Dr. David Anderson: The Biology of Aggression, Mating, & Arousal | Huberman Lab Podcast #89

[@babetteshine1656]

I just want to say that I have been sober for 1.5 years now and I have been listening to your Monday podcasts for 1.5 years. You have played a huge part in my recovery. I have a whole set of coping mechanisms thanks to you that I don't think I would have tried if it wasn't for how well they are explained on the Huberman Lab Podcasts. Thank You!!!!

[@shwetaaaaaaaaaaaa]

Kudos 👍🏻🍒 Wish you all the luck for your amazing recovery ✨😊

[@samtahmassebi5588]

Congrats! Enjoy the path! :)

[@terallweideman7672]

Thats incredible

[@dshizznitrb3]

8 days in and im losing my mind. picking fights in NA meetings. starting fights with everyone close to me

[@5857Farm]

@@dshizznitrb3 Remember that's part of it and normal. Now you just have to harness your aggression and be disciplined. Take it and direct it. Best of luck to you in your sobriety and new life!

[@tiagobarbosa5324]

It would be interesting a podcast about social pain, loneliness, and fear of loneliness and ways to cope (not limited to social prescribing), I have a disability and feel overwhelmed by these things

[@chikacherrycola9189]

I truly understand🧡💜🧡

[@flamingaish]

+1

[@El_Capitano_O]

Actually it's a new trend with the emerging technologies behaviors. New young Generations in big cities are feeling more lonely than ever. It's also an interesting topic before we move to the Metaverse

[@victorsavkov8363]

John Vervaeke's course Awakening from the Meaning Crisis might be a place to look at.

[@MorawskiGRK]

@@El_Capitano_O Lol "move to the Metaverse"

[@hankalorinczova]

*Dear Dr Andrew Huberman!* I really hope that you will create these great video podcasts as long as possible! It will be amazing and fascinating to watch even your 100th, 1 000th, 10 000th podcast and even much more beyond. Such a genius and tremendous amount of videos, knowledge, intellect, genius, wisdom, information...

[@marasteinhour6443]

Agree ! we need this as there is to much false information out there!

[@michaelmarini8044]

@@marasteinhour6443 zz

[@everyonesalama4447]

Agree, this is revolutionary

[@marasteinhour6443]

Yesssss!!!!!!

[@joannevanegmond592]

I get up early (2:30am) five days a week to drive to work, and I listen to you and your guests while I drive. I have listened and watched you from the beginning of your KZbin page started and I have to say you and your guests have expanded my brain. I understand so much more about who we are and why we do what we do. And how to help my mind and body function at a higher level than before. I’m 47 and feel younger than I have ever felt same with my husband! Thank you so much for sharing your love of science and the desire to share it for us all Andrew!

[@CeceKruchkoSmith]

OMG 😭 I've been following you for years - first on Instagram. Every new podcast is 'exactly what the Doc ordered'. In sinc with my life ❤️ When my daughter was diagnosed with stage 4 cancer - out came podcasts about how to deal with pain. A few months later I was diagnosed with cancer. Now I take estrogen suppressant wondering why? Now your guest is talking about it! I don't believe in a one all-knowing God but by golly, there is some force looking after all of us working hard to better our lives and the lives of others. Thank you Doctor. You earn your title well. Forever grateful for you and the folks that raised you.

[@ironmaven1760]

very well said...I hope you and your daughter are doing well under the circumstances. Last year I lost my mom to cancer. I immediately went back into therapy head first. I knew I needed it desperately. These podcasts of Dr. Hubermans, yes they are life savers foe me. Thank you Doc..you are well loved and needed!!💘💘

[@adrianramirez6705]

I’m perplexed how you always seem to find a way to communicate such complicated ideas such effectively, as well as navigating the conversation to make it as clear as possible. I appreciate you and your work so much. Thank you!

[@wendymorison2994]

Just want to echo this expression of gratitude because I think there is a deficit of acknowledgment and encouragement for continuing meaningful work. Your podcast is genuinely life changing. It is quite incredible that we are given access to cutting edge science in such an accessible way, both intellectually and materially. I found Dr Anderson to be one of your most eloquent speakers. He must be an incredible teacher and I look forward to reading his book. I hope you will have the capacity to continue investing the time and energy this podcast requires. As Dr Anderson said, your questions and observations were totally on point enabling more to be shared in a short period of time.

[@auroraborealis13579]

RESEARCH 😂

[@ryancxe]

Thank you Dr. Huberman for what you do everyday 🤍

[@daedra40]

The Four F's = Freezing, Feeding, Fighting, and Mating. I see what you did there Doctor 😉

[@sm-os5fq]

F**k may b

[@daedra40]

@@sm-os5fq I think you're seeing it too 🤣

[@jibbyfrantz6818]

Heard that too and I was like oooooo he’s good!

