Ketamine: Benefits and Risks for Depression, PTSD & Neuroplasticity | Huberman Lab Podcast

In this episode, I explain how ketamine causes rewiring of brain circuits and dissociative states to relieve symptoms of depression and post-traumatic stress disorder (PTSD). I explain how ketamine impacts both the brain’s glutamate and its endogenous opioid pathways, which together regulate mood and well-being. I discuss how ketamine therapy is used clinically to treat major depression, bipolar depression, obsessive-compulsive disorder (OCD), suicidality and other psychiatric challenges. I also describe how ketamine causes the subjective effects of dissociation and euphoria and, at higher doses, is an anesthetic. I compare the different routes of ketamine administration, dosages and forms of ketamine, and if micro-dosing ketamine is effective. I also highlight the potential risks of recreational ketamine use (and the colloquial term ‘K-holes’). This episode should interest anyone interested in ketamine, treatments for depression, neuroplasticity mechanisms, psychiatry and mental health.
#HubermanLab #Science
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Articles
Antidepressant effects of ketamine in depressed patients: bit.ly/44YTGxY
Attenuation of antidepressant and antisuicidal effects of ketamine by opioid receptor antagonism: go.nature.com/3qesrR8
atai Life Sciences Announces Results from Phase 2a Trial of PCN-101 (R-ketamine) for Treatment-Resistant Depression: bit.ly/47j6wsC
Comparative effects of (S)-ketamine and racemic (R/S)-ketamine on psychopathology, state of consciousness and neurocognitive performance in healthy volunteers: bit.ly/44WMxOR
Ketamine Metabolite (2R,6R)-Hydroxynorketamine Interacts with μ and κ Opioid Receptors: bit.ly/44e4SWB
Other Resources
The Science & Treatment of Bipolar Disorder (Huberman Lab episode): hubermanlab.com/the-science-a...
Timestamps
00:00:00 Ketamine
00:02:29 Sponsors: ROKA & Eight Sleep
00:05:13 Ketamine & PCP; Clinical & Recreational Use
00:09:00 Depression & Current Treatments
00:15:17 Preclinical Models of Depression & Ketamine; “Learned Helplessness”
00:22:11 Ketamine & Clinical Uses; Depression & Suicidality
00:28:32 Ketamine & Other Psychiatric Challenges; Relief & Durability
00:33:24 Sponsor: AG1
00:34:29 NMDA Receptor & Neuroplasticity
00:41:36 Excitatory & Inhibitory Communication, Seizure, NMDA Receptors & Ketamine
00:48:26 How Ketamine Functions in Brain; Acute & Long-Term Effects
00:55:36 Brain-Derived Neurotrophic Factor (BDNF) & Ketamine Therapy
01:02:28 Sponsor: LMNT
01:03:40 Ketamine & Opioid Pathway
01:10:00 Divergent Mechanisms of Immediate & Long-Term Effects
01:15:45 Habenula, Pro-Depressive Behaviors & Ketamine Therapy
01:20:36 Ketamine & Context-Dependent Strategy; Reward Pathway
01:22:45 Dissociative States
01:26:04 Doses & Routes of Administration; “K-holes”; Risk & Caution
01:32:25 Ketamine Forms; R-, S- vs R/S- Ketamine; Micro-Dosing
01:38:24 Ketamine: Effects & Therapy
01:40:40 Zero-Cost Support, KZbin Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter
The Huberman Lab podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user’s own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions.
Title Card Photo Credit: Mike Blabac - www.blabacphoto.com

[@BrownGeorge-pw2xo]

Lsd, ketamine, dmt and psilocybin containing mushroom are amazing. I was diagnosed with Cptsd 20 years ago as a teenage. Spent my whole life fighting Cptsd. I suffered severe depression and mental disorder. Not until my mom recommended me to psilocybin mushrooms treatment. Psilocybin treatment saved my life honestly. 8 years totally clean. Never thought I would be saying this about mushrooms.

[@Ronkaja]

Congrats on your recovery. Most persons never realizes psilocybin can be used as a miracle medication to save lives. Years back i wrote an entire essay about psychedelics. they saved you from death bud, lets be honest here.

[@Bastianbishops]

Can you help me with the reliable source 🙏. I'm 56 and have suffered for years with addiction, anxiety and severe ptsd, I got my panic attacks under control myself years ago and they have come back with a vengeance, I'm constantly trying to take full breaths but can't get the full satisfying breath out, it's absolutely crippling me, i live in Germany. I don't know much about these mushrooms. Really need a reliable source!! Can't wait to get them

[@DonnHowes]

YES sure of Dr.benfungi. Did straight shrooms in few days. Left me like a blank slate after words, no more addictions, pains, ptsd and depression. Shit saved my life, all thanks to Dr.benfungi

[@SusanaGomez-mp8sk]

100% agree I used to have Psychosis and paranoid thoughts like "people thinking about me talking about me etc. Very odd behavior after getting off Adderall from 7-16. Antidepressants at 18-29. 31 now. I took way to much, but took about 20g of Gold caps (Psilocybin containing mushroom) I analyzed my entire life. The emotions that came out helped me understand behavior etc more. Wont ever need to do it again because I'm happy and contempt forever, but I wish more people did this to alter their perception of reality. Would help with healing much trauma

[@gefferystones2814]

How do I reach out to him? Is he on insta

[@lubaerlikh7170]

7 ketamine sessions, ptsd and suicidal ideation free for over 6 months now. My anxiety is also reduced by 70%. No more smoking. Sleep is finally getting better too. I finally started to exercise 3 times a week which further contributes to the improvement of my symptoms. What ketamine did for me was to make my brain unstuck on trauma which ptsd victims experience and gave me the ability to move on with my life and not relive the past over and over.

[@KingKong_CH]

Same here ❤ Ketamin helped me to free my mind from depression.

[@amandac6232]

What delivery method did You take?

[@deeznuts3145]

Wow that’s so fascinating. Which one did you do. Heard the iv one then the one you do at home. But heard the one you do at home isn’t strong?

[@pierrearr]

How long did it take to complete the 7 sessions?

[@lubaerlikh7170]

@@pierrearr 7 weeks, once a week

[@Sharon-fc2jt]

After decades of depression and failed psychotherapy and pharmaceutical treatments and a LOT of wasted healthcare dollars, I got complete relief from Ketamine and have been depression free for 3 years with NO added medications or psychotherapy. Exercise, sleep, good nutrition and meditation keep me mentally healthy now 😊

[@pacattack6772]

congratulations :) I have spent half my life trying psych meds for depression and anxiety and doing therapy (ages 13-25 now) and can't afford IV ketamine because insurance won't cover it but am able to afford the psycholytic small dose from a compounding pharmacy. do you think I can expect similar changes? did you do IV treatments?

[@matthewgateoperators2406]

​@pacattack6772 Yes, it should help, I've tried both

[@cma3436]

After your initial treatment did you have to go in for any boosters? Or did you just do the six standard infusions? And thank you in advance. I've gone through three infusions and I've got three more to go.

