Polycythemia Vera (PV) - Myeloproliferative Neoplasm (MPN) - Erythrocytosis - Hematology

[@MedicosisPerfectionalis]

🦠Antibiotics Lectures: www.medicosisperfectionalis.com/ 📝 Download Notes: www.medicosisperfectionalis.com/

[@nisreenalgrni3635]

The answer is C??

[@fhb1997]

Just thought I should let you know you are genuinely the only reason I know any haematology. On behalf of every medical student on the planet: thank you SO much.

[@MedicosisPerfectionalis]

My pleasure 😇 That’s why I wake up every morning...to help students 😊

[@ankitashinchan6289]

@@MedicosisPerfectionalis thanku so much for ur hardwork❤❤❤

[@nazimuddincp9291]

Unique presentation. You dissect the subject. And simplify it. Proud Egyptian

[@kemigishaimmaculate5894]

As I watch this I realize other lecturers make this work seem so difficult when it's actually easier with u

[@iitssonic3192]

I am a lecturer of hematology, but really I am learning the the excited way of lecturing from you, thank you

[@MedicosisPerfectionalis]

Thanks a ton, dear! I am honored!

[@ThatsWhy-]

He is very smart and intelligent . I love Dr. Medicosis

[@EylulTurksever]

Watching your videos before the respective lectures in class is making a real difference. Much more retained knowledge afterwards.

[@MedicosisPerfectionalis]

I appreciate you so much, Eylül! Thank you so much for supporting my channel!

[@tukerokuntai4671]

Am a medical student but i can really say you have widened my hematology understanding through your lectures thanks much 🙏🙏

[@MedicosisPerfectionalis]

My pleasure 😇

[@joed9285]

I’m not a student, I suffer from PV and this instruction really helped me understand this better despite a couple years of previous research. Also, sadly, I’m not an old guy! Great job and thank you.

[@BeeCJ]

I felt the same! More information than I have found or that my doctors have explained to me in a year. And I don’t think I’m that old either. Lol

[@NileshKumar-Dl1wli]

Joe d...what kind of test have done for pv confirmation

[@natelindsey7778]

I feel the same way bro, I’m only 26

[@marieparklaneinstituut3611]

I am diagnose with PV and right now taking. Ascal en hydroxyurea. I suffer from itchiness mostly back of my body. Thanks for this info

[@marieparklaneinstituut3611]

Is this a fatal sickness or shall I say. cancer?

[@GoodnightJLH]

Thank you. I’m a retired female physician. My HCT is 55. Platelets 552. WBC 12K. And I just tested positive for JAK2 mutation. Thanks for the brief yet thorough explanation.

[@MedicosisPerfectionalis]

You’re very welcome! How is your health, doctor?

[@GoodnightJLH]

I’m afraid I feel awful. Multiple vague symptoms. I’m also healing from parathyroidectomy surgery. I was hoping that would fix most of my symptoms but it looks like that won’t be the case. The burning feet, night sweats, fatigue and joint pain are especially bothersome. I quit practicing due to these symptoms.

[@mardinjacob2134]

My last exam in medical school is in less than 3 weeks and I just came over your videos. Wanted to let you know that YOU ARE AWESOME!!! Thank you, thank you, thank you! #Gratitude

[@MedicosisPerfectionalis]

Grateful people are the best...I am honored! Keep at it, you will pass if you stay focused 👏

[@amolpreetkaur3443]

Same.. mine is in a week. N i just wanted to finish heamat so bad

[@MedicosisPerfectionalis]

Study hard...You can do it 👏

[@godwindabere1677]

You are bloody good. Your videos are literally carrying me through hematology in my clinical classes

[@itsthemadge]

I was diagnosed with PRV and I found this super interesting and informative! Thankyou

[@lorraineday4141]

It took a years and years to get diagnosed with PV. So this is great maybe it can help educate doctors on what to watch for so patients don't suffer as I did.

[@MedicosisPerfectionalis]

I am so sorry to hear that you went through this!

[@سهيالفرجابي]

I can't prescribe how amazing are these lectures.. Thank u so much for your help

[@MedicosisPerfectionalis]

Glad you like them! Thank you! Would you please help me by sharing?