[@daedra40]

@@jibbyfrantz6818 🤣🤣 He is certainly is! Smooth 😜

[@wyrdler]

And then the way he says “What the FUnction…”

[@williamlocklier4302]

Notes: Discussion centered - not many tools or protocols discussed. This was a very interesting one, which surprised me as I already thought I knew everything I needed to for this topic. ______________________________________________________________________________________________General_________________________________________________________________________________________ 1. Emotions are a type of internal state like sleep and arousal. Emotions are discussed here on a neurobiological process rather than feelings. Understanding feelings require understanding consciousness which we cannot yet measure or quantify. 2. Dimensions of emotions - arousal (how intense is it) and valance (is it good or bad). 3. Persistence is a defining characteristic of emotions. Not all states are persistent - like no longer being hungry when you eat but emotions like anger may last long after the initial stimulus. 4. Generalizations are also unique to emotions, where a trigger in one event can apply to another with different context. Coming home from work angry or happy changing the outcome of interactions with family. 5. Motivation states (like hunger) are states are very specific. 6. Research is still being done but Anderson believes that arousal is not generic and that valance is determined in different contexts by pathways in the brain rather than just neurochemicals like dopamine. ____________________________________________________________________________________________Aggression________________________________________________________________________________________ 1. The term aggression is more closely tied to actions than it is as a state. 2. Aggression could reflect states like anger, fear or even hunger (predatory aggression). 3. Mice lab experiment using optogenetics that activated specific neurons in the ventromedial hypothalamus (VMH) - result was that the mice were become aggressive and attacked others until turned off. 3c. Electrical shock treatment didn't work on the mice because it only shocked the top of the VMH - Dr. Anderson likens the VMH to a pear where the fear neurons are on the bottom and the upper has fear neurons. 3cc. The male mice actually began to ask for the treatment via nose-poking or pressing a bar. It seemed as if if they enjoyed the aggression and opportunity to lay hands (teeth) on other mice. Thus a positive valance. 4. Circuits responsible for defensive aggression and predatory aggression (mice catching crickets) are found elsewhere in the brain. 5. Fear degrades the desire in offensive aggression and enhances the desire in defensive aggression. 6. There may be a final pathway for all aggression located in the substantia in nominata (the substance with no name). __________________________________________________________________________________Hydraulic Pressure System for States________________________________________________________________________ 1. States act similar to hydraulic pressure in that they build based on a need or desire like finding food and water. Motivation states like these are uncomfortable and thus negatively valanced. 2. Activating neurons associated with sexual drive in mice showed no change in behavior until another mouse or an item (kumquat) was placed in their cage. Then they would try to mate with it. 3. Same thing happened when they activated neurons associated in aggressive behavior. The mouse attacked another or an item (glove). 4. There's a gradual buildup of this need, desire or want and then all at once it gets released once an opportunity presents itself. 5. 43:25 Huberman juxtaposes this conversation to humans that use porn as an outlet or release of that sexual drive as a solution opposed to seeking mates. Names the no-fap community. Hilarious. _____________________________________________________________________________Aggression Continued More Mice Discussions____________________________________________________________________ 1. When the fear neurons in the VMH are activated there is arousal with associated dilated pupils, increase in stress hormones and elevated heart rate even though they freeze respond (stop moving). 2. The VMH projects to and receives signals from about 30 different parts of the brain, acting like an antenna and broadcasting satellite. Thus requiring the mouse (and presumably human) to make various amounts of cost-benefit analyses before engaging in risky behavior like aggression that could threaten its life. 3. Estrogen has more of an effect on aggression than testosterone does. Giving animals aromatase blockers prevents the conversion of testosterone to estrogen and lowers the desire for mating and fighting. 4. Male mice tend to fight much more quickly than females. Female mice show a change in behavior and neuronal activity from virginity to maternity (weening pups) where they go from sexual arousal to aggressive behavior in the contact of the same or different mice (regardless whether or not the pups are with her). Doesn't happen in males. 5. Male mice are wired via specific pathways to only attack other male mice and only mate with female mice. _______________________________________________________________________________________Aggression and Sex____________________________________________________________________________________ 1. The medial pre-optic (MPOA) brain region is where sexual behavior in male mice take place. Stimulating those neurons causes mice in the midst of fighting to stop fighting, begin singing and trying to mount the other male mouse. 2. Medial pre-optic is the "make love not war neurons" while the VMH is the "make war not love neurons." There are dense connections between the two. Possibly to monitor the activity of the other in order to ensure a mate isn't attacked and visa versa. 3. Fetishes are a result of combining something normally aversive to our survival instincts (infectious components like fee, feces or even violence) with a reward. Unsure if mice have them. Jury still out. 4. Unsure whether fighting in animals that are mating / fighting is apart of the mating ritual. 5. Most male on male mouse mounting is dominant behavior rather than sexual. Generally when rats mount female mice they sing, when they mount males they don't. Mounting in male on male mice typically lowers as they become more experienced with fighting and learn how to attack. 6. Female on female mounting is observed after the female mouse is mounted by a male then placed back with her sister litter mates. Motivation unsure if for dominance or not. 7. When the MPOA region of the brain is stimulated in female mice while being mounted by a male mouse, they crawl out from under and mount the male mouse. ____________________________________________________________________________________Pain Modulation and Fear__________________________________________________________________________________ 1. The Periaqueductal Gray (PAG) area of the brain is implicated in fear and panic and freezing. Likened to an old style telephone switch board with connections being rerouted. 2. The MPOA and VMH communicate with the PAG. 3. Fear induced analgesia - when an animal is in a high state of fear there is a repression in pain felt. __________________________________________________________________________________Tachykinins and Social Isolation___________________________________________________________________________ 1. Tachykinins - a family of neuropeptides (short pieces of protein that are encoded by genes to be active in specific neurons) that is related to social isolation. 2. When flies in an experiment experienced social isolation tachykinin went up and when they shut the gene responsible for it down it repressed responses with aggression. 3. Increases aggressiveness, fear and anxiety for mice. Drugs used to block tachykinin can be used to allow a mouse that would normally kill to not when placed from isolation back into community. 4. Dr. Anderson is convinced of the potential utility in these drugs for humans but most pharmaceuticals companies don't want to take on the financial liability. 5. Andrew Huberman notes a seen relationship in school shooters that often exhibit social isolation tendencies. _______________________________________________________________________________Heat Maps and Mind-Body Connection__________________________________________________________________________ 1. Somatic Marker Hypothesis - the idea that our subjective feeling of a particular emotion is in part associated with what is happening in a particular part of our body. 2. Neurons in these areas receive signals from the hypothalamus and thus gives changes in blood pressure, hear rate, etc.. 3. There is a heat map that outlines the specific areas of the body that heat up when we experience certain emotional states. 3. The vagus nerve fibers coming out of your skull a fibers are connected to different organs in your body to control certain processes like breathing, contraction, etc. 4. The vagal fibers sense things happening in your bodies (like a tight gut) and also are influenced by information outside of our brain to influence our body. 5. Dr. Anderson closes saying more research should be done on the ability to turn on and off specific nerve fibers in areas of the body to see how it influences our emotional states and feelings of wellbeing. Takeaway quote: "The same behavior can reflect different states, and different states can converge on multiple behaviors." - Andrew Huberman

