Melatonin CONTROLS Autophagy, Mitophagy, & Mitochondrial Biogenesis

Welcome back fellow Mitochondriacs! Today we take a deep dive into melatonin's role at regulating mitochondrial dynamics, mitochondrial fission, fusion, mitophagy, mitochondrial biogenesis, and autophagy as a whole. We also see a level of discernment, in which melatonin either inhibits or initiates these processes, when it best serves the body.
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#autophagy #mitochondrialdisease #melatonin

[@DrCaseyPeavler]

What aspect of melatonin’s effect on mitochondria was most surprising to you?

[@Herbert_Knavs]

What is not. Everything. Thank you soo much.

[@noelwatson6303]

Your videos are like a breath of fresh air. As a stage four pancreatic cancer survivor of 50 months I have identified many of the supplements that you discuss so clearly and enthusiastically. I have no doubt whatsoever that your KZbin channel will go from strength to strength and I certainly for one will be constantly extolling its merits.

[@DrCaseyPeavler]

That is extremely kind of you and encouraging for me. Thank you so much. I do hope to reach as many people as I can and even be a small part to their health journey.

[@DrCaseyPeavler]

I am so happy you are a 50 month survivor of such a horrible disease! God bless you!

[@DCLearningtoLive]

great information, the fact melatonin controls autophagy start to finish makes sense, as recovery mostly happens while sleeping. peak production and sleep hours 8pm-12am best hours of sleep. an intelligent hormone, and system that shows the body knows exactly what it is doing if you feed it the right lifestyle. incredible, thank you.

[@DrCaseyPeavler]

It is incredible isn’t it? Hard to fathom almost. I am glad you enjoyed it!

[@lauradiaconu6211]

😊​@@DrCaseyPeavler

[@donaldkraft7371]

Another great video, i wish I had a better understanding of this complex system, but if you pay attention,there is a lot to learn. Just an update on my rectal cancer journey, growth still receding very fast, very little discharge, had to stop the Capecitabine at 9 days due to toxic overload., took 3 days to feel better. I started taking 900 mg Artemisinin a few days before the overload, The same happened on previous 14 day cycle before adding Artemisinin. Will get blood work tomorrow with vitamin ‘’D’’, see Oncologist on Thursday and will add Fenbendazol tomorrow, still on 16 hr fast and two meals, low carbs.

[@DrCaseyPeavler]

Amazing news! Please keep us all updated on your progress? Any way you could share your entire protocol with our community?

[@donaldkraft7371]

Yes, I’m working out the plan,waiting for lab results, it’s based on many of the top tidbits from PHD’s and DR’s like you and my success of avoiding muscle pains and no Cardio events considering that I have high risk factors with no Cardio pharmaceuticals for the past 24 yrs.[father died of heart attack at 47, mom had one at 65, I have a calcium score of 515, that was self inflicted by super high intensity training, 13 marathons in one year, Mt biking very steep hills, In-line skating, short line water skiing. [ck out ‘’American Biohacker’’ Russ Scala’’ his research indicates high calcium build up from trauma from HIT sports and high Cardiovascular events.

[@DrCaseyPeavler]

Interesting. The going theory is that it is endothelial dysfunction caused by oxidative stress and chronic inflammation. I imagine I speak for several of us who look forward to seeing your plan/protocol!

[@stanleyyu2079]

Artemisinin can deplete iron. Don't take Tylenol while on fenben. Interesting info regarding to calcium buildup caused by intensed exercise. Curious if you take magnesium and vitamin k2 supplements.

[@DrCaseyPeavler]

Great question about the K2!

[@ea6051]

i think the most amazing thing is how all these processes somehow came together out of a primordial soup of stuff (inlcuding the state of the atmosphere and sunlight at the time) and evolved the complex biological processes we see in the world today. as for melatonin-all of its functions are simply amazing to me.

[@ws7001]

And with a self replicating mechanism! I would like to see the probability calculations for this ATP Synthase motor and associated mechanisms to arise with replication and precise positioning. Anyone? Mind boggling. Keep up the great work Dr Peavler!

[@DrCaseyPeavler]

It is really…I personally believe in creation but either way is spectacular and miraculous.