[@zmzm.osman001]

Stay Happy Prof ❤❤❤ for ur lectures. # High blood viscosity is due to: High Cellular Count Or *** Reduced Plasma Volume not Increase Plasma Volume (I THINK SO) 14:09 #Case Answer: C.

[@hazwanumar85]

I Diagnosis Polycythemia Rubra Vera PRV/PV from ealy 2014 and I know I have PV In 2012... In May 2015, I have experienced in Transients Ischemic Attack symptoms TIA with MRA scan showing severe stenosis in L proximal M1 it's means Blood clot in brain... I have to keep Red Blood Count *Hemoglobin* in 14g to 16g with 2 or 3 monthly Venesection... Apa yg aku Nak share Kat sini, betapa bernilai nya hidup di waktu sihat tapi di saat ini AKU Belajar lebih menghargai segalanya yang ada di SEKELILINGKU... Thank you Allah atas segala pengalaman ni...

[@GoodKnight5252]

I'd like to add a correction: Major WHO criteria are as follows: Hemoglobin >16.5 g/dL in men and >16 g/dL in women, or hematocrit >49% in men and >48% in women, or red cell mass >25% above mean normal predicted value Bone marrow biopsy showing hypercellularity for age with trilineage growth (panmyelosis) including prominent erythroid, granulocytic, and megakaryocytic proliferation with pleomorphic, mature megakaryocytes (differences in size) Presence of JAK2V617F or JAK2 exon 12 mutation The minor WHO criterion is as follows: Serum erythropoietin level below the reference range for normal So i actually don't know if this is a correction or maybe you're using different criteria than the WHO but in my uni we use WHO so whatever :) Thanks for the video! Reference: ashpublications.org/blood/article/127/20/2391/35255/The-2016-revision-to-the-World-Health-Organization emedicine.medscape.com/article/205114-workup#c1

[@aishaabdullahimohammed6480]

Same❤

[@bgirllui69]

Answer C is correct in my opinion.

[@saurabhdhabeknight]

I can tell that this guy is a nerd, but he's kinda like the stud among the nerds😎🤣🤣

[@MedicosisPerfectionalis]

Haha 😂

[@Msaliba13]

I wish my instructors can explain the way you do. Awesome job! Keep it up ✌️

[@MedicosisPerfectionalis]

I am so honored and humbled...So happy to hear that...You made my day!

[@kimc506]

I found out I had ET after a neck injury and clot in my vertebral artery developed. 5 strokes before I found out. I was 43 at the time. I have no difficulties related to those strokes (strokes of luck). I recently started itching like crazy after a shower. I tried everything I could think of to fix what I thought was my dry skin. I changed my skin and hair products. I just learned from your videos that I probably have converted to PV!! All the labs were so different and that dang itching. Tried Benedryl today and it helped a little. Thank you!

[@MedicosisPerfectionalis]

My pleasure...Please talk to your doctor, because I am not one...I wish you the best of luck!

[@kimc506]

@@MedicosisPerfectionalis oh I have talked and talked and will talk some more... thanks

[@georgehotham1312]

Thanks now I no more about my PV in the last 9 minutes then I have in the last 2 years since been diagnosed . Big thanks my friend

[@MedicosisPerfectionalis]

You’re very welcome! This condition is treatable. Please follow up with a good oncologist...You can get through this. Good luck to you!

[@mmns2910]

How are you filling now, my mum has been diagnosed with PV last January and just wanted to know how other patients are? Thank you.

[@georgehotham1312]

@@mmns2910 I am feeling absolutely 💯 percent doesn't have much of a impact on my daily life now and again I feel tired 😴 . But as long as I get a good 8 hours sleep a night it's fine .hope you're mum is OK and if you need a chat I am here don't mind 😉 answering any questions .

[@mmns2910]

@@georgehotham1312 Thank you for the kind response, much appreciated. My mum is feeling very tired and has swelling in her legs with some bruises but going every 3 weeks on check ups. It's nice to know that she is not the only one and it means a lot to have a community that are supportive with one another. Thank you.

