmol/L (282-455 ng/dL) exists for older men, which predicts survival independent of other risk factors."

[@rebeccacrawford602]

I would love to know what kind of products Dr. Sinclair personally uses on his skin. And I was really hoping cellulite was going to be addressed in this episode.

[@KE-zo4zy]

He looks his age. He appears to be heavily botoxed including the crows feet, and hair looks dyed. Being thin helps. But Being an aging researcher, he doesn’t look any younger than the males you see walking around Los Angeles.

[@jjbenjamin8488]

Why would cellulite be addressed? That’s not aging, that’s excess adipose tissue. Just gotta lose it.

[@arbo3495]

@@KE-zo4zy he's 52, I'd say he looks 40.

[@KE-zo4zy]

@@arbo3495 maybe where you live. But in LA 40yr old men look late 20s to early 30s. This researcher looks his age, clearly in his 50s. It’s not a mystery how so many people in LA look young. Many in LA takes their looks seriously & maintain a youthful appearance by exercise, eating healthy, cut out alcohol and sugar, limit sun exposure, use medical grade & Rx skincare e.g., tretinoin, maintain frequent light cosmetic procedures (botox/dysport, skin peels, gentle lasers, RF skin tightening at gentle settings not to melt fat, PRF injections, etc.) Maintaining a youthful appearance is not difficult if you do the proper things.

[@chrisbusby4395]

@@KE-zo4zy yes hair dyed which fine but in his book he said he had no grey hair and that is untrue

[@the_notorious_bas]

Nice conversation! As for Finasteride, from what I understand, is that Dutasteride is even more effective. I quote: "The main difference between finasteride and dutasteride is that finasteride is selective for type II 5AR while dutasteride inhibits both type I and type II. Dutasteride not only blocks both types of receptors but also does so much more effectively. This may be a result of the much longer half-life of dutasteride compared to finasteride (~4 weeks vs. 6-8 hours respectively). Dutasteride has been shown to be 3 times more potent than finasteride at inhibiting type II 5AR and more than 100 times at inhibiting type I 5AR. Furthermore, oral dutasteride decreases serum DHT concentrations by up to 90% while finasteride only reduces DHT by 70%."

[@commonomics]

PLEASE do an episode on fertility for both men and women. I’m suffering from recurrent miscarriages and I would love to have some literature interpreted into layman’s terms.

[@marlenegold280]

Even having suboptimal thyroid function affects fertility and risk of miscarriage. High insulin resistance can too. Weight that is too low or too high affects fertility; ‘weight’ as in body fat composition, not just weight in a scale.

[@JeffCaplan313]

Eat more folate-containing foods (not folic acid).

[@janetstauffer9138]

So sorry to hear that. There are probably better people for infertility issues. I hope you find them. 😢💙

[@artamige]

Hi, I'm wondering do you eat dairy?

[@duckslave]

I’ve emailed pictures to David at his Harvard lab of the re-birth of hair on my formerly mostly-bald head - and it’s dark, not gray hair. This rather amazing phenomenon occurred within two months of taking the same supplements as David, and has only become more evident over time. At age 75 (Epigenetic age via Horvath clock is 60), having my hair back is a great thrill! I’m surprised you didn’t discuss this sort of thing since the color-changing and re-growth was observed in the Stanford thymus regeneration trial using growth hormone, DHEA and Metformin. Keep up the great work!!

[@duckslave]

@@AnotherMountainWmn just watch David’s podcast - NMN, Resveratrol, quercetin, Fisetin, Metformin and EVOO. Always check with your doctor!

[@boblully5053]

Lies

[@duckslave]

@@boblully5053 Pictures don’t lie.

[@boblully5053]

@@duckslave show pics

[@duckslave]

@@boblully5053 - how?

[@cailllou25]

I've been using tretinoin daily for the last 20 years, since I was in my early 30s. I'm 50 now and my skin looks better than it looked when I started it. I don't see any side effect or accelerate aging, at least not yet.