[@searabia]

I had chronic pain for years and was in a deep melancholic depression. I was not getting out of bed, crying throughout the day, not eating, unable to sleep or sleeping too much. I had my first Ketamine IV infusion earlier this week at the hospital and within hours was eating again, have slept well, began to run again, began doing pilates and restarting my doctoral program again later this month (was going to take time off due to my pain and mood). This was an extraordinary experience for me and beautiful for me. I know that I am not the only one. No more pain! No more tears! I feel reborn.

[@miamilawyerdaddy]

Chronic lumbar pain after 3 surgeries. Considering ketamine. Hopeful!

[@clintsprague3512]

That's awesome!!

[@heyitsj3092]

I’ve been dealing with Chronic Lumbar pain for years with no diagnosis available from any professional which has also influenced my depression. I’m thinking about trying Ketamine from Joyous.

[@vocals1111]

​@@heyitsj3092chronic back pain 40 years, planning on trying this soon too, good luck

[@vocals1111]

​@@miamilawyerdaddyme 2 good luck

[@amandathemystic1828]

My mom did ketamine treatment earlier this year before she passed away from cancer. It helped her so much with the depression and fear of dying. Unfortunately, she was only here long enough to do two sessions.

[@elizabethwilk9615]

Am sorry for your lost.

[@jobunny919]

I am so sorry for your loss.

[@johnstallings4049]

Peace & ❤ to you! ❄️🌎❄️

[@mcd5478]

Thank you for sharing this

[@m.a.r.k3136]

🙏 RIP 🙏

[@philippabertacco7919]

Thank you for this!! I've just completed my 3 week ketamine infusion programme and my life is forever changed. My kids now have a mom who feels alive again. ❤

[@pattycarlin1745]

Philippa, so happy for you (and your kids! :) Am considering this as a treatment protocol for anxiety/depression and wondering if you might share some of your positive experience? Many thanks!

[@bryanutility9609]

@@pattycarlin1745try lifting weights, and walking in the sun. Turn off screens & create action in your life. So something you can be proud of. Modern society is sick.

[@starlightpancake]

@@pattycarlin1745I highly recommend Ketamine therapy for anxiety! It works so well with the nervous system

[@theycallmedip]

Don't be discouraged if you feel the need to have boosters. It's really common and is universally accepted that the treatment doesn't last forever without more treatment

[@bryanutility9609]

@@theycallmedip you shouldn’t need any boosters of ketamine 😂. It doesn’t fix you. You can only fix yourself. Fix what you’re doing wrong with your life

[@cp627]

I’ve been doing Ketamine treatment for over a year now. Nothing has helped me get over my depression and PTSD more. It not just the Ketamine though. You have to be willing to make positive changes to you life as well.

[@nushamawellness]

Yes! Ketamine isn't a cure or a magic pill. It's a tool. People who set intentions, integrate, and apply what they've learned from the sessions are the ones who experience the most profound results. Thanks for sharing your story!

[@jtjdt]

Combine your ketamine clinical, intravenous, supervised treatment with BrainTap InHarmony Alpha - ‘I am pure love, 33 mins,’ followed by the ‘Energy Clearing’ at the end of your session. Then, the week of your treatment, do BrainTap’s BreakThrough PTSD Hypnosis with Lion’s Mane mushroom twice daily, and I guarantee your brain, body, and spirit will be clear and balanced. For others who are experiencing imbalance and losing hope, please research the “Safe & Sound Protocol” or SSP. Much love to you on your journey.

[@JM-qe4sx]

Jesus is my cure, something that is spiritual must overcome something so traumatic one experiences in life. That's my personal belief. That we must match death with life and only God fulfills like that. It solves why we are here and why not dead. Obviously, we don't have all the answers, but it's comforting, and it works for me.

[@Leila550]

Same. Been working with it for 2 months and have made more progress in talk therapy in 2 months than I have in 20 years. Shit works but you also gotta do the work.

[@lupeg8602]

@@nushamawellnesscan you explain what you needed to integrate to get the most results please

[@luvstargypsy]

My daughter teen was struggling with suicidal ideation and self-harm, and the children's hospital was doing a trial and used it on her only one time! she hasn't had any of those behaviors since! I'd like to add my daughter has struggled with PDA Autism and adhd her whole life.

[@TheWilliamHoganExperience]

I was treated with a single dose back in 2018 for treatment resistant depression and extreme anxiety that began in my teenage years. I've been well ever since. Last year I was formally diagnosed as autistic. At age 57. Has your daughter been screened for autism? It's often missed in people who are not intellectually disabled. Especially in girls, where it presents very differently than in boys. I ask because it was the stress of dealing with (masking) undiagnosed autism that led to my severe anxiety and resulting depression and shut-downs. My autism was missed by dozens of psychiatrists and psychologists. It took an autism diagnosis specialist at Kaiser and a 4 hour interview and and exhaustive history starting with childhood to make the diagnosis. Autistic people are known to react differently than ordinary people to a variety of drugs. Your daughters 1 treatment cure mirrors my own. My journey towards formal diagnosis began with a self adminstered online screening test that took 10 minutes to complete. It suggested I seek further evaluation as I scored high on autistic traits. Beware though - most of these screening tests are outdated and gender biased towards detecting male autistic behaviors, interests and traits. Either way, I'm glad to hear about another person having the same miraculous expereince with the drug as I had =)

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[@JohnVanDeVoort]

As a pharmacist, I always appreciate listening to your podcasts. Very informative and balanced with evidence and insights.

[@johnforcillo1267]

Same here. Pharmacist as well. The level of information and how it is explained is impressive.

[@runningturtle4815]

I broke my leg last year & had to have surgery. When I came out of surgery & was waking-up. I was in Extremely terrible Pain. I heard the nurses talking about the amount of opiates id been given & I wasn't able to have anymore. Yet I was still in Horrible pain tho. I heard them mention that maybe they should try & give me Ketamine. A short time later I recall feeling like my Leg was across the room. Then out in the hall & then it was outside the Hospital. The pain fading away the farther away my leg seemed to be to me. Ketamine worked wonders for the pain I was experiencing for sure. I just Figured I'd share my Ketamine experience with everyone. Peace & much love Dr. Huberman & everyone

[@griffindoherty8532]

I've been extremely depressed since I was probably about 8 years old and throughout my life I've attempted suicide., I'm 28 now and over the course of the past 15 years I've been on every antidepressant you could possibly think of, late last year I did ketamine under medical supervision and just that five rounds of ketamine has done more than 15 years of antidepressants ever did. I feel like ketamine gave me a second lease on life, I'm happier now than I've ever been.

[@bryanutility9609]

Notice you didn’t mention anything about exercise, nature, or accomplishments of any kind.

[@justmorenoise]

@@bryanutility9609dude, the people I meet in the psych hospital would be doing far more exercise, meditation making their bed, walking in nature then you so it’s no cure. If positive thinking, healthy eating and active discipline was the cure these people wouldn’t be killing themselves.

[@Joshua-mt2kb]

@@bryanutility9609what’s the point being made here?

