Off-Label Rapamycin Experiences & Doses | 7 - RF#2

[@optispan]

We enjoyed answering many of your questions on our recent R-Files AMA episode: kzbin.info/www/bejne/iGPbqnV9ZaiApc0. Feel free to comment there with more questions, we will keep doing these!

[@AlexanderRodriguez-pc7xe]

I am 40 years old, with low back pain and left knee pain since my early thirties, it was tolerable most of the time and sometimes (twice a week) I needed NSAIDs. I started at the beginning of last year with 3mg which I escalated weekly up to 5mg per week and by the third week I was pain free, the only side effect was insomnia on the days of use. In total, 9 months of continuous use, and now in my third month of rest, the pain has returned but more attenuated. I plan to restart next month. Thank you for all of your work

[@szghasem]

My wife and I've been taking 6mg/week for 1.5 years, with a total of 4 months off (6 on, 2 off, 6 on, 2 off). Her lifelong arthritis is significantly better and her overall health has improved. My shoulder injury pain (from renovation) that would not go away is almost cured but teeth health questionable. Got the shingles vaccine recently, hoping Rapamycin will further improve efficacy. We'll probably continue as long as we can afford and until proven otherwise.

[@Kitdzn]

Where do you source your Rapamycin?

[@szghasem]

@@Kitdzn From Türkıye every time we visit

[@xmonikerhotmailcom]

Plant based diet for mouth health.

[@oesdscied]

Thanks for your work, and objectivity even in this compelling N=1 story. I appreciate your continual comments about the potential for placebo, and sharing the rationale for your trial. I have been cycling 5-6 mg/week on and off for a couple of years. I had experienced a similar shoulder challenge when lifting and would moderate the weight on bench press and shoulder press. The pain would occasionally make it impossible for me to lift heavy for weeks, but thankfully this has not been an issue for a couple of years. Is rapa the causal mechanism for relief from the pain? Maybe, just have to wait for some human trials to get more evidence.

[@adjusted-bunny]

Hey Matt. I had frozen shoulder in both of them some years ago. And the doctor told me that there wasn't a lot I could do. It went on for more than a year. Then I decided to fast for 5 days (water only) to lose some kilos. After the fasting period my frozen shoulders were healed. I did some research and found out that during fasting hydroxy-butyrate is produced which has an anti-inflammatory effect. Now I am starting to think that it might have been because of a downregulation of mTOR.

[@Krunch2020]

Genius!

[@bill9989]

Thanks, Matt. I just started rapamycin. I'm in my third week (5 mg per week). I started very late in life (74 years). I wish I had started earlier. I'm battling plantar faciitus in my left foot. It's been getting better since before the rapamycin, but I'm hoping it helps me get beyond it.

[@optispan]

We hope it helps you!

[@Tranilawoffice]

Did you mean 10-12 weeks on and then 6-9 WEEKS off or “months”? You said “months” but just want to be sure.

[@mkaeberlein]

So far, it's always been at least 6 months between cycles for me - MK

[@bostaurus1]

Maybe you could take a lower dose as you are elderly

[@bill9989]

@bostaurus1 here's a tip. Never tell the elderly they are elderly even though it is painfully obvious. 😆 But thanks for the advice.

[@jonathonmills3563]

In an upcoming video maybe you could address the following; In the NIH ITP studies, were there a difference in cancer mortality rates between the controls and Rapamycin cohorts?

[@mkaeberlein]

Good question. My recollection of that data is that the tumor burden at time of death was comparable between rapamycin treated and untreated but, of course, the time of death was significantly later in the treated animals. One interpretation of this is that rapamycin *delayed* cancer progression but did not prevent it, at least at the doses used in the ITP studies. One minor point that's also worth noting is that we don't really know what the cancer mortality rate is in either case, because most laboratory mice are euthanized before they die. Sometimes this is because of visible tumors, but often it's for more nebulous reasons like unexplained weight loss above a pre-specified threshold. That could be caused by cancer but could also obviously be caused by other underlying pathologies.

[@houndofzoltan]

Interesting, although as far as I know the mice they use almost all die of cancer due to their breeding.

[@mkaeberlein]

@@houndofzoltan Yes, and no. The ITP mice are a mixed background, so it's probably not due to their breeding. More likely, it's simply that mice when allowed to reach old age (which they don't in the wild, due to predation) are more prone to cancer than humans *because* there has been little selection to prevent cancer (precisely because they never reach 3 years of age in the wild). Regardless, rapamycin delays or reverses age-related functional declines and pathology in every tissue and organ where it has been studied, so it's clear the effects of rapamycin go far beyond simply impacting cancer.