[@memastarful]

A very wise elderly Jamaican pastor once told me, " Feelings are real, but they're not always correct."

[@memastarful]

@@priapulida that's crazy

[@memastarful]

@@priapulida I think my old Jamaican pastor friend was just trying to say keep your emotions in check, use discernment.

[@memastarful]

@@priapulida I'm not sure about that but I will respect and process your personal perspective. Have a blessed week

[@keylanoslokj1806]

Based

[@keylanoslokj1806]

@@priapulida that's how the overemotional manipulators that purport the narrative act

[@ortestusg.8818]

Thank you so much, Professor Huberman! As I Psychiatrist I find useful information for my practice in every single podcast, that you release! I'd love you to make a podcast about cannabis and it's relation to psychosis and schizophrenia - to be honest I'm not quite sure what to think about the data I have read about that topic! Keep up the great work, you make my Mondays a thing I really look forward to! Cheers from Germany!

[@madeleineameliacoopergreen5398]

Hi Dr. Huberman! Could you please make an episode geared specifically towards young people? I’m a young adult who binge-watches your episodes and would love some advice on how I can set myself up for the best life possible. So many of my friends also love watching your videos, and I know we’d all appreciate an episode about how we can do a better job of growing up :) Thank you so much for being one of the most important teachers in my life! You’re the best.

[@snegic999]

Dear mister Huberman, I'm a big fan of yours and I've learned so much during the course of your podcasts. The conversation with Dr. Anderson is one of the best academic conversations I've ever heard, in terms of scientific value of the knowledge presented being relatively easy to understand. I want to emphasize your great contribution in helping understand difficult and sometimes unreachable perspectives of scientific research - your effort is a bridge between us regular listeners and pure scientific terminology and methods that can be very tough to understand even for those who have previous knowledge of the subject. This podcast is great example of such value, and let me say that your questions and summaries help a lot in understanding the knowledge presented by your guests. I'm master of philosophy with special postgraduate interest in philosophy of science, and I very much appreciate scientific approach to almost every subject. Most of your podcasts exactly suit my intellectual perspectives. If you allow, I would like to suggest that you invite Mr Bessel van der Kolk (the author of the famous book "The body keeps the score") to your podcast. I know you read the comments, so once again thank you for your amazing effort and know that you have helped a whole lot of people in they everyday lives. My best regards.

