Intermittent Fasting for Fatty Liver | New clinical trial

[@Ransom1867]

There’s so much misinformation being shared on KZbin (often times by someone trying to sell their supplements or other products) that’s it’s refreshing to come across some science-based analysis. I appreciate that you breakdown some of the gaps in current scientific evidence on particular issues. Thank you!

[@markotrieste]

Let's put it this way: fasting and TRE are, for me, much easier ways to limit my caloric intake than eating with a scale.

[@NutritionMadeSimple]

good reason to do it!

[@sheilabailey4005]

Me too! I can better control my calories with fasting/TRE. Also I do way better by eating low carb (NOT Keto), especially with controlling my hunger.

[@JWB671]

Hogwash… I eat four times a day, almost 6 pounds of food, and am 175lbs at 6’3” tall. You just need to eat the right foods in the right amounts. It takes seconds to weigh each food and record the amount. The apps figure out the calorie for you.

[@Barnaclebeard]

@@JWB671 "I prefer apples." "Hogwash. I eat oranges five times a day." Umm, okay?

[@esotericsolitaire]

Agree

[@mattlevault5140]

I agree with other commenters that the difference in the fasting window wasn't big enough. I've done TRE- 2 meals a day - and clean(er) diet for the past 3 years. I do a minimum of 8/16 with some days 4/20 and a 24 hour fast mixed in about once every 2 weeks. It gets easier after the first few months. A 24 hour fast is not hard anymore. I lost 50 pounds and took my A1C from pre-diabetic to the low end of normal. IMO the individual results from the study speak volumes - do what works for you...

[@simonround2439]

I tried time restricted eating and it didn't seem to have a huge impact on my weight. Then I experimented with keto and I lost 20lbs completely effortlessly. However, I did find that it took until midday for me to become hungry so I naturally made my eating window between 12-8pm. It works perfectly for me. I've maintained my new weight for a year now.

[@jeanpaultongeren125]

thats a great routine. I used to have that..

[@IntoTheVerticalBlank]

Keto + 16/8 seems to help me a lot. I do tend to eat more eggs than beef and butter though. I think I have seen the same success as you because at first on 16/8 my body started to immediately shed all kinds of :stuff" that was stuck in my mid section from eating far too may high processed carbs for so during Covid. I cut those of course and immediately saw a huge difference. My wife though has not had the same success right away. It depends on your body and what the actual problems are, but Keto + 16/8 seems to work for me.

[@Struwwel2]

At the start of this year (2023), I switched from a low fat/high carb diet to a high fat/low carb diet. At this writing (April 30, 2023) I've lost 45 lbs, from 260 down to 215, and apart from the carbs the only real restriction I've occasionally observed is to stop eating after 8pm. I'm supposed to have some bloodwork done to see how that has been affected, but in general I feel healthier.

[@eclampsium]

Yep, the strategies are complimentary and when superimposed one onto the other lead to great results. As always as on C0v1d, there were no silver bullet but a conjunction of medications…

[@chewiewins]

Keto with reduced appetite synergistic with IF and even OMAD

[@obscurazone]

Im glad that you finally quickly mentioned "food quality". I spent the entire video thinking it's a very simplified analysis - we have no idea what these people were eating. Also, there are so many variables that could influence this study. A person's existing BMI will change very differently if they're on a keto diet with intermittent fasting (for example) compared to a person with the same bmi and fasting window, but with zero dietary restrictions. Critically, in order for this study to offer up any truly useful information, everyone from both groups would need to follow exactly the same diet. It would also be important, that all participants were starting from a baseline where they had similarly "in tact" gallbladders, intestines, and pancreases, as these organs all obviously need to be working in tandem with some efficacy in order to reduce/fix fatty liver. By virtue of the fact the study was indeed to help people with fatty livers, proves that these individuals were already working with compromised organs, so the baseline would have been pretty much impossible to ascertain. A more logical experiment in my (entirely unprofessional) opinion, would be to use a bit of common sense and approach the study of fasting in line with our evolution as a species. We know full well already, that our bodies have evolved to function in semi starvation states. We are not designed to graze all day/night - food was scarce and our makeup is still basically that of a hunter gatherer. I bet it the test group had all specifically eaten a paleo or healthy keto diet for six months, and fasted 18 hours between 2 meals, the results on their fatty liver outcomes would have looked very different.