[@bryanutility9609]

@@Joshua-mt2kb the truth about depression

[@newbootgoofin__]

@@bryanutility9609what’s the point you’re trying to make? Spit it out.

[@chaddelany8876]

"'Better life through chemistry' still requires a better life" is such a fantastic quote.

[@Greg.Olson2299]

I just tried KETAMINE,.. DMT for the first time. I felt as if i was in the center of the universe. I didn't go crazy after such an extreme experience.

[@MorganSantillanes]

Psychedelics should only be used with great care and respect, I would love to feel same man , how do you source em

[@SusanHoskins-df9kk]

dr.perryshrooms is your guy. Got all kinds of psychedelics stuff. Guided me through my first ever experience

[@JamesHinkle-lu9yy]

Yes, dr.perryshrooms. There's a lot of potential in psychedelics

[@TimTalley6388]

The use of magic mushrooms can completely help one get over addiction and depression. but there’s a big risk if you eat the wrong type

[@CastroTristen]

hm. will dr.perryshrooms post to me in LA?

[@Jennifer-bw7ku]

Psychedelics are just an exceptional mental health breakthrough. It's quite fascinating how effective they are against depression and anxiety. Saved my life.

[@patriaciasmith3499]

Can you help with the reliable source I would really appreciate it. Many people talk about mushrooms and psychedelics but nobody talks about where to get them. Very hard to get a reliable source here in Australia. Really need!

[@APOLLINAIREBARTHOLOMIEU]

Yes, dr.sporessss. I have the same experience with anxiety, depression, PTSD and addiction and Mushrooms definitely made a huge huge difference to why am clean today.

[@elizabethwilliams6651]

I wish they were readily available in my place. Microdosing was my next plan of care for my husband. He is 59 & has so many mental health issues plus probable CTE & a TBI that left him in a coma 8 days. It's too late now I had to get a TPO as he's 6'6 300+ pound homicidal maniac. He's constantly talking about killing someone. He's violent. Anyone reading this Familiar w/ BPD know if it is common for an obsession with violence.

[@patriaciasmith3499]

Is he on instagram?

[@APOLLINAIREBARTHOLOMIEU]

Yes he is. dr.sporessss

[@suellenmay2624]

Thank you for your work! I'd love to see an episode on Depersonalization and Derealization Disorder or dissociation in general. I work as a therapist and find this to be more common than one might suspect and little understanding of dissociation states that are not due to medications/illegal drugs.

[@taylorbailey5155]

My Dad is a neurologist and recently started a Ketamine and TMS clinic. Patients lives have been changed through the treatments and my brother who works as one of the providers at my Dad’s clinic plays your videos during some of the patient’s TMS treatments as they are familiar with you and have a mutual love of you and your podcasts. Thank you for what you do Dr. Huberman!

[@martinoplaya7805]

It was such a well-written episode, especially the segment about glutamate in the brain and the balance between inhibitory and excitatory neurons. I found myself rewinding parts that I might have missed just to ensure I caught everything 💯

[@haithammihawk8215]

I've been following your works since the earlier months of the channel and i still have the same thought on my mind whenever i watch a new episode... "we can't appreciate you enough" Please keep up the fantastic work sir

[@thenighttimecook8377]

Hoping for an episode on Neurofeedback and PTSD. Thanks so much for your podcasts. They have helped so much.

[@robbengingery5494]

Ketamine has been life changing, and saving for some of my patients. Note the paradoxical effect of doses larger than .5mg/kg. i.e. this has been shown in some people to make them more depressed Thank you for all of your podcasts. Excellent

[@potocabengo7010]

Thank you for this video, Dr. Huberman. Would it be possible to do an episode on Complex PTSD, please?

[@lindagirl1140]

I second that. Complex ptsd please…

[@Fresh4life]

Seriously. Yes third. All the knowledge the better. Truly is very much needed.

[@ChristianLeFer]

Yes 🙌 another vote!

[@TheArtofMedicine]

Fantastic review. As a compounding pharmacist, we've dispensed Ketamine to thousands of patients in IN, SL, rectal, oral, and even topical! Please consider getting a compounding pharmacist on your podcast! We have a wealth of knowledge applicable to many of the topics you've discussed.

[@deprofundis3293]

Hi! I'm super curious about your opinion on intra nasal ketamine. I've been doing Spravato for a couple of months but am looking to switch to at-home compounded format. But I'm reading some reddit posts saying that people don't usually like the nasal at-home version for some reason or that it's not as effective. I really don't want to do the oral version unless absolutely necessary...

[@TheArtofMedicine]

Great question. It is very similar (the esketamine in Spravato is part of the nasal spray from a compounding pharmacy. It all depends on dose and directions from your provider. Make sure the compounding pharmacy is legitimate too! Easy way is to see if they are PCAB accredited. @@deprofundis3293

[@giancarlogalvani6461]

@TheArtofMedicine need help...do you know if I can take Spravato 84mg twice a week with my Methadone 170mg daily and receive the depression treatment of Ketamin? Does anyone know? Help me understand more clearly the depression effects with my use of Methadone...

[@Dmgolfer22]

@@giancarlogalvani6461most ketamine clinics won’t treat you if your currently on MAT for opioid use.

[@HMohr]

What a great episode. Andrew Huberman deserves the Nobel prize for science education on a global level. I feel he's like the Carl Sagan of our generation , although less poetic. What a great joy to be able to be exposed to this kind of information/knowledge.

[@MrMusic238]

I tried 2 courses of ketamine infusions. It was a great experience and lifted me a bit mentally, it really felt like it was sorting through the hard drive of my brain, but it turned out my depression was caused by undiagnosed inattentive adhd and executive dysfunction problems. Now medicated for that I’m not depressed anymore.

[@bunnycouture]

PLEASE share what meds are helping you now bc that sounds so much like me, but I havent figured out good meds yet :/ ✌🏼

[@camillagm]

+1. Please, share which meds are helping you. I started elvanse and felt a huge improvement in my depression, bofore seeing any improvement in my focus. But after 3 months I'm starting to see the depression slightly increase again. Not sure yet if it's related or not.

[@andrestein6022]

@bunnycouturecrystalswimwea7426 everyone is so different, in reaction to those drugs, that anything helping one person is by no means likely to help you also

[@Iamandthatiam]

What are you taking?

[@jamesa6080]

Poppin addys🎉

[@crystina99]

You can't even imagine how precious this explanation is for my life situation... how can I thank you? Cheers from italy

[@kristenslater6112]

Hi Dr. Huberman-fellow Stanford faculty here. I am a pain psychologist in the Stanford Pain Management Clinic. We have many patients with comorbid chronic pain and depression. We offer inpatient ketamine infusions for pain and many patients are under the impression this will also help their depression. Love your emphasis on dosage/delivery mechanisms impacting outcomes-curious if you have any thoughts on how the ketamine protocol for chronic pain may (or may not) impact depression? Thanks so much-LOVE your podcast and use your information often in my personal and professional life.