[@ea6051]

@@DrCaseyPeavler I believe in creation as well especially after starting to learn about just how complex biochemistry is (not to mention the brain and all its wonders). another youtube channel called "smarter everyday" recently did a video on the "motors" that drive flagella. mind boggling!

[@holysmoke7043]

Your heart knows what is. Many nudges and events tell real story. Continuous fellowship regardless of thought. You are LOVED.

[@DrCaseyPeavler]

It’s hard not to believe seeing how unbelievingly complex and beautiful all of this is. And we are just scratching the surface…

[@jxgardner]

Casey, I love the science, complex indeed.. I note that the melatonin dose in these animal experiments are 100s of mg in the human equivalent.. I’ve taken 100mg melatonin with no apparent side effects.. We not talking about the pineal gland and sleep here, it’s the metabolism of multiple trillions of cells in all your organs ! Hence high dose melatonin may eventually become the medical norm…except for the fact it’s a natural supplement and can’t be a ‘medication’..

[@DrCaseyPeavler]

I still think we are not capturing what we are capable of synthesizing under solar/IR exposure well. One must maximize solar exposure and absolute darkness before supplemental melatonin is even considered imho

[@raykinney9907]

@@DrCaseyPeavler Yes, agreed! Given, the different active forms of D3, what other forms of melatonin might there be acting yet us not yet noticing?

[@DrCaseyPeavler]

Well there are clearly powerful active melatonin metabolites Ray. 2-hydroxymelatonin is more powerful against colon cancer than melatonin just to give one example.

[@raykinney9907]

@@DrCaseyPeavler Yes, I was just thinking that with so much now known, how much might remain to yet discover about even more.

[@DrCaseyPeavler]

Honestly, probably still the majority of it lol.

[@paultraynorbsc627]

Brilliant been using Melatonin off and on for over thirty years

[@DrCaseyPeavler]

Why have you been using it? Just curious

[@jasonk4315]

Another great video. Can you talk about how to increase melatonin, which decreases as we add. Including getting more sunlight and external supplementation. Thx!

[@DrCaseyPeavler]

Yeah that sounds like fun actually. I am going to go now into metabolic therapy drugs and supplements pretty hard and heavy for the next foreseeable future. I hope some additional studies come out about infrared light and melatonin in the meantime 🙏

[@DrCaseyPeavler]

I think I have answered this question on another comment thread. For specific questions reach out to me via email. It’s in the description of every video.

[@andaf557]

Very informative video, thank you! I had severe issues with my eyes, getting red/dry/ itchy and within few days of taking melatonin, my eyes got back to normal.

[@DrCaseyPeavler]

That is amazing news! Melatonin is a regenerative powerhouse molecule!

[@MsElaine122]

peptides are offering revolutionary benefits. Mitochondria; SS-31, MOTS-C. Yes expensive, but can solve problems other modes can't. Good luck

[@DrCaseyPeavler]

I am personally not a huge fan but thank you for your input

[@paulhindle3961]

Thank you very much for all the information. I'm making sure I get my sunlight exposer, maybe an IR lamp for winter. I am 63 next month so concerned about my nighttime levels. What I started doing is applying an aloe vera/melatonin mixture I made to my face, shoulders and arms each night. It's about 200mg in the topical aloe lotion. It seems that bypassing the liver as well as transdermal delivery extends the bioavailability and duration. So far so good. I am not treating any known conditions except general aging.

[@DrCaseyPeavler]

Thank you for your feedback and sharing your concerns. Adequate sun/IR exposure and avoidance of artificial light at night should be adequate for most people for general health. However, if you have significant diseases, would do that plus supplemental melatonin in discussion with your integrative/functional doctor.

[@paulhindle3961]

@@DrCaseyPeavler Thank you Dr Peaver. I assume that even if I'm careful to avoid artificial light that as I age I will still be producing less than ideal melatonin? It sounds like melatonin is sufficiently benign that mega dosing at night as a prophylactic strategy to slow aging and avoid disease may be a reasonable risk/reward scenario.

[@DrCaseyPeavler]

I would say as you age you need more sun not less. My mentor Dr. Jack Kruse would likely agree with that as well. Supplemental melatonin would only be for extreme cases like cancer imho.