[@chriscyborg2187]

I look forward towards mondays to find what new topic we'll get! It's exciting 🙌🏼🥳

[@user-uw7gb9lc7e]

🤯 great guest! What a pleasure to hear the incredible work being done by Dr Anderson. So excited for the future of his research and hope you have him back again.

[@shirintobie-paul3501]

Thank you Dr. Huberman, team, sponsors and supporters ☀️ THANK YOU DR. DAVID ANDERSON!

[@bobthemadmonkey]

This is one of the most interesting episodes yet Andrew, please have more talks with him

[@julielynn86]

I had to pause the video again at 21:08 to say that so far this is my favorite podcast I've seen of yours. It's awesome. Absolutely fascinating. I'm pumped. 😊

[@nathandutenhoffer]

Always great to start the week off with Huberman lab.

[@JohnLentSelflessHero]

Only about halfway through this episode, and it is AMAZING. Without a doubt one your best to date. I could easily see an entire hour dedicated to each of the subtopics that this episode touches on. Things this triggered in my mind as I was listening: Flight or Fight Response. There is a ton of discussion of this in pop-culture, and it is almost always directed at the Amygdala, not the VMH. But it is amazing to learn how closely those two things are located in the VMH. In the Marine Corps boot camp, they very intentionally try to take advantage of the neuroplasticity of recruits, such that we run towards danger instead of away from it. My guess is this is a "neurons that fire together wire together" effect - create very positive valence emotional responses from triggering your fight response, and very negative valence emotional responses from triggering your flight response. Do that enough times over the course of three months, with enough intensity, and maybe it creates a physiological change in the VMH, such that it takes something much scarier to shut down the aggression response. Competitive Behavior. In previous episodes you have touched on the differences between "beating up a much less skilled opponent" and "pushing yourself against an equal or slightly better opponent." We do not generally learn from say striking out a small child in Little League, but we do learn from struggling to strike out an NCAA baseball player. I wonder how much this effects the valence of violence or the invocation of fear. Our brains seem to love learning - it is very rewarding to overcome a challenge and get better. It is not emotionally rewarding to just succeed at something we consider trivial. So, maybe we will feel really good about aggression IF that aggression leads to a learning experience (ie overcoming someone or something challenging) but not so good about aggression when it is does not do this (hurting a much smaller opponent leads to shame and guilt). Menstruation and Aggression. It is both common folk wisdom and pretty clearly demonstrated science that in the few days before a woman menstruates, she will exhibit a lot more aggression and sexual desire. When you were discussing the effect of estrogen on the VMH, this is the very first thing I thought about. Perhaps the "hair trigger" before violence that many women experience during that time is exactly the same as mice when you overstimulate that brain area and then introduce a target into the cage. The difference between whether it is expressed as sexual behavior or violent behavior is something I would love to learn more about (as would many men in relationships with women I presume). Twitter. Just like with physical challenges in competitive behavior above, I imagine the social media argument behavior is related to the reward that comes from overcoming someone at your own or slightly higher talent. I know that I am more often than not, unsatisfied (negative valence) when I find myself engaging in debates with people whose arguments I consider facile on the internet. But when I discover someone whose arguments are at least as good or maybe better than my own, it feels very good - there is a sense satisfaction (serotonin) that comes either from success or defeat in a debate with someone who knows a lot about a topic. Science Fiction Dystopia. Thinking about David Sinclair and his work on using genetics to restore or improve vision, and the parallels between that and the optogenetic experiments in mice, I found myself thinking some very concerning things about how this could be used by unscrupulous groups in positions of authority. Knocking out the genes responsible for aggression (either or both defensive and offensive) in for example, enemy soldiers in a military setting, using a virus to trigger the change. Playing around with the thresholds for fear shutting down aggression in order to subjugate a population / suppress democratic resistance. "Clockwork Orange" -like interventions for persons convicted of violent criminal offenses. This topic touches on so many areas - I'm sure I could go on at length. Absolutely fascinating work - more like this please!

[@JohnLentSelflessHero]

Adding on to the section on Twitter, it also seems to have the "slot machine" effect. Many, many, many negative valence interactions, with random intermittent reward interactions. Keeps you engaged the same way a slot machine does. Good for twitter ad revenue, bad for human development.

[@anondoggo]

I just want to say that this podcast really gave me my life and future back. I had insomina almost every night during senior high and first years of college, and even at one point developed some ADHD-like symptoms, to a point that I felt like I would not be able to complete my education. I managed to graduate with excellent grades and is now in grad school thanks to these videos that are so easily accessible and executable and most importantly almost immediately effective (before I found this channel I have often tried tools that don't work which cause me to just plunge into a state of despair). Thank you so much for everything that you do.