[@BigBWalter]

Every time a new video is posted on this channel, I know it's going to be well worth a watch!

[@spiral-m]

Most of the time when I skip an evening meal, I end up having significantly more energy the next day - despite being a thin type. Wholefood plant based for 11+ years and never looking back!

[@jamessullenriot]

I've been plant based for almost 20 years. My cholesterol was on the high end of normal and I was showing "signs of fatty liver" in my numbers. That was 2 years ago. I would intermittent fast and even did 3 - 5 days water fasts a few times a year. For me it didn't really budge numbers. What did? Just going whole food plant based. Essentially wiping out anything that had a nutritional label on it. At 46, every number on my blood test was the best it has ever been in my life, including teens and early 20s numbers. After fasting and intermittent fasting I realized that as strict as I was, there were always bad decisions made during my eating windows. My relationship with food being whole food only is much healthier and my numbers prove it.

[@xiamengbaby]

Can you further explain what you eat? Even some foods that I thought were healthy, like legumes, have a nutrition label.

[@jamessullenriot]

@@xiamengbaby Sorry, I should have said label with ingredients. Legumes have a label but they are whole foods.

[@xiamengbaby]

@jamessullenriot ah, makes more sense. Thanks for the follow up.

[@kiramiftari9486]

I do see a lot of masochistic/ disordered eating behavior with clients who OMAD or are strict with IF

[@hata6290]

@@kiramiftari9486exactly

[@wl9275]

The algorithm just put up this channel, and I really like it. I find the acronyms so prevalent in the field of nutrition science that it is hard to read the studies. I am therefore grateful for someone else who takes notice of the research and summarises it for me in a logical and critical way. I have subscribed, and now have a whole wealth of studies to wade through.

[@dinapawlow1622]

TRE has made it possible for me to keep a weight loss of 30 lbs for 6 years. TRE gives me the willpower needed to control my eating. I eat once a day, at noon, then stop, won’t eat until the next day at noon. The kitchen closes at 2:00pm and I just say to myself ´you’ll eat tomorrow ´. As I said, I lack the will power ,TRE somehow gives me that willpower.

[@AffordableMovesUSA]

The kitchen closes at 2pm😂😂😂

[@pureturk02]

I've gained weight on a whole food plant based diet before. But it's almost impossible to do that when eating only 1 hour a day and fasting for 23 hours. Edit: Thanks for all your videos! Have changed the foods I eat

[@cydeYT]

Seriously??? I've recently switched to WFPB while bulking and it's such a huge volume of food that I have to eat.

[@kinpatu]

@@cydeYT I gained 40lbs (of fat) on WFPB, and my lipid panel went severely abnormal. Trigs to 500mg/dL.

[@Atypical_Chad]

​@@kinpatu would love to know what you were eating and what your calories looked like.

[@kinpatu]

@@Atypical_Chad Various beans and grains for protein, a lot of fruit, broccoli, cauliflower, cabbage, etc. Some nuts & seed. Pretty much any plant I wouldn't say no to. I was clearly hypercaloric, based on the severe weight gain. I tried mixing it up with different foods. No matter what I tried, I basically couldn't stop eating. I had to eat every 3~4 hours or I'd be so hangry you couldn't be around me.

[@Atypical_Chad]

@kinpatu interesting. Eating that frequently would def add the cals up. I easily hit 2600-2800 cals if I eat that frequently without restraint. And any training/working out? Or just sedentary?

[@dexterne]

Totally agree with your bottom line: pick the strategy (omad, tre, whatever) that helps YOU stick to reasonable calories from high quality sources for your metabolism/activity level.

[@texasca9753]

