How Your Digestive System Fights Pathogens

Our digestive system does a lot more than just break down food for us. It actually has a role in our immunity. In this episode, Patrick explores how immune system checkpoints within the digestive tract protect us from pathogens.
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There’s a long and winding canal that goes from our mouths to our anuses called the alimentary canal or sometimes the gastrointestinal tract. This tube starts and ends outside of your body, and it’s how you process and extract nutrients and materials from the food you eat. But it’s also a spot for potential pathogens to sneak in.
Our digestive system interfaces with all kinds of nasty germs, and as a result, it’s armed with multiple immune system resources to protect our insides from the outside.
Digestion itself is a long process and involves everything from mechanically grinding down food in our mouths to treating food with enzymes so that we can absorb the nutrients better. Therefore, there isn’t just one immune system checkpoint - there are safeguards along the entire system.
#digestivesystem #human #physiology #seeker #humanseries
Read More:
Introduction to the Digestive System
training.seer.cancer.gov/anat...
“The digestive system includes the digestive tract and its accessory organs, which process food into molecules that can be absorbed and utilized by the cells of the body. Food is broken down, bit by bit, until the molecules are small enough to be absorbed and the waste products are eliminated.”
Physiology - Digestion
www.ncbi.nlm.nih.gov/books/NB...
“Digestion is the process of mechanically and enzymatically breaking down food into substances for absorption into the bloodstream. The food contains three macronutrients that require digestion before they can be absorbed: fats, carbohydrates, and proteins. Through the process of digestion, these macronutrients are broken down into molecules that can traverse the intestinal epithelium and enter the bloodstream for use in the body.”
Immunity in the Gut
www.immunology.org/public-inf...
“The large intestine (colon) has a large resident population of microbiota, consisting of at least 1012 organisms per gram of luminal contents. These organisms, together with the antigenic load provided by the diet and the constant threat of potential pathogens, means the intestinal immune system encounters more antigen than any other part of the body.”
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[@Corporis]

Host and writer here. Did any of y’all see that episode of the Magic Schoolbus where they shrink down and go through that kid’s digestive system?

[@kholozondi9904]

Nope. Didn't air in my country but very similar once off episodes of different cartoons did.

[@renebelmontez489]

Arnold… yeah I remember. Poor kid, he always had the worst experiences.

[@aarondelgado3421]

You should be ashamed of yourself for believing in Evolution!

[@megamanx466]

@@aarondelgado3421 Why? 🤨

[@megamanx466]

Yeah about 30 years ago. Was a cool episode! 😅 Also, one of my favorite movies growing up was 'Innerspace'. Also a really cool movie with a silly plot. 😏

[@Master_Therion]

How do you know when your digestive system has failed to protect you from pathogens? You just have a gut feeling.

[@Khemani_RL]

Nice one 😂

[@muteebbhat1024]

You must have at least 3000 iq

[@carnsoaks1]

@@muteebbhat1024 Genius, you could outsmart a donald.

[@farirai.natalie]

The video I didn’t know I needed

[@jonbilgutay2]

No wonder stomach viruses are so short lived; with all these immune systems, as well as vomiting and diarriah, we get the germs out fast.

[@Gold63Beast]

I see someone saw Vsauce’s video on holes lmao. We are donuts lol.

[@shivamshandilya573]

Or are we?

[@luissemedo3597]

A 7 holed donut

[@adityasonawane686]

@@luissemedo3597 the ears and other etc arent actually holes Watch the v sauce video of holes

[@luissemedo3597]

@@adityasonawane686 ... I did, maybe you should watch it again

[@adityasonawane686]

@@luissemedo3597 hmmm oookkkkk sure

[@casbot71]

So having my appendix removed has had long term effects… Great, not only did I have the problem that it was imploded instead of the regular exploded. And it was removed with just a few hours to go before 💥, so they removed some of the surrounding tissue as well. All in all this is a design flaw…

[@SymphonyTaylor]

*I’ve been having gut issues lately and this honestly helped me understand my gut more.* 💯

[@SymphonyTaylor]

@@cosmic_love_5 I might have SIBO so I don’t know

[@headhonchotheone9041]

You eat a lot of nonsense that's why .

[@headhonchotheone9041]

You must go vegan .

[@frankotradez]

@@headhonchotheone9041 lol u don’t even know what she eats

[@kspradeep8397]

Gut can be revitalized by using only organic foods, complete no to processed foods, organic fruits, drinking red wine in certain doses, yoghurt, sprouts, vegetable salads

[@gracioussaxena8318]

Didn't think I'd hear "our anuses" in my life.