[@Fhajdhebsnsjdjhd]

Im been using athletic greens for a number of years now

[@rizla8602]

Is this you on profile picture?

[@Fritz.program]

@@Fhajdhebsnsjdjhd 😂🤣

[@TheFracturedfuture]

Your skin does look great.

[@cailllou25]

@@hhjhj393 It's not only about look, it's about being healthy as well. Skin is our largest organ.

[@ashleywessel780]

Your personalities compliment and play off each other very nicely. Great conversation and info, thank you guys

[@ableinternational3611]

As always packed with great info. Questions: 1. Are the topical cream such as Rogain and Retinol for men only or both? 2. About Hyaluronic Acid, is it effective to take it pill firms? 3. Couldn't find topical nicotinamide, but found nicotinic acid. The internet says nicotinic acid is niacin. Is it true? They do have topical nicotinamide? Which one is more effective? 4. Will it be helpful to take keratin pill for hair, nail and skin? Sorry for so many questions

[@reverseaging5387]

Thanks!

[@kimdorcy5150]

I think the right timing for HRT is key. I am 45 but have been on HRT for about a year. The results I have experienced are lowered blood pressure , change in appetite and food cravings to where I dont crave sugary snacks and imnot hungry through the day if I eat healthy meals. ThT said I have changed the way I eat and excluded manufactured oils fast food , and cut as much added sugar as possible. I've increased intake of whole foods and I never was one to eat fast food so that was easy. I cut out sodas years ago. If the outside is a reflection of the inside then things are going in the right direction. I also use oneskin daily with sunscreen. 365 days a year I use sunscreen. My dad has had skin cancer removed 2 times. he grew up in a time where they just didn't wear sunscreen like we do now.

[@rumnas185]

This is my favorite channel on KZbin. I’m so thankful for your videos!

[@meta4kl237]

At 29:18 he says he tried the product one time that was sent to him and "it seemed to work". WTF!!! You can't tell if a product for skin care is effective after 1 use.

[@KenzXYZ]

as for hair loss and perhaps greying hair I have a theory that not washing them too often helps. also avoiding the BS shampoos. also avoiding hot water and hot air hair dryer

[@davkaaltan]

What was the pill for grey hair and hair growth ? Was it called AV3 pill or?

[@kat-ij4po]

I’ve just discovered this channel and Dr. Sinclair- he is fantastic. As a woman about the same age as David, this episode is of intense interest to me, but it covers a LOT of ground in a very short span and I’m hoping there are subsequent podcasts that go into a lot more detail. Not sure what is being recommended here in terms of hormone replacement for post menopausal women and confused as to other actionable takeaways. Hoping they slow all of this down and elaborate in subsequent podcasts that I just haven’t listened to yet! From prior podcasts I’m really clear that NMM, Resveratrol, Quercetin are great to take in the morning with a bit of fat - I’m on it!

[@janetbederman3924]

When you are healthy, you look good. They go together

[@LTPottenger]

I do lots of red light/near infrared. Great for skin and also joints and wounds.

[@Nando_lifts2021]

Where do you purchase your red bulbs? Do the have to be infrared?

[@LTPottenger]

@@Nando_lifts2021 The infrared ones do the same job but penetrate further. It's best to get a bit of each. I get combo LED bulbs from amazon, they are cheap and powerful.

[@ca9878]

I'm glad they talk about menopause! So many women are going through this and all it's bad vicious side effect.

[@DocJaeBass]

Another hugely exciting podcast. I've turned off my movie channels and am rewatching this entire series and taking notes for my evening entertainment and education.Thank you.

