Healthy Aging Tips Using The Microbiome • Dr Michael Lustgarten PhD

[@katesmyth9485]

I totally disagree with his diet and theory but it's a good listen anyway. I'm thriving on pure Carnivore...my blood markers just taken this week are perfect and I'm 67. I will never again eat plants with all the toxins they come with. I feel like I'm 30..I reversed IR..arthritis...hypothyroidism...headaches...lowered Triglycerides by half...perfect GGT function...low blood insulin..my BG never goes over 90...and I can sleep well without drugs..no anxiety anymore..I can go on and on.

[@MarjorieBurnett]

Ditto Kathryn! Im 68 and feel exactly the same.Keto/ carnivore keeps me and my 70 yr old hubby healthier than we've ever been.

[@conqueragingordietrying123]

What works for me can be different for everyone. I don't promote my diet as the best diet, and in the video I promote the idea to make sure that your biomarkers are where they should be in terms of health, rather than being married to a dietary ideology and hoping that your health is ok.

[@katesmyth9485]

Yep I got that and biomarkers look like I'm 30 not 67 on Carnivore...so much improved from one year ago. Its transformative.

[@gyunge3617]

@@conqueragingordietrying123 I totally agree with you. I tried keto carnivore and it wasn't for me. I feel a lot better with some plants like Kimchi, saurkraut, broccoli, brussel sprout etc added on. I guess everyone has different biology. Thanks!

[@conqueragingordietrying123]

@@katesmyth9485 Ok, here are my biomarkers, which show a biological age that is 15-20 years younger than my chronological age. Care to share yours? michaellustgarten.com/2018/06/26/maximizing-health-and-lifespan-is-calorie-restriction-essential/

[@Biohackerslab]

Summarised show notes & links here 👉www.biohackerslab.com/ep92-dr-michael-lustgarten/ [00:20] - Introducing, Dr Michael Lustgarten, PhD, Scientist II in the Nutrition, Exercise Physiology, and Sarcopenia Laboratory at the Human Nutrition Research Center on Aging. His research currently focuses on the role of the gut microbiome and serum metabolome on muscle mass and function in older adults. In addition to his contributions to numerous scientific publications, he is the author of a book titled ]Microbial Burden: A Major Cause Of Aging And Age-Related Disease. (Biohackers Lab tip: Listen to our interview with Dr Amy Proal for more about the what is the microbiome & its role in disease) [01:39] - Michael explains how the microbiome affects the 4 leading hallmarks of ageing covered in his book; telomere shortening, oxidative stress, inflammation & insulin resistance. [04:32] - Studies with rodents show that high caloric diets stimulate the breakdown of the gut barrier which allows microbes to enter the bloodstream and negatively affect cells accelerating ageing. [05:29] - Because the health of our gut lining determines how well we age, Michael recommends a high-fiber diet as a strategy to help the bacteria in the microbiome improve gut lining function. [06:41] - Michael explains how too much protein may decrease gut barrier function, but also the flip side of making sure there’s enough protein in the diet to maintain muscle mass and specific amino-acids that actually help maintain the gut barrier. [10:11] - What biomarkers should we be looking at in blood tests to determine if we’re getting the right amount of protein in our diet? [14:18] - We discuss sarcopenia and how to deal with it in terms of protein intake and kidney function. (Biohackers Lab tip: Listen to our interview with Prof Stuart Phillips for advice on how much protein you should have to avoid muscle loss) [17:09] - There’s lots of success stories coming out from people fixing their intestinal permeability by going on a strict carnivore diet. Michael advocates a personalised approach and tracking your blood work to ensure the diet isn’t causing any other health issues. (Biohackers Lab tip: Listen to our interviews with Dr Zsofia Clemens and Mikhaila Peterson for information about the health benefits of the carnivore diet) [21:25] - Michael explains that while he has been tracking his glucose levels he is considering doing his insulin as well. Glucose levels aren’t always indicative of insulin resistance, which is a major marker for ageing. [23:01] - On his website, Michael has shared an interesting experiment where he adjusted his gut microbiome to try and improve his deep sleep. He believes the gut plays a strong role on influencing how well the brain functions. (Biohackers Lab tip: Listen to our interview with Dr Ben Bikman PhD for more info on insulin and insulin resistance) [27:25] - For people looking to improve their microbiome health with probiotic supplements, Michael recommends starting by getting their microbiome analysed, figuring out if there are specific bacteria they want to increase and rechecking the microbiome after supplementation. [31:22] - What’s Michael’s take on faecal transplants? Like probiotic supplements, these can be used to seed desirable bacteria that are lacking in the microbiome. However, Michael warns that unless you address the underlying issues, the biome will revert back to its original state. [35:26] - What about using faecal transplants for longevity reasons? Michael believes that a good diet and exercise should be the priority as the benefits are well known. [37:41] - Michael talks about the complex interactions between different microbes in our gut (bacteria, viruses, fungi, archaea) and how little we really know about this. [40:32] - An increase in adipose tissue as we age may be a compensatory mechanism against the microbial burden. [42:57] - On his mission to improve his longevity, how does Michael handle fat in terms of its benefits versus it being a potential indicator for microbial burden? Michael shares some tips that can help you stay on the right track. [46:02] - Cellular ageing still happens without the microbiome. Even though we can improve longevity by optimising the microbiome, to truly extend our lives beyond a current limits, we’ll need to address the issue of cellular ageing. [46:59] - Mitochondria affect longevity, and increases of circulating mtDNA can be an indicator of microbial burden. (Biohackers Lab tip: Listen to our interview with Dr Lee Know to learn more about how mitochondria affect longevity) [50:16] - Michael shares that the current focus of his experiments is his biological age and how to keep it as low as possible. [53:03] - To follow Michael and find out more, he has Twitter and Facebook @michael_lustgarten, and also his website michaellustgarten.com If someone wants to send him an email they can find it on his research papers.