For me intermittent fasting is the easiest diet I've ever been on, and being in my 70's I've been on lots of diets. The main things IMF has done for me: 1. It easy, feels natural and I can stick to it 2. I no longer fear being hungry,. Feeling a little hunger at times has made me more aware of real hunger verses something else like boredom making me want to eat Real hunger usually goes away after 20 minutes or so. 3 My sugar/carb cravings are much less 4 I actually enjoy IMF, and I feel good. Back in the day I tried Atkins for 2 years. I felt awful the whole time. Never got that energy you were supposed to get. With IMF I have experienced better energy levels and increased activitie because of it. 5 I really don't worry about calories. I do try to mostly eat whole unprocessed food.. Salads are now something I really enjoy. I don't do keto. 6 I sleep more hours during the night and feel more rested. Being a morning person, my eating window is usually 8 AM to 2 PM. But I do change it up some. Some days I don't fast at all. Those are the hardest days just because I do NOT want to eat later in the days, I have to make myself do. And I used to eat my last meal around 8 PM and often snack later. 7 My cholesterol and fasring glucose numbers are better as well as my BP. My doctor is pleased. Weight loss has been slow but steady, which is what I want. There are lots of books out there on TRE with goals beyond Weight loss. Many include changing up the length of fasting so that the body is being gently stressed more often, which they believe makes it stronger. IDK about that but I know it works for me. Do a little research, if it's something that sounds right for you try it. Give it a little time to get use to. If it's right for you continue, if not, just stop. Note: I watched a podcast with Jessie Inchauspe, not an author I've read. She has a new book coming out and was talking about starting the day with a savory meal (whenever your first meal is) as a way to have good energy as well as eating food in a certain order. My energy was already good but eating this way has been a real surprise -- I feel even better energy, steady through out the day, less brain fog too. Being my age this is a much appreciated improvement in the feeling of well-being. I felt pretty chipper before, but hey who wouldn't want to feel even better? She is far from the only person I've read or listened to on IMF, and I've gotten something from all of them.

[@chrisshave7129]

Gil, thank you for your content and Hi from the UK! I found your channel a couple of weeks ago and IMO it's THE most balanced and objective content I have found. I have been overweight all my life (I'm 57), suffered from gout for half my life, and 4 years ago all my blood markers were heading in the wrong direction. I have Dr Ken Berry and other prominent KZbinrs to thank for getting me onto a better path which I have achieved through low carb/keto and TRE which seems to work for me. What your content has informed and changed my mind on is regarding saturated fat and it's impact on my ApoB and LDL. I've been having a 2 egg omlette pretty much every day for the last 4 years, which the keto 'comminuty' seems to feel is fine. I'm awaiting the results of a full set of blood work so will be interesting to see my ApoB and Triglyceride numbers now and compare to 4 years ago, but I'm already making a choice to replace the eggs with other gout friendly sources of protein for every other day.

[@redelfshotthefood8213]

Please comment under this thread on your results. I’m very interested. I’ve been eating hard boiled eggs most days as a protein source at breakfast...

[@TheFoxholeLife]

IF simplifies things by helping us not to think about food and food preparation all the time. Instead go cycling at night. Worked wonders for me.

[@jackolantern7342]

True. The problem is overeating during the window -I kept making this mistake.

[@Relativecalm2]

Interesting conclusions being drawn, especially given the mania and hype for fasting that has been so prevalent in recent years. Thank you for the clear articulation of both the research parameters and the outcomes. 👍

[@bruceclark4754]

Very clear and informative as always. Thanks so mu h for your brilliant channel

[@Alesini100]

Very good information, and very well explained! Thanks so much!

[@adjusted-bunny]

Thanks for your service!

[@mongofan1]

Thanks, Gil, Alex

[@DonRua]

Thank you for another informative session.

[@joetrolo7076]

I've been doing intermittent fasting for a little over 2 years now. I pretty much eat all my food between 4 and 8 p.m. Don't get me wrong I only try to get this right 90% of the time I definitely allow myself to go off schedule, especially since I've been at my goal weight within 2 or 3 lb for about a year-and-a-half. I'm surprised there was any difference at all between 8 to 4 and 8 to 7. Only a three-hour difference. I would have like to seen it with an 18 and 6 schedule... I was definitely insulin resistant when I started and lost 40 lbs. My A1C I tested last month is 5.2., down from 5.5 last year. Good luck and congratulations to anybody who's watching these videos and trying to improve the quality of their lives!🥳

[@100jakkk]

So, basically, they compared two models of IF - 16:8 and 13:11 and both with caloric restriction. 13 hours of fasting and 11 hours of eating is still valid IF. Comparison, to give us some answers, should compare some IF and wide "eating window" like many people on Standard American Diet have - first meal at 7 and eating right to the moment when they go to bed. And it will give an answer whether IF works or not. Question of why it works - whether there is an voodoo ancient pathway of miracles or just caloric restriction is an another question. Without IF, even done unintentionally (like "I don't snack between meals and I don't eat when sun goes down", which often gives 12/12 IF pattern), avoiding snacking and adding additional calories is way harder than with IF.