[@napaman2104]

Thank you Dr Peavler, A question and a comment. So what is the best way to get melatonin into our system? Also your videos are so very technical that i wonder if perhaps they're more intended for the medical professionals instead of a layperson such as myself.

[@DrCaseyPeavler]

If you watch the first melatonin video about boosting your endogenous melatonin production, you would likely get a lot of benefit. For most people, getting infrared exposure and true darkness at night should be more than enough

[@napaman2104]

Thank you I will watch that. I watched the one about how beneficial the sunlight is and vitamin D and I for years have been someone who gets a tremendous amount of sun without sun block despite what we've been told all these years about it being damaging. Never believed it and have always been suspicious of sunscreens or sunblock.

[@DrCaseyPeavler]

Blocking the sun is like withholding water or air. It is required for health and function.

[@raykinney9907]

@@napaman2104 Yes! This has been my approach too, but I pay a price socially. I participate in an annual reunion gathering outdoors, camping on a great swimming river in the Oregon cascade range mountains. About fifty great friends attend regularly, spending a great deal of time in sun and water.... and staring into a campfire when fire restrictions are not in effect. Two and a half weeks is a great addition for so many that seem to live indoors for much of their work lives. I feel that these are very intelligent people, yet appear to be so under informed about everything we are talking about here. I get asked if I want any sunscreen or sunglasses, when they notice, but they usually shake their heads when I decline, and move a bit away if I comment about why I don't use them. I think I become a bit of an 'environmental terrorist' suspect. Then, no hope for my credibility when they ask if I've had the latest 'booster' yet! I wonder if a better approach toward educating about all of our points might be more effectively done if we approach by talking about health benefits to our DOGS. I've noticed so much health concern exists for our pets, and people across society seem far more able to listen to any suggestions of health environmental precautions from veterinarians, that knee jerk reactions are reduced enough people listen far better. Educating vets, by supplying reattach papers might be a more effective general approach to wider education??!??

[@raykinney9907]

'research papers' that is.

[@1truthseeking8]

Got any detailed videos on how to support/fight mold/fungal infection? It seems lifelong exposure to mold and lead to Achlorhydria...

[@bulkypug3811]

Excuse me but this channel is for mitochondriacs and not for you mold toxicity types. Let the specialist stick to his speciality! What do you think this is? Take your suffering someplace else!

[@DrCaseyPeavler]

I personally believe the overall human cellular environment and function trump treatments. Let me expand on this. When I was doing my functional medicine training, there was a Lyme and mold specialist. He talked about how these patients had been to doctor after doctor, received antibiotics or antifungals. They never really got better. However, once he improved the other aspects of health, hormones, mitochondria, gut, etc. The symptoms were not as bothersome and the patients improved without lifelong treatment. You cannot get well in the same environment in which you got sick.

[@holysmoke7043]

Thank you for the information.

[@DrCaseyPeavler]

You are very welcome! It is my pleasure!

[@insbpo2679]

Great info. Thanks

[@DrCaseyPeavler]

You are very welcome! I am glad you find it useful!

[@GsGeorg]

Excellent thank you

[@DrCaseyPeavler]

You are very welcome!

[@raykinney9907]

Yes, amazing!

[@DrCaseyPeavler]

Truly!

[@abdelilahbenahmed4350]

Tnx dr Casey for this excellent scientific content delivered in words understandable by everyone but that could have been even more outstanding if some actionable suggestions have been made about dosing. The poison is the dose.

[@DrCaseyPeavler]

Thank you for your feedback! This is a multiple part micro-series that kind of builds on the prior video. You may get some value from starting at the beginning or at least the video about boosting your melatonin. I don’t generally recommend melatonin just because you can make nearly unlimited amounts when exposed to solar light.

[@smarzig]

Add a vitamind lamp.. u can get a used sperti lamp for cheap on fn or cl

[@DrCaseyPeavler]

And they are nice! The d-minder app will calculate D from the Sperti! Would personally use it in combination with photobiomodulation device such as EMR-Tek

[@startingtoday4663]

Fascinating. Surprised how it can regulate (increase/decrease) levels of mitochondria activity. QUESTIONS . Which complex (1-5) does melatonin affect? how? Also do you have any pinion on supplementation and dosage?