[@VEERODPHX]

I would like to know about how effective it is for pain too. I have trigeminal neuralgia. My neurologist recommended I try ketamine but I have been concerned about any side effects. I

[@RobG1729]

​@@VEERODPHX I have received IV ketamine for peripheral neuropathy through the Stanford Pain Clinic, an in-patient treatment at Stanford Hospital. The relief has been greater than any I'd experienced in nine years of chronic pain.

[@sonyaromero5186]

Thank you for this deep dive on the topic. Ketamin therapy has changed my life and patterns of thinking. I no longer go down negative ruminating loops in my mind. Neuroplasticity at it's finest! I completed 6 sessions over 15 days back in September and have not felt like I needed to go in for a "maintenance session" and it's almost been a year. Huge success for me! Thank for all you do in the name of science, Andrew!

[@pierrearr]

Hi Sonya, glad to hear about your success. I'm considering ketamine therapy to save my life. Would you be so kind to answer some questions I have about ketamine therapy in private? I'm desperate and I would appreciate your insight.

[@sonyaromero5186]

@@pierrearr Absolutely, ask away!

[@pierrearr]

@@sonyaromero5186 My message was deleted apparently. I asked if you'd be willing to speak with me somewhere else than here? I would be so thankful.

[@iceshawty9751]

@@sonyaromero5186 what methods of ketamine intake did you use? how much g and per what time? I am looking forward to your response. Thank you. 💝

[@sonyaromero5186]

@iceshawty9751 the clinic I went to administered the ketamine intramuscular, so just a shot in the arm. They give one shot which sends you out there then they give another shot about 15 minutes later to keep the effects going for about an hour. I don't remember the dosages but I do know they increased it each session because you do gain a tolerance to it a bit but that and your initial dosage will all depend on how quickly your body metabolizes the ketamine, which is different for every person. Hope that helps 💫

[@rohamhadidchi1196]

Hi Dr Huberman. I’m a neuroscience undergraduate student. Great explanation of NDMA receptor function. I’ve also seen it explained as AMPA is the friend who is always willing to go out but he’s kind of boring. NMDA is the one who takes a lot of convincing but when he comes he’s really exciting. Biology is truly amazing.

[@Alx-L]

Hola Andrew! Since Episode 1 you've been my company during Covid, Shanghai lockdowns (3 months in 60 sqm), finishing my MBA where the protocols for focus, creativity, sleep, manage stress and conquer depression plus many others, helped me a lot. I've got married, relocated in another country in South East Asia and ready to listen about Ketamine from Kuala Lumpur while hitting the gym, trying to not get too much bright light before going to bed and taking my 1000Mls EPA !😂 Yes sir! You've been a friend for a long time, people hear you around the world and just wanted to thank you for such a great and honest podcast!!! Chau y abrazos!

[@bowen324]

Thank you, Andrew! I discovered your podcast about 5 weeks ago and I've been thoroughly enjoying your broad range of content and the fascinating insights your content brings.

[@scottallen5269]

Thank you, for your attention to so many details, and sharing so much important information. I’ve been considering trying this method, to help me work through my depression and anxiety. You answered some questions I had, and helped me understand better,how it works. Keep up the great works, it’s much needed.

[@keelimk]

I have been doing IM Ketamine assisted therapy for 1 year now. It has been absolutely transformative. PTSD thoughts and flashbacks I don’t think about anymore, it’s not at the front of my mind . I haven’t forgotten about them but instead it’s like previously I was hauling a heavy suitcase and now it’s like wearing a backpack. It’s easier to carry. Ketamine therapy has also heavily helped my depression, panic attacks, and job retention. I’m manic depressive bipolar type 2 and through the last year I have stopped having panic attacks before work. I can get myself to work, stay at work and feel less depressive overall. I appreciate the little things in life. I have a higher sense of spirituality and a clearer view of what I enjoy about life. It feels as if ketamine is creating new positive tracks in the road. Ridding the old path and creating and deepening a new one. One of the most amazing experiences I’ve been lucky enough to experience.

[@WiLDFILMZ55555]

Good for you!! I'm going in next am for 6 IV infusions. Ptsd , TBI hoping this saves my life!

[@jocs8824]

were you on any mood stabilisers or antidepressants before during and after ketamine? Are you still doing well? No signs of it worsening your mental health over the long run/subsequent treatments?

[@HarpaAI]

