Leptin Function, Signaling via the LepR, & Overall Physiological Effects

[@richardnorris7948]

In Dr. Robert Lustig's videos on sugar, he points out that one of the end products of fructose metabolism is uric acid. This is after the degradation of ATP into AMP and ultimately into Uric Acid. He states that they have found that uric acid is actually the inhibitor of leptin. Uric acid also contributes to hypertension by causing inflammation in the kidneys' glomeruli which impairs its ability to excrete sodium.

[@Taliatekito]

Amazing! Will need to listen to 5 more times!

[@LikeTheVik]

By far one of the best channels on youtube. Yours and JJ medicine are my favorite

[@her1250ald]

Very interesting especially the inflammatory element. Just one point, fat cell count is reported as being set at adolescence, not birth. There is, of course, there is a genetic component

[@claudelorrain-bouchard6941]

Very interesting, having a debate over MSG recently and one possible (but not seemingly conclusive) impact of MSG is that it can affect the Leptin receptors or the whole chain somewhere. I still think it's more to do with foods high on MSG also tend to have more sugar... no food is eaten in a vaccuum... and some tests just use unrealistically high levels of MSG to "prove that it's bad"....

[@terrellbrashears6156]

Thank you that was beautiful.

[@sannankhan3702]

Loved the drgaon ball z reference to Majin buu, beautiful presentation

[@rosanas3873]

It could be useful to post the sources in the description

[@yogayantra]

thank you so much!!! I have a question though, does the adipose cell turn into brown? does this happen in BAT or in any adipose tissue? Thanks a lot

[@hussammohamed6401]

thsnk youuu soooo much for this effort

[@haneensiyam7496]

that was amazing

[@rizkisari9715]

I like the way you're using Bhu as thumbnail 😆

[@melinavdw342]

Thank you

[@videnz2664]

by sugar do you mean only fructose or glucose too? (when you say inflammation caused by sugar)

[@genesis530]

Why can't they pharmacologically find a way to raise leptin levels or increase their sensitivity in obese individuals with leptin resistance? Whether with synthetic leptin or reuptake inhibitor or something? I know you can increase sensitivity with diet and exercise changes, but people don't and it's very hard. Obesity is very expensive. Food addiction is a thing and if they could find a way to fix at least one aspect of this maybe it could help? Just wondering. I've been a nutrition hobbiest for a long time after recovering from morbid obesity myself naturally and have always been looking for reasons why they couldn't find a way to hormonally fix these smaller things that really add up. The prescribe speed as appetite suppressants and staple stomachs though.

[@zakyvids6566]

Exactly and Iam also surprised that vagus nerve function is not looked at either I feel like vagus nerve lepton and obesity might also have something something in common As for your original question why don’t they find a way to raise leptin? Apologies for saying this but it is expensive to treat obesity if obesity is treated a significant portion no diseases can be reduced or even eliminated and that is bad for business

[@colbybucknam4086]

How does JAK get the ATP, or phosphates, in the first place in order to phosphorylate the LepR?

[@zehravigna4873]

More fat=more leptin release. But I don't understand, why therefore obese people stay obese although they produce a lot of leptin due to their adipose tissu ?

[@kevinmathew4884]

Maybe, something in their diet and lifestyle is making them resistent to leptin. Their hypothalamus seems to be unable to effectively detect the satiety signals produced by leptin. Probably highly refined and processed foods (including ubiquitous usage of inflammatory hydrogenated vegetable oils etc) may have got a role to play. kzbin.info/www/bejne/j6CWhYWYoK6lpdk

[@palc9591]

Exactly my question

[@alexanderohanlon8825]

Certain areas of the hypothalamus become resistant to the signal, much like insulin resistant... therefore fat cells keep pumping it out as negative feed back system stops, that and if fat cells swell (hypoplasia i think) they become dysfunctional thus produce too much, again the brain can't handle it so resistance occures.

[@videnz2664]

he talks about it at the end of the video

[@clockedinathletics]

they become leptin resistant

[@fithess1]

Great

[@ArtificialStudios]

What if that person with more fat tissue has low leptin instead of high? How can this be fixed

[@AristonSparta]

Leptin injections. I just watched a video about it Here is link kzbin.info/www/bejne/pX-WqKJ-f5yNers

[@ArtificialStudios]

@@AristonSparta how about glp 1 agonist injections? leptin is 10s of thousands of $

[@AristonSparta]

@@ArtificialStudiosI have no idea. Possibly 🤷‍♂️