Long term potentiation/depression

A discussion of long term potentiation in the context of learning and memory.
The explanation of classical conditioning is simplified and each dendrite labelled would represent many dendrites making up the circuits associated with each stimulus and behavior. Also, although LTP has been heavily studied in the hippocampus, classical conditioning associated with an audible tone would take place in the lateral amygdala. For more in-depth information check out this review of evidence linking LTP and classical conditioning:
Neurosci Biobehav Rev. 2006;30(2):188-202. Epub 2005 Aug 24.
Neural circuits and mechanisms involved in Pavlovian fear conditioning: a critical review.
Kim JJ1, Jung MW.
or if you don't have access, this paper is free and almost as informative: physrev.physiology.org/content...

[@iiiarmchair]

A great introduction to LTP and easy to watch/listen to. Thank you!

[@ginasofia8908]

Thank you sooo much! This was super clear and helpful and so much better than other videos. I am grateful for your channel. Well done. God bless you!!

[@ManuTarot]

Thanks for the information...love it! Conditioning, long term potentiation and memory...

[@amila_]

This video and you as well were sent from heaven

[@iriebluetooth]

Hey everyone, I researched and designed each of these in one night as an MS1 in med school so I didn't have time for a full script but I appreciate all of the comments. Thanks for watching and you can now follow me on twitter @DrBlue_JT.

[@JoeSmith-st9lc]

I learn from watching videos, and I hate reading textbooks. You did a very good job!

[@jwk131]

Excellent video! Thank you :)

[@JohnEusebioToronto]

Great video. Very clear and good level of detail. I agree with @poweredman, though. A script might help, a a bit more polish to the visuals might make for easier comprehension. Still, loved it. Keep it up.

[@Subzero09]

Great informative video

[@hatemmohamed9489]

thanx alot , this is so helping

[@cassert24]

Thank you for the great video! One question is, in the Pavlov's dog experiment example, wouldn't the leaked Ca2+s affect the other kinds of synapses which are not activated while giving food, if the leakage itself only causes the other synapses to have LTP?

[@cristig243]

Nice try with Pavlov but it sounds like over simplification. Except for this, 5 stars

[@LexXxii22]

Thank you!!!

[@klnm59]

It's my understanding that LTP is only associated with exlicit declarative learning and memory, of which classical conditioning is not a part. it is also my understanding that classical conditoning occurs outside the hippocampus and occurs in the part of the brain most associated with the senses involved. Why is classical conditioning being used as an example to explain LTP?

[@iriebluetooth]

LTP has definitely been studied in the context of classical conditioning and I just find it to be a useful example but it is more complex than the video shows. Click on "show more" below the video for a little more detail. I hope it helps.

[@jamstahjam]

I'm just super super depressed and for some reason this helps.. I'm surprised how much I understand.

[@Nothinlefttoloze]

This has absolutely nothing with depression. This is for memory. I'm just wondering, how does this help with your "super depression"?

[@filmic1]

Heavy...!! so that's what's going on... No wonder fear (PTSD) can be so ingrained and depression so difficult to treat.

[@CarolRobertsonPsychosensory]

Yes, and is the reason that depotentiation generated by Havening Techniques is so wonderful

[@nevilbot]

How can hippocampal LTP be induced and how is LTP measured please?

[@valeskacidjofre3109]

+neville bode is measured by excitatory sinapses peaks (I think above +40 mV, with electrodes) and the AMPARs/NMDARs ratio, but i'm not sure. AMPARs are the one that response first with glutamate binding but you need a bigger amount of glutamate for activating de NMDA receptors in the post sinaptic neuron

[@aleclopez-rodriguez4532]

You can induce it with a tetnatic stimulation which is a high frequency shot. The greater the stimulus in the presynaptic cell, the larger the action potential = more Ca++ into the cell == more NT released into the synapse. The NT Glu binds to both AMPAr and NMDAr .... AMPA opening up let's Na+ into the postsynaptic terminal, depolarizing it. depolarization with eject the Mg2+ ...... basically LTP and LTD can be measured/predicted based on the NMDAr activity .... which is essentially the [Ca2+]i level.

[@svetlinavasileva109]

When you describe the difference between LTP and Ltd you say that Calcium activates different mehcanisms ... kianeses and phosphitases? I am sure that I am ot spelling them correctly, Could you please give me the correct spelling :) Otherwise, very helpful video :)

[@edkes123]

Kinases and phosphatases

[@poweredman]

Hello! I enjoyed the explanation, but here are 2 pieces of advice (cuz i compared your video to other videos i've watched and learned from): - write a script. you pause a lot and say "hum" a few times, and that really comes off as insecurity, which might make people uninterested. - use your drawing tools to their full potential! make larger drawings and try to make them more symmetric so that they look more appealing. :) I swear i'm just giving these opinions as positive criticism and hope you improve and make greater videos in the future :)

[@swapnilkuma7702]

Just play it fast Dumbo....!!

[@user-pv1ng2od2n]

i think the contebt is good but your voice is kinda sleepy and slow try to put more speed or something in it :)

[@WinryRockbellElric]

UGH NO ONE IS EXPLAINING WHAT THIS LITERALLY DOES AND I I AM MERELY TRYING TO PASS PSYCHOLOGY CLASS AND GET OUT OF HERE

[@hc2828]

+Izumi Blair Biopsych? I have a final on this stuff too so i feel you!

[@WinryRockbellElric]

yesssss omg... yep I'm ok now though! I passed! I hope you got a high score, too!

[@iiiarmchair]

I disagree with the negative comments about how you have presented. You come across as knowing the subject. The material is interesting enough (made more interesting perhaps, by your hand drawings), so the occasional 'err and arrr' went un-noticed! I'd suggest you don't try to improve this video, it really does put the message over clearly enough! Cheers!

[@patriciacharoenrook3033]

Q PESAO ERES COLEGAAAAAAAAAAAAAA