🎯 Key Takeaways for quick navigation: 00:00 💡 Ketamine is being used clinically for depression, suicidality, and PTSD treatment, but also has a potential for abuse. 02:08 🌱 Ketamine's clinical use is grounded in its effects on depression and its potential to change neural circuitry through neuroplasticity. 07:30 🌐 The landscape around ketamine has evolved, with crossover between clinical use and recreational abuse, leading to various effects and potential addiction. 11:53 🧠 Ketamine shares some properties with PCP, but its clinical benefits, especially in depression, have gained significant attention in recent years. 17:03 🏊 Ketamine's unique mode of action, including inducing dissociative states, has garnered interest for both its clinical and recreational aspects. 19:09 🔬 Research has shown that low doses of ketamine can counteract learned helplessness, indicating potential antidepressant effects. 20:30 🐭 Ketamine's effects in preclinical models and its ability to prolong active behavior in animals suggest a link to antidepressant properties. 20:58 🧪 Ketamine's action as an NMDA receptor antagonist challenges the traditional understanding of neuroplasticity, leading to questions about its mechanisms. 11:40 🧪 Despite its role as an NMDA antagonist, ketamine paradoxically enhances positive behavior in certain contexts, defying expectations. 21:55 🧩 Ketamine, despite blocking neuroplasticity, has been found to provide relief from depression in both preclinical animal models and clinical trials. 22:50 🌟 Early studies in the year 2000 revealed ketamine's remarkable effects in treating depression, especially in patients unresponsive to other treatments like SSRIs. 24:13 🕒 Ketamine's effects include a rapid onset of euphoric and dissociative states, leading to immediate relief from depression, which can last for several days after administration. 25:21 💡 The antidepressant effects of ketamine have short, medium, and long-term mechanisms, making it effective for treating a variety of psychiatric challenges beyond depression. 26:04 ⏳ Ketamine offers faster relief compared to traditional antidepressants, which can take weeks or months to show effects. 27:00 🚫 Ketamine is not a "miracle drug," but it significantly decreases feelings of depression, suicidality, helplessness, and worthlessness. 28:10 🧠 Ketamine's mechanism involves binding to NMDA receptors and inducing changes in neural circuits, contributing to its rapid and lasting antidepressant effects. 30:01 ❌ The short duration of ketamine's effects and the potential for habit formation pose challenges for using it as a long-term treatment. 32:06 🔑 Ketamine's multiple mechanisms suggest it acts through immediate relief, medium-term symptom reduction, and long-term neural changes for its antidepressant effects. 36:12 🔍 The NMDA receptor, a key player in neuroplasticity, is activated by unusual patterns of neuronal activity, leading to adaptive changes in neural circuits. 41:55 🧠 The NMDA receptor's role in neuroplasticity helps explain how ketamine's NMDA receptor blockade can induce rapid and lasting changes in neural circuits, providing relief from depression. 42:38 🧠 Neurotransmission involves excitatory and inhibitory neurons. 43:49 🧠 Seizures result from runaway excitation; balance between inhibition and excitation prevents seizures. 46:06 🧪 Ketamine blocks NMDA receptors, yet increases neuroplasticity in mood-related brain circuits. 47:54 🔄 Ketamine allows excitatory neurons to fire in bursts, inducing neuroplastic changes. 51:14 🧬 Ketamine's interaction with inhibitory neurons leads to increased excitatory communication. 55:22 🔀 Ketamine may mimic the effects of brain-derived neurotrophic factor (BDNF) in promoting neuroplasticity. 56:03 🧪 BDNF is a key player in ketamine's relief for depression, possibly involving ketamine-induced BDNF release. 59:43 💡 Ketamine's unique mechanism for relieving depression involves NMDA receptor suppression and BDNF activation. 01:00:11 🧪 Ketamine might also act as a growth factor, similar to BDNF, promoting lasting changes in mood-related circuits. 01:02:05 🧪 Ketamine could potentially mimic the effects of BDNF and bind to its receptors to induce neural changes. 01:03:42 💊 Ketamine can also interact with opioid receptors, contributing to its recreational and medical effects. 01:04:37 🧠 Ketamine can bind to various opioid receptors, leading to effects like pain relief, changes in mood, and even euphoria. It hits both the glutamate-related system and the endogenous opioid system. 01:05:47 💊 Hydroxy nor ketamine (HNK), a metabolite of ketamine, has high specificity for the MU opioid receptor. It suggests that part of ketamine's effects may be due to activating the opioid system. 01:09:46 🧪 Blocking the MU opioid receptor using Naltrexone alongside ketamine diminishes the antidepressant effects. This implies that the opioid receptor pathway is responsible for these effects. 01:16:04 🔀 Neural circuits play a crucial role in translating ketamine-induced changes into behavioral outcomes. The drug shifts individuals toward engaging in anti-depressive behaviors and context-dependent strategies. 01:20:12 🌟 Ketamine alters connectivity between brain regions involved in reward processing and context-dependent strategy building, promoting engagement in adaptive behaviors. 01:24:13 💭 Ketamine's dissociative effects stem from an uncoupling of neocortical and subcortical brain networks, leading to the emergence of Theta brain wave patterns, which contribute to its dream-like effects. 01:25:52 🧠 Ketamine produces distinct brain activity patterns and dissociation, with varying effects based on dosage and delivery method. 01:27:15 💊 Oral and sublingual ketamine absorption is limited, with only a portion converted into metabolically active form, affecting dosages needed for desired effects. 01:27:56 ⚖️ Different delivery methods of ketamine (injection, oral, sublingual) require different dosages to achieve similar effects due to varied bioavailability. 01:29:19 ⚠️ The "K-hole" is a state of deep anesthesia caused by high doses of ketamine, potentially dangerous and prone to deadly effects, especially when combined with other substances. 01:30:31 🚗 Ketamine use requires caution due to its potential to induce deep unconsciousness, leading to risky behaviors like driving, and it can induce seizures in susceptible individuals. 01:32:53 🔄 Different modes of ketamine administration (oral, sublingual, rectal) result in varying metabolic processes and effects, with rectal administration bypassing the liver. 01:34:41 🤔 The effectiveness of different ketamine isomers (R, S, RS) for treating depression varies, with SR (combined) form being most potent, followed by S, then R forms. 01:37:02 🔬 As of now, there's no clinical evidence supporting the effectiveness of microdosing ketamine for treating depression, unlike macrodoses. 01:40:02 ✅ Ketamine's antidepressant effects involve changes in neuroplasticity and brain circuits, but maintaining positive behaviors is crucial for sustained benefits. Made with HARPA AI

[@jasontaylor2050]

Thanks for this.

[@holliebingham1311]

Thank you so much Dr. Huberman, I could never thank you enough for what you do for all of us. 💗🙏✨

[@fk9424]

Thank you Andrew for bringing all of this into the public consciousness, and doing so in a manner that is digestible both to the curious as well as those facing the long and lonely road of depression (in its various forms, treatment resistant for these purposes). Your chats give seriousness and credibility where these topics/alternatives are often dismissed.

[@user-si6cf5vh4v]

Andrew, I just discovered your video podcasts and as an new yet avid supporter of ketamine use to help major depression and/or TRD, I found this video to be EXTREMELY HELPFUL, and given the extent of the medical and biological knowledge this entails, you do a FANTASTIC job of explaining this in layman's terms. I plan to save this and send to those who may find it useful. I know i did, so thank you!

[@kathy-ht3fi]

❤ Very clear teaching for myself. Thank you. I have been taking Paxil for 25 years and I am now at the highest dose and starting Ketamine Therapy September 2023 with a Psychiatrist. Your information has helped with my Anxiety concerning this process. 🦋

[@nikolausbaumgarten]

No mention of severe bladder damage as a risk from prolonged Ketamine use? Anecdotal wisdom on the internet is that consuming green tea or NAC before taking Ketamine is supposed to mitigate bladder damage. Would be interested to hear what the science says on that.

[@1LaOriental]

Great question. I take NAC and am considering ketamine therapy for depression, etc. I had one session with a professional-a lovely man, btw-but did not experience any relief from the depression. It cost me $2000.00 😩I may try again.

[@elliotgold]

There will be massive class action lawsuits over bladder injury in 5-10 years. It’s never mentioned, yet IV ketamine therapy is administered identically to the way scientists create Ketamine Cystitis in rats.

[@TravelBits222]

The amazing professor everyone should have the chance to have in college. Thank God for the internet which gives us the opportunity to listen to you, Dr. Huberman! The way you explain things is amazing. Thank You!

[@alexandrerighi]

Hate it when the summary part arrives. It means episode is over. This particular one is so packed with info I'd gladly rewatch it.

[@charlesmiller600]

As a ketamine provider, I greatly appreciate this data driven approach to ketamine education in the treatment of mental health disorders. We need more science-based education in our field. The misinformation from "psychedelic enthusiasts" has refocused the patient's attention from improving lifestyle practices outside of the administration setting instead focus on some experiential or transformational ketamine induced realization. While mindset matters, as you stated, the long term effectiveness and viability as a treatment appear days to weeks after the ketamine administration and they are compounded over a series to get maximum longevity. Thank you again for this clear explanation.

[@ThreeCorners123]

Andrew, this was so well done, and very well timed for me! I am on my last weeks of a six week at home assisted oral ketamine treatment, and so much of this rings true! The treatment has been incredible especially because I was prepared, mentally and emotionally to make some big changes. Better living through chemistry still requires better living… SO TRUE. Thank you for all you do!