[@georgehotham1312]

@@mmns2910 Your welcome as long as she is been seen by hematology team she be well looked after took me about a year to settle into my treatment plan and only going every 3 months now . And like I said feeling OK now 🙂 Tell your mum she be fine and much love to you all

[@mdzeeshanparveez3779]

Not all hero's wear capes. Gon' pass my boards just because of you🙇🏻‍♂️

[@MedicosisPerfectionalis]

Haha 😂 Thank you so much 😊 Good luck to you!

[@nanamimi7385]

I just found this video. My husband has polycythemia vera for about 9 years now. We never know how he gets it. I hope to get the answer here. I'll watch the video when I get home later.

[@gianinaelenna3779]

"It's called gravity" 😂 That made me laugh for some reason, thank you so much ! 😂❤

[@MedicosisPerfectionalis]

😅😂...My pleasure! Take care 😊

[@dorindragos]

Mutated JAK2 does not stimulate, but simulate EPO and TPO receptor activation.

[@noyb470]

this was an amazing lecture on PV. I am an NP student about to take my boards. Thanks :)

[@MedicosisPerfectionalis]

My pleasure 😇 Good luck 🍀

[@sniko1]

Thanks a lot I study my exams with your videos

[@MedicosisPerfectionalis]

Wonderful...Keep slaying it!

[@ShermanCassidy]

I think you need to update this. It may be primarily diagnosed of the elderly--but you are incorrect in calling it a disease of the elderly. But there are many people who are diagnosed with PV and have the JAK 2 gene mutation.

[@dr.zinaart5274]

The answer is C baby 😂💕

[@MedicosisPerfectionalis]

😁 Correct!

[@amani1487]

yep

[@shaidasabah2606]

Thank you so much, your lectures are perfect . the major and minor criteria are different from what i have learned that was the only confusing part of this lecture . ALL LOVE FROM REPUBLIC OF TURKEY

[@MedicosisPerfectionalis]

Thank you 🙏 I think the guidelines have changed.

[@brhoomahmed3321]

I love you pro 💙 I am from Yemen. Best doctor 🔥

[@MedicosisPerfectionalis]

Thank you!

[@Dr.Nusrat2066]

Ans is C. Hypercellular bonemarrow with panmyelosis

[@mahiehussein]

Funny + educated = amazing person! Thanks man!

[@MedicosisPerfectionalis]

Thanks for your continuous encouragement!

[@musallamlama84]

Answer of case study is C

[@anandsuresh6]

Myeloproliferative baby. Haha loving your videos

[@MedicosisPerfectionalis]

Happy to hear that 😎

[@scylla324]

U r saving my life literally!!! missed a few lectures and feel like i am gonna die in the next exam keep up the good work!!! Thank you sooooooo much T.T

[@MedicosisPerfectionalis]

You will do great...Keep it up 👍👍

[@MedicosisPerfectionalis]

I made a mistake in this video...In CML, there is actually increased basophils (not neutrophils, which was a mistake)

[@sagarsaha588]

WHO 2016 criteria modified FOR PV changed sir…Hb more than 16.5gm/dl for male .16gm/do for female.Thank you for your nice presentation ❤

[@GhadaJ]

I thank sooooo much you really help me in studying pathology i ammmmmmmm sooooooo thankful

[@helsshaks3847]

I am learning from you more than my DR. I have pv and Mastocytosis. SM-AHN

[@MedicosisPerfectionalis]

Thank you so much for watching! I am so sorry you’re going through this...It must’ve been hard!

[@aregahailu2487]

Please do you take drugs . I am PV patient living in third world with no drugs available

[@mollya2106]

My brother aged 71 died two days ago. He had Polycythemia Vera and Myelofibrosis. He had multiple strokes and blood clots over the last few years. He fell and cracked his ribs and nicked his liver. Within a couple of weeks his body couldn’t fight any more. Rectal bleeding, inability to eat, cirrhosis of the liver, infection from IV and severe pain.

[@MedicosisPerfectionalis]

Oh! I am so sorry! My condolences!

[@mollya2106]

Thank you. May God be with all those with chronic illness.