[@luckyhanger1326]

Always great content...thanks for sharing!

[@DavidKD2050]

I think you hit the nail on the head with the calorie restriction being a factor drowning out the potential for a clear picture of what is happening, or what would happen long term with maintenance caloric intake

[@leykimayri]

Jeez, both groups were fasting, the only difference is that the control group had a shorter fasting period than the other one. You said they were eating from 8 am to 7 pm so basically the ones in the control group were fasting for 13 hours every day...

[@artichokeenthusiast]

Yeah, this was pretty hilarious to me. When I'm eating normally I could totally eat/nibble on stuff all the way until midnight. Stopping at 7 pm would actually be a drastic lifestyle change

[@Olvenskol]

My own experience is that it is simply easier to restrict calories while doing intermitent fasting. I naturally eat fewer overall calories on 2 meals a day instead of 3. Perhaps this is the main benefit!

[@peterfaber7124]

Why even do a study like this? The intervention difference between the groups is so small. And why no mention of weightloss? I would expect there to be huge weightloss over a whole year eating so few calories. I check the paper, but nope. Only about 9kg. And that was in the first 6 months. So things don't add up. For example, to maintain a BMI of 35, a 1,65 m tall woman would have to eat around 2200 to 2500 calories a day. IF she really ate the suggested 1200 to 1500 calories, she would have been in a 1000 calorie deficit, not the suggested 600. So it's pretty clear that compliance was a big issue.

[@sunspot42]

Bingo. Also, the average person practicing caloric restriction doesn’t have a nutritionist checking in with them periodically to see how they’re complying. What’s compliance like when the watching eye isn’t there? I find IF way, way easier to stick to than caloric restrictions. And good luck getting accurate caloric numbers for the food you eat in the first place, especially if you eat out.

[@johncalberg1573]

What kind of calories did they get? how was the protein vs carbs mix?

[@mikatsuno]

One of my hypothesis is that, some people in the controlled group might have eaten right before sleeping, which worsens the efficiency of digestion. Which, I'm surprised you did not mention.

[@burt591]

Can you make a video about Omeprazole?

[@dmmcmah1]

For me personally TRE has had dramatic effects. Before I started, I had high fasting blood sugars (120-130) and A1C (6.4), and my ALT had spiked to over 100. After a year of TRE my ALT was back within normal range, my fasting blood sugars were 90-100 and my A1C is down to 5.1. I'd like to see studies comparing people doing TRE AND a low carb or keto diet versus those doing a low fat diet.

[@sebacatana]

Great break-down! Thanks!

[@IvanRandomDude]

I like how people are inventing 578 different diets just to reduce calories.

[@NoLimitsNatty]

Excellent information. Thanks.

[@DrSamsHealth]

Haven't seen the whole video and I already wonder 1) why not having a classical 2x2 design (regular diet x LCD; TRE x non-TRE) and 2) how come the feeding window of non-TRE group is so close to the TRE group (just 3 hours extra) - kinda invalidates everything PS. You covered both items, I just need to be more patient :)

[@michaelchristensen2786]

No surprise here. As you said, an 8 hour eating window compared to a 11 hour eating window is just too minor to have any significant effect.

[@DWMtukwila]

It is unfortunate that they did not have the time period from 5 or 6 pm and noon the next day. It is quite easy and I talked to others who do intermittent fasting (myself included) is this time period is very, very common. I am also thinking about autophagy as well. I love this channel! I am geared toward solid evidence, but I do not have sufficient science background to determine which studies are the most well-done.

[@liviu388]

I also think that the time difference between the two groups in this study was too small for an impact. And I like the fact that they chose to place the fasting interval in the evening.

[@sylon7717]

Great video! Can you do a video on caffeine? Sources tea, coffee, and is it healthy or not? How much, ect. There is so much data out there that is hard to make sense of.

[@majesticbutterfly]

Than you Dr Calvalho!❤

[@drmitofit2673]

I don't think that's how most people do intermittent fasting/time restricted eating. In the study they basically skipped dinner, but it is much easier and effective to skip breakfast. Extending your sleeping fast until noon or 1 pm is simpler and better for compliance. One can drink two cups of coffee and workout in the morning as a natural appetite suppressant. It probably has to do with evolution and diurnal rhythm. Cavemen didn't have a refrig or cupboard full of breakfast food in the morning and probably had to work hard for their first meal that didn't come until at least midday.