[@BartlettMoore]

Many thanks for this highly informative discussion of ketamine. I have suffered from chronic major depression for decades--since long before you and I met--and it is highly encouraging to learn more about the potential for this treatment. Cheers, Bart

[@thatguitarguy99]

When I finished watching this, I immediately went and listened to Tim Ferris's podcast on ketamine and am so excited about all of the science and research happening in the psychedelic realm. I've had good results combatting depression with psilocybin but am very curious of the therapeutic effects of ketamine now. Cheers to the psychedelic revolution 😁

[@bungle3912]

Ketamine is incredible for heroin withdrawal. I came off methadone and it was out of my system for a couple of weeks, but I felt depressed and like I was constantly in withdrawal. I did a pretty large amount of K and all the depression and withdrawal feeling completely disappeared.

[@Beanths]

I love how there is a pivotal change of perspective on the medical sector. 10 years ago was so different from today's views. Massive gains and leaps.

[@rachelreyes4128]

Congratulations on your success!! I never get tired of listening to you talk science 🧬 🙂Thank you for all you do 🫶🏻blessings ✨💕

[@Unanythang]

Andrew. You're doing God's work man. Thank you so much for the content that you provide us.

[@vorostabletta5345]

Professor, I immensely enjoy your lectures without a miss. Can you please share with us some youtubers/channels that you like to listen to as a mean of learning new things? I usually binge your new episodes on the day they are posted.

[@paulcorcoran9719]

Loved this episode as always!! Would love to see an episode on skin health and all things skin related !!

[@elleseven1589]

Thank you for the amazing work you and your team do. Truly life changing. I would love to hear you deliver a podcast on the physiological, neural, mental, and other impacts of surgery and the return to health after. Specifically, the science of returning to exercise and the changes the body undergoes and in what order. What is the feedback loop? How is it impacted by anesthesia and the body's experience of surgery?

[@Mariahmcam]

What an interesting topic to review! Thank you for the deep drive Dr.Huberman. 🤓

[@malcolmsteen9915]

As always a well rounded and informative episode! In the final 10 minutes of the episode with Maya Shankar she mentions ways to keep yourself motivated while pursuing goals. One strategy was to incorporate a pleasurable experience, such as music when completing a task that is otherwise difficult to stay motivated for. At first this sounded wrong, where on a different episode about the dopamine system you spoke out against using rewards for hard tasks. Is the difference the timing of the positive stimuli, meaning in the first case it’s concurrent while in the latter it’s after the fact?

[@alisaleon1]

Started IM Ketamine treatment at my doctor's clinic two weeks ago and adding in therapy. Thank you for your amazing informative science based, no BS podcasts!

[@LouisOfficial22]

I can help you get them.

[@danielplainview1]

Thank you, Andrew, for reversing and doing a deep dive on the layman’s response to “intra-rectal administration”. This absolutely made my day.

[@vocals1111]

You can't say deep dive and rectal in same sentence 😅

[@louisevilloen2908]

Thank you Dr Huberman and team. You are much appreciated.

[@WalkWithGraceThisEra]

Huberman is like a walking meta-meta analysis. Much appreciated content as always, Doc.

[@siewtohong7138]

Dr Huberman I’m not that smart, it’s going to take me days to process all that information. Appreciate that you are always trying to to be so thorough in your lectures in such a short amount of time!!

[@ernestinagonzalez2673]

that does not mean you are not smart, you just take longer to process and absorb. Please never question your intelligence you just process differently than neurotypicals. I am a neurodivergent that always felt dumb until I found what worked for me.

[@siewtohong7138]

@@ernestinagonzalez2673 thanks for your encouragement! You say it so gently and kindly! May God bless you always!

[@InnerPotentialPulse]

Your videos always teach something no mater with who or about what you guys talk about it always comes to a point where you teach people new perspectives and new things

[@tonyesfandiari2123]

Thanks for all your hard work. Your footprint on knowledge and humanity will shine for long time to come.

[@vdeoc6036]

as someone who has taken a bunch of ssri's & other meds for depression without any sort of relief, and who is currently considering ketamine treatment, thank you

[@Sharon-fc2jt]

I had decades of all sorts of anti depression meds with absolutely no benefit. My ketamine (spravato) treatments provided a cure. I have been depression free for 3 years. But…with me…I incorporated meditation with ketamine. I do not know if ketamine alone was the cure. I just googled meditation and got an app…no professional training.

[@fancypants90210]

I'm picking up what you're putting down, Huberman.

[@larryprimeau5885]

I've taken it because I've had a difficult time meditating and after several self administered doses I was able to meditate easily and naturally.

[@lilbrit1811]

I did ketamine assisted therapy for cptsd and no longer wanting to be here back inJanuary. My life has changed. It was the best thing I’ve ever done for myself. I also really committed myself to doing the integration and I do it daily because even now in august I see daily learning moments, tools, moments to heal something even if it’s a tiny little moment that triggers me.

[@pacattack6772]

can I ask if you did IV (psychedelic) or sublingual or intranasal (psycholytic) dose for this process? I am unable to afford the cost of IV ketamine therapy despite being a strong candidate having tried all other antidepressants with no avail - I have "treatment resistant depression", c-ptsd big time and have been doing talk therapy in various modalities since age 14 (now am 25). I am starting low dose psycholytic at home ketamine treatment and am wondering if taking it during therapy sessions would be helpful for increasing the likelihood of my brain accepting new ideas/making new connections. Thanks!

[@pacattack6772]

congrats on recovery btw - never linear but progress is progress

[@starlightpancake]

Ketamine therapy absolutely saved my life

[@mikewatkins422]

Fascinating on so many levels. Thank you Andrew.

[@Mothhole]

A study titled, not entitled. I love this channel!

[@andrestein6022]

There needs to be studies on ketamine and autistics. There seems to be something special going on with that population and ketamine

[@camdamcool6125]

Good one 😅

[@Gretstarret]

Can you elaborate what you mean? Havent heard anything about this connection before.

[@andrestein6022]

@@camdamcool6125 ? I don't know what you mean

[@andrestein6022]

@@Gretstarret seems to be especially useful and effective for us. Even helps regulate many of the social symptoms in my experience and that of those I've spoken with

[@ReligionAndMaterialismDebunked]

:3 Early crew. :3

[@chrisward1056]

Thanks Andrew, this chemical changed my life. I have used this recreationally, and trust me it’s an extremely profound experience. On high doses it was extremely psychedelic, if you want to explore your own mind, do it safely, set and setting remember 😀👍

[@jleeeejl]

Was waiting for this for awhile thank you

[@captainheartspace6583]

This guy is on point, the best breakdown.

[@adrianagiraldo9315]

The one that was missing 😊. Can’t wait! This one is an interesting one as well! Happy HuberMonday everyone 🧠💜💪🏽.

[@James-sumr-23]

Hi Dr Huberman, longtime listener first time commenter, from here in the UK. Thank you so much for yet another incredibly informative podcast episode. I was surprised you didn't touch on "Ketamine Bladder". Here in the UK we have the highest per capita recreational Ket use in the world and irreversible bladder damage is seen by both the medical and user community as a pretty widespread side effect. Do you have any thoughts on this e.g. if there is sufficient/insufficient evidence or if different modes of delivery are more or less risky. I'm aware of journalism by Chris Hamby in the NYT raising concerns oral administration is riskier than IV in regard to US home prescriptions but of course an NYT investigation isn't exactly a scientific paper!