[@catsaresocute650]

Can I ask how you overcome that insomina?

[@jessievonhippel9562]

Please do an updated podcast about vision, how to improve vision in these times of even more heavy all day/night computer and smart phone use, and please pull together all the protocols on vision spread out in other episodes (reset for performance, energize protocol, balance, learning new skills, movement, etc.). Thank you so much for all you have given us!

[@theccft]

33:56 thats hilarious. "I like to call them the 4 Fs, fighting, feeding, freezing and mating"

[@jessicablakely6802]

I'm just popping in to say THANK YOU for creatiing a platform to discuss, and dissect the current relevant literature on various topics!

[@catherinerossba-fineartma-6619]

Another epic episode - so deeply relevant and highly existential in many ways - doc Andrew Huberman you’ve hit it out-of-the-ball-park once again - thank you for delivering this incredibly valuable library. It’s really a gift to learn from you and your guests - you are changing my life - and, the lives of many - you are very much appreciated. This podcast makes both Monday mornings and the learning of science so palatable! 💪❤️👏

[@khuzaimahhaleem4994]

Isn't it awesome that I can access this world class educational content for free from a small town in Pakistan and get just as educated as anybody from a suburb in New York. We live in truly surreal times

[@atthepokertable]

You are favourite Neuroscientist Mr. Huberman, thank you

[@desertplanet]

Thank you. Would love a podcast focused on headaches--causes and what to do when medications don't work.

[@auroraborealis13579]

As someone who suffers from weekly migraines and occasional headaches, I also would love an episode dedicated to the subject!

[@dianamatei7823]

Thank you for all those involved for this discussion🤗

[@AwareParenting]

Wow! What a fascinating trip right to the edges of our understanding. Thank you Dr Anderson and thank you Team Huberman.

[@nataliaweir5943]

I would like to propose a topic. How to overcome a shopping addiction and the normalisation of shopping addiction in our society. I have struggled since childhood of hoarding and both of my parents are hoarders who love to shop. I would love nothing more but to live in a minimal house with just the bare essentials. But I genuinely struggle to achieve that. Whether it's physical shopping, online shopping or second-hand thrifting to find that bargain, I would like to know the neuroscience behind this impulsive behaviour.

[@vikaschawla22]

Another powerful one 😊 you have changed my life 🙏🏼May God bless you always. 🙏🏼

[@PEERSEEMANN]

A suggestion for an episode: as musicians we depend on our hearing, but many of us suffer from hearing loss. Especially the combination of daily homestudio work and touring contributes to this. I would be interested in ways to enhance hearing focus or to train the brain, personally I‘m doing this with shifting sine waves from 4-6 kHz etc. Would be very appreciated.

[@sjskousen]

Try using electronic shooter ear protection. It allows you to hear sounds around you but electronically suppresses any loud noise that affects your hearing. Make certain to get protection with good data supporting any claims. Not all electronic ear protection products provide the same protection. This provides a novel use for these.

[@PEERSEEMANN]

@@sjskousen thanks, very appreciated.

[@user_jp007]

I appreciate you very much for your excellent and helpful series. 心より感謝いたします。 谢谢，感謝。

[@adrianf.6410]

4 Fs: Feeding, Freezing, Fighting and Mating. Ice cold delivery Sir.

[@skippinsoslo]

One of my favorite episodes so far. Thanks so much for doing this

[@byronpickering3006]

Just wanted to say this is by far my favourite podcasts. Such great info and interesting guests. I have learned so much from your channel. Take care!

[@supersonicscientist4126]

I really liked the discussion about the applicability on pets. Many pets are still kept singularly even though research now points at that they should have a mate (dogs, birds, bunnies). Moreover, many breeds are quite short-lived, leading to bereavement among the surviving pets. Sometimes integration with new mates can be difficult, due to aggression and territorial behaviour, at the same time, long spans of isolation are really bad for pets health and make them lose their social skills (which makes then integration with new mates even more difficult). I see a field of application (and maybe even randomized testing outside the lab) here as well. I am personally familiar with dogs and rats, and both really suffer from being alone. Also particularly with rats, integrations are lengthy and often tiresome, and come along with lots of fights and aggression. Many pet keepers would cherish a possibility to support their furry friends througout such periods.