[@SunFellow941]

How come you never posted the rest of that interview with the lipid wonk? He was going to tell us what he thought of the omega 3/ omega 6 balance argument.

[@Kaztrofy]

It would have been interesting to see the results if the difference in fasting hours were bigger. Many people eating unhealthy have eating patterns between 12-16 hours, while those taking fasting seriously have a much smaller eating window of between 4-6 hours. I usually have a big coffee with cream and blue cheese and nuts on the side at noon, then i have large meal at 4 pm. Ketovore, and both my weight and bloodwork has improved, not to mention controlling hunger and satiety.

[@wendyn9780]

I have been struggling with my weight. I have been trying restricted eating hours but when I do that I get a weird combo of slight nausea and being ravenous at night and cannot sleep well. It’s a relief to get this study’s information. I am going to try allowing a longer eating window and see if it is then easier to be consistent with reducing calories.

[@LiveYourLifeWithJoy]

Water fast 🙏

[@binyaminroscher4516]

I would love for you to review the keto diet with intermittent fasting and it's effects on people in regards to diabetes / insulin resistance (instead of the focus on weight loss). In other words, people at low risk of diabetes, might just benefit from eating less while those at higher risk of diabetes could possibly greatly benefit from a keto intermittent fasting. Forget weight loss, we know that pretty much has to do with overall caloric intake. I want to know about energy levels and diabetic risks. Thanks for making these videos! FYI... from personal experience on a long term keto intermittent fasting diet, I find my overall energy levels higher BUT, I find it more difficult / impossible on the keto diet with intermittent fasting to be able to do the same level of resistance training. The carbs definitely seem to help provide more of a boost of short term energy while working out but my overall energy level is lower from the roller coaster insulin rides when I did not follow the keto intermittent fasting diet. This is just my personal opinion of my personal experience on a keto intermittent fasting.

[@rn5697]

Excellent 🥇but can we have some series on stress, relaxation, depression, anxiety, mental health, neurological diseases? PS. Lesser calories + whole food plant based diet or Whole food diet is the best combination

[@NutritionMadeSimple]

hi, we have some content on diet & mental health: kzbin.info/www/bejne/fJ3IfqeKeqqMosU

[@rn5697]

@@NutritionMadeSimple Some other tricks...is not all about eating

[@bryanleaman5942]

I have a very modest weight loss goal to improve cholesterol, blood pressure and glucose and at least delay meds for my family history of issues. So far, TRE is the only thing that I've been able to adhere to consistently enough to make lasting progress in reducing caloric intake. It's easier for me to stick to a hard and fast rule.

[@operasinger2126]

Thank you for making video.

[@jean-paulvega4449]

Has the effect of fasting on autophagy been analyzed in humans rather than yeast and rats? Do CR and fasting affect autophagy in the same way? Thanks

[@embarq12]

From what I have read, it seems that for autophagy to kick in the fasting period needs to be more than 24 hrs. TRE may not trigger it

[@hUgO6191]

That is an amazing question which was what made me stop fasting. I was doing one meal a day (while maintaining/ gaining weight) for the supposed benefits of autophagy. However I've stopped because from what I've read / heard it seemed that it was too short of a time to induce autophagy and it's actually questionable whether autophagy in humans are a good thing. If you go to the typical fasting advocates you will only hear about the benefits studied in mice. In people when calories are equated there are usually no differences or minimal differences (like the example in this video). So right now my point of view is that most if not all of the benefits of fasting can be attributed to caloric restriction. What really stopped me from fasting believing that autophagy would provide some benefits that weren't provided by caloric restriction was the fact that the famous 16-8 is based on mice. How long can a mouse go before starving? 3 days. How long a human? 40+ days. Things aren't always as simple as linear relationships but I find it hard to believe that the starvation response that mice have after 16 hours is the same that we do after 16 or even 24 hours. The equivalent should be much longer. So if you want the benefits of autophagy we would need to fast much longer in my opinion. But then again we are not mice so autophagy might not even be good for us. As well as the tradeoff that must be taken into account of loss of muscle mass when doing longer fasts. Tldr as a person that is not qualified to advice anyone but has been curious with it for the past years, I don't believe that fasting has any meaningful impact besides CR. it's not useless, if it works as a way to control your weight great, but I don't think there's anything magic about fasting that can't be achieved with CR

[@donwinston]

Exercising will increase autophagy way more than any kind of silly fast.

