I can’t take the burning feel so I started with 0.025% tretinoin thrice a week until I finished the tube. Then I went on to 0.05% 4 times a week until i finished the tube. Now, I apply 0.1% once a week and 0.05% six days a week. I think the key is to 持之以恒. If you apply to the extent that it’s so painful and you discontinue the use of tretinoin, then it’s such a pity. I think find a way that suits you keeping in mind that the goal is to apply the highest dosage daily.