Preventing and Treating Cardiovascular Disease | Lipid Series Part 3 | Dr Thomas Dayspring | Ep 253

In Episode #253, Dr Thomas Dayspring joins me to round out our three-part masterclass on blood lipids and atherosclerotic heart disease. In Episode #251, we covered what blood lipids are and what happens when things go wrong within the lipid transportation system, and in Episode #252 we looked towards how to test and understand your blood lipids as an individual. Make sure to listen to those episodes first.
👇 Visit The Proof website for supporting studies and the full show notes 👇 theproof.com/podcast/
In this episode, Part Three of the lipid series, we discuss interventions to lower risk of atherosclerotic cardiovascular disease (ASCVD). Both Dr Dayspring and I believe in a lifestyle-first approach to lipid optimisation. As discussed in previous episodes with the likes of Dr Gil Carvalho and Dr David Jenkins, there is no doubt that nutrition is the most powerful lifestyle tool we have to dramatically lower ApoB. In some cases, certain people will be able to lower their ApoB by around 30% through diet alone.
This conversation is designed to help you better understand the treatment options available if you do require a pharmaceutical approach. As Dr Dayspring says: you need to be your own advocate, which means developing some level of understanding to gain more autonomy over your health.
Given Dr Dayspring’s expertise in both research and practice, this episode focuses almost exclusively on the available pharmaceutical drugs to lower ApoB, an elevation of which is essential for developing atherosclerosis. We walk through four main drug classes - ezetimibe, statins, bempedoic acid, and PCSK9 inhibitors - discussing their mechanism of action, effectiveness, and safety profile.
If you are currently struggling with ASCVD or are at risk, I hope you found this episode and series empowering. Even if this does not appear to be a concern for you in the foreseeable future, it’s important to be equipped with this knowledge on one of the Western world’s biggest killers. Dr Dayspring offered extremely well-informed insight into this topic over the course of this series, and I am grateful to have had a field leader on the show to embark on this deep dive.
00:00 - Intro
03:42 - Evolution of cardiovascular disease treatments
07:30 - Are we becoming a drug-dependent society?
13:54 - Bile acid sequestrants, statins, and more
35:12 - Cholesterol-lowering drugs and cognition
47:39 - Is Bempedoic acid a good statin alternative?
55:46 - Ezetimibe and nuances you should know
1:03:52 - PCSK9 inhibitors
1:15:18 - Do statins increase the risk of diabetes?
1:19:40 - Gene therapy targeting PCSK9
1:24:08 - Pelacarsen for lowering Lp(a)
1:26:58 - Can we take drugs that raise HDL to lower cardiovascular disease risk?
1:35:19 - HDL and atherosclerosis
1:47:08 - Elevated triglycerides and atherosclerosis
2:05:32 - Takeaways
2:08:51 - Outro
Connect with Dr Thomas Dayspring on Twitter @DrLipid.
If you have any additional questions you would like answered in the future, let me know in the comments.
We are also currently working on a summary PDF highlighting the key learnings from each part of the series. To receive a copy of this simply submit your email at theproof.com/lipidseries. We are also working on transcripts for these episodes, with the release date to be advised soon.
The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends.
Enjoy, friends.
Simon
====
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[@AdnAwd24]

as a Doctor and someone listened to the first series with Peter Attia few years back, and have my notes, I found myself updating my notes with this 3 part series, full of appreciating and gratitude to you. I can say this is the best lipid content you will ever encounter in your life either in medical school or the internent or any other place thank you so much Dr Tom Dayspring, I started reading Outlive and very happy to see your name mentioned multiple times and Simon, you did a GREAT public service by hosting and mediating this series, you are a top level interviewer and a humble human who is eager to learn and share information greetings from Sudan.

[@dwights1464]

I'm not a doctor but with a 435 CAC score in 2019, I began immersing myself in everything I could learn about atherosclerosis and also came across Peter Attia's multipart series with Dr. Dayspring. Having no medical training, I've had to listen to that series 3 times before having a small understanding of the topic. However, I knew I was listening to unrivalled brilliance, which certainly is evident again in Simon's series here!