[@adrianagNeuroFit]

Thank you Andrew as always... the Neuroscience of GUILT is next pleassseeeee... 🙏🙏🙏 there is sooo much talked about guilt out there that I am super curious about the actual BIOLOGY and NEUROSCIENCE of GUILT 🧠🙌💪🏽 We have had anger, depression, playfulness, gratitude, and grief episodes. Even though not all of the above are considered emotions, these subjects were critical and SUPER fascinating🙌🙏💪🏽🧠🧠... Guilt next?🤔🙏🙏🙌🙌💪🏽💪🏽💪🏽🧠

[@carolsaia7401]

In Chinese Medicine and holistics, guilt and grief are related to the large intestine. (Holding onto old shit). Colon cancer anyone? Emotions relate to organs. Stomach- Anxiety- indigestion, ulcers. Liver is anger. Sadness Lungs/heart. See the book and the Therapy of Applied Kinesiology, Dr Charles Krebs, "A Revolutionary Way of Thinking". Three in One Concepts. A Look into the theory of Chinese Medicine too.

[@TheKrispyfort]

Neurobiology of guilt, shame, or both?

[@svetlioramos3345]

Simply the best podcast!❤️

[@mahmoudalsayed1138]

What a beautiful conversation between two incredible scientists that was!

[@lindasalfen593]

I think I’m in love with Dr. Andrew Huberman..

[@Theo-ul8qm]

The discussion on arousal and valence I find particularly fascinating. I recall how it took me a while to grasp the meaning of the word ‘arousal’ in English, because I don’t have a word like this in my native language. All words that describe ‘arousal’ or emotions associated with heightened arousal include the valence by definition. Thank you for another great episode!

[@karimahclintonfilms]

Thank you Dr. Huberman for this Podcast. Excellent questions and discussion.

[@maddisonwojtus8938]

I am a massive fan of this podcast, this type of research and knowledge dissemination is so critical in an era where the scientific method has seemingly become secondary to the antidotal wisdom of the social media "influencer". While all contents of this podcast were engrossing, in particular, the topic of the vagus nerve mentioned briefly at the end piqued my interest. It would be fantastic if you could have Stephen W. Porges, an American psychiatrist and neuroscientist on the podcast as his most seminal works have centered around this very structure. I am a psychotherapist myself, and his work on polyvagal theory has been utterly groundbreaking in the treatment of traumatized individuals.

[@ShirleyMcalpine]

Thank you Dr Andrew! This question has been on my mind for a long time.

[@MsJVM]

Do you think you could talk about cholesterol, coronary artery disease, heart health, how diet affects the cardiovascular system, what would be heart healthy diet and so forth. Also (un)related Dr. Stephan Guyenet would be a tremendous guest.

[@ponternal]

Hi, Dr. Huberman can you do a podcast on the effects that being low-status and lonely has on your physiology? I think it's an increasingly relevant topic, especially nowadays with the rise in the loneliness of both genders and with the rise of incels.

[@catsaresocute650]

Hmmm, he'd first need to explain the (non) existance of status and what is, in so far that exists, activated

[@catsaresocute650]

Hint: I think it's a defence behavior, based on socialy ingraned definitions of things one should be but I am open to actual education on it that's not LoBsTeRs

[@shekibomran6524]

Position in a social or dominance hierarchy has a strong correlation to testosterone and dopamine levels, i.e. it is pivotal for happiness and feelings of confidence.

[@catsaresocute650]

@@shekibomran6524 dosn't that make you think this concept is BS. Because by it's nature it creates problems

[@shekibomran6524]

@@catsaresocute650 well I believe it, the evolutionary mechanism, works elegantly. The more a human seeks to and is successful accomplishing goals, the more it is rewarded by happiness by it's neurochemical body. The more it's emotions and feelings become expansive. The opposite is true. If one tends to fail, continually, in certain aspects of meeting needs in life, the more one tends to shut down, the emotions become restrictive due to a cascade of dropping testosterone and baseline dopamine levels.

[@SarinaMotta]

Hi! It'd be so useful if you would tackle migraines and protocols to prevent them or treating them. Migraines have really been controlling my life and I think it's unfortunately a pretty common experience, for women at least. Thank you! Your content is truly incredible!

[@ichigorae3234]

I have a prolonged head injury and I keep telling people that something happened, some switches turned from gold to red in my head and I have felt very scared and on edge since and i feel like one of those rats that went from being happy and ok, to needing to fight, and then, as soon as I get enough space, it's like food, I am not angry, im just shaking and completely aware that I need a minute, but i feel uncontrollable rage when someone tries to engage with me when i wake up or when my head feels super sensitive. So something is triggering this in my head through trauma and now I cant hang out with anyone cause i dont know what is triggering this stimulation in my head. This is really helpful information you are giving thank you.

[@brettinwagner3318]

These podcasts get me through the tedious part of my work day without fail. Thank you 😁

[@Peter11blz]

Dr. Huberman, could you make an episode on the topic of studying, especially about studying for an exam or SAT? Like: "How to Study". And, in the episode, you could describe the science, the tools and the protocols, as usual. Many thanks!