[@Greg-su8nu]

Just recently learned about NMN plus other things. Am now almost 2 weeks into using NMN, TMG, Resveratrol, DHEA plus a few other things. Am 58, almost 59. I smoked tobacco for 45 years. Am overweight and have diverticulitis. I've been vaping instead of smoking tobacco for the last 7 years. Now, 2 weeks into supplements am going to try 2 rounds of P90X. The TMG seems to have cleared brain fog but that might also be combined with NMN. Anxious to see what this body can do over the next 180 days. Am 5'10", 224lbs. Was in pretty good shape 7 years ago. I did P90X,5 times and P90X+ once. After that I was diagnosed with Diverticulitis and haven't been able to do routine normally since. So went from 180 to 225. Anxious to see what I can do with these supplements. Exciting. Thanks for sharing all this info. Look forward to a better tomorrow.

[@Mexicobeanpole]

Great video. Thank you so much. The thing I find confusing is the idea that thin and smaller people live longer. But, I’ve had both my Primary doctor and my Gyno tell me at 60, that I was getting too thin, and to “be careful”. They said that if you get really sick, being too thin can be bad, because your body has no fat stores to draw from, and also the increase of osteoporosis in older thin women. I’m 60, and thin, but not underweight thin.

[@michelles2299]

Because of bone density concerns if you get osteoporosis and break a hip it will shorten your life

[@miradohnal5112]

that's why the hormonal therapy can be greatly beneficial specially (and not just for thin skinny) for thin people to reduce osteoporosis risk and heart diseases. Something to look at even if you are 60years old.

[@loridouglas5576]

Why is it always ‘suffering’ through menopause? As someone who’s ‘survived’ I would suggest that it can be seen as a natural transition and a part of graceful aging.

[@crh251]

Lori, I think some women truly do suffer. 20% of women breeze right through it. Their periods just stop. My mom was one of them. 60% of women have moderate issues, and the other 20% have their worlds turned upside down. They suffer horribly with anxiety, etc. They can be suicidal. Fortunately, I was one of the 60% of women. I did suffer from broken sleep, hot flashes, night sweats, heart palpitations, weight gain, night sweats, etc. for nine years. I’m post menopausal now and am glad most of it is behind me.

[@marlenegold280]

@@crh251 How long until those symptoms you mentioned subside? Later were you able to lose the weight you gained?

[@SuzanneU]

It sounds as if you were lucky. I got chronic migraine that requires emergency treatment over and over. The headaches were so severe that I had to stop working. The hot flashes were incessant - my clothes and hair stuck to me all the time. I had to wash myself down and change my clothes several times a day. The night sweats were so intense that my husband thought I was wetting the bed. Brain fog and mood swings made my life even more unpleasant. I suffered - there was nothing graceful about this. After nearly two years, including eight months in a chronic pain clinic, I raised a ruckus and demanded a female gynaecologist. She prescribed bioidentical estradiol and within two months the migraine and hot flashes were under control. I went back to school, earned two degrees, and now work in a job I love. Don't patronize and belittle women who genuinely suffer through menopause.

[@TheblondJane25]

Love David Sinclair explanation, the facts, his voice and appearance!

[@peterschmid9878]

He's had work done, you understand. Right?

[@bt9124]

The other chap's voice by contrast, grates rather. And that cap needs a string of onions, a French accent, a bicycle and a little handbag dog.

[@donahileti9282]

Thank you for your very interesting podcasts. I was delighted to hear that this episode will be on HRT and womens ageing. Sadly male boldness took central stage. Please please please present an episode dedicated to menopause. Most doctors are not trained in menopause and the whole world acts as though it does not exist…

[@ybigirl]

YES! There is next to no info on female BHRT which includes testosterone. Given the beautification effects of testosterone for both men and women, I was surprised to see this topic completely glossed over. :(

[@bt9124]

Menopause is Not Sexy and yet if the fact that it is also Great News is talked up, maybe it'd get more interest? I am SO glad that those mood-toppling hormones are finito.