[@SET12DSP]

I'm not a Doctor either but I have found that Cholesterol really isn't an issue after listening and following the advice of Dr. Linus Pauling a 2-time Nobel Prize winner and Dr. Thomas Levy. Know anyone that has lowered a CAC Score by 30%? Well I have from 660 to 458.

[@obtuseangler768]

I'm not any Dr either but I'm naturally gifted when it comes to soaking up info like an alien sponge. When my Dr recently sent me some info via UpToDate, I had to politely explain that I fo was old news, from 2016 and 2018 and that there was a far superior trial in 2019 looking at PCSK9 and lp(a) called the ANITSCHKOW trial. Keep in kind she's in the small minority of GPs in North America even testing for lp(a). If you arent trying your best to play Dr for yourself you could be an idiot...? RDA for D3 is 800iu for me. I need 700%, about 5400iu to have proper serum levels. Greetings from Canada!

[@newyorkguy158]

​@@SET12DSPThe problem is not cholesterol, at least not directly. It's the ApoB lipoprotein that carries cholesterol. And you are at high risk of an event. Statins can lower that risk.

[@SET12DSP]

@newyorkguy158 I'm hardly even worried! Have you had a Coronary Artery Calcium score? If so, and it's above zero...are you reversing yours? Or do you know anyone that has? I'm certainly reversing mine!

[@vegrunner6688]

When your guest looks like a mustache-less Wilford Brimley, sounds like Danny DeVito, and has the mind of a great scientist combined with great storytelling ability, I can sit through six hours of a technical podcast! Thank you, Simon; an amazing interview! How does this content have only 479 likes on youtube today? That was a masterclass on lipids bar none.

[@cyumadbrosummit3534]

We need more doctors like this man!

[@lucvandermeeren]

Not only was the information presented mindblowing but so was Thomas himself. How is it possible that one brain can store so much information? Tom's explanations were so detailed yet he never looked at prepared notes. Truly great series - thank you.

[@nozika84]

Simon you are world class Man! and Dr. Dayspring is out of this world when it comes to digging extremely deep but also explaining in very simple terms. I have watched all 3 and this has truly changed my perspective. Keep up the great work. and thanks a ton

[@woofinu]

Thank you both. Son of a fireman found in a phone book!

[@jp7357]

I’ve been waiting all day for this … as usual, dr dayspring does not disappoint !!! … great interview.

[@lf7065]

Even though a lot of this conversation was way over my head, I really enjoyed listening to it because of the sheer joy this gentleman conveyed. How wonderful to observe someone who passionately loves what he does for a living! 🥰

[@Unaveragetrainguy]

Dr. Dayspring keeps saying 'talk to your doctor' but i've consulted a plethora of doctors and relevant specialists, and all seem to be pretty old school about lipids and CVD. So far have not been able to access a 'lipidologist (even via the professional association, there aren't many). I've resorted to ordering APO-B and and LP(a) tests out-of-pocket, and keep on searching. It's frustrating.

[@ellianaredick6817]

Thanks Simon and Dr. Dayspring! Amazing information. We all need to be our own best advocate.

[@Joy80JJ]

Thank you to Simon & Dr. Dayspring. Such great info for all.

[@sectionalsofa]

Great interview! My cardiologist is very good... smart, reasonable...but she doesn't have two hours and twelve minutes to spend with me. Thank you both for filling in the gaps with such important information.

[@kza5964]

Hi Simon, I’d really love to hear you go one on one with Dr. Lustig. Surprising you haven’t had him as a guest yet. Dr. Fung would be another great guest.

[@kza5964]

@@TheProofWithSimonHill Thanks. I’m keenly looking forward to that. Please ask him why he doesn’t talk about ApoB.

[@Laurie494]

This series was a Master Class. I loved it, and I'm sure I'll listen to it again. Thank you both

[@gj9933]

I just love listening to this man he is brilliant!

[@condoguy710]

this is a fantastic series. Dr Dayspring blows my mind. Ironically though, the message is that statins have little to no side effects for anyone who starts them, yet the leading cardiologist in the country is totally intolerant to all statins, even zettia!! Super safe drugs? hmmm.

[@newyorkguy158]

Who is the leading cardiologist in the country? According to whom and what criteria?

