Ketosis & Ketogenic Diet: Brain & Mental Health, Metabolism, Diet & Exercise, Cancer, Diabetes

About the guest: Dominic D'Agostino, PhD is a researcher and professor at the University of South Florida, where his lab studies metabolism, human biology, and related subjects.
Episode summary: Nick and Dr. D'Agostino discuss: ketosis and the ketogenic diet; effects of ketosis on diabetes, insulin resistance & metabolic health; effects on brain & mental health; relationship with exercise performance; cholesterol, LDL, triglycerides & other biomarkers; cancer; and more.
*This content is never meant to serve as medical advice.
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ABOUT Nick Jikomes:
Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.
#Science #Podcast #Biology #Diet #Disease #Medicine #Diabetes #Metabolism #Food #Nutrition #Obesity #Cancer #KetogenicDiet #Ketosis #Insulin
0:00:00 Intro
0:02:25 Dominic D'Agostino conversation

[@MindAndMatter]

All M&M content is available on Substack. Podcast, writing, free weekly newsletter: [mindandmatter.substack.com] If you enjoy M&M content and want to provide further support, read this: [mindandmatter.substack.com/p/how-to-support-mind-and-matter?Fsearch%2Fsupport&] Thanks!

[@cynthiasmith1457]

67 yrs old.. diabetes 2 and all the medabilic issues attached. Stopped all meds fired doctor three years ago and started keto...fasting and daily exercise. All biomarkers optimal but high LDL. Small trade off! Feel great! Thank you doctors for spreading the word!!

[@dinomiles7999]

you woke up !❤ . I Fucking love it ! ❤ Tell everyone that you k now . ❤ Happy for you , you escaped the medical matrix ❤ .

[@dinomiles7999]

I'll a swer for Dr. DOM ❤ It's the Rockefeller medical and food matrix $$$$ . All by design to keep us sick ❤ 😢. Eyes mind heart and soul wide open. NO FEAR ! You are all potential pharmaceutical customers . ❤

[@ananila8143]

Good health to you! Amazing!

[@ScienceAppliedForGood]

Thanks for inviting Dom D'Agostino. In a recent talk Tim Noakes mentioned an interesting idea that actually being in a ketosis is a natural state for humans, while using carbohydrates for food is an adaptation that has happened very recently from evolutionary point of view.

[@nataliajimenez1870]

I think this is particularly applicable for people whose ancestors lived in higher latitudes and had to depend mainly on animal foods during the hundreds of thousands of years that the Earth was going through the Ice Ages. So whites and Northeast Asians and Native Americans (who descended from Siberians) would be particularly well adapted to mainly carnivorous diet. People descended from people from Equatorial regions might be better adapted to the inclusion of carbs in their diets

[@hyperTorless]

I don't understand how one can come to this conclusion. The closest to a keto diet we find in ancestral communities are the inuits (who eat mostly northern fatty fishes and muscle gluycogen), and they have specific mutation to *not* be in ketosis. If anything this is an argument against ketosis.

[@bobcocampo]

Please have a discussion on Students and effects of keto 🥑🥓🥚🧀 on memory, learning and other cognitive function

Wonderfull interview w Dom D'Agostino 👍 He is always providing us with the best information in the field of health from the first hand. I love to hear him again and again. And by the way - you put him very good questions! That also matter. Thanks.

[@MindAndMatter]

Thanks! mindandmatter.substack.com/

[@drkstatom]

Great, informative episode.

[@brendahall8665]

One of the best informative talks I've listened to in a while!

[@MindAndMatter]

Thank you. I would recommend also my first conversation with Dominic: mindandmatter.substack.com/p/dominic-dagostino-metabolism-fat?

[@cheryldavis6011]

What a deep discussion on such fascinating subjects…I will definitely be listening to this again!

[@MindAndMatter]

Thank you, Cheryl. I would recommend also my first conversation with Dominic: mindandmatter.substack.com/p/dominic-dagostino-metabolism-fat?

[@karenohanlon4183]

I find that sleep is very poor when doing total fasting. How can this be managed.

[@nataliajimenez1870]

Fasting can sharply increase stress hormones, so that can lead to poor sleep. You may try adding some fats at night when you are fasting, like having a chamomile tea and add butter or coconut oil to it (and blend it so it emulsifies and becomes easier to drink). With fat you are adding calories but you are not triggering an insulin response and fats tend to reduce stress hormones. Just be careful not to add a huge amount of fat and just enough to help calm your brain. Also long fasts may not be that good. Try to limit them to 36hrs once a week unless you have a very severe condition (like cancer)

[@hyperTorless]

You need insulin spikes for producing serotonin which allows your body to enter in a sleep mode. It can be argued that both keto and fasting relies on the same mechanisms of emergency gluconeogenesis, which implies a cascade of stress-related hormones, and an under-utilization of insulin (which is used in lots of other things than "storing fat"). I simply wouldn't fast.

[@bobcocampo]

How fast will you be in ketosis with carnivore 🥩 zero carbohydrates diet?