[@bt9124]

@@LouiesLog Mine has never been without her hot flushes? She rather likes them. Brrrr-rr

[@ybigirl]

@@bt9124 For me peri-menopause was a nightmare. I went in search of a solution, being initially wary of HRT. But reading medical papers and evidence that BHRT provides benefits with respect to immune function, tissue strength, and not to mention brain health sent me in search of a CYCLIC hormone provider. (IMHO, those giving women static dosages are doing them a disservice, if not weakening the hormones' abilities to function as the body intended.) But, that doesn't mean it hasn't been challenging to figure out what is correct FOR ME. I agree with Dr. Sinclair that women (in their 25th year, or so) should have their hormones tested daily for a month. This would provide a detailed view as to appropriate dosing after the age of 35. I am one of those with the opinion that many issues of aging in women may be managed with earlier progesterone treatment, especially with respect to sleep cycles, tissue repair, and (moods) brain function.

[@HuyLe-up3mx]

@@ybigirl agreed. Check for progesterone deficiency in early 30s

[@jeffreymckenzie3961]

Could listen to these guys all day

[@mr.roni0570]

Wow. It's becoming one of my favorite podcast series. I'm not gonna miss anyone. Keep up the good work and keep up educating us. Take love.

[@fionmor4893]

I'm wondering if DMSO could push the HA into the skin for a better result instead of injecting?... for those who don't know.....DMSO is Dimethyl sulfoxide is an organosulfur compound with the formula₂SO. This colorless liquid is an important polar aprotic solvent that dissolves both polar and nonpolar compounds and is miscible in a wide range of organic solvents as well as water. It has a relatively high boiling point.

[@aaliyahlee1265]

Thanks to Dr. Sinclair. I've always loved his videos. It's through him I learned about the benefits that NMN provides. Because with age comes with health issues. When you reach about 60, you often need major medical attention. But ever since I'm taking the vitruvin NMN supplement, it changed my life and the way I live everyday!

[@annewilliams9279]

Now I don't worry much about getting old and reach 60s and beyond, as we finally have supplements to depend on. I'm 45 and taking vitruvin NMN for almost a year now. I am grateful that I've known this at the early age, so getting 50s and beyond will not be a problem to me :)

[@aaliyahlee1265]

@@annewilliams9279 really good for you!

[@meloniedodaro2030]

Fantastic episode. I’m going to watch all of the others you have here on your channel. Question: Have you stopped posting new episodes or will you be sharing more again in the future? Thank you!

[@inhocsignovinces8061]

Laser skin resurfacing, which wasn't mentioned, seems to be one of the best current anti-aging treatments out there, working both through hormesis (skin regrowth) and literally wiping out the below the surface senescent skin cells and cross-links (advanced glycation end products).

[@dollyproductions1]

Yes. i had this and it took 10 years off my face

[@barbarafairbanks4578]

In Hoc Signi Vinces - yes, I agree - found this 'anti-aging cosmetics' podcast to be sloppily presented with so many anti-aging procedures completely omitted, as to be laughable. Well-versed anti-aging YT Beauty Influencers are SO much more informative than this disappointing podcast :/

[@BadMannerKorea]

Depending on the treatment, it can damage fat. Which is a huge problem because as you get older fat naturally decreases around the eyes and other parts of your face. It’s really important to find somebody who knows what they’re doing and to get a less invasive laser, depending on your needs.

[@moniquecobb9051]

I’m 49! No one ever believes me & took this photo 6 mos ago w no filter. I use The Body Shop Vitamin C moisturizer day and night. I also use $9.00 Collagen cream from Walmart. Works wonders!!! Good luck.💋

[@taismonteiro374]

Best podcast so far! Thank you so much, Dr. David Sinclair!

[@gloria6396]

THE 2 OF U TOGETHER R WONDERFUL FOR ME 2 UNDERSTAND I WISH THIS WOULD GO LONGER THAN 8 PODCASTS

[@moontiggsland]

Thank you for mentioning microneedling. I work with a similar technique with tattooing equipment to restructure scar tissue. The pain really depends on the area, depth and in women sometimes depending on what part of their menstrual circle they're at their pain threshold.