[@enriquelopez9803]

Thank both for these excellent videos. At 1:48, Dr. Dayspring explains that you can lower triglycerides (for people with extremely high triglycerides) by going on a no fat diet. Typically, we think of high triglycerides as being a problem with excess sugar or carb intake. Please delve into this further. This raises the question that maybe people on a high carb low fat diet can keep their triglycerides low due to not having fat in the diet (like the Mastering Diabetes diet plan)? I know that the Mastering Diabetes plan is centered on raising insulin sensitivity. Still, I was surprised to hear Dr. Dayspring say that people with extremely high triglycerides can lower them with a no fat diet as he did not explain if this is due to an increase in insulin sensitivity caused by eliminating fat in the diet.

[@grainneskerries]

Thank you for this 3 part series. I don’t have a science background but really understood this information.

[@emilybarry9410]

Words can’t express how thankful I am to you 2 for this series! I will definitely be re-listening to all episodes and am eagerly awaiting the PDF. We need more education on this in the general pop 🙏 ❤ 🤗

[@douglasgoodman226]

Fantastic. Kudos, Simon & Thomas

[@carinaekstrom1]

I bet this will be very useful to a lot of people. Thank you 🙏🏼.

[@elmeric7086]

Soooo awesome. Thanks for this great interview.

[@sabby123456789]

Thank you so much for this podcast with Tom!😊

[@DemeterN]

Heartfelt thanks for this highly informative series and for bringing out all of the relevant information on almost every aspect of lipids and cardiovascular health and developments within the field. Your supportive interview style allowed Dr. Dayspring to share his knowledge in a joyful and caring way. I'm willing to bet this series will save lives. It made me much more receptive to the idea of a statin and I was dead set against it coming in. Looking forward to the series summary pdf

[@gretchenbrocksmith658]

Absolutely loved the series!!! As a PGY-1 (or soon to be in July) and becoming more and more aware of how nutrition and exercise play a huge role in our health. I only wish I was able to take notes while listening. (I was usually driving or listening at work.) Dr. Dayspring is amazing and can't wait to learn more about lipids. He makes them fun! Your podcast is also one of my favorite to listen to!

[@ericscavetta2311]

So informative! Following Dr.Dayspring, I tested and learned I am a hyper-absorber/hypo-producer. My HMO primary care physician suggested a mid to high dose statin (despite this), so I’ve scheduled a visit to discuss Zetia-monotherapy or combination with lose-dose statin instead. Even though I feel awkward as a patient questioning a professional’s recommendation, it is my own health... Thank you for all you both do!

[@azdhan]

Excellent! Many thanks for sharing Simon

[@TheProofWithSimonHill]

Hello Friends, I'm curious to know which part of the conversation you found the most insightful and engaging. Also, if you have any other questions related to this subject, please post them below this comment. I'll make sure to include them in our next discussion.

[@user-ry7wf3df9h]

I'm a nurse and found all of this helpful. My husband and I are vegan and he has always had high cholesterol- including LDL. Just had his first ApoB it was 136! His doc wasn't concerned... because all his other labs were normal and he had a calcium scoring test of 0 last year. At least now I have good knowledge of what we need to order on our own so we can make an informed decision on what to do going forward. I appreciate all of this info! I would like to hear more about how our risks increase as we go through peri-menopause/ menopause and how HRT can help with those risks. Thank you. :)

[@rogerscales2069]

I would enjoy a debate between Dr. Dayspring and Dr. Nadir Ali regarding the many studies and the efficacy of statins. They are certainly on different wavelengths.