[@MedicosisPerfectionalis]

Amen 🙏

[@malathabushanab2222]

Wallahi i really dunno how to thank you you do more than you even expect urself ur foing💜💜💜

[@MedicosisPerfectionalis]

Thank you 🙏

[@thislifeisagame9540]

What's the answer to the question at the end? I can't find his "next video "

[@happiness965]

The explanation was too good but I have a small doubt-Why is splenomegaly present in polycythemia vera but not in secondary polycythemia?

[@nonr74]

i'm 24 and recently i was diagnosed with polycythemia vera, hope they will find the cure soon, just hope :(

[@AlexXBT97]

how are you doing now

[@432_mdaqueel9]

Me tooo

[@goodnessattah8113]

Great video Answer is C.

[@stardeewan2477]

Ur way of teaching is best Kindly add new treatment options of topic Like prv now adays jak 2 inhitirs withbname ruxolitinib , peg alfa interferon. R also treatment options.. Anywz quite helpful

[@MedicosisPerfectionalis]

Thank you so much for your honest and valuable feedback

[@gta_vice_city69]

Option c is correct Hyper cellular marrow with pan myelosis.

[@jerry-rsuprien4441]

this dude is a genious

[@MedicosisPerfectionalis]

Wow 🤩 Thank you ☺️

[@Dbryan00]

Great video as always. Just needed to mention that JAK2 mutation doesn’t cause JAK 2 to stimulate EPO or TPO receptors. It’s a signal transducing protein hence the mutation causes it to be constitutively active without EPO or TPO stimulation.

[@MedicosisPerfectionalis]

You’re correct!

[@ronnieross3493]

Answer is C Btw great video

[@MedicosisPerfectionalis]

Excellent...and thanks 🙏

[@user-nq1hq3md1h]

Thank you 🙏 The answer is c

[@jjaytx]

Great info, but the amount ads you have is rediculous.

[@MedicosisPerfectionalis]

Thanks for your honest feedback!

[@uni-cats742]

These videos saved me and my marks thank you

[@MedicosisPerfectionalis]

Thank you so much 😊 Can you please help me by sharing?

[@saphurahnabaasa3156]

I like your style of teaching. Mostly that "baby" thing

[@tahiransari3917]

Your way of teaching very good

[@MedicosisPerfectionalis]

I truly appreciate it

[@mukeshverma15]

Ans - C hypercellular marrow with panmyelosis baby 😀😀

[@MedicosisPerfectionalis]

Excellent

[@ayaali5425]

Great job it is not just informative it's funny too 👏👏👏👏

[@MedicosisPerfectionalis]

Thank you so much 😊 Can you please help me by sharing?

[@g.ioanaeliza7886]

this video is so well done, i am amazed.Thank you, you're awesome !

[@MedicosisPerfectionalis]

Thank you so much, dear, for your encouraging words. Can you please help me by sharing?

[@mmesomachuba-okpalifo7872]

Thank you for all you do❤

[@losh1411]

one of the best medical channels on KZbin, Thank you so much you made my life much easier and you draw a laugh on my face Baby :p

[@MedicosisPerfectionalis]

Hehehe! Thank you ☺️

[@shenekamal6722]

I study my exam with your videos♥️😍 my medical life saver ♥️Thanks sir🙌🏻🙏🏻

[@MedicosisPerfectionalis]

My pleasure 😇...That’s an honor...so happy to have you at “Medicosis”...Good luck with your exam 😃

[@gurpreetpuri83]

By the way Hb in RBCs carry oxygen not the platelets. Please correct at 6minute and 14 seconds.

[@tahiransari3917]

Everything is covered from your lecture

[@MedicosisPerfectionalis]

Thanks 🙏

[@juliuskitty2426]

Thank you for the great videos. I am 63, female, fit, active, nonsmoker, 2 glasses of wine per week, no other issues except removal of half my thyroid and take 88 mg per day. I cook everything from scratch, Mediterranean diet. I noticed my ferritin levels raising over the last two years, now at 390 and then in the last eight months my platelet counts were going up, now at 600, I was diagnosed with ET JAK2. Bone Marrow biopsy taken waiting for results. Do you think that there is any correlation to the ferritin? My doctors just kept saying I had Covid or I was fighting a cold. Thanks so much!

