How PRP or Platelet Rich Plasma helps reduce inflammation and pain ? (TAMIL )

The growth factors and bio molecules in PRP - how PRP works to heal your injuries.
Platelet-Rich Plasma (PRP) therapy involves using a concentration of a patient’s own platelets to accelerate healing. The growth factors present in PRP play a crucial role in this process. Here are the main growth factors found in PRP and their functions:
1. Platelet-Derived Growth Factor (PDGF):
• Function: Stimulates cell growth and division, particularly in blood vessels and collagen production. It is essential for tissue repair and regeneration.
2. Transforming Growth Factor-Beta (TGF-β):
• Function: Regulates inflammation and plays a significant role in the formation of new blood vessels, collagen synthesis, and tissue regeneration. It helps control the immune response to injury.
3. Vascular Endothelial Growth Factor (VEGF):
• Function: Promotes the formation of new blood vessels (angiogenesis). This is critical for supplying nutrients and oxygen to damaged tissues and for the healing process.
4. Epidermal Growth Factor (EGF):
• Function: Stimulates cell growth, differentiation, and survival. It is particularly important in wound healing and the regeneration of the skin and other tissues.
5. Insulin-Like Growth Factor-1 (IGF-1):
• Function: Supports cell growth and development, particularly in bone and muscle tissues. It also helps in the regeneration of damaged tissues and stimulates the production of collagen.
6. Fibroblast Growth Factor (FGF):
• Function: Promotes the proliferation and differentiation of various cell types, including fibroblasts, which are crucial for the formation of connective tissue and wound healing.
7. Hepatocyte Growth Factor (HGF):
• Function: Plays a role in cell growth, cell motility, and morphogenesis. It is particularly important for tissue regeneration and repair, especially in the liver and epithelial tissues.
8. Basic Fibroblast Growth Factor (bFGF):
• Function: Enhances the proliferation of a variety of cells, including endothelial cells that line blood vessels, thus aiding in the formation of new blood vessels and tissue repair.
9. Platelet-Derived Angiogenesis Factor (PDAF):
• Function: Specifically promotes angiogenesis, the development of new blood vessels from pre-existing ones, which is vital for supplying nutrients and oxygen to healing tissues.
These growth factors work synergistically to accelerate tissue repair and regeneration, making PRP therapy effective in treating various conditions such as tendon injuries, osteoarthritis, and enhancing healing after surgical procedures.
In addition to growth factors, Platelet-Rich Plasma (PRP) contains a variety of other biomolecules that contribute to its therapeutic effects. These include:
1. Cytokines:
• Examples: Interleukins (IL-1, IL-6, IL-8), Tumor Necrosis Factor-alpha (TNF-α).
• Functions: These signaling proteins regulate immune responses, inflammation, and tissue repair processes.
2. Adhesion Molecules:
• Examples: Fibrin, Fibronectin, Vitronectin.
• Functions: Facilitate cell adhesion, migration, and the formation of a scaffold for tissue regeneration. Fibrin, in particular, forms a matrix that supports cell growth and tissue repair.
3. Chemokines:
• Examples: Monocyte Chemoattractant Protein-1 (MCP-1), Stromal Cell-Derived Factor-1 (SDF-1).
• Functions: Attract immune cells to the site of injury, aiding in the inflammatory response and subsequent healing process.
4. Proteins:
• Examples: Albumin, Immunoglobulins.
• Functions: Albumin helps maintain osmotic pressure and transports various substances, while immunoglobulins play a role in immune defense.
5. Enzymes and Enzyme Inhibitors:
• Examples: Matrix Metalloproteinases (MMPs) and their inhibitors (TIMPs).
• Functions: MMPs degrade extracellular matrix components, facilitating tissue remodeling, while TIMPs regulate MMP activity to ensure balanced tissue repair.
6. Platelet Microparticles:
• Functions: These small vesicles contain growth factors, cytokines, and other signaling molecules that further contribute to tissue repair and regeneration.
7. Lipid Mediators:
• Examples: Prostaglandins, Leukotrienes.
• Functions: These molecules are involved in the regulation of inflammation and pain, playing a role in the healing process.
8. Hormones:
• Examples: Serotonin.
• Functions: Serotonin released from platelets can contribute to vasoconstriction and wound healing.
9. Extracellular Vesicles (Exosomes):
• Functions: These vesicles carry proteins, lipids, and RNA, and play a role in cell-to-cell communication, promoting tissue repair and regeneration.
These biomolecules collectively enhance the healing properties of PRP by modulating inflammation, promoting cell proliferation and differentiation, and supporting the formation of new blood vessels and extracellular matrix.
Dr Santhosh Jacob
DNB,MCh.,DABRM
Orthopedic & Sports surgeon
Ref
Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020

