Olink Podcast | Ep 14 DUOX2 IL 17C and IBD (Inflammatory Bowel Disease)

Welcome to Olink Proteomics in Proximity Podcast!
Below are some useful resources from this episode:
Highlighted publication: Grasberger H, Magis AT, Sheng E, Conomos MP, Zhang M, Garzotto LS, Hou G, Bishu S, Nagao-Kitamoto H, El-Zaatari M, Kitamoto S, Kamada N, Stidham RW, Akiba Y, Kaunitz J, Haberman Y, Kugathasan S, Denson LA, Omenn GS, Kao JY. DUOX2 variants associate with preclinical disturbances in microbiota-immune homeostasis and increased inflammatory bowel disease risk. J Clin Invest. 2021 May 3;131(9):e141676. doi: 10.1172/JCI141676. PMID: 33651715; PMCID: PMC8087203. www.ncbi.nlm.nih.gov/pmc/arti...
Highlighted platform that was used to measure proteins in this study with a qPCR readout (Olink® Target 96): olink.com/products-services/t...
Learn more about the Crohn’s & Colitis Foundation, which is non-profit, volunteer-fueled organization dedicated to finding cures for Crohn's disease and ulcerative colitis: www.crohnscolitisfoundation.o...
In the fall of 2021, Dr. Andres Hurtado-Lorenzo spoke at a Boston Olink event, and his 25-minute presentation is available here where he discusses the discovery and follow-up work with both RNA and protein biomarkers for Crohn's Disease: 7074596.fs1.hubspotuserconten...
Olink® Insight is an open-access resource, which aims to support the user throughout the Olink user journey, starting from product selection and study setup to post-run analysis and visualization of data output. Features include a pathway browser to reveal and understand connections between proteins and human biology, a publication browser, automatic annotations, and access to exclusive data sets. Sign up for free: insight.olink.com/
Here is general information about inflammatory bowel disease (IBD) from the U.S. Centers for Disease Control and Prevention (CDC): www.cdc.gov/ibd/what-is-IBD.h....
Here is general information from GeneCards about DUOX2, one of the protein biomarkers identified in this study: www.genecards.org/cgi-bin/car...
Here is general information from GeneCards about IL-17C, one of the protein biomarkers identified in this study: www.genecards.org/cgi-bin/car...
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In case you were wondering, Proteomics in Proximity refers to the principle underlying Olink Proteomics assay technology called the Proximity Extension Assay (PEA), and more information about the assay and how it works can be found here: bit.ly/3Rt7YiY
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WHAT IS PROTEOMICS IN PROXIMITY?
Proteomics in Proximity discusses the intersection of proteomics with genomics for drug target discovery, the application of proteomics to reveal disease biomarkers, and current trends in using proteomics to unlock biological mechanisms. Co-hosted by Olink's Dale Yuzuki, Cindy Lawley and Sarantis Chlamydas.