[@MyContestPix]

Explain this. At 7:13, Tom admits heart disease is starting to rise and he has no idea why?? Maybe because the so-called benefits of statins have diminished/leveled off or people are not taking statins because of their adverse side effects or both? Give that medicine/technology has improved over the last decade this is a troubling sign given that statins are being over prescribed?? Are we at a point of diminishing returns no matter what drug companies tell us? Drug companies are all too happy to push any study that shows their drugs lower heart disease, but at what risk/cost? Is quality of life just as important? No doubt there are people with genetic issues who have no choice but to take the drug, but what about the other 95-99%? Where are studies that show the benefit of statins vs their side effects/risks? Who makes that judgment? The doctors or patients? Bet those studies rarely get published? Most doctors should be ethical and care for their patients, but that's not always a reality. Doctors are stressed and overworked so they spend 10-20 minutes/patient which means they can't give them the best treatment. The best they can do is recommend a pill, set up some tests and make an appointment in X months. How many people have doctors like that? The holistic approach to medicine isn't something the US health system is known for. Instead, people are treated like cattle. It's the American way in a unforgiving, capitalistic system where profits and insurance companies reign supreme! We rank towards the bottom of OECD countries in terms of health care outcomes. Where does the USA rank in health care? Despite having the most expensive health care system, the United States ranks last overall compared with six other industrialized countries-Australia, Canada, Germany, the Netherlands, New Zealand, and the United Kingdom-on measures of quality, efficiency, access to care, equity, and the ability to lead long, healthy, In 2021, the U.S. spent 17.8 percent of gross domestic product (GDP) on health care, nearly twice as much as the average OECD country. Health spending per person in the U.S. was nearly two times higher than in the closest country, Germany, and four times higher than in South Korea. What is the OECD health statistics for the United States? The United States recorded the largest drop in life expectancy of any OECD country during the pandemic, falling from 78.9 in 2019 to 77.3 in 2020 - a decline of 1.6 years, compared to 0.6 years on average. 19.9% compared with the 2015-2019 average. Bottomline, no matter how many drugs Americans take, it's not making a difference because our health care system sucks, unless you can afford it. Politicians will tell you everyone has "access" which is complete BS! We all know the poor, lower class, low paying jobs, and contractors in our gig economy they have no or crappy insurance with high deductibles. So, unless people have an employer-based health plan, they have to fund their own insurance from these money-grubbing, stingy companies and hope it covers all catastrophes. So, taking a pill is just a small part of the equation to good health. You also need a good doctor that subscribes to a holistic approach/system, a good health care plan that covers all your essential needs and enough money to fund it. The odds of getting all of this is slim to none for a majority of Americans unless you work at a fortune 1000 company, Congress or are independently wealthy. Ain't America great???

[@MyContestPix]

@@Feed_Bleed_Read zzzzzzzzz! Your lack of thought shows your ignorance.

[@bjreed1251]

Thank you Simon and Dr. Dayspring, what a wonderful resource to share with your viewers!

The amount of knowledge this man has is too damn high!

[@tracygmaine3252]

Thank you Simon ❤

[@hypnotiqpits13]

I was on the high-dose, had a heart attack at 39 physically, and mentally declined while on statins

[@user-ry7wf3df9h]

Seriously so thankful for this series. My husband has always had high LDL's and recently had. an ApoB of 136 despite being vegan and monitoring our food. We ordered the sterol test he suggested and his absorption was really high. He's going to the doc this week to try to get on Ezetimibe and go from there. Because his calcium scoring was zero his doc dismissed the ApoB. It's great to know we can go to see the doc armed with information! Thank you both !

[@llogne]

I refused to take a statin, but after hearing the clear explanation from Dr. Tom Dayspring, I'll start with the babydose of simvastatine and ezetimibe. Thanks a lot you both!

[@christophalcmeonides8537]

The knowledge you(one) can extract from a scientist is always analogous, primevally, a)to the sc.knowledge & b)the sharpness(to pose the right questions) of the one taking the interview! (good ex. Dr. P.Attia) I think you're on the exact same path & It was in that regard I wrote GREAT! Grats/ chr.

[@kunverjihirani276]

Keep up the good work! 😊

[@MichaelToub]

Great Video!!

[@espinosalexis]

Dear Simon, could you please invite Dr. David Diamond & Dr. Jeff Volek to the show? They have been publishing interesting research in high level scientific journals in this area and it would be great if you could discuss their findings here. Many thanks.