[@akalui007]

Very good point

[@coadabunica]

I felt like he touched on ketamine addiction almost like it was porn addiction, meanwhile this is as serious as it gets, from cognitive impairment to permanent body damage, infamously the bladder but also leads to kidneys, liver, gastrointestinal issues and even to the respiratory tract.

[@a.d1775]

best roa for minimisation is iv, its about the least amount of ketamine passing through your body, it all goes through your bladder so the less you have to take for an effective dose the better

[@Letstalkitoutnow]

I think he touched on doing in rectum so it wouldn’t hurt the liver as much. I maybe be wrong I’m no doctor. 😢😊

[@a.d1775]

@@Letstalkitoutnow this is only true with oral tho, intranasal, intravenous both work too. rectal is a very nice way to take it, but however its very hard to get a good bioavailability. if administering at home its maybe about as good as intranasal, but if in an infusion setting, you are just risking unnecessary bladder problems because you choose not to IV

[@user-mm5qw6xz5w]

Thks for your work. Following you from France. I've started using ketamine a year ago for recreational purpose. But after being experiencing hard and drug resistant depression I manage to get out of 15 years of depression, start going back to the gym. Still buying out of any medical control but I've been so close to end my life for years that I can say it's been a life changer for me. Wish there are more open minded doctor's like u in France. But still it's good to see that I'm not crazy seeing it as a therapeutic drug, not a recreational one. Again thanks for your work. Best regards

[@JahongirPardayev-zr5hv]

Yeah , l like to listen to your podcast, I try to learn something by watching your podcasts in every section , it is a great job

[@danmchardy6424]

As someone who suffered greatly from anxiety and depression, ketamine really saved my life. The effects for me were instantaneous, I'm not religious but I experienced a closeness with the universe and, dare I say, God. I've only used the substance a couple of times when things got particularly bad, however, I had profound experiences that were long lasting in that they offered "hope." Not hope that I could just begin relying on the drug, but that my old perspective and feelings weren't the only possible experience. Remembering how the relief felt gave me a mental snapshot i still go back to now when I'm suffering. I understand that the drug has possibility for abuse, but I think the stigma around it is horrible. Especially, for something that did so much for me when I was in desperate need.

[@user-ew6fk5rh7g]

As always Fantastic episode, thanks.I have a question: how danger is it to try ketamine treatment for someone that is bi polar I and had experienced psychosis in the past especially when using cannabis.

[@YourDreamLifeIsWaiting]

You are so good at explaining "the science." Your recordings may be long but it's because they're thorough. I just got a job with a ketamine infusion center. This job was divinely brought to me and now (after decades of effort to heal trauma) I am starting ketamine infusions on Monday. SO LOOKING FORWARD to a change in brain chemistry/function that does not take months and months of effort and repeated experience to solidify the change. 🎉🥳🤸‍♀️🙏

[@sdreborn]

let me start off by saying thank you for doing what you do. I've completely changed my life in all aspects because of the knowledge I've learned from your podcast! I currently take adderall for my ADD and i have been taking 25m seroquel to help go to sleep. it seems to work wonderfully. is it keeping me from hitting all sleep stages though? I was wondering if you could do an episode on seroquel? thank you so much for what you do!

[@solmarcurtiss1824]

My buddy is pretty spun out on ketamine right now. Im pretty surprised about how little time was spent on the dangers of this drug

[@rudiranck8656]

Here for BDNF and Neuroplasticity!

[@joecarl6143]

You are an excellent teacher. I enjoy your diverse approach with delivering information to your viewers. As someone with ADHD that alone is inspiration enough to learn, let alone the subject applies directly to my current situation. Thank you for your content and knowledge!

[@electricmiragemedia]

Very glad to see you cover this :)

[@abuorayieta]

Neurons are like another universe, so interesting. I am one of those who wellbutrin don't work so I just quit. I was scared of ketamine due to the addictive part. I now use gym, nutrition, talk therapy, proper sleep & supplements to alleviate the depression. It works as long as I don't get a trigger which puts me in a hole once in a while. I would like to treat it completely. Thank you Andrew for this, the knowledge helps.

[@FoursWithin]

Used clinically it's not likely for someone to become addicted. Addiction would come with a pattern of habitual use. Which isn't how it's administered clinically.

[@Intronautics]

Throw in some meditation and you’ll be unstoppable! ;)

[@gaigequalmann9570]

Excellent episode. As an avid (past) user of ketamine it definitely answered some of the mechanical questions I had about what my brain’s been through. I would have liked to hear a little more about the recreational side of things - it’s hard to find a non-biased report on side effects, usually it’s coming from a “rehab perspective” which basically makes it sound like psychedelic meth. I’ll share one thing: if you snort ketamine, spit the drip (the bit that goes down the back of your throat). To my understanding (and someone please correct this if it’s not or not exactly true) once swallowed and processed by your organs, it crystallizes in the bladder and can cause lesions and ulcers and mess up the urethra. A friend (long time user) recently had to have surgery for this and it sounds awful. If you’re going to party, try and stay out of the hospital;)

[@conorhennell2623]

as far as i know ingesting ketamine in any way can form crystals in your bladder so spitting the drip isnt going to do a great deal, its the main reason to have caution doing it recreationally and not try not to abuse it. i know of people in their early 30s who had their bladder removed from only a few years of heavy use.

[@AnKieu-oq7iz]

Recently discovered your channel and am enjoying your informative content. I will be starting K treatment next week in tandem with my TMS to help with my ptsd and long term depressive symptoms since my concussion. I appreciate your explanation on the neuro pathways involved so that I can confidently communicate to my friends and family who are sus about clinic based K treatment.

[@gregzaks6649]

I didn't know what ketamine is, the subject did not interest me at all, yet I am listening avidly, such is the magic of your podcasts 😊

[@2020kinner]

I have been doing ketamine infusions with lidocaine for a few years now at a very high dose 500-700 an hour for 4 hours this is done in a pain clinic for a very aggressive form of CRPS that started in my hand and spread through out my entire body it is very rare but I was the luck one. Ketamine saved my life it breaks the pain cycle and is the only thing that does but the treatment.

[@vocals1111]

Glad for you, I'm trying it soon, had 14 back surgeries and am at wits end dealing with all the pain. Around here they mix the 2 together but it's once a week for 6 total but not 4 hours long. Where do they do it how you said, I'm in PA

[@elliotgold]

Are you experiencing bladder pain? Do you have the urge to urinate frequently?

[@painless29]

Hey, Huberman. First off, congrats on the great work in the episode and on the channel overall. I’m an anesthesiologist and follow your work. When revisiting the topic, I’d like to suggest delving into the other long-term risks of ketamine use, especially the cognitive and genitourinary aspects, as it would be great to know the valuable insights you and your colleagues would bring to the subject. Cheers!

