Generation of Action Potential | How Action Potential is Generated in neurons, muscles etc?

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Video Summary:
Resting membrane potential is inside negative. The stimulus that brings the voltage to the threshold produces an action potential. Here, the influx of Na by voltage-gated Na channel produces depolarization. Then Na channels close and K channels open. The exit of K causes repolarization of the membrane. The altered concentration gradients of Na and K are reestablished by the Na-K ATPase pump. Voltage-gated Na channels have an activation gate and an inactivation gate. Opening of activation gate during depolarization allows passage of Na. Then closing inactivation gates stops the Na entry contributing to repolarization. The channel returns to its initial state after resting membrane potential is reestablished. Change in a concentration gradient of Na and K for a single action potential is very very small and millions of action potentials can be passed before the gradient reduces to a significant level. Duration and shape of the action potential can vary in different cells. And finally, generation of action potential involves a positive feedback loop which is rare in the body.
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Vipul Navadiya
DISCLAIMER: This video is for education purposes only. Although every effort is made to ensure the accuracy of the material, viewers should refer to the appropriate regulatory body/authorized websites, guidelines, and other suitable sources of information as deemed relevant and applicable. In view of the possibility of human error or changes in medical science, any person or organization involved in the preparation of this work accepts no responsibility for any errors or omissions, or results obtained from the use of information in this video.

[@nourinshenesh22]

Sir ur channel needs to be advertised....it's super good for physiology concepts. I had lot of doubt abt action potential but now everything is super clear just bcz of u sir. Thank you sir, I will say about your channel to all my friends.

[@NonstopNeuron]

Thank you Nourin. That will be a great support.😊

[@ecotone2023]

For the first time in my life I actually understood action potential.......a big thanks to you

[@pahalshah4375]

This is like the best channel ever!!!Thank you sir especially for clearing out that last part about Na -K pump, even I used to think the same..you are such a wonderful teacher!!!!

[@NonstopNeuron]

Most welcome. Please share the videos. Thanks a lot.

[@swarnendukhanra699]

that last point of re generation just cleared my whole idea which hours of classed was never able to clear .... thanks a lot for this

[@NonstopNeuron]

Most welcome. Please keep sharing 😊

[@Darshana719]

My fav channel always❤❤

[@taichiqu]

Many many thanks. Your 11-minute 29-second video saved me lots of hours. How beautiful !!

[@neeleshpatel2013]

I was also struggling with the Loss of gradient now thanks to you my doubt got cleared...you're a lone star in dark

[@genuine8879]

You've hit the nail in all of the things I needed to hear about action potential. Just like you, I've had the same dilemma of what you say in 9:41, where I also had the same confusion when i learned first that the action potential can be generated without the Na K pump for more than a thousand times (or something like that). Bless u

[@NonstopNeuron]

Happy to know that all the extra efforts to create that last part of the video was worth it.

[@uttamghosh503]

Awesome!!!! Salute to this Great Teacher. Your " Nonstop Neuron" will Activate us.🙏🙏

[@NonstopNeuron]

Most welcome, Uttam. If you are liking my videos, please share with your friends and colleagues too. It helps all of us. Thank you.

[@uttamghosh503]

@@NonstopNeuron Oh !!! Sure.

[@najiyanasreenkt9760]

Great work..... 👍👍👍 Thank you sir😊

[@ammarasattar7809]

Extraordinary explanation thank you so much for making such a video 🖤🔥

[@chamodalakshani2883]

Thankyou ❤️

[@arpitadey4641]

Such a crystal clear presentation. In future I would recommend this video to more people. Thank you for such a beautiful way of making the concept so easy and understandable 🙂

[@NonstopNeuron]

Thank you so much. It will help us a lot.

[@falgunibadiyani-rs9qk]

It was really great video, like I understand everything, until today everything was so confusing, thank you to make this.

[@Sakshee0]

This saved me alot of time !x

[@richarddekoa7657]

this was so simple Sir

[@RAININGBLOOD09]

boutta roll up a backwood n watch this and get educated gang

[@Aishwaryap_1411]

Understood the concept very clearly sir ,u teach better than my college professor. Tq so much sirr 😊❤

[@NonstopNeuron]

Most welcome

[@anjalinimbargi7957]

Awesome video l like ur all video one of brilliant explanations thank you so much😊 sir

[@jaletaabdi6298]

Thankyou so much for helping me by exelent video

[@xinhaofan396]

Thank you! very nice

[@NonstopNeuron]

Welcome 😊

[@nomann5244]

outstanding

[@mubashira5046]

Wow tanku so much .sir

[@pridvipravin2068]

You are my god🛐

[@mindrelaxmakers.6029]

Nice presentation 👍💝💝

[@NonstopNeuron]

Thank you 😊

[@HASSAN_WISAL]

LANGEMAN Embryology lectures PLZ

[@abdulelahx5482]

Perfect No patreon need to suppoort you

[@vamos11558..]

Classic🐐

[@KarsazKaJinn]

How is hyperpolarization reversed? How will the membrane potential return to resting potential after having become more negative than the resting potential?

[@ither6897]

The sodium potassium pump re establish the resting membrane potential, by pumping 3 sodium out and two potassium in. Also leak channels help as well,their transport is passive.

[@JosefaCotroneo]

3:35

[@cynelim]

is -90mV not hyperpolarization? resting membrane potential is -70mV. thats what i was taught.

[@NonstopNeuron]

Resting membrane Potentials are different for different types of cells. Also values in different books might vary

[@fatman9644]

And whats the action Potential for? I dont know much about this subject, so i am asking myself why the Body is doing that when it consumes ATP to get it Back to normal.

[@NonstopNeuron]

For transmission of impulse. In simple words, it's a way of communication with with other cells. Action potential is like a message that travels along the membrane very fast.

[@thecomiccook3487]

❤

[@FarahAbdallah-hf9qk]

Did sodium potassium pump works at resting membrane potential ¿

[@NonstopNeuron]

sodium potassium pump works all the time.

[@rishabhrajput6383]

Sir, why na+ have two gates and not k+... What's the need of having two gates...

[@NonstopNeuron]

It allows a refractory period before the next action potential.

[@rishabhrajput6383]

@@NonstopNeuron isn't it'll be achieved through one gate only? Gate is closed no movement of Na+, action potential can't be generated..

[@NonstopNeuron]

But a stimulus would open it. During this, the second closed gate keeps the channel close.

[@rishabhrajput6383]

@@NonstopNeuron sir, but at a single time only one gate is open or closed.... So it can be achieved by only one gate.. Either it is open or closed..

[@MuthuThala-ih2wu]

No book of physiology has written the RMP of neurons is -90mv Do cross check before u post a video. Many aspirants might believe it and choose that option in MCQ type neet exams. Ur videos r good but be extra cautious from next time. RMP of neuronal cells ~ -70mv Skeletal muscle cells~-90mv Pacemaker cells have restless membrane potentials