[@DrCaseyPeavler]

Great question, just the fact it signals PGC-1a and controls mitochondrial biogenesis means it affects all mitochondrial expressed genes which take part in respiratory complex formation. Yes the fact it can act as gas brake for mitophagy, autophagy, even control of ROS/RNS is wild to me.

[@DrCaseyPeavler]

I personally don’t recommend supplementing unless extreme situation or cancer. Adequate solar/IR exposure and darkness at night should be more than sufficient. However, if you had cancer, would discuss dosing and scheduling with your integrative oncologist.

[@startingtoday4663]

@@DrCaseyPeavler thanks for your reply.

[@DrCaseyPeavler]

You are very welcome!

[@DrCaseyPeavler]

Happy to be of assistance!

[@williambuckley6128]

I take 4 grams/day to help with treatment of metastatic prostate cancer.

[@DrCaseyPeavler]

Have you noticed any positive change? Those are huge doses!

[@tsmilingatu]

I’m currently battling stage 4 Merkel cell skin cancer. This is something I would like to incorporate with my health regimen. Is there a suggestion on how much melatonin to take? Also I was thinking of taking liquid instead of pill form. Is there a big difference? Any information you can share would be greatly appreciated.

[@DrCaseyPeavler]

What I can share is that melatonin is a powerful cancer fighter. I would have you do an exhaustive critical evaluation of how you got sick in the first place. One cannot get well in the same environment in which they got sick. You should work with a like-minded local healthcare provider for this. Then in a discussion about therapeutics see what makes the most sense for your specific case and needs. I hope this helps! God bless your fight!

[@tsmilingatu]

@@DrCaseyPeavler Thank you so much for this information. I will see what I can find out. Thanks again.

[@DrCaseyPeavler]

You are very welcome!

[@ezvahedi1387]

really amazing . thanks a lot

[@DrCaseyPeavler]

You are very welcome! Hope it was helpful!

[@EyesOnCarnivore]

So my vision has improved greatly after going on the carnivore diet and also I spend a lot of time in the sun. I have been thinking about Peter hydroxybutyrate gene expression and how Epigenetics might change mitochondria to benefit vision repair. Thanks.

[@DrCaseyPeavler]

I’m not sure what you mean about Peter hydroxybutyrate, do you meant Beta? BHB is not a gene, it’s the ketone body created from the breakdown of fat and ketogenic amino acids. The retina is EXTREMELY mitochondrial dense. So improving mitochondrial function would likely have direct benefit on eyes and visual function.

[@EyesOnCarnivore]

@@DrCaseyPeavler nice. Yes I meant BHB with its properties doing gene expression. I know about it as a fuel source and working on the inflammation pathways. I have retinitis pigmentosa and in the past one year have improved 37 letters on the eye chart in one eye. I am trying to figure out why and a few others are as well. More info on my channel thanks love your work.

[@DrCaseyPeavler]

You would be someone that could likely benefit from moving closer to the equator for max year round sun exposure and probably aggressive red light therapy…just my $0.02

[@DrCaseyPeavler]

That is amazing progress for your vision by the way! Amazing news!

[@nuki3234]

Supplement? yes or no?

[@DrCaseyPeavler]

Depends on your health situation. In most cases no, get adequate infrared and darkness at night and your body will make nearly unlimited quantities.

[@nuki3234]

@@DrCaseyPeavler Thanks. I am doing a lot of sunlight.and enjoy the videos

[@DrCaseyPeavler]

Great!! As much as I like you watching the videos, I like you out in the sun even more!

[@raykinney9907]

@@DrCaseyPeavler I'm busy peeling hundred of pears, on the deck in the sun while I listened to my 'first pass' of this presentation. More passes tonight, with more pointed attention.

[@DrCaseyPeavler]

I found this video to be one of the impressive in terms of content. Melatonin is a super hero!