[@6minutehealth]

Ditto: And add Robert Kraussto that list, who inspired Jeff Volek and now collaborates with him after 2 decades of independent research doing insightfuly feeding studies (in humans)

[@wanderlusttom]

Tom is a godsend

[@user-kj5ng3vm7g]

This podcast is fantastic! I am still left with a question. I have an FH diagnosis (APoB genetic mutation) and am I currently on 10mg of Ezetimibe, 20mg of Rosuvastatin, and a PCSK9 inhibitor. They have dropped my levels to an LDL-C of 25gm/dL and an APoB of 42mg/dL which my doctor thinks is fantastic. I am really nervous about my LCL-C being too low. Should I lower my Rosuvastatin dose?

[@glizzforman8094]

Could you please explain what foods cause what your talking about and what foods are ideal for daily consumption, in your opinion?

[@woofinu]

One question: Where do I find the show notes (for the lipid parameter limits)? I looked in the description and in "The Proof" site, and didn't find them there. Thanks.

[@hankhardisty9433]

Thank you.

[@easyacademy8110]

Clear explanation!! Thank you.

[@TheProofWithSimonHill]

Glad it was helpful!

[@carinaekstrom1]

So would the HDL be lower when there is no emergency, or chronic problem?

[@jimjim-hx6fd]

Interesting, my trigs have always trended a little higher (150-180), and my HDL, even during a three-year period in my early 20s when I was running 50 miles a week, trends lower (30-40). But my LDL trends pretty low as well (70-80), and because of this I always thought I was safe. The trig talk towards the end gave me some real food for thought, though. Interesting series!

[@newyorkguy158]

Your ApoB could be a lot higher and that is the key metric.

[@peterfarnsworth9495]

This is one of the best if not the best three part podcasts that I have listened to . My only frustration is trying to translate the blood test metrics into Australian standards . Will this be done once the pdf transcript is done ?

[@RXP91]

Hey Simon thanks for the cheat sheet. I was bummed that my ApoB was 90 despite being WFPB. I was hoping it’d be near to 50 for prevention but I see in the cheat sheet 80 is a good value if no other risk factors so that’s achievable for me 😊

[@kenc4104]

When he says that each doubling of statin dose increases LDL reduction by 7-8%, is that absolute (i.e. 63% to 70%) or relative (i,e, 69.3 to 70%) for 100 to 30 reduction example)

[@gif24gt60]

Is citrus bergamot just as good?

[@clint4004]

"Losing Weight & burning fat" should be recognized as stored lipid reduction this implies increased ldl and apob for clearance via the liver and caloric consumption.

[@cadupradoo]

Hi, Simon! I must have left about 5 positive comments in this series already! Simply spetacular work. I have one technical doubt, however, after have listened during months to yours and other podcasts about ApoB x LDL-c. I do understand that you say that counting for ApoB we are actually accounting for every athoregenic molecule, since one molecule of ApoB is present in each LDL, VLDL, etc. So we often summarize that non-HDL-c is the sum of the cholesterol inside those particles, whereas ApoB counts how many of these particles. However, I don't understand how can that be, if my lab results of ApoB are in concentration (mg/dl). I could see that as a non-issue if we could use the molar mass of an ApoB particle and convert it back and forward between number weight. Still, how can that be true, if we know that LDL particles may be of different size? How could the same ApoB unique particle surround the lipid content of different sized spheres have the same weight? That been said, I could only convert an ApoB measurement of mg/dl to number of particles/dl if the molar mass is constant, but in order for it to be constant, i would need more than one ApoB particle to involve a larger LDL particle when comparing to a smaller one. Does that make any sense? Thanks again!!

[@tbearthai]

Really enjoy listening to Dr. Dayspring. Although at times it's difficult to follow. But overall I learned so much. Love this channel. Keep up the good work! Finally can anyone tell me if Polyphenols in Dark Chocolate 90% is favorable to lipids and overall healthy in moderation whilst confronting atherosclerosis?

