How To Test For Leaky Gut, A Science-Based Review

We hear a lot about healing leaky gut, but how do we know we have it in the first place? Is a stool test enough? In this episode, I’ll review the most effective and least effective leaky gut tests. Let’s get the most accurate results, so you can move closer to healing! Watch now.
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And if you have any questions or topics you would like covered in the future, let me know in the comments!
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Featured Studies
📉 Probiotics fortify intestinal barrier function:
pubmed.ncbi.nlm.nih.gov/37168...
📉 Fecal zonulin is elevated in Crohn's disease and in cigarette smokers:
pubmed.ncbi.nlm.nih.gov/29034...
📉Probiotic supplementation affects markers of intestinal barrier, oxidation, and inflammation in trained men:
pubmed.ncbi.nlm.nih.gov/22992...
📉Associations between food-specific IgG antibodies and intestinal permeability biomarkers:
pubmed.ncbi.nlm.nih.gov/36147...
📉Is there a possible correlation between antibodies against lipopolysaccharide, intestinal and blood-brain barrier proteins in IBD subjects?: pubmed.ncbi.nlm.nih.gov/30959...
📉The Relationships between Intestinal Permeability and Target Antibodies for a Spectrum of Autoimmune Diseases: pubmed.ncbi.nlm.nih.gov/38003...
📉A case for improved assessment of gut permeability: a meta-analysis quantifying the lactulose:mannitol ratio in coeliac and Crohn's disease: pubmed.ncbi.nlm.nih.gov/35012...
📉Probiotics fortify intestinal barrier function: pubmed.ncbi.nlm.nih.gov/37168...
📉Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome: pubmed.ncbi.nlm.nih.gov/30108...
📉Psychological and Gastrointestinal Symptoms of Patients with Irritable Bowel Syndrome Undergoing a Low-FODMAP Diet: The Role of the Intestinal Barrier: pubmed.ncbi.nlm.nih.gov/34371...
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DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment.
Music featured in this video: "Modern Technology" by Andrew G, audiojungle.net/user/andrew_g
*Full transcript available on KZbin by clicking the “Show transcript” button on the bottom right of the video.

[@DrRuscioDC]

Get practical, science-based insights straight to your inbox: drruscio.com/signup/

[@jeanm7755]

Thanks so much… Once again, Dr. Ruscio… For doing the research for us. Very helpful information here.

[@DrRuscioDC]

My pleasure!

[@yurynsk3533]

Great as usual. Looking forward for new video!

[@DrRuscioDC]

Thank you so much!

[@SandyBatten1962]

Would the presence of E Coli in a blood test indicate or suggest intestinal permeability? E coli belongs in the bowel which is an area of the GI so if it's showing up in a blood test how is that occurring please. Lovn your content ❤

[@illuminationgoddess3]

Thanks

[@DrRuscioDC]

You’re welcome!

[@Killerbee67]

Great information! I had the Vibrant wheat zoomers test 3 times now. First time I was in the red zone for Anti-Zonulin IgG The 2nd time I was in the yellow zone with a 98 . Third time and one year later I tested 96 only moving 2 points in a year. Normal range with Vibrant is 89 and lower. Now I haven’t eaten gluten or wheat in over 3 years… and of course Vibrant recommends a gluten free diet. I have no symptoms of leaky gut and my body is working as it should. Could the test be off or maybe it something else I’m eating. It’s really baffling to me because I’m so careful. I will get another test in October but none of this is cheap… all my other test for Intestinal Permeability came out in the normal range. Sorry this is long and Thank you for any thoughts.

[@slimcharles1016]

Thanks for your video! Is stool testing valid for other measures besides zonulin? Or should we treat based on symptoms alone?

[@DrRuscioDC]

Stool testing can be useful for certain tests, while serum (blood) is better for others. Is there a specific test you had in mind? Also, in general, I think a symptoms-first approach is valid even if there’s no conclusive testing - some conditions are very difficult to test for reliably.

[@michswan1005]

What do you think about MRT (Mediator release test) and the LEAP diet? Thank you for all your help!

[@DrRuscioDC]

Low FODMAP or another elimination diet is usually suitable for most people, but I could see this being valuable in specialized cases where extreme intolerances or digestive disorders are present with no known cause. Have you tried it?

[@sailuvijl6621]

How can i tell doctor i gave low acid i dont want to take ppi i am so tired n sick of this

[@DrRuscioDC]

I’m so sorry you’re going through this. Unfortunately, low stomach acid isn’t well-understood or commonly diagnosed. Some doctors may be willing and able to test for it. There are things you can try on your own, though, like a trial of apple cider vinegar or betaine HCL with meals to see if they improve your symptoms.

[@sailuvijl6621]

@@DrRuscioDC hmm I can't tolerate apple cider vinegar.i lost my life to these gi doctors without proper knowledge they gave steroids ciprofloxin which is black box warning medicine my body was burnt all went into my blood they didn't know I had leaky gut Mold was the culprit now my family saying I am mentally ill n sick.i tried to come to your office didn't get appointment

[@suegoodwin1243]

Do you know any accurate gut tests in UK pls

[@DrRuscioDC]

Hi there! What specifically are you looking for? I think GI Map by Diagnostic Solutions is offered internationally, but make sure to check with them/your provider: www.diagnosticsolutionslab.com/about. For what it’s worth, we work with international patients in our virtual clinic, so can provide routes to solid testing there.

[@Ikaytas1]

For someone living in India, I do not have many resources to heal my SIFO and IMO. Dr. Ruscio can you please suggest what people like us can do? I treated my Hydrogen sibo herbally (Curcumin, berberine, thiamine, betaine hcl, probiotics and magnesium). But even with allicin im unable to beat IMO and Candida.

[@mohammedwaheed1431]

Wht u r suffering from?)

[@DrRuscioDC]

@@Ikaytas1 Have you tried probiotics or prescription antifungals?

[@Ikaytas1]

@@DrRuscioDC antifungal i did try flucanozole, but it made me feel sick. I wasn't sure if that's a die off symptom or if it wasn't working. I've stuck to herbals ever since. Probiotics I was on 25 Billion (lacto, bifido, sach boul), i increased it to 50 billion after a month. Just switched to another brand of Probiotic today (10 billion), this one doesn't have any Prebiotics in it, rather has more varities in each strain.

[@sailuvijl6621]

Where r u same issues going on nobody trusts I am so tired n sick

[@rabyarana5018]

I felt better when I took antifungal

[@notaras1985]

Have you ever tried the no plants GAPS diet in your patients with heavy leaky gut?

[@DrRuscioDC]

We’ve mostly done low FODMAP in the clinic, though stricter elimination diets aren’t a bad idea, especially if your intolerances are severe. We’ve done elemental diets with some patients, for example - hard to get much stricter than that

[@notaras1985]

@@DrRuscioDC what's your opinion on Candida? Dr Michael Biamonte talks about how resilient it is. And you need to cycle the antifungals every few weeks. And how it manifests co-infections with certain viruses. And comorbidities against thyroid function etc