Dr. Dominic D’Agostino, Ph.D.: Effects of Ketosis + Fasting on Mitochondrial Health and Epigenetics

In this episode, we are joined Dr. Dominic D’Agostino, Ph.D. He is an Associate Professor with tenure at the University of South Florida where he teaches students of the Morsani College of Medicine and the Department of Molecular Pharmacology and Physiology, with a focus on such topics as neuropharmacology, medical biochemistry, physiology, neuroscience, and neuropharmacology. He is also a Research Scientist at the Institute for Human and Machine Cognition(IHMC) to assist with their efforts towards optimizing the safety, health and resilience of the warfighter and astronaut.
Dr. D’Agostino chats with host Dr. Scott Sherr on manta rays being ketogenic, his early research in the field of oxidative stress, ketones in cancer, ketones and its effect on mitochondrial function, ketones and epigenetics, and so much more.
What we discussed:
00:00:22 - Introduction
00:02:12 - Manta Rays are ketogenic
00:03:54 - Is it common for fish to use ketones as fuel?
00:05:22 - How Dr. D’Agostino got into the ketogenic diet
00:08:49 - Oxidative stress
00:09:49 - Ketones in cancer
00:13:12 - The ketogenic diet
00:14:56 - The protein sparing modified ketogenic diet
00:16:24 - How Dr. D’Agostino got involved in the optimal performance world
00:19:53 - Ketones and its effects on mitochondial function
00:27:11 - Ketones and Epigenetics
00:30:43 - Dr. D’Agostino’s thoughts on ketones over the years
00:34:02 - The mechanism of a ketone induced increase in insulin
00:38:18 - Maintaining ketosis for long periods of time
00:45:07 - The Ketogenic diet and neurotransmitters
00:54:16 - Effects of long term ketogenic diets of menstrual cycle
00:56:26 - Ketonegic diet and microbiome
01:01:49 - The best way to keep your glucose from spiking
01:04:11 - Ketogenic diet and endocannabinoid system
01:07:21 - Dr. D’Agostino’s exciting project on metabolic psychiatry
Find more from Smarter, Not Harder:
Website: troscriptions.com/blogs/podcast / homehope.org
Instagram: @troscriptions | @homehopeorg
Find out more about Dr. Dominic D’Agostino:
Website: ketonutrition.org/
Website: linktr.ee/Domdagostino
Twitter: / dominicdagosti2
Instagram: / dominic.dagostino.kt
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[@VSS1]

Dom is the best!

[@maurosp]

Amazing content but low volume audio

[@sariatidipetto5447]

Best every podcast I see today! Thank you

[@clifdunbar7405]

Very appreciated

[@lentilpaff7864]

What was the supplement Dom takes to help him sleep? He said he takes 300-500mg, but Dr. Sherr spoke over the name of the supplement.

[@johnnyvee3339]

CR works in mice and other lab organisms yes, but it's strongly indicated that it's not very effective in long lived mammals. (for reasons having to do with differences in evolutionary adaptation) Since the ketogenic diet in many ways emulate the fasted/CR state, how do we know it translates to humans? Why can't someone look at the epigenetics in humans on a ketogenic diet in an RCT trial for example? We need more of that type of data and not yet another mouse study.

[@jimmcgorty4014]

Wonderful discussion

[@bobcocampo]

Please have an experiment on how to improve intelligence of keto with grade 1 to grade 12

[@JohnSmith-zs1bf]

Interesting. Right at the edge of my understanding. Chris Palmer is also talking about mitochondrial biogenesis resulting from ketogenic diet improving mental health disorders. I never had my blood levels measured, but I would like to know if it any kind of weight gain/bulking on a ketogenic diet would result in those same deleterious effects as having too many ketones via exogenous sources, and are those deleterious effect (especially feeding cancer cells with the extra energy) are on par with having a carb-rich diet or not.

[@bbhealing107]

What's the name of the supplement mentioned for sleep?

[@clifdunbar7405]

Fenny bute

[@mikerudd4943]

Nascent for sure

[@bobcocampo]

What is the effects of keto to memory and learning

[@mikerudd4943]

My lan tested blood ketones is 28. Typically my urine test is 30 to 40. Dom didn't really spec out what is too high to not spike an insulin increase? I have stage 4, and I am doing everything I can to keep ketones present as a fuel. But I want my glucose/insulin low to try to starve the cancer. Thoughts? Is 28 too far up? If so how would I regulate down? It's all diet induced

[@chamuuemura5314]

I don’t have a clue but replying to offer support and maybe one comment will encourage someone else. If stage 4 some type of disease/cancer maybe an oncologist might know better.

[@catherinetd9668]

Re: people who appear carb tolerant bc their A12 remains low. I heard researcher suggest that this may be bc the pancreas is pumping out more and more insulin to keep blood sugar “normal”, but eventually this may exhaust the pancreas. Would HOMA-IR to measure insulin reveal this effect? If A1c is low but insulin is high, maybe we’re not really carb tolerant?

[@satxsatxsatx]

Your point is exactly why someone with a A1C below six must must test for fasting insulin level A1C may be 5.5 but the pancreas is providing a high level of insulin to maintain that level of glucose To be tested Fasting glucose level Fasting insulin level Preferably with a 24-hour fast

[@eileenromps9266]

Doesn’t alcohol stop ketone production? You said it lowers glucose?

[@Dggb2345]

Doc you’re taking into the null area of that condenser microphone. That kind of microphone typically has three patterns Omni. Figure 8. Cardiod. You should speak into the side of the microphone.

[@marcusmatthews8255]

Volume is kind of low

[@baileystruss7319]

Why does one study show damaged heart mitochondria and fibrosis with ketosis?

[@machinotaur]

In which study? Many studies I've seen use a ton of seed oils, 30%+ calories from polyunsaturated fat (and most of that linoleic), that'll induce heart damage every time if you run the experiment long enough. It's like running a low fat diet study but feeding them mainly table sugar, very academically dishonest.

[@tomclayton]

Your presentations are way too long. Why don’t you just say what needs to be said?