Metabolism | Triglyceride Synthesis

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[@PeterBilberg]

Very lovely video, thank you so much for you content Ninja Nerd. However I do think the 3 fatty acyl-CoA you have made in the beginning is a little bit misleading, since it should be CoA-SH bound to the carbonyl group with a thioester bond right? The CoA should be drawn in the other end and the Oxygen shouldn't be present right? Please correct me if I'm wrong.

[@Radjehuty]

You're completely correct. CoA is bound by a thioester bond and there is no carboxyl group at the end of the fatty acid chain. The second oxygen comes from the glycerol chain itself where it forms an ester bond between the glycerol chain and the fatty acid chain allowing the CoA-SH to dissociate. Also to nit-pick a tad, What he calls a "DAG" is only technically incorrect in that "DAG" refers to the dephosphorylated form of Phosphatidic acid. It's not a huge deal conceptually because he still does a great job at explaining the flow of events for TAG synthesis but since DAG itself is involved in other metabolic pathways and is itself a second messenger in cellular signaling cascades, I thought it worth it to know that DAG itself is a bit more distinct from PA.

[@sharafina97liner]

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+cupcakechip So happy to help! Glad we were able to make you enjoy it!

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sir please zoom out the camera in the end so that we could take a screenshot of the lectures. thanks

[@ahmadsahil2157]

Agreed

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[@RepublikSivizien]

The ⁻O-CO-(CH₂)ₙ-CH₃-CoA notation is a bit weird, I guess you mean H₃C-(CH₂)ₙ-CO-S-CoA or something like this? Usually, there is no 5-bond-carbon and the FA-synthesis should result in something like R-CO-S-CoA.

[@maheshbhatt8422]

Yes.. the notation is not weird. I would call it wrong. It misleads. H₃C-(CH₂)ₙ-CO-S-CoA this one is correct.

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One of the best doctors I have ever seen, Your videos have really helped me sir and keep it up

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how did it go?

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[@caleb6709]

Questions: Is the second fatty acid in a TAG always an unsaturated fatty acid? Does this mean that fatty acids 1 and 2 will always be saturated? Furthermore, are the answers important in the context of nutritional ketosis?

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Most thankful from Jordan

[@kagumirebenjo3775]

Why should the second fatty acid necessarily be unsaturated??

[@ВладеславЛи]

thank you, best explanation of the situation !!!

[@juandrayo]

So happy I watched the fatty acid synthesis and oxidation videos you advised!

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[@SeptimusCreed]

Great video as always. There are a few things I wish you'd mentioned. First of all I only learned later that Glycerol 3-phosphate is made directly from DHAP via Glycerol 3-phosphate dehydrogenase. I don't believe you mentioned that. Also a mention about glyceroneogenesis would have been great. Anyway. Thanks for the video. Maybe I'll actually survive Biochem with this.

[@NinjaNerdOfficial]

+SeptimusCreed thank you very much I hope the video was able to help. Best of luck in your future endeavors

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we are coming from all over the world here ! I am from algeria and u guys ?

[@ibrahimfurkankaya5572]

When a phosphate group linked to a glycerol molecule its formula become C3H7O3PO3-2, you guys add an additional oxygen atom and a negative charge. The rest is awesome thank you :DD

[@johnpowell9174]

pKa1=1.0, pKa2=8.0 for phosphatidic acids, so at physiological pH, almost all are singly-protonated, that is -HP04-1

[@seanluong6064]

@@johnpowell9174 I think the main issue he is pointing out is that it should be PO3 linked to the glycerol backbone (resulting in O-PO3), instead of the O-PO4 that is shown

[@johnpowell9174]

@@seanluong6064 Agreed.. There a structural formula issue

[@christianramos9006]

Another great video as always!!