[@parkinplay5931]

Nope, just got onto Carnivore a month ago after doing Paleo & Keto combo; I always found that I was still hungry after eating a 4 person serving myself; since going carnivore I'm more satisfied with less food and I actually drink more water now than I did before; carnivore is the last stop for me.

[@sarasimm6668]

My microbiome is messed up. I have IBS type C with visceral hypersenstivity. I do hope this research can hurry up and find some answers. I'm in the UK and happy to take part in any studies. I look out for them, but there's nothing at present. I cannot tolerate fibre at all anymore.

[@tracyhunter251]

I've just added a spore based probiotic, that survives the stomach acid, to further seed my biome with strains of bacillus (very old strains) and 300 mcg of K2, for any arterial calcification, Microbiome labs or Kiran Krishnan, they have a bunch of yourtubes, thanks for all the various perspectives!

[@Deanriley]

What’s his t-shirt say?

[@conqueragingordietrying123]

There is no greater wealth than health

[@immortalsofar7977]

As soon as I heard him talk about being vegan and consuming all that fiber I knew his paradigm was outdated. Cutting edge (ironically) = zero carb. I've completely reversed my autoimmune issues with two things... carnivore diet and 20g glutamine every morning on empty stomach. My gut is now healed and solid. Eating like I was a teen again.

[@conqueragingordietrying123]

I went vegan for a year, I'm not vegan anymore. The point is to try different things, find out what works best for you.

[@mrazik131]

When he said high fiber diet i went sure paper knowledge bs.

[@conqueragingordietrying123]

I have blood test data to back up my diet. My biological age is 15-20 years younger than my chronological, so it's not paper knowledge BS: michaellustgarten.com/2018/06/26/maximizing-health-and-lifespan-is-calorie-restriction-essential/

[@tohopes]

@@conqueragingordietrying123 You have low (normal) bilirubin. I hope you're taking spirulina.

[@conqueragingordietrying123]

@@tohopes My average bilirubin value from those tests is 0.55, which has been reported to be within the range that is associated with reduced risk of death from all causes (0.5 - 0.7): www.ncbi.nlm.nih.gov/pmc/articles/PMC3984185/ Moreover, bilirubin increases during aging, with values close to 0.5 indicative of biologic youth, relative to higher values: content.sciendo.com/view/journals/anre/80/4/article-p335.xml So I disagree that my bilirubin levels are low.

[@ellesab4873]

If butyrate improves gut barrier function and also is a short chain fatty acid that feeds beneficial gut bacteria and if glutamine (an amino acid) and glycine both contribute to healthy digestion then it sounds like a ketogentic diet will definitely help and perhaps the need for fibre is not necessary. Also it would be nice to have human studies not animal studies when talking about human health. Rat studies does not translate well in humans in my opinion. I have also read that carnosein (exclusively in animal protein) and therefore carnivorous diets could be beneficial in aging processes because carnosein helps suppress some of those processes like glycation. Finally, have a look at this study: www.nature.com/articles/nature12820 A reduction in firmicutes and an increase in bacteroids was observed. However, I did enjoy this conversation!

[@foxybob222]

Vit E has extended mine by 10 yrs so far above the other males in my family line !!

[@immortalsofar7977]

What did you notice changed when taking vit e?

[@foxybob222]

@@immortalsofar7977 i had more stamina when working steep mountains and less leg cramps were the main things i remember if fact if i started to get a leg cramp while driving home, i would pop a capsule and put the oil under my tongue and it would stop it in a few mins !!