[@sfudge]

The menstrual pain threshold is no joke. I practice martial arts and find my pain threshold and cold tolerance absolutely plummets for a few days each month. Things that I normally don't even perceive as pain suddenly feel like catastrophic injuries 😂

[@sonnyecho9195]

What is the name of that process Ginny? Is there a yt channel that discusses this technique?

[@pontevedra660]

aaaahhh Doc, you are so sweetly great in your advertisements..... I trust you with my life, as you have led me, inspired me, through so many hurdles in my life.

[@RunToTheHills999]

Live long and prosper

[@juliak2591]

I enjoyed this talk very much. Dr. Sinclair is clear and thorough. The interviewer is excellent as well. I had all my questions answered. Thank you!

[@crh251]

As a woman, I started looking into bioidenticals as a preventative measure once I went through menopause. My blood pressure had elevated, but the hormones brought it back down again. Supposedly one out of two women in post menopause have a heart attack. That’s a scary statistic.

[@audreyboyle52]

Yes we could do with an entire podcast on female HRT

[@SuzanneU]

HRT gave me a life! both the chronic migraine and incessant hot flashes were under control in a couple of weeks. I was able to go back to school and earn two degrees instead of spending most of my days i'm a dark room, doped to the eyeballs.

[@MattMick]

Bit of a contradiction here with alcohol and an earlier episode about red wine and resveritrol. Didn’t David previously say he enjoys a glass of red wine but he’s saying here he’s given up alcohol? Some clarification please?

[@cecipalacios1007]

As always a great conversation! Since I do not use gloves when I am around my kitchen I thought that doing the skin fold on my hands would not be a good indicator so I did it on my foot and the difference is day and night. This considering that Skin’s thickness is so much alike..

[@ektamarya]

Can you please do an episode on eye aging, foods to eat, this is getting more important with everyone spending more time on screens and also with indoors and cold weather facing dry eyes.

[@shaynadavidovhansonrealtor]

They say Astaxanthine is really good for eye health.. as well as Lutein.

[@lisengel2498]

Interesting talk - I am 78 - and for some time I started eating 90 % whole food plants with Greens, beans, onions, mushrooms, nuts, seeds, berries and what I have observed is that my nails are getting stronger and that they grow faster 😊🍀💚🎶

[@barbarafairbanks4578]

Lis Engel...you are fortunate. Some of us don't have time to watch our nails grow🤣

[@setme4ree]

What kind of beans and mushrooms

[@lukekennedy2410]

Cut out the beans and its perfect....unless your pressure cooking the lectins out of the beans your doomed contrary to how they make you feel

[@g.e.boroush5176]

@@lukekennedy2410 Cooking destroys/removes the lectins. In order to eat beans they must be thoroughly cooked. One cannot eat raw uncooked beans as they are hard as rocks. Once the beans are at a point they can be chewed and swallowed, the lectins are long gone. Moot point.

[@lisengel2498]

HahA I Think it takes a bit of Body awareness - to know whether your hair and nails are strong and grow fast and healthy 😊💜

[@jewelleryaddict]

Thank you for including help for specifics on women's aging. So hard to find relevant info on it usually we are passed by as most studies in past did not include women because of our "difficult" hormones as we are usually told. Even if that's the problem women have more chronic illnesses and take most of the drugs made leaving us to play Russian roulette with whatever drugs we are given hoping they will work the same in us as a man. So bravo for including women's specific problems in you talks.

[@julius1972100]

New Subscriber from the Philippines🇵🇭🇵🇭🇵🇭🇵🇭 Thank you fir your informative and free knowledge you are sharing to mankind. More power to your channel

[@KirstiCheetahh]

I love my menopause, no symptoms, does not feel like aging! I love having no more periods! I think I live it well because I was looking forward to it, positivity is powerful. Keto, IF and sports help too. Vitamin D3 and K2 and sports help to avoid osteoporosis and CVD. No need for unnatural hormone replacement therapies!