[@rishovdas2756]

@ninjanerdscience We cannot call MAG (Monoacylglycerol) and DAG (Diacylglycerol) without removing the phosphate group attached to the respective compounds. and in Step #3 conversion of Phosphatidic acid to DAG should take place first using phosphatase enzyme and in the next step we add the last Fatty acyl CoA to make it TAG. Anyways, Thank you for this amazing video. Love to revise through this.

[@estherruth2781]

It can be called a DAG phosphate or a MAG phosphate

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You saved my life

[@drvonyt8897]

What an excellent video, just like all others!

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Great work, thanks for every video

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Good Job ❤

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Benefiting medical students is a great jop ❤

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Speechless!!!😮😍😍😍❤❤❤❤❤❤❤❤

[@shaniewright3509]

Loved this video! You explained this process very well and I was able to make sense of it all. Thank you :D

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You make it so simple ❤ thats awsome 🐼 thank you it really helped 💙

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My Goat❤

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you're amazing! thank you so much!

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[@benombura3901]

I think we can call the lysophosphatidic acid MAG only if we get to dephosphorylate it and similarly phosphatidic acid once dephosphorylated is when we get DAG if not so they are different structures.However, the lecture is great.

[@WA4OSH]

What chooses which types fats are added to the glyceride base. Fully saturated fats are flatter and the resulting try g is more dense.

[@chhavirawat5500]

Thankyou sir. This vedio is very easy to understand .Very nice explanation. 👍

[@viratkohli5367]

Thanx sir for ur best explanation

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i really like how you explaining the things which i can understand it clearly. thank you for the great videos!!!

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great lecture u made everything clear thanks sir

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+zena said You’re welcome!

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Toooo good explanation.... Thanks a lot brother👦

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Thank you for making me pass my biochemistry exams with your lectures , i love you man 💜🙏

[@kerstinschwarz5222]

bc the O is already drawn in the Glyceral-3-phosphate shouldn't it be PO3 ^-2 instead? Anyways thank you for these videos, i have such a hard time with Biochemistry and these are a lifesaver

[@malirax354]

thank you very much Zack it was so helpful as everytime

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Thank you sir for helping us

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Hi ninga nerds ❤❤ fav thing ever

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thanks so much, this is very helpful. may God bless u

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So good!

[@jasminea4384]

Could you do a video on phospholipid synthesis next?

[@aylin5615]

I’m watching this after five years and thaaanks❤ just a question.. you told the fatty acid chain that is gonna attach to carbon No. 2 in glycerol should be unsaturated but how simple saturated triglycerides are made? Or we don’t have simple saturated triglycerides naturally?

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Very nice explained .useful to me👍

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Thanks a lot ❤

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Thank you so much !!!!

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Wow, what an informative video!

[@steveholmes1736]

To the person who said their watching this for fun; Well,me too!

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my hero

[@AAABBB-oq3rk]

that was absolutely fantastic explanation for that process thank you so much 🧡🧡🌹

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Thank you so much

[@tashachiks2663]

Omw this is so understandable ...please please please do a protein metabolism video series

[@angelicaday6125]

these triglycerides are synthesized by glucose breakdown? Pyruvate? Meaning the initial process.

[@habibanoori2579]

Very useful. Tanks.

[@jansamuelc.jardenico8094]

What reference do you use?

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Best ever , love your concepts and how u make it easy ! Great job ✅❤

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Thank you. It really helped a lot!!!

[@Adam131-o8t]

greetings, in this lecture, you said that the 2nd fatty acid that is to be added to the glycerol backbone has to be unsaturated, so what about the 1st fatty acid that is to be added? does the 1st fatty acid have to be saturated fatty acid?? thank you in advance.

[@wonghokman8392]

for each fatty acid, the end side of the long carbon chain should be -CH2CoA? also, this is an esterification, the hydroxyl group should react with carboxyl group ,thus the oxygen minus should act as electron donor. Right？

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Unpopular statement: I'm watching this for fun.

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Thank you!!!

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Many thanks to you! You are great! Keep up your good job!