[@IvanRandomDude]

@@donwinston But it's hard. It's much easier to starve yourself

[@j.joseph5353]

The methodology is questionable. If you want people to be successful at IF, the feeding window should be later in the day. Much later. It's easy for most people to skip breakfast. It's very possible to push lunch off for an hour or so. But people are MUCH less likely to agree to go to bed hungry. The eating window should have been from 2pm-8pm or something similar to achieve better results and increase the likelihood of compliance. A late lunch and normal dinner would have been far easier for most people to accept than a breakfast and lunch.

[@patrikSMD]

I know, I’m off topic… maybe try to use a tripod, please. The camera shaking is irritating 😬

[@lpodverde]

What do you think about soy? Is it safe for people with thyroid issues? I had subclinical tsh levels, and im worried because i ate tofu for a couple of months daily.

[@liberalduh9807]

THANK YOU GIL! I’m 64y and I’ve abused sugar badly for 20-30 years (pops), and wondering how much damage has been done, and if diet can improve fatty liver disease (that I probably have to some degree)..

[@nolan4339]

I have heard that Fructose needs to be processed by the liver (like alcohol is), so I think such a study should probably also try to include fructose intake when studying non-alcoholic fatty liver disease.

[@1truemoose]

What are your thoughts on choline and TMAO?

[@mamaisalwaysright2935]

You have to build up to fasting. Incrementally increase fasting window over time.

[@stellasternchen]

ok, what about autophagy though? Is there a benefit in intermittant fasting?

[@jerrystrozyk8182]

Question: is the growling of the stomach a triggering mechanism to any functions in the body? Is it more beneficial to hold off on eating during a fast until the noise stops? I've never seen anyone speak on this subject.

[@AndrewPawley11]

Excellent!

[@cmel714]

Good study.... I'd like to see TRE and no TRE the second group at 11 hours was still kind of TRE. A group that ate all the time to see how insulin and HBA1C levels would look, with a constantly elevated insulin level.

[@zeshef]

Doesn't fructose (endogenous and exogenous) take the same metabolic pathway in the liver as alcohol? Both lead fo FLD. Sometimes more calories could mean the presence of more fructose.

[@donwinston]

No. Studies using "trace analysis" indicate that over 90% of the fat in people with fatty liver disease comes from the fat they eat and not from carbs/sugar turned into fat. Fructose is primarily converted to glucose by the liver. If you are not in a caloric surplus then there is no way your liver is going to turn anything you eat into fat.

[@Tinky1rs]

Nope, different enzymes.

[@kinpatu]

I'm a bit skeptical of the assumption that the outliers on the waterfall plot must be non-compliant. If you made a waterfall plot of Apo(B) level changes when doing a strict whole foods plant based diet, I would be an outlier (with significant rise in Apo(B) level), and it definitely wouldn't be due to noncompliance. This is why I find pattern associations and mean data somewhat useless; only individual response is actionable. I wish the waterfall plots would be shown in more studies.

[@tiekamskaidriba3691]

Hi! I love your videos because of all of those scientific research reviews. But I have two questions for you: 1.What about the general view that our bodies much better assimilate vitamins and minerals from animal food? I even had the google stating this once when I looked for sources of some vitamins. 2. What do you think about nutritional yeast and it as a source of vitamin b1? I really hope I can find your views on those questions some day. Thank you!

[@r.kitt.3987]

Hmm. I know since I started eating a ketogenic diet along with an fasting of 20/4 (20 hours fasting) I feel Better at 45 than I did at 25. Not to mention I lost over 50 lbs and all of my labs are outstanding now. I'm a huge believer of Intermittent fasting and prolonged fasting. I fast once or twice a month for 72 hours. I sleep better, my mental focus and clarity have never been better and my overall sense of wellness has never been better.

[@Nicksonian]

TRE encourages calorie restriction. I do TRE by eating two meals a day. Although not guaranteed, dropping one meal a day is generally going to drop your calorie intake. Many nutrition influencers try to assign magical properties to TRE, when most likely it boils down to the old, “it’s all about calories,” which so many want to bury. I have been eating later, not breaking the fast until noon, but certain life changes has me thinking I’ll now try the eat early strategy.