[@Godisgreat438]

Not at all boring.... Pls continue researches nd teaching the public as well..... Most welcome.... Hats off to u .. 💥

[@sumas.kitchen62]

Hi Sir, I am a biotechnologist, All of your informations are crisp and clear and as you told its proved once. I did my PRP in your hospital . As sokn as you suggested i read research articles in PUBMED. Then undergone PRP. You did it. Now I got big relief and my inflammationa gone.which I had for an year. 20:09 Thank you very much sir.

[@DrSanthoshJacob]

That’s great to hear

[@deviraja9554]

Though it's difficult to understand fully, I'm happy to know about this new procedure( "new" for me) through you doc. Thanks for your sincere effort in trying to educate us.

[@mdhanalakshmi6493]

Great information, though highly technical. Thanks for your concern.

[@1dauolg]

Very nice presentation sir

[@arunathangadurai6059]

Hello Doctor...... this is one of your , the best message in your field I ever find from you..... congrats, Doctor..... The best and very kind of useful message this is...... 👌 👍 🎉 This is the way, your professional message could be.....Thanks

[@user-bz8nb6dh5o]

I am bhms very useful for in topic thank you sir

[@vincentraj9897]

Thank you dr for the information. Very useful. It makes us to take an action on our health problems to the right solution. Please dr i am expecting more information about this and also about knees problem and how PRP used

[@indianaaruvi1326]

Thanks for the valuable information Doc. Please make a video on "Starch Resistant" and 1) How it works ? 2) How to a adapt Starch Resistance cooking in our daily routine? 3) Is it good to use chilled/refridgerated food? 4) Pros n cons. I don't find any clear explanation on this topic. Please open-up a new way for it. Thanks in Advance Doc.

[@SarumathiSaru-ne6ek]

Hello doctor Good morning While giving useful information to people The interest in it reveals the enthusiasm in your mind

[@DrSanthoshJacob]

Thanks

[@rama91152]

Thanks for a very informative video Doctor!

[@DrSanthoshJacob]

Glad it was helpful!

[@haseka2007]

Thanku so much for the detailed information dr. Really helpful. Requesting to share how prp helps for skin and hair dr if possible.

[@bharanishrikanthan1039]

Thanks doctor clearly explained. Very useful

[@DrSanthoshJacob]

You are welcome

[@GM-ct7eg]

Very nice to hear this sir, Thank you

[@DrSanthoshJacob]

Your welcome

[@vasanthaashokan9626]

Very useful Dr

[@deeptibalakrishnan330]

Thank you for sharing such valuable information to common people like us 🙏

[@DrSanthoshJacob]

I will share more 🤗🫂

[@deeptibalakrishnan330]

Thank you Dr. 🤗🙏

[@injonj]

Thanks and I woukd like to explore this option for my shoulder pain due to disc degeneration at c5 level. Please let me know how ro go about with this.

[@kalyanidorairaj1298]

Very well explained doctor. I have meniscus tear on one leg and due to which the other leg is also giving pain. Now I am on bone and muscle strengthening exercises which has given relief from pain. Do I continue ? Will the relief stay with the continued exercises ? Please clarify doctor

[@pradeepasanthosh9187]

Hi sir..Can you please talk about sickle cell anaema and treatment available for that..

[@user-br1ls7dc7j]

Jakab Sir vanakkam. Pancreas le beta cell regeneration pannuvingula please reply.

[@rahul-jd6os]

Talk About Stem Cells

[@vikramdv1212]

Good morning doctor, I have a grade 2 tear in acl in left knee and also grade 2 tear in right knee. I am now reducing my weight as you suggested.I can tolerate the pain as of now with limited physical activities including running. I need your recommendation to undergo PRP and continue weight reduction or else to reduce the weight first?