[@devaapurna608]

Watching this (with the grasp of a dog trying to read The NY Times) I decided to give melatonin another try. As months ago I had an epic fail after taking a 5 mg before bedtime and staggering everywhere the following day. I am 5' and 87 lbs (clothes on). BUT I just read the entire warning label, and it said not to take "if lymphoproliferative". Well duh. The cancer spread lymphedema into both arms a couple of months ago (I reduce it by short stints of wild arm swinging), but the swelling is back the next day, so rinse, repeat. Dang. Hoped to add it to the sun baths. Fear I will never achieve the blackout at night stuff. Too busy as co-caregiver for my terminally ill son-in-law, late grocery runs and internet research. Trying to stay alive for my 89th birthday next April 20th (Easter Sunday in 2025). Then maybe even longer. When I lived in India (late '70's) an old wizened psychic told me I would die at 87. Never remembered until well into cancer on my 87th birthday. Yikes. So 88 now but started over a year late on the alternative healing (I hope) path. The bright sun baths, carnivore diet and repurposed drugs are at least staying rapid proliferation now, it seems. Am so grateful for your videos too.👌👏👍😘

[@DrCaseyPeavler]

I pray for you to heal completely from your illness! I am honored you like the videos! I have much more still left to share!

[@devaapurna608]

@@DrCaseyPeavler Infinite thanks for your videos and prayers.🙏💖🌌

[@DrCaseyPeavler]

Thank you, I need your prayers!

[@grmalinda6251]

I use castor oil in my armpits. No more pain in arm or breast.

[@DrCaseyPeavler]

I am glad your pain has improved!

[@robinricksecker4950]

I take 400 mg every 2 hours from 8am until Bedtime, which I double to 800 mg at midnight. Is is for hormone positive Invasive Ductile Carcinoma. I'm guessing you talk about phase separation somewhere, but i haven't found it, so you may be using different words. I notice you are talking about melatonin, but not how to use it or how much and how often. Is it in a different video, and i just haven't come across it yet?

[@DrCaseyPeavler]

Thank you for sharing your story and usage of high dose melatonin. Have you seen it make a difference for you since implementing it? I try not to talk about specific recommendations on KZbin. That would be more appropriate for a doctor/patient relationship.

[@Hansen23900]

Can’t take more than about 1 mg or ill get super dry eyes and a morning headache

[@DrCaseyPeavler]

That is interesting. Sounds like max sun and infrared exposure for you!

[@DrCaseyPeavler]

Have you tried different brands?

[@raykinney9907]

@@DrCaseyPeavler Of sun;night???

[@DrCaseyPeavler]

Haha I mean of supplements. But sun and dark first and foremost.

[@richardkirby5560]

Could Mt take over some of the roles of D during winter months in Northern latitudes?

[@DrCaseyPeavler]

That’s a wonderful question….they clearly have some overlapping functions. I would still want to get D during winter somehow either by tropical trips or artificial UV. It’s too important to be without…

[@raykinney9907]

And, you can brush your teeth with it! And paint your house!

[@DrCaseyPeavler]

Haha let me know how that works out…

[@HarryJensen-kr4qz]

I'm getting this weird feeling I'm only a vessel mitochondria use to flourish. Maybe I'm not me 🤔. Maybe my consciousness is a collective of mitochondria?

[@DrCaseyPeavler]

Definitely an interesting take. I’m not God, I do not know, but it is an interesting idea. All I can say for sure, is that mitochondrial health equals your health. Take care of them.

[@johnisgitt7631]

Melatonin helped me sleep. It also helped my brain not work well during the day.

[@DrCaseyPeavler]

I think a lot of people have that experience, which is why I only recommend supplemental melatonin in extreme cases. You can make your own endogenous melatonin and reap all the benefits.

[@youonlyliveonce6000]

I’m sorry😢 I feel groggy no matter what brand or how small the dose🥱 anything I can do to continue to try melatonin and counteract the grogginess. I feel like I’m drugged💉Please help🙏🙏

[@DrCaseyPeavler]

I would MAXIMIZE sun exposure from sun up to sunset, even being in shade is ok for the infrared portion although if you can at least get some direct exposure would be more beneficial. Then after sunset, absolutely no artificial light, blue blockers, black out curtains, sleep mask, etc.