[@mahabubulhasan4944]

Go ahead..up more and more..it will be a blessing fr us..thanks

[@Kelly-nt2rq]

The hydroxyurea stopped having an effect about a year and a half in. They started giving something called jackify and that has been holding steady for the last couple of years

[@aregahailu2487]

My dear I am PV patient living in third world .doctors have no drugs to prescribe so please send me these two drugs .thank you

[@Kelly-nt2rq]

@aregahailu2487 1. Getting diagnosed with pv is an extremely time consuming, intensive and expensive process. So I find it very hard to believe that the doctors you have there were willing and able to do all of that just to not treat you for the disease. 2. Hydroxyurea is a chemotherapy drug. You can get it through any Dr who treats cancer. 3. Jackafy is $20,000 for one months supply.

[@alprincmalki]

My rbc are high but i don't have itching after shower so what is that

[@mskb1412]

I am one of whom I Watch most of your videos for a while and I find them them very enjoyable and informative But I want to note something, there are 3 Major criteria to diagnose PV and bone marrow is one of them. For diagnosis it is required to have 3 major and 1 minor. Thank you

[@MedicosisPerfectionalis]

They updated the guidelines

[@ingorichter649]

OK, all kind of Myeloproliferstive Disorders are severe, but this one seems to be very bad. My CML may be one of the main reasons due to a huge but silent heart attack forming a big trombus in the left ventricle followed by strokes which temporarly damaged my ability to speak correctly. It may be caused by anisocytisis of to high and inconstant count of platelets during rising CML. Now I am on Imatinib in collaboration with heart protection therapy and feel well again. If Imatinib will cause resistance of BCR-ABL due to t(9;22) Bosutinib will be my next TKI. Nilotinib and Dasatinib does not be suitable due to my predamaged heart. Question: Is it in the meantime posible to treat PV and ET also with JAK2 inhibitors similar to the effective treatment of CML using TKIs like mentioned above?

[@kemnana8740]

Crystal Clear Great job !

[@MedicosisPerfectionalis]

Cool! I am glad you liked it!

[@manarsmaan2624]

thank you for the great lecture . i have a question please mentioned in your lecture in time 1:39 . when PV converted PM so the patient will have anemia in PM after having high hemoglobin in PV ?

[@payalnayak2176]

What was your inspiration behind this channel?....Great work Sir.....huge respect

[@MedicosisPerfectionalis]

Seeing medical students in the library losing it! 😂 So, I decided to help!

[@fatimabasheer344]

@@MedicosisPerfectionalis 😅So you're a doctor? actually im curious for a while

[@creepyrocking2078]

Today got a nightmare that in my blood reports my rbc's were unusually high(i know in my dream that its a type of cancer but didn't know the name and what disease it is) I cried and woke up suddenly

[@ihsanendo8932]

Amazing videos.. im ur new fan now! 😊😊😊 thank u so much.. God bless u

[@MedicosisPerfectionalis]

God bless you too

[@rihabashri]

Lectures ‏‪ good

[@_fffeline]

Well, I'm here to study about PV because someone I really cared about has it, and I wanna be educated about this disease.

[@MedicosisPerfectionalis]

Best of luck to you and to that person.

[@aregahailu2487]

@@MedicosisPerfectionalis please I am PV patient no drug here in Africa for it like hydro something

[@fatimanaqvi2378]

Ans hypercellular with panmyelosis

[@kamalezwoskf761]

Omg… fantastic Job man you r creative 😍😍😍

[@MedicosisPerfectionalis]

Thanks 🙏

[@gayathrijinesh3004]

You are amazing. Hats off!

[@MedicosisPerfectionalis]

Thanks 😊

[@draqib6818]

Is JAK-2 is negative in PV patients sometimes?

[@raniaabdelrahim6563]

It's the alot of "baby" that regain my attention when I go daydreaming 😂❤

[@MedicosisPerfectionalis]

:)

[@srinivasaraosirasapalli5104]

very interesting lecture.your way of teaching is very good.i entirely depend on your videos for indian pg medical entrance.sir please post videos on pharmacology also

[@MedicosisPerfectionalis]

That’s amazing! Thanks a lot for your continuous support and encouragement...I wish you the best! And yes, I will consider doing pharmacology.