[@VAIRAMgaming]

Hello sir, L4-L5 disc bulge nu February la MRI paathu sonnanga... Naal aaga aaga athuve permanent ah cure aagiruma pls reply illana enna pannuna permanent ah cure aagum

[@rosiethebeaglepet9645]

Sir is fish oil capsule is safe to consume

[@sangeethaselvakumaran9015]

🙏

[@nivedhar1136]

Hi Sir, Recently I got diagnosed with Thyroid and Gluten, Dairy intolerance. Dietitian advised me to take a very minimal amount of dairy but gluten I'm not able to tolerate at all. Sometimes even if I don't have the allergic foods, I'm getting diarrhoea. Sometimes I'm suspicious of having IBS. Is it because I don't have enough good bacteria? If so, shall i take any probiotic supplements for increasing the good gut bacteria?

[@Harinisridharanca]

Sir, will you please give a video for strength training suitable for scoliosis. I am just 32, but got to understand i have a minor bend when i started to exercise.

[@raekerrigan3369]

Dr for protein can we take any powder protein available in shops?

[@dishanthkemu4959]

Dr neenhe prp hairuku enna panum endu soleve ila ealum enda athuku oru video podunge (including male pattern baldness )

[@mukeshmuthamilan7218]

Is this procedure covered in general health insurance?

[@injonj]

How is it different from Ozone therapy?

[@annaduraim1388]

Doctor im romotide arthritis patients na cheeya seeds sapudalama please reply me sir

[@rizastalent]

Doctor, will you visit coimbatore

[@sivasankarisubramanian1676]

Fibromyalgia pain management paththi video podunga doctor... Mudiyala 😢

[@sakthivelr7881]

Laburm tear ku prp use pannalam ah sir ?

[@premkumarc3571]

Excellent smart and simple presentation, my wife is suffering from knee pain ,how I can contact you , I am residing at Thrissur kerala.

[@DrSanthoshJacob]

Thanks … be well T nagar , contact number :- 87547 66819 , ‪89253 61058‬ & ‪99402 48416‬ .

[@premkumarc3571]

🙏

[@vanitharanganathan4689]

Thanks Dr for your effort in bringing awareness. I have fair understanding how prp helps in healing inflammation. You did BMAC with HA for my mom and no improvement on her knees. Does SVF Stromal Vascular Fraction ( derived from fat cells) along with PRP help in pain reduction for severe conditions when compared to BMAC or PRP? Can you please talk about SVF in your upcoming videos. Thanks

[@DrSanthoshJacob]

Hello 👋 and when was the procedure done and please ask her to contact my team . I would like to see her once again .

[@user-gt4hy9jx3x]

Howmuch prp cost for osteoarthritis sir

[@kappukuppu7034]

prolotherapy injection ennanu konjam solluna doctor

[@seetha110378]

I took PRP treatment in your hospital for my shoulder and back injuries. Following the diet plan, no sugar, physio everything suggested in your hospital. But even after 8 months no improvement in my pain both in Shoulder and back. Its a failed in my case doctor. Sorry

[@Hemachander-pg6cl]

Akka back pain Naa keerai then dates then first wash stomach and redus beli t Fat core muscle strength pannunga thopa irundha back pain varum ok va then daily green vegetable and fruit 1month sari aggum Naa experience la solluran

[@DrSanthoshJacob]

Please do come back so that I can assess you better and figure why you don’t have relief

[@Hemachander-pg6cl]

@@DrSanthoshJacob sir ostrioporosis ku oru complete diet and life change habit pathi sollunga sir And stondium and boron rich food pls tell me sir

[@arokiajayakumari8162]

Hi can we give PRP for autism kids

[@dekayjack]

Hi doctor, I'm a 26 yo male with desiccated disc at L5 - S1, I have undergone microdiscectomy a year ago for bulge, although im better now, sometimes pain is unbearable. Will PRP help the desiccated disc heal ?

[@DrSanthoshJacob]

Exercise and nutrition will really help . Need an mri if pain is increasing .

[@dekayjack]

​@@DrSanthoshJacobThank you doctor.

[@seetha110378]

PRP did not help me in L5-S1 disc bulge

[@DrSanthoshJacob]

@@seetha110378 there are many reasons as to why PRP might not work 1. Significant disc protrusion which cannot regress by non mechanical means or just by reducing inflammation 2. Dosage of PRP was not sufficient 3. Post procedure rehab done was not enough to strengthen the back and core 4. Obesity in general which increases inflammation and reduces healing rate 5. Delivery of PRP away from region of pathology, many times it appears like the problem might be in the disc on mri where as in reality it might be somewhere else like in the facet or post ligamentous structures

[@user-vl3me1xf9u]

Hi sir i am 29 i suffering from condromalaciapetala pain

[@DrSanthoshJacob]

Weight loss / reduce added sugar / core and knee strengthening