[@katprowler6805]

What if you are already a bit underweight but has nafld? This path would not be sustainable for those in this group.

[@Antilli]

How reliable are calories in the first place?

[@stevestephens8925]

hello. this is off topic. my question is: do i need to take a coQ10 supplement if i'm on a statin (crestor). thanks for your videos, they have cleared up alot of confusion for me so far.

[@dbtest117]

A question I have regarding Non alcoholic fatty liver disease. For what I understand ethanol and fructose have one common ground with each other and that is it’s only the liver that really metabolises them. Therefore is my assumption correct that a non alcoholic fatty liver could be attributed to to much intake of fructose. Normal sugar is 50% fructose and 50% glucose. Where the glucose component would be metabolised in the whole body and therefore not affecting the liver as much as the fructose?

[@brucejensen3081]

I did drop 35lb and gained probably 15 lb of muscle in a year. I did double calorie intake, but excercise went up, so i guess i was in calorie restriction. My triglyceride went from 8.2 to 1.5. I have put 12lb back on, which is pretty much all muscle. Be interesting to see what has happened to my triglyceride. I assume my liver is less fatty

[@dewsplash]

For me both keto and IF combine to make eating less calories quite easy. Not enough time to eat too much, plus I dont feel hunger the same way anymore due to ketosis. In 138 days i have lost 70lbs and im only 5lbs away from my goal weight. I do a "healthy keto". Limiting saturated fat somewhat. Keep in mind I was very motivated to lose the weight. Only cheating I did at all was a few drinks every 2 or 3 weeks. Highly recommended for people (like me) who found restricting calories uncomfortable and difficult to maintain.

[@RogerHyam]

Are there some trials comparing early vs late 16:8 fasting? (I'm biased towards doing noon till 8pm myself) It also seems like eating before or after noon is more significant than a convenient window like this. Being active and not eating is different from being asleep or slobbing out in front of the TV and not eating perhaps? Stopping eating at 4pm is pretty antisocial which would have negative effects on mental health.

[@RS-cl5wg]

Have you done a video about the best foods for memory & focus. How to prevent/reverse dementia

[@jeanpaultongeren125]

blue berries, salmon, dark chocolate, coffee, walnuts these are just the things I can think off.

[@Jon-es-i6o]

I don’t know if I missed it, but it would be useful to know why TRE is good for prolonged insulin resistance reversal. After all, that’s the main weapon in combating NAFLD.

[@donwinston]

No it is not. Losing weight is how you get rid of fat. Insulin has little or nothing to do with it. The new drugs like Ozempic INCREASE insulin and people lose significant amounts of weight. Please stop listening to high fat low carb diet zealots. Almost everything they say is completely bogus.

[@k.h.6991]

Losing weight is the most reliable way to improve insulin resistance. Like Gil keeps repeating: TRE works when it helps people with their calorie restriction, so they lose weight.

[@dianeladico1769]

T2D, WFPB and I found early TRF significantly improved my fasting glucose numbers.

[@tomb8430]

Eat between 8am - 4pm? That almost seems like a normal eating pattern. Not restrictive.

[@manicminer4573]

The point is, skipping breakfast as a form of TRE is easy, which makes coloric reduction feasible to maintain long term.

[@jan-ck7td]

For me two healthy meals a day and not snacking 5 days a week is the way to keep calories under control. In the weekend I am less strict, to keep live pleasurable for me. When you don't restrict calories by counting, the eating window is probably less important then meal frequency. It least for me this seems to be true.

[@michaelshepperd1844]

Would you consider doing a video on Fast Acting Flushing Niacin? Would you talk about the efficacy and how it works.

[@Ren-j7n]

Could you please do a more detailed video on fatty liver(non-alcoholic fatty liver) and any scientifically proven effective methods to reverse it(if there exists any)?

[@abdullah-yh7vb]

What about muscle mass between the 2 groups?

[@c.t.1893]

Hello Dr. Gil, I'm curious if you could do a reaction video and simultaneously give us information on whether this actually works. A man named Bryan John doing something called 'Blueprint', a science based lifestyle that involves numerous supplements, blood tests, MRIs all in an attempt to reverse his epigenetic aging back to 18. Was curious as to what you may think, and whether there's any truth to it at all. I know you typically just talk about diet, but it would be interesting to hear what you think of his diet, his body fat level and all these supplements. I believe he takes roughly around 100 pills a day or something along those lines. This 'blueprint' is also on his free website, where everything is listed, including all the scientific literature.

