Notch Signaling Pathway | Purpose and Mechanism

[@Brickkzz]

Brilliant concise video! I think the cleavage of intracellular domain of Notch is usually called gamma-secretase.

[@Endymion5000]

Excellent! Clear, concise, and very understandable. Just subscribed!

[@ReginaHüttner]

great explanation, thanks!

[@animatedbiologywitharpan]

Nice explanation

[@michellew4634]

so helpful! thanks for making this!

[@roabashmail8433]

Thaank you soo much it is more than helpful it is treasure !! thanks a gain

[@ExploreWithMe15-y8w]

very informative and helpful

[@christopherchen6937]

Wow!!! It's very brilliant!!!!! Thanks!!!!

[@danielgladish2502]

4:38 by p21 are you referring to RAS or CDKN1?

[@elizabethhu4508]

From what I read, I thought the NICD translocates into the nucleus first and then binds CSL? Am I wrong?

[@jazminefulgencio1543]

you're right. NICD translocates to the nucleus where it interacts with CSL

[@bluemug111]

Thank you so much

[@nasranaizi2714]

what does the NOTCH acronym stand for?

[@SeeWoelfin]

It is not an acronym. It comes from Drosophila research: the phenotype which showed a little 'notch' in the wing. As this is a highly conserved pathway, similar genes are found in humans.

[@sanjaisrao484]

Thanks

[@ezfit3367]

1:27

[@marwaali4821]

Thank you

[@victorf.martins8296]

JJ Medicine make a video explaining the erbb4 signaling pathway please

[@lifestylesocial2966]

4.57 what is the name of ligand?

[@woodbinson457]

Love of my life

[@dukherdohonekorunrodone6346]

mind bomb!!

[@alexkmile]

the whole video is a mind bomb!!

[@mohammedelberawi8440]

Thanks very much