[@hypnotiqpits13]

I am on a PSK9 inhibitor. It is a five minute injection. Not three seconds! My doctor has me on it once a month though not every two weeks. What will dictate that

[@nettiewalsh5620]

I had an MI at 57 This so an amazing podcast . How do I get this information from you

[@hypnotiqpits13]

Maybe I misunderstood at some point but it was this guy saying that the side effects we feel from statins are always made up? That’s a lie if that’s what he said I kept pulling my garbage with every single stop they put me on. They would run my labs after six months and my muscle count would be super high so they would have to pull me off of them and it will take a few wants to start feeling

[@mmortal03]

35:12 desmosterol discussion (brain cholesterol and cognition)

[@grasmi]

Any thoughts on natural interventions? I got my cholesterol back down to a level when I was eating SUPER clean about 10 years ago, but I’m definitely not eating as well as I was back then, and I’m now about 10 years older (42 now). My apob dropped by about 25% (81 to 62) from my previous test, and all other lipid markers improved too. I am eating marginally better than I was at the previous test about 6 months ago, but the only other change I made was taking an unheaped teaspoon of Amla each morning. Amla tastes freaking awful, but if it can take my cholesterol and apob down by that much, I’ll suck it up. It wasn’t the only change I made (I’ve been eating a bit better too), but given my markers are back to a level that matches when I know for certain I was eating a lot better than I am now, I’m fairly confident the Amla has to be having some impact. Has anyone else tried Amla? Any success? I’m almost tempted to stop taking Amla for a month and get another test, but don’t really want to intentionally take actions to increase my cholesterol. After Amla, ldl 117>78, trig 88>62 Hdl stable around 50, apob 81>62

[@grasmi]

@@markgarcia5845 smoothies would definitely work, but I'm not really into them at the moment. I do eat oatmeal every day, but don't want to ruin it :). The amla is not _too_ bad, I just spoon it in my mouth first thing and gulp down some water with it - the taste works well to help wake you up and make sure your reflexes are still working. :) Did you notice any significant changes in your lipid measurements after starting amla?

[@adamswift1747]

I used it too in the past and then found out it was often contaminated with metals.

[@healthyteddy]

I couldn't even get beyond the smell of amla. I started taking psyllium husk powder and lowered the fat of my food and got into normal ranges in 2 months. Lots of info on psyllium for blood sugar, pressure and lipids.

[@joshbonifacio6366]

Simon, may I ask you share some of the tactics you used to lower your LDL-C from 120 to around 70 as you mentioned in the podcast.

[@k.h.6991]

Look at the episode about the portfolio diet.

[@AnnLeske]

Thankyou Simon, this series is so interesting and the detailed content simply explained by Dr Dayspring. Simon, can you please do a short video on converting the US blood lipid figures you and Dr Dayspring use so comfortably to the AUSSie figures we receive when we ask for a cholesterol test.

[@reason3581]

If my ApoB was 40 my whole life would the amount of plack be zero? Is there a level of ApoB below which trans-cytosis suddenly drops to zero or is there a linear relationship between the two?

[@reason3581]

@@TheProofWithSimonHill Yes, exactly.

[@daven6145]

If you're found to have FH at age 70, with levels of LDL of 190, could you have had normal levels of cholesterol at age 50?

[@hypnotiqpits13]

Can somebody sum up the bullet points

[@Eagle_Delta]

Not all apoB is atherogenic high-carb diets also increase apoB and reduce apo A

[@mihelbergel]

Some good science in this video, but most of it was an infomercial for pharmaceuticals.

[@mihelbergel]

Yes, it is a huge problem. Probably the biggest problem our country faces. Ultimately, our current path of blanket use of pharmaceuticals will collapse the U.S. economy because there will be more sick and disabled people than there will be working people to support them. Chronic disease, like ASCVD, is getting worse not better. Blanket use of drugs, like statins, is putting a band aid over the root cause an is making things worse. Plus all the side effects like diabetes, myopathy, and other disabling side effects. For a very targeted number of people there is benefit to drugs, but we must stop pushing rampant use of pharmaceuticals as a means for everyone. We must push root cause treatment in place of drugs and only use drugs when absolutely necessary. Clinical trials of these drugs are very misleading and misrepresented. They do not have the efficacy that we are led to believe. I could go on and on with piles of data, but people either get it or they don't. Let's stick to laser focus treatment with drugs for targeted people, and let's promote the root cause treatments that will prevent collapse of our society.

[@christophalcmeonides8537]

Great ! Keep on the good work, mate :)!