[@GhostSal]

I’d recommend staying away from those heat treatments for maintaining facial collagen, after I did 3 treatments I noticed looking much older, not younger. It was a huge mistake, I looked a lot better before the treatments. Everyone used to think I was in my 30s and after only 3 treatments everyone added 15 years to their guesses.Needless to say I’m really depressed over this and don’t know how I can reverse the damage. Any advice?

[@asiaisreal7302]

What is making your skin look aged?

[@GhostSal]

@@asiaisreal7302 I’m pretty sure it was called thermalift skin fighting. It didn’t promote collagen, it actually destroyed it. I noticed things like volume loss and asymmetrical loss at that (probably due to where the heat was concentrated versus where it wasn’t applied as much). Due to the thinning more wrinkles than before (actually I hadn’t even noticed wrinkles before treatment and dermatologist would say before the same thing to me that I didn’t have any)

[@catherineblair550]

@@GhostSal ah yes. The person that did you did places they should not have. They didn't know what they were doing. Consider a fat transfer procedure. A good place to go is Cos Med in TJ.

[@GhostSal]

@@catherineblair550 Thanks for the recommendation, fat transfer is an art form though, you really need someone that has an artistic touch and the right medical knowledge. Are there any specific doctors you’d recommend?

[@teddyli4763]

Thank you to athletic greens for sponsoring this

[@adbc8737]

You are helping so many people improve their health! Thank You! 🌀💚🌀

[@Vidyut_Gore]

I'm a smoker approaching 50 and my skin snapped back instantly in the skin pinch test. I was quite pleased. I honestly hadn't expected it to. I don't inhale but am a pretty heavy smoker so I was sure I've wrecked it pretty bad. Seems my skin wants to help me. Now to quit smoking and help it I guess.

[@nina-xw6ku]

Thank you for address menopause.....would love a dedicated video on this topic from your perspective.

[@tappersuzie]

no need to apologize for speaking on a subject for which you do not share the body part. An orthopedic surgeon does not have to break his/her own bones to know how to fix someone else's broken bones .... you guys are doing great - much appreciation.

[@lunagsd4771]

Until women’s fertility can be extended and preserved, we have not truly reached reversing or suppressing aging. What is more youthful and a sign of age than fertility.

[@gregoryoch6163]

Yes, are there studies or anything being worked on now, showing how that can be extended with the new approaches? @davidsinclairpodcast

[@katewilson5269]

For the last few months, I've been taking one tablet each day of NMN-Vitruvin Health supplement. I'm astounded to discover that my metabolism now functions as well as it did when I was a younger. Other outcomes aren't nearly as visible yet, but I saw a significant boost in energy and concentration. I'm going to order another few rounds from their website. It took around just 3-4 days to see a difference.

[@cristinalusardi2857]

PUEDES PONER TAMBIÉN SUBTÍTULOS EN ESPAÑOL, PARA MILES DE HISPANOS QUE QUIEREN ENTENDER TODO LO QUE DICES.

[@djane1130]

Sunscreen is promoted for skin health yet I hear so much about oxybenzene I believe it’s called, being the main ingredient of most sunscreens. This ingredient is an endocrine disrupter and cancer causing agent according to many research studies. One study found traces of this chemical in the a test subject 7 days after it was applied. I wonder if David Sinclair or colleagues have information on this?

[@Chris-ni2pc]

I was wondering for a while why some of my greys returned back to its regular colour, the explaination of it being stress induced and environmental makes a lot of sense

[@strahinjamacesic3974]

Could you elaborate a bit please? :)

[@Chris-ni2pc]

@@strahinjamacesic3974 watching the video is your best bet

[@strahinjamacesic3974]

@@Chris-ni2pc did already :) Just wanted to hear about your personal story about how you coped with stress and how it managed to.reverse your gray hair. :) Thanks anyway.