[@LeslieTaylorFit]

This comes from ingestion of troche crystals that irritate the urethra if you do 2x a wk. If you cycle or dont swallow fully, it helps too

[@LeslieTaylorFit]

Not as likely with doses discussed

[@painless29]

@@LeslieTaylorFit Hi, Leslie. It's not specifically related to the oral ingestion, since it happens in all routes of administration. It's a complex mechanism related to the NDMA receptor antagonism (which happens systemically). Be careful and let a trained physician assess the risk for you if you use it. Cheers

[@LeslieTaylorFit]

​@painless29 Hi, I speak from personal experience and from the Dr. While true it can happen with other delivery, the crystals make it much more likely to occur. Never had any issues ever with infusions.

[@painless29]

@@LeslieTaylorFit Look, whatever you've been told about the troches being responsible for ketamine-induced cystitis isn't backed by scientific evidence, at least none that I'm aware of. I'd be glad to read any material you're using as a source to claim this. If the basis is merely anecdotal or opinion-based, it doesn't hold up against more solid scientific evidence. Regarding the risk, obviously, the higher the dose, frequency, and duration of use, the greater the risks are (individual variations in response to medication should also be considered). However, a statistically defined safety threshold hasn't been established yet. So the recommendation is always to use the lowest effective dose for the shortest possible time. This is the case with many, if not all, of the medications we take. Always seek the most qualified professional, and get second and third opinions if necessary. Wish you the best

[@colonyofweirdos4520]

Such a wonderful episode.

[@---m---]

ketamine is such a profound experience. everyone should give it a try.

[@isabelbarragan5314]

This is a terrific episode from Dr. Andrew Huberman as usual he delivers powerful information. I would like to know how a regular person could find a clinic/psiquiatric who would precribe and do sessions for ketamine. Medical system is sometimes a laberint where you could get lost specially in mental health, and I do not want to depend on antidepressants only. I would love to have answers from anybody that have tips or experiences. Thanks Dr. Huberman :)

[@iamanempoweredone6064]

@@ThreefiddyI’m interested in how to get this safely. Could you share with us any resources that you have?

[@Sonu_sharmaa_21]

I'm from India ... always love to watch you as a great teacher ❤

[@user-gg2rt7kw9w]

Hi Andrew, really appreciate the work you are doing! I enjoy listening to your podcasts and would like to suggest two potential guests - the first one is Dr.David Katz who is deeply knowledgeable in nutrition, and the second one is the Game Changer's James Wilks. Thanks!

[@mikemartin1894]

I have PTSD and am antidepressant resistant..have been on the sublingual troches at 80 mgs for about 2 months. It is no miracle drug but in the way it has treated my depression etc. It has worked wonders and has absolutely changed my life in a positive way. I as always appreciate your amazing podcast..I hope you can one day do an episode or if not have one already on the benefits and negative effects of kratom..there is a lot of controversy as of recent I'm the news Was hoping someone like you can break it down once and for all.🙏 Thank you brother

[@jennimuraira]

I am one month in on the same dose. So far so good for me, complex ptsd from childhood trauma and some depression/anxiety. I have felt more “space” and less emotionally reactive. Less extremes.

[@jennimuraira]

@@pacattack6772 Hi, I started with a small dose and was moved up to 80 over a couple weeks. I use Joyous, I have had a great experience with them. I take mine and then usually lay down and relax with music or a guided meditation on my lunch break. It is not psychedelic for me, but mildly dissociative and very relaxing. I have never experienced a large dose of ketamine.

[@terrapreta1]

Terrific content. Still hoping for an episode devoted specifically to dissociation and dissociative disorders. 🤞

[@bryanutility9609]

Some people are just broken.

[@garypuckettmuse]

@@bryanutility9609 hilarious.

[@putulalu6558]

Sir ! I am very thankful to you for making these informative and life changing videos ! I would like you to ask a question which is very concerning for me right now ! That is how to stop graying of hair and reverse graying of hair ! Also I would be very pleased if you can make another video on how to learn deeply . And last one thing i want to appreciate you and your work which had made a great impact on my life and i am looking forward to you for many other exciting desciplines ! Thank you!

[@ethanbillig8511]

Thank you for your passionately detailed report! Much love.

[@fredrikperry]

Could you do an episode on Parkinsons Disease? My father has had it for 5 years and since we don’t live in the same country it’s hard for me to help him, so would like to learn more so I can give him tips and must-do’s! (There’s no way he’d sit through an entire podcast) - Fred ps. Love all you do

[@Rakutan-san]

Depression haunted my life from a very young age, and I was put on a bunch of SSRIs as a child in an attempt to deal with it. None worked, and I just had to live suffering from MDD for over a decade before the possibility of Ketamine was bought to my attention. It was the first thing that actually had real effects, and while I get to enjoy the repercussions of most of my life spent severely depressed, at least now I have the opportunity to try and turn my life around. This was a fascinating look into the mechanics of the drug that has provided me a chance to actually live, rather than simply trying not to give into despair, and I thank you for the excellent lecture and extensive evaluation of the drug, Dr. Huberman. I'm unsure if floating ideas for episodes in comments like this is correct, but I'd be really interested in your understanding of the limits of therapy versus pharmacology (and it is possible you have already discussed this topic and I haven't yet encountered your video on it.) From my understanding both often need to work in tandem, but there are so many different schools of therapy, and figuring out which ones are effective, and for which kinds of problems, is often quite difficult in my experience. Never mind determining which kinds of medications might assist in dealing with specific issues, which are worth the downsides, etc.

[@bunnycouture]

From personal experience, MDMA assisted therapy is even MORE helpful and beneficial than K...totally different neural pathways and everyone's system is different of course, but persistent MDD for me and that's BY FAR the best I've found✌🏼

[@alisonmercer5946]

​@@bunnycouturewhere are u? I love that drug too but there is no way I could get that prescribed and it sure does work against depression, My god

[@bryanutility9609]

Sounds like your life just sucks. Most likely there is nothing wrong with your brain. Once you stop identifying with depression and realize you can live a better life, like being healthy and free your “feelings” will change.

[@alisonmercer5946]

@@bryanutility9609 but if u have thought and lived a certain way for very long time even if u figure out a lot of things are lies depression lies and or anxiety lies and figure some things you thought were bad ways of thinking of things and u know more the things u need to do in life but u suck at applying it like simple things u feel like it is impossible . Certain things I thought were depression or I couldn't do because of depression I felt less depressed and I can do things now and oh boy I'm gonna get this place tidied and organised . Boy, did I ever not be able to do some simple life things like organising. I kinda lost it , it made me anxious and it seemed utterly impossible to get it all done. I was way too upset and idk why just trying to be organised could be such a disaster . was even more disorganised with piles in other places lol. I can laugh now but the level of angst? Rage! Despair I felt cause I couldn't organise was over the top. I just felt I should be able to do this and it was not that way at all! I understand being so messed up u don't even care or have the energy or any motivation for life stuff like showering getting out I f bed and being really just really super non functioning. I get it . But I don't get , even now, why such a seemingly simple thing as organising cash be so difficult ? I do know if I focus on a little areas or just certain things i actually can organise lol cause I'm no where near good yet hut

[@alisonmercer5946]

Omg that comment I need a diary seriously wow and I have not even finished it