[@deborahhall9744]

So much great information. But I winced to hear Dr. Dayspring say "we are in our infancy" with respect to understanding HDL function. My HDL is 125 mg/dl and rising year to year. Also have elevated LP(a). All other levels are good to a little high and I am on Rosuvastatin and PCSK9. But what to do about the HDL?

[@newyorkguy158]

What is your ApoB?

[@deborahhall9744]

@@newyorkguy158 95

[@ronniedio7152]

Interesting he has side effects from statins .. sucks the Pcsk9s are too expensive. I had a side effect from red yeast rice I started loosing large clumps of hair after 6 weeks, ... I had LDL at 180 I lowered it to 118 using citrus bergamot so I guess I better get the sterol test I didn't know that sterols could have a negative effect strange tho the beta sisterol did nothing for me so maybe a sterol is not the active ingredient in citrus bergamot

[@brucebeverly2629]

Please read the Wikipedia article on "red yeast rice." It contains the same chemical (fungus) as lovastatin, but the concentration in red yeast rice is not well controlled (and potentially harmful, according to the FDA). It is a controversial supplement, so beware!

[@JV-iq1kw]

As of July 10, 2023, the FDA approves expanded indication for Novartis Leqvio® (inclisiran) to include treatment of adults with high LDL-C and who are at increased risk of heart disease.

[@SET12DSP]

No thank you! Reversing my heart disease without drugs and I'm not kidding. 30% reversal so far.

[@SET12DSP]

Like why on earth 🌎 would I ever want to use a drug or drugs to reverse my heart disease when Linus Pauling has long had a very simple answer to reversal using High dose vitamin C with Lysine and Proline. No side effects but of course there is no money in it for big Pharma or Cardiologists.

[@eugeniebreida1583]

Geez . . . I am so very appreciative of this Series, tho have only listened to this Ep. (first YT sent my way). Saving, will share and re-listen, taking notes. Honestly, I hope you or a listener set up detailed Chapter Titles, as wading through so much audio again will take true commitment. As a short term “meat eater” (food sensitivities elimination effort), I am all ears. Thinking of an asap $99 finger prick lab mentioned herein. (SkinnyMass_???_Responder??

[@aitchl2134]

The introduction of trans fats was another major contributor to ASD!

[@beepbeepnj2658]

Yes and artificial industrial manufactured trans fats such as partially hydrogenated cottonseed oil had no cholesterol or animal fats yet the FDA removed these trans fats from the USA diet even though it was a high profit item. In the 1950's a real biochemist Dr. Fred Kummerow who lived to age 102 got the arteries of people who died from heart disease and he found high levels of these trans fats in the arteries, he did not find butter or olive oil in them, but he tried non stop for over 50 years to get the trans fats out of the diet until he had to sue the FDA and they finally took his advice about 7 years ago.

[@chokam8500]

Pharmaceutical representatives at their best, good propaganda interview. Eat natural foods, greens, good fats and meats, no over processed foods. Nothing in a box or a can. Shame on you both , a lot of jumbo jargon to confuse a simple minded lazy people who don’t want to take 30 minutes a day to cook a healthy meal once a day, and fast for sometimes 😢

[@dwights1464]

You've got to be kidding me! How can anyone think about listening to the drivel from KZbin hucksters selling their nutritional supplements and off-the-wall books on cardiovascular health when there's a brilliant mind like Dr. Dayspring out there? I'd put Dr. Dayspring's knowledge up against any of those KZbin health gurus when it comes to understanding the role of cholesterol in cardiovascular disease. Thank you so much Simon!

[@SET12DSP]

Dr. Dayspring you say! I don't think so. My money is on Dr Linus Pauling a 2-time Nobel Prize winner who also was awarded 48 PhD's over his lifetime. Know anyone that has reversed a CAC Score? Without drugs? I have with Linus Paulings Heart Protocol. It's said to be impossible. Dr. Thomas Levy Cardiologist has a book that expands on Paulings work. Levy has the proof. It's nice not to take meds.

[@zvikaso]

Hi. Thanks for the video. I am still skeptic about the granularity of ApoB data and the conclusions thereof. Not all ApoB are atherogenic. Some are big and fluffy. So if A has ApoB of 90, and