[@SaynabChannel]

The answer is (C) dear

[@HH-nd2vq]

Why B12 is increased in Polycythemia vera?

[@my2sonznme419]

Aquagenic Pruritus is nothing like what is described here. My youngest son has it, developed it in HS after taking an acne medicine. We thought he was allergic to the medicine, but the itching has never gone away, it's been 8 or 9 nine years now. So quite the opposite is true regarding hot showers. With AP, the hottest shower possible followed immediately by cotton clothing gives mild relief to the itching. NO antihistamine has ever worked. Having tanned skin the summer helps, but fading of the tan makes winter almost intolerable. All waters, sweating, especially a cold sweat. No doctors even know what to do here where we live, it's ridiculous. Would you do a specific video on your research for AP, there are people all over the world suffering with no one to help. Some people, poor souls, itch to the point of drawing blood and contemplating suicide. I feel there is an answer out there, it will just take someone caring enough to find it. Bless you.

[@rubasarkez9917]

Creative ! Thank you so much 😍

[@MedicosisPerfectionalis]

My pleasure 😇

[@Sa-yh1eq]

since theres an increase in cell turnover, shouldn't we have jaundice too?

[@fatimabasheer344]

The answer is c hypercellular marrow with Panmyelosis?

[@davidgbenro8048]

answer is C

[@poojapargi5048]

Option c

[@Lycheemolala_nrn]

The answer is C, right?

[@schliemannheinrich6997]

Primary Myelofibrosis (PMF). Polycythemia Vera (PV), and Essential Thrombocythemia (ET)

[@MedicosisPerfectionalis]

???

[@Beatriz-xd1nv]

I liked your imformation in a more interesting way ,can you made a video how is treated this cancer to the blood .please Thank you

[@MedicosisPerfectionalis]

Thank you so much 😊

[@loriedavis7839]

My 39 year old son has PV. When he was diagnosed, we were asked if he had ever been exposed to anything? I recently wondered if the chemicals found in the Round Up weed killer may be a cause as he played baseball (no weeds on a baseball field) and has been exposed to it. Thanks for your video. Lorie

[@MedicosisPerfectionalis]

I’ve never heard of that. Please don’t confuse legal precedent with medical evidence!

[@loriedavis7839]

@@MedicosisPerfectionalis When he was diagnosed in 2014 a doctor in Minnesota asked the question about exposure. Thank you for your reply.

[@sampatk4948]

@@loriedavis7839 how is he doing now ?

[@hafsakhan7366]

Ans is C.

[@noorashereef2847]

among myeloproliferative neoplasm AML, ALL to comes right?

[@muhammadhussnain4014]

option C

[@nemanjababic7141]

What triggers the transformation to Leukemia/MF? Can we avoid the transformation from occuring? Also, what happens if it is neither primary nor secondary erythrocytosis? Genetic studies rule out primary PV, normal level of EPO, normal organs, but still high HBC, RBC and Hematocrit? Thanks. I am asking because I am the case study here myself 😂

[@fathurrochman2469]

Is it possible to have high count of erythrocytes while the hct and hgb is relatively normal/low?

[@MedicosisPerfectionalis]

Everything is possible. Labs are not 100% accurate. Moreover, some thalassemia patients will have exactly that.

[@fathurrochman2469]

@@MedicosisPerfectionalis Been testing it 5 times in different labs and the results are relatively the same as well, thought the rbc count aren’t that high, only around 7-8 million, blood smears only shows microcytic hypochrome (fe deficience anemia due to inadequate food intake) and anisopoikilocytosis. It’s mostly asymptomatic though, except for the bradycardia (40-55 bpm), ecg seems normal. No histories of blood disease, pulmonary disease, smoking or living in high altitude.

[@nikagracialegaspi]

Correct me if I'm wrong but I think the criteria for PV is all 3 major or 2 major plus 1 minor?

[@appyy666]

Very well explained 👏 Cheers.

[@MedicosisPerfectionalis]

Thank you so much 😊