[@collinmorris]

So great to see how this podcast and channel has grown. grateful for your work Andrew. Looking forward to digging into this episode!

[@limbandtreeremoval]

Great to hear, And anxious to see the future and progression of science of mind (psychology/ neuropsychology) body... For the betterment of humanity!

[@coldtreasure]

Absolutely incredible! As always 💯 thank you for sharing your insights ⚡

[@lindythompson6196]

Excellent! I look forward to his return. Super questions!

[@rosemarie3144]

Thank you, Dr. H. So timely, as always. Please share your assessment of inflammation reduction through DC current (grounding). Many thanks for another stellar episode.

[@mpullano]

This episode is insanely interesting! The complex scientific breakdowns, observations and terminology can convolute or disguise some of the more obvious truths. Living creatures Trumpet or Compete for Mating Rights. Hence the reasons the brains circuitry is so closing connected for the Five Fs. Feeding, Fighting, Fleeing, F***ing, Freezing!

[@nonilavar2336]

Question about managing your anger: does combative sports (box, MMA,etc) help in becoming less aggressive? That is: if we are angry and start punching a bag, will it help us manage our anger better in different situation?

[@ChrisAtcher]

Love this podcast. Thank you Andrew for doing this show, it’s so informative and fascinating. 🤙

[@emorylewman5120]

an episode about the science of abuse would be so helpful to help people discover signs of abuse

[@blasebaker]

Thank you Andrew. Your videos are so fascinating.

[@breahsuzanneshaffer]

I'm obsessed with him. Such great questions to his guests and peers.

[@TheOnlyWAYtoStayHere]

Another great episode. Never disappoint always the best show on yt right now. Thanks brother

[@daveduren5263]

You have the absolute best guest on your show……again I may be a couple behind, ( I download them) but I’ve listened to every episode since the beginning!!!

[@mariamorris954]

Mil Gracias Andrew a ti y tu equipo. ❤️

[@allangraham3649]

Thanks to yourself, David and all involved in production! :)

[@FrenchCanadianGuy]

Very good guest! I like how he explains it very well. About what Andrew said in the begining, I can attest that TRT makes you more of who you are for sure. It's like you are expressing yourself more into reality, in all the way that your body can. It has to be taken into account when doing exogenous test.

[@Reelsahib]

Thanks!

[@hubermanlab]

Thank you for your interest in science! Best wishes, Andrew

[@joytoboroff6694]

You’ve generously received given us so much valuable information impacting our lives. Can’t thank you enough. In fact so much it’s hard to keep up. Joy

[@karenkatmom3635]

I always learn something from your videos - thank you!

[@jo-annebaker4666]

Hi Andrew, went to a lecture a few years ago with a Prof who was studying antisocial & criminal behaviour & she found that Monoamine uptake was different in these individuals from general public, just wondering if you have come across this in research on aggression ? many thanks for all your hard work well appreciated

[@paullearmonth7058]

Thank you for your interest in science

[@emy_2510]

Thank you Drs Andrew and David!

[@ZenMaster762]

Reading the book currently. Very well done blending the professional presentation of an academic/scientific document and yet made accessible to lay audiences as much as possible.

[@andydufresne299]

Thank you, David and Andrew, for interesting dialogue. Peace.

[@marzia.throughthelookingglass]

The temperature thing sounds crazy, as someone who have lived in tropical countries and people are the most peaceful.

[@reneeroyal4682]

I would love to hear you interview Philip Zimbardo regarding the Stanford Prison Experiment, heard his lecture about it in undergrad. Sadly the world needs to better understand the phenomenon today and learn to prevent it. Curious what his thoughts are about the global current events.

[@adrianagNeuroFit]

I am Curious about the studies Dr Anderson was referring to about the Vagus Nerve mapping (for a lack of a better word)... Any guidance 💪🏽🙌💜

[@silverado5603]

I'm not a person who is into podcasts, but your channel changed my views about it.

[@vicrider2124]

I 100% agree with your analysis that social isolation causes aggression. We have long known this about "Mountain Men" and "homeless" and the people refer to as the "Lone Wolfs" in society. I have developed my theory that certain people can become Ferrell and psychotic if they are never accepted by a group. It is what is driving the LGBTQ community growth in gen Z. They finally found a group who accepts them for all of their awkwardness. I did a college paper on researched Columbine and learned that those shooters were socially isolated and outcasts. Additionally they were persistently bullied. I'm just sayin...it doesn't' justify their reactions but when some people on the the fringes anyway and they are pushed by mean people they are gonna snap. Schools need to intervene early to stop the isolation I believe.