[@saulgoodman2018]

How about uranus?

[@adityasonawane686]

@@saulgoodman2018 😂I thought that

[@QueenElsaVeganfromEurope]

@@adityasonawane686　へーーお

[@adityasonawane686]

@@QueenElsaVeganfromEurope what??!!??

[@queenofdramatech]

Can you talk about what happens when your immune system goes awry in your gut AKA discuss Chon's and Ulcerative Colitis.

[@01DOGG01]

When I was a youngin in school, they asked the class where food went after it went into your stomach. I answered 'blood'. And they agreed. Now I understand that they were looking for another, a lot more smelly answer lol. They didn't expect my response.

[@nikolas8741]

Eat your self

[@teehanming]

Again, please make the sound volume louder please. You the only channel that I need to up my volume

[@Melissa0774]

How close are they to knowing what causes ulceritive colitis? After seeing this video, I would think they would know the cause by now, but I don't think they really do yet.

[@thinkdifferent4021]

This channel and its content is super cool and super infomative, but idk why these types of super hardworking channels are not getting enough views and subscribers!!? Great work.👍

[@wilsonbeltran4245]

Hi, you have a wonderful way to explain and make understand how things work in our body. I am wondering if I can you make a video explaining how the digestive system is damaged for gastroparesis due to diabetes and it would be possible to reverse?

[@jamesgrifaord7608]

Amazing and well explained thank you

[@naveenraj2008eee]

Great video.. Nice to learn. Thanks seeker..🙏👍

[@Dudleymiddleton]

Tell Homer Simpson he's a long donut - then he'll eat himself lol !

[@MadhavanSureshRobos]

This is great. It'll be even better if it's made simpler for a common with little technical knowledge as there seems to be a lot of words thrown at me and I retain lesser. Great effort though thanks.

[@rajendrakhanvilkar9362]

Great video

[@aaronwilson9763]

QUESTION: how does "food poisoning" fit into this dialog? ...what is chemically happening?

[@AwesomeMusicLady]

That video would be interesting

[@electronresonator8882]

Researchers : "appendix is not useless remnant of evolution" Charles Darwin : "impossible !!"

[@Lunarplex]

And I’m watching this with a stomach bug 😞 there are some things our wonderful alimentary canal can’t fight.

[@azhari7968]

I'm relieved that you showed someone's mouth without any tonsils in it

[@sweithshetty9463]

Honestly, I expected a lot more when I read the title..even someone going to school will know all these things

[@alparslankorkmaz2964]

Nice video.

[@dogarualexandru-stefan]

This needs a more in depth detail video, or better yet a hole series, in wich, each portion has its own episode.

[@jimbox31]

“Awkward Work Bingo”!!!! I’m winning!!!

[@muhammadosama350]

my appendix blast in my stomach? so my immune system is weaker? can you please make video about appendix its use and its danger?

[@meghabisht7456]

Gut microbiome and appendix play role in innate immunity.. interesting🤩🤩 want to know more....

[@xsforreal]

I don't like the thought of being referred to as a long donut lol

[@mrdeath9132]

😂

[@saulgoodman2018]

2:25 looks like pieces of corn. Which looks the same coming out, as going in.

[@PuneetMehra]

So, If we get our appendix removed, will we not lower our immunity?

[@rockers6963]

plz make vedio on apendix

[@Universalbeing0]

Isn't it awesome being human?

[@megamanx466]

Sometimes. 😅

[@Universalbeing0]

@@megamanx466 I should've said most of the time at the end 😅

[@davidsweeney111]

the gut is the reason why we need to sleep, do a video on that please

[@megamanx466]

Hmm...why with the gut and not the brain? 🤔

[@hypergraphic]

Fun fact, I get frequent cold sores and no joke, French kissing my wife helps them heal faster. She hardly ever gets them, so I think there is some definite immune system boosting going on 😉

[@megamanx466]

Could be just the saliva, which your own mouth could probably provide, but would be less fun. Also, doing that during an outbreak may be more likely to cause an outbreak on her. 😅

[@sash2590]

Accurate

[@pvtpain66k]

Peyers patch. I just watched Cells at Work. >_>

[@megamanx466]

Interesting anime. If you ever get the time and inclination, I'd suggest the 80's movie 'Innerspace'. 😅

[@emilianom6975]

We are apparently a 7 hole donut according to Vsauce

[@justsomepersononyoutube9271]

The future is the best

[@Bassotronics]

I’m a Krispy Kreme walking donut.