[@Deusaga]

I wouldn't follow what he does tbh. He looks like he aged 20 years in the last 5 years.

[@creativesource3514]

@@Deusaga that's not true but also irrelevant. It's not what he looks like that's interesting..it's his physiological readings.

[@c.t.1893]

@@Deusaga I don't, I just find it interesting and would love to see an actual doctor who isn't biased react to it. I lead a simpler healthy lifestyle, not even close to his extremes, but I still find it fascinating.

[@donwinston]

Does he believe in magic genies too?

[@JohnBarrow1961]

His name is Bryan Johnson.

[@seanwhitehall4652]

I'm sticking with my solution as long as I can: cardio to the point of near death experiences. Then eat lots of beans, veggies, milk, misc

[@torrejef]

Were there analysis on what they are that make up their caloric intake?

[@jackylcs1986]

how about Low Calories diet non-TRE vs normal calories diet with TRE?

[@neatengineering]

A relative's 15 year-old son was recently diagnosed with fatty liver. (About a month after Halloween, but the symptoms started earlier.) He was not at all overweight, but was a bit sedentary. He has cut aweet foods, sugared drinks including fruit juice, and reduced processed carbs. He's feelibf much better, his migranes and lethargy have improved, and he's exercising more. His next checkup is in a month. It's worrisome when thin fifteen year-olds are getting fatty liver.

[@shannonhawkins3442]

8-4pm or 8-7pm is still close to each other and seems like time restricted 12 hour fasting vs 15-16 hour fast.

[@luisluis5306]

What if you ate ze bugs?

[@eclampsium]

At 6:14 i don’t understand that is all up to calories restriction, but the tre seemed better in the low compliance group. Plus, i’ve seen TRE vs bariatric patient photos of similar weight loss and and omg, what a difference in the cosmetic result becouse of the autophagy vs the frequent insulin liberation setting, despite same weigh reduction. We should never forget to look to realistical practical results besides numbers…

[@2072]

What is missing in all of these studies is snaking habits. Do the participants allow themselves to snack? Most people I know do snack, even if it's just a fruit or some candies here and there, this can have a huge impact (any food intake raises insulin levels and thus may help maintain insulin resistance instead of lowering it). I used to snack a lot until I started drastically restrict sugar intakes overall, up to the point I stopped depending on it and the craving for sugar sources just disappeared, I only eat twice a day but I do not snack at all in between my meals. (what I do could be describe as a mix between keto and Mediterranean + intermittent fasting with the 2nd meal being lighter)

[@TenTempeh]

My problem with TRE is I struggle finding a variety of breakfasts that can bring enough calories & nutrients overall for me. Therefore, my eating window is between lunch and dinner. Which is not optimal (considering circadian rhythms)... Aaaaaaaaaa

[@gbrew839]

7:53 I agree, it would be interesting to to see a 4 or 6 hour window

[@beoz658]

Can intermittent fasting cause gallstones?

[@michaelchapman8359]

From what I understand, for TRE to be effective the window should be both smaller and also shifted so that the insulin hormone is not triggered until as many hours after waking as possible. For example waking at 7am but not breaking your fast until noon, then not eating anything after 6 pm.

[@ProfFeinman]

This would have been a better study if there were some idea behind it. And, as you say, if there were a difference in the time intervals.

[@mertonhirsch4734]

Moderate caloric deficits largely trump macros, timing and even bad food choices to some degree.

[@jackiedixon5076]

What about the fasting benefits of autophagy or is that a real thing?

[@nonfictionone]

Sort of confirms what I am now thinking. Any benefits from restricted eating times are solely from reduced caloric consumption. I do omad. I have found it extremely easy. No plan to change it. Was hoping for autophagy benefits. Unlikely. But it’s easy so I’m sticking with it.

[@jimmaxwell2259]

This experiment repeated, with a 2hour time restricted eating window versus an all day eating window(some folks snack after midnight etc) could be very illuminating. Some anecdotal evidence that 'fuller' benefits only obtained after regular 20 hour plus fasting...so would love to see that tested in a proper randomised trial.