[@newyorkskier]

At what concentration does it impart these effects? Most people take 3-5 mg of melatonin, but I suspect that you need to take in excess of 100 mg to have any of these benefits. Sure, to induce sleep you need very low concentration, but for the effects mentioned in the video it may need a totally different concentration in the body

[@DrCaseyPeavler]

Fantastic question you raise. 100mg would be crazy supraphysiologic level. Safe but clearly supraphysiologic. These processes happen even with lower melatonin levels than ideal, so would have to assume happens at sub-therapeutic, therapeutic, and supra-physiologic levels on a dose response basis. I have not see a curve or graphic to put this hypothesis into picture format, but I will be on the lookout. I do feel confident in saying you can achieve all of these benefits from endogenous production. The question is how much are you making? Adequate sun? Infrared? Darkness?

[@newyorkskier]

@@DrCaseyPeavler I was purely guessing. I have no data to support what I said. The animal studies seem to indicate higher doses to induce autophagy (taking into consideration the mouse to human dose conversion ratio. But I do admit I have no idea if 100 mg is the right doze. I have tried up to 50 mg and have found no crudely observable side effects, but whether it provides added benefits is a question that we still don't know

[@DrCaseyPeavler]

We are all N=1 experiments at the end of the day. If we are fairly methodical you can look for both subjective and objective data points when implementing a new intervention. I would be interested to hear your results with some testing…

[@Roberto-cg2gr]

Does it mean that sunlight helps cancer?

[@DrCaseyPeavler]

AB-SOLUTELY! Through multiple mechanisms, one of them being melatonin production. Others would include, alpha, beta, gamma MSH which are anti-inflammatory. Melanin which can donate electrons when interacting with light to power redox chemistry. Beta endorphin, met-enkephalin both of which are inflammatory. Vitamin D and its bioactive D3 and L3 metabolites. Plus its role in circadian biology and circadian clock genes.

[@Roberto-cg2gr]

@@DrCaseyPeavler Why is it that our government is not recommending increase in Vitamin D levels? Should sunlight be a priority since Cancer is already the second in the most number of deaths around the world 🌎?

[@DrCaseyPeavler]

To be accurate it’s not just vitamin D. It’s everything the sun does which is far beyond just vitamin D, which is very important. The cynic in me tells me they want us sick and debilitated. They make a lot of money on us sick. Not so much well and vibrant…

[@MsElaine122]

Missing dosing, thresholds at each stair step up in dosing. Frustrating!!!! Marginally interesting without dosing!!!

[@DrCaseyPeavler]

Thank you for your feedback. I will not be doing a lot of dosing on this channel as I cannot be practicing medicine over KZbin, plus a one size fits all is not a good plan. I do not in general supplemental melatonin. I recommend you maximize endogenous production

[@Sean-h4l]

It probably was excellent information, but I'll never know, as : (a) He spoke Too Fast (b) His speech was often disjointed; definitely not smooth/easy listening - especially in the beginning. Perhaps best Not to have those Coffees before the presentation! Sorry for being a wet blanket!

[@DrCaseyPeavler]

Haha you might be surprised…no coffee BEFORE the presentation! After, no promises. I am working on my speed, fluency and overall comfortability on the camera. Thanks for your feedback

[@norasmission7394]

Iodine

[@DrCaseyPeavler]

What do you mean exactly? Can you expand on your point a bit?

[@markaguilera493]

Should we go shirtless to benefit from ir?..

[@DrCaseyPeavler]

NIR can penetrate your body 10-30cm! It can go through clothing per physicists but I think the more skin directly affected by light, the better.

[@markaguilera493]

@@DrCaseyPeavler OK thanks. How about uv? How deep do they go?

[@DrCaseyPeavler]

UV is such a powerful short wavelength it does get blocked by most things including clothes due to its photoelectric effects. You need direct skin exposure.

[@markaguilera493]

@@DrCaseyPeavler OK thanks.

[@DrCaseyPeavler]

You are very welcome!

[@terminator3728]

Is this guy AI? He looks and sounds like a robot

[@DrCaseyPeavler]

Rich coming from a T-800…haha no not AI

[@terminator3728]

@@DrCaseyPeavler I'm messing bro lol

[@DrCaseyPeavler]

But people keep asking the same question lol