[@Chris-ni2pc]

​@@strahinjamacesic3974 Right, sorry i didn't understand your questioning :) Doing the free Wim hof youtube video kinda helped me where im at today. I usually do it in the morning and helps prep for the day ahead. Going to the gym is a big stress reliever as my job is pretty annoying saying that though my biggest stressor at the moment is money and I'm trying to fix that by replacing my job with making money online so i can FIRE (financially independent retire early). Ideally in terms of cardio i prefer to do low intensity and trying to achieve minimum 10,000 steps, i would like to get 20,000 but not enough time in my day. I also do HIIT 2 or 3 times a week on air bike. I think quitting video games is another reason as it helped free up time and can be pretty toxic. Finding time to laugh as well seems pretty important to me as well, but now I'm rambling... hope this helps 😆

[@strahinjamacesic3974]

@@Chris-ni2pc thanks Chris for the extensive answer. :) Loving the FIRE concept :D I am doing 16/8 fasting, and trying to get on with doing Wim Hoff showers just I hate the cold so much :D But doing my best. :) Thanks again for answering. :)

[@dietzyfly]

0 seconds ago I have been looking at the "longevity community" for any answers on menopause. This is the closest I've heard yet--and it wasn't very illuminating. Menopause is taken so lightly, even joked about, in our culture. I could barely go to work because I couldn't sleep....I was an emotional wreck, no energy to work out, I thought I was losing my mind. It infuriates me that half the world has to suffer through hell.....very little studies are ever performed on women's health. I've been on HRT for a year now and it has saved my life.

[@catherineblair550]

People in vegetarian countries suffer less menopause. Google it. I am vegan and I had zero symptoms. But it's not just ANY vegan diet, it's a low fat low oil vegan diet. And the addition of soy in the form of tempeh.

[@amperage8032]

I had the same experience and saw drastic changes without my hormones. I am extremely healthy but couldn’t overcome the deficit. I tried for the better part of a decade. However not all women suffer like this so sometimes I think that’s why the subject matter is not given enough attention. There is a lot of misinformation too, and not everyone is up to date on current research or wants to be. There can be strong opinions on this topic. It’s really not his area to specialize in so that could explain the shortened segment.

[@jpintero6330]

Melissa55 here on KZbin has used Retin A everyday for 38 years. She looks about 40 and it hasn't hurt her one bit.

[@irandiaz2895]

I always look forward to listening to his content. I would love to work with David Sinclair one day.

[@dorothytaylor-dasilva7329]

Never heard of a skin pinch taking so long. At 67, mine is still less than 2 secs. Used this to assess hygration/dehydration.

[@barbarafairbanks4578]

Dorothy Taylor-Dasilva - Nice brag, but it all depends on the position of the hand. Easy to fake a fast skin pinch recovery (or fool yourself), if the hand is not completely relaxed, lying flat against a flat surface, fingers outstretched. Just sayin...

[@Mexicobeanpole]

Me too Dorothy. I’m 60, and it’s definitely less than 2 seconds. My husband said he thought it was less than 1 second. But, I’ll assess again in a few years. I drink nothing but one coffee in the morning, and then water all day consistently.. Maybe that’s why?

[@barbarafairbanks4578]

@@Mexicobeanpole If you're in your 60s and you really believe your skin pinch recovery time is 2s... but wait! no, it's actually 1 second ? You 1) Aren't doing the test correctly, and/or... 2) you are deluded. Even a very young person's skin pinch won't snap back in 1 sec. The idea you have a 1sec skin pinch recovery @60 YO because you believe its because you only have 1C coffee/per day (are you aware that science recommends @ least 2c/day for better antioxidant & brain health?)... and that you drink water consistently every day - is even more delusional.

[@markpettus6929]

Don't look into the centrifuge with long hair! It will definitely be messy. Great , as always. Near infrared light and red light with well established photobiomodulation mechanisms with respect to skin-system health. e.g. type 4 collagen production, protection from UVB exposure, 4th phase of water bioenergetics, mito function (via cyt-C-oxidase up-regulation. and other pathways), etc. Skin, as the largest organ, with the greatest surface area, is best suited as a complex "photo-receptor", translating the EM-biophotonic environmental conditions to the biologic systems they protect. Grateful thanks for your sharing so generously.