[@mercyshaver5264]

Highly INTERESTING! Thank you

[@chikacherrycola9189]

You Motivate & Inspire ‘Dr. Huberman’ while making ‘Monday’ a BETTER Day🧡💜🧡 I ‘Work Out’ to ‘THIS’ Podcast’ so PLEASE Know😇 You make Such An IMPACT🌟🌟🌟🌟🌟

[@gracemogaka7486]

This is a very fascinating podcast indeed....

[@lawrencevanrensburg6427]

Truly heartbreaking what is being done to mice in labs.

[@RosyRosieRose]

It’s a bit weird huh..? Sometimes through this podcast, David seemed a little excited over the experiments and it reminded me of kids that burn ants with a magnifying glass. Science and medicine are pretty challenging fields, not for the faint hearted 💔😰

[@Kryptic712]

Thankfully the mice likely don’t get lasting ptsd with them getting stimulated into aggression. I’ve had pet rats and mice and they are very resilient animals. Very adaptable

[@catsaresocute650]

Thanks for pointing it out, I was feeling the same way. He did mention his lab didn't use them that way anymore at some other podacst.

[@ikojogi179]

Thank you for posting this, although a chance was missed to talk about mating on episode 69, I'm really looking forward to this!

[@ponternal]

Huberman should do a podcast on the effects being a low-status sexless male has on your physiology.

[@LasVegasSand_s]

The discussions about Tachykinins was fascinating. And it's a true shame that such mismatch in incentives is standing in the way of taking what could likely be a promising step!

[@daveduren5263]

Thanks for spelling that for me!!!!

[@blasebaker]

On the heat topic. I find it so interesting that I immediately get grouchy when experiencing a hot flash in menopause.

[@GVS]

"I like to call them the four Fs...feeding, freezing, fighting and...mating"

[@Sh0chip]

Hello David I absolutely loved the video you created on ADHD which has helped me immensely. I also have Tourette's syndrome which doesn't have as much information or research out there, I'd love to see a video explaining Tourettes and the neuroscience behind It, Thank you sm for your videos, certainly helping many of us.

[@cmalkemus]

How about these topics?!? Emotional intelligence - how to increase it Addiction science The philosophy of Stoicism and how it can help us cope Alcohol follow up - Q and A Phobias Effective Communication styles Guilt and shame Latest science on Nature vs nurture

[@phnification]

This episode was truly fascinating. Thank you!

[@Laiba003]

I'm very thankful to you for making all this amazing stuff accessible to the masses. I prefer listening to the podcast on Google Podcast but recently your uploads are not playing there for me. Other channels work fine. But, I'm facing this issue w one of my fav channels🤦🏻‍♀️ Is there any technical lag? Please do check n resolve it🙁 Thank you🌸

[@ERROR674]

1:05:15 Regarding the definition of fetishes, couldn't you argue that any sexual desire/attraction/behaviour is towards something one could regard as disgusting, especially when you consider that throughout most of human evolution, hygiene, as we know and practice it today, wasn't even a thing? Ultimately, it's all towards components of the human body. Any "normal" sexual desire or behaviour could be considered disgusting by someone depending on their sex/sexual orientation.

[@napoleon2564]

It’s not a matter if anyone could see it as disgusting, it’s a matter of averages. P in V is normal, and everything that deviates from there is abnormal to a greater or lesser degree. Butts, for example, are a slight deviation but fairly normal because it’s a clear analog to P in V, but feet are an extreme deviation. As to cleanliness, that’s why monogamy was societally enforced for so long. Can’t get an std if you’ve never had sex with anyone but your spouse.

[@fayekalan]

I found this interesting too and somewhat surprising,

[@da-be-ju]

It was simplistic at best. Feet are no more infectious than, say, mouth - just think halitosis. Plenty of foot fetishists are only attracted to clean feet and implying otherwise is like saying that wanting to kiss someone on the mouth is due to being attracted to their halitosis.

[@WilsonIChou]

W CONTENT CREATOR W NEURO SCIENTIST W GUEST

[@keylanoslokj1806]

Violence, death or the ability of death, and arousal are Very intimately linked. Especially in females.

[@samp.a.3445]

Here we go!

[@obigspritztkenobi487]

Traumas play a big role in this things too, i'd assume. ppl who got hurt in childhood are more likely to also hurt other people and get aggresive faster. friend of mine actually became calm and less aggresive after his first cycles of roids.

[@user-mwreixqw]

.

[@scottcauley6862]

Do you have any plans on delving into the exponential increase of autoimmune disorders, e.g., Raynaud's Phenomenon, Scleroderma, Lipedema, NASH, etc., effective treatments and how they're related? Dr. Karen Herbst is, I believe, the foremost expert on Lipedema in the United States. Judging from her knowledge, personality, demeanor and ability to articulate, she would make a good interviewee.

[@snuggle_sesh]

Andrew kindly do an episode on procrastination please❤️