[@jasonloke274]

Wow

[@thebongringtone8952]

You know that everyone can imagine everything 🔥🤟❣️❣️❣️❣️❣️

[@Pseudo___]

Imagine a googleplex of balls

[@AdityaBolt]

Host looks like Matt from yes theory!

[@211teitake]

So how does tonsils work as a checkpoint?

[@megamanx466]

Probably the gag reflex. 😅

[@MichaelProds99]

I was gonna write 'I was gonna write 'First' but I remembered I had a life' but I remembered I had a life

[@megamanx466]

Lol... needs an small edit bud. 😅

[@visheshsharma93]

just like many other seeker videos, this video is too quiet

[@gamereditor59ner22]

"The power is yours!" - Captain Planet ....Even though it is not environmental information.

[@megamanx466]

"Knowing is half the battle." -G.I.Joe 😅

[@dudeguy3391]

he just had to say it didnt he.

[@HernanPastenes]

That ain't no Patrick star 🌟

[@chomes8048]

People with tonsils and appendix removed: *Concerned*

[@karanarora1468]

👍

[@irzeeshan___]

We are safe...

[@davidwilkie9551]

The whole message, holography, in the big picture, is restricted to understanding aspects of real-time Infinity, and some aspects are Scientific Categorization of Superspin Modulation positioning function cause-effect in Actuality-Singularity Perspective, in e-Pi-i Principle, so it's stratified focal matricies of Quantum Chemistry atomistic arrangements of pure-math ideal gas of time-timing sync-duration recirculation, and according to Documentaries on UCTV, our biological integration of Predator-prey balance included in bodily defences is an unexpectedly fine balance of pathogens and general ecology of life somewhat similar in concept to the Anthropic Principle Imagery projection-drawing composed of Holographic AM-FM Communication In-form-ation alignments. It is not what I expected to think of about what, how and why things happen as they do in continuous creation cause-effect connection. E=mC² logarithmic condensation wave-packaging formation is Quantum Chemistry, and fundamental to Be Here Now holography dimensionality coordination shaping. One should not be surprised, but also the wonder of Sciencing Re-search is surprising that there is no actual limit on things to learn.

[@alstonmiller212]

What I'm a🍩 all I knew was a lie!

[@buymefrommaxico8894]

Wait isn’t we opposite back of lobster?

[@swarnarekha]

GALT MALT

[@jcstang8952]

Wait. I thought the human immune system didn't exists, according to W.H.O.

[@TELEVISIBLE]

hi 😉

[@philsophkenny]

😀

[@BeanOnTheFlipside]

Someone on the internet just called me a donut

[@mrdeath9132]

😂

[@SteveVi0lence]

You stole that opening from vsauce

[@pinemaple5115]

wondering how much he took to learn this 🙄

[@dulynoted2427]

I'm a cannoli

[@carnsoaks1]

Honestly, rather than long donuts, better to say "A Worm wrapped in Bacon." I mean, like really now, a freaking donut? Stoopid.

[@DrVishalT]

The comment is section is like nerd comicon

[@richardcheng7622]

Sometimes it’s up to the guts.

[@nickyohare2839]

So spit on wounds got you.

[@megamanx466]

As long as you have a clean mouth, then you should be fine. Saliva also has blood coagulants to help start the sealing/healing process. I've heard in a country in South America, they have a believe that you should have a pregnant woman spit on it, which scientifically has been shown to have a higher concentration of coagulants and antibacterial properties. 😅

[@brunodosreis]

Topology 101 😂

[@axem.8338]

'Taking a tour from the elementary canal' I dont like where this is going

[@megamanx466]

Lol. Alimentary Canal? 😅

[@mohammedshaik9647]

I'm not first, I'm not last, But most importantly, *nobody asked*

[@mrdeath9132]

👍

[@rickjames5998]

who is this joker

[@NyanCatzzz]

Rick.

[@Corporis]

No, this is Patrick

[@charliemaybe]

What is this, third party rob dahm

[@shiroi1000]

WTF WHERE IS EVAN ANTON !!!!

[@3divy]

First

[@NyanCatzzz]

Shudup

[@tadeuszreytan8654]

BORING

[@ibadullahtahir7541]

SHAME ON THIS VIDEO AND THIS CHANNELS

[@megamanx466]

Why?

[@vaibhavjaiswal6416]

First

[@NyanCatzzz]

Shudup