[@jonathonmills3563]

I started weekly Sirolimus a month ago, moving to up to 6mg next week. I’m looking forward to following your experience and watching the interviews you do with others.

[@SilverFan21k]

Congrats on 1K subscribers 🎉

[@juhamartikainen3050]

I am becoming older too and some pains are creeping up. Good information to know that RM could be one option.

[@Tranilawoffice]

I’ve been taking 9 mg 1x per week on a 8 week on 5 week off cycle for about 8 months. I haven’t had a single side effect. I’m actually considering upping it to 10mg on the same schedule. The dose given to dogs in your study at 1mg per kg would equate to 10mg for me.

[@mkaeberlein]

We've tested three doses in our dog studies so far: 0.1 mg/kg given 3x per week, 0.05 mg/kg given 3x per week, and 0.15 mg/kg given once per week. It's tough to do a true dose equivalency, but a rule of thumb would be to divide the dog dose by 2: www.ncbi.nlm.nih.gov/pmc/articles/PMC4804402/ - MK

[@natureowl]

You weigh 22 pounds?

[@Tranilawoffice]

@ ???

[@SusanTamas]

Can you use Rapamycine with meth-blue?

[@lauraironstalksms]

Is Rapamycin available in the UK? I have excruciating pain due to frozen shoulders in both my shoulders. I really need help

[@rogehnimunoz4327]

Thank you so much. I’m about to start taking it. I’m learning a lot from your experience.

[@SilverFan21k]

You might be King of Rapamycin.

[@HaMashiachSaves]

I’ve taken 5mg every Monday since June 2021. I’m 53 now 😃

[@FatherGorgony]

I also healed my shoulder after 40 days as a result of taking three eggs every other day with spinach, mushrooms and eggplant under Greek feta. The most surprising thing is that I did not notice any side effects

[@jaimemarun2841]

Excellent Matt: Is it true that grapefruit juice allows you to take a lower dose? Is it true that taking 200 cc of grapefruit juice per day with the weekly dose of rapamycin of 2 mg would be equivalent to having taken 7 mg of rapamycin?

[@Nando_lifts2021]

Where do you get your rapamycin and anyone know a online store that is quality?

[@LLee0]

Where should I buy rapamycin? Which is trustworthy? Anyone?

[@captainremington]

As a throat cancer survivor, what is your approach for these people planning to use Rapa for longevity? İs it a counterindication or not?

[@workingTchr]

The cycling off for some months is an idea I never really understood until now. Since we don't know everything about rapamycin, if there's no advantage to continual dosing as such, why risk it.

[@FrankKachinski]

Many runners struggle with IT Band Friction Syndrome which I understand is the result of chronic local inflammation in the knee. Do you think this might be a likely use case, or is this too different?

[@drdonavon]

I was wondering if you would explain your rationale behind only taking rapamycin for 3 months out of the year. Or if you've explained that in another video that I haven't gotten to.

[@francoiskroll3927]

Thanks for the amazing podcast! May I ask if your view on continuous use of rapamycin changed in any way after your survey study? Do you still cycle on & off? Thanks!

[@leeyost9917]

How do you get the rapamycin?

[@fishnski9211]

How do you buy Rap and getting the best deal?

[@thecheapdvdstore]

I can give you the details of where I purchase mine for £2 a tab

[@BenGoldfarb-i4b]

What is the purpose of cycling? I’ve been taking Rapa for three years without any breaks. The only issue I had was a short period of mouth sores. On a positive note, I’ve had a slight decrease in appetite.

[@penguinlieo4723]

need OFF (washout time)

[@zakkiuddin5551]

What medicine did you take for mouth sores

[@xinjiesamli7431]

For the weekly dose, just take all 6 mg in one go?

[@patrickteysseire4233]

PRP would have worked quickly.(Platelet rich Plasma) I had the same problem.

[@lucycooper55]

Does 1 mg twice a week do anything at all ? Combined with 1X a week methotrexate? Along with cosentyx every 2 weeks .. asking for a friend 😉

[@davesax11]

Anyone else cycle off periodically? Grapefruit extends half life of several meds. Contraindicated for some.

[@AspergersSyndromeDaily]

My problem is finding a doctor who prescribe it

[@thaidomain]

It surely does not make you look younger.😊

[@penguinlieo4723]

Everolimus better than Rapamycin

[@lowbarbillcraig3689]

I understand your reasoning why rapamycin caused the relief, but ... ... the specialist told you this goes away by itself PS - I do find you agreeably skeptical pretty often, and am listening to you in preference of the more cheerleading crowd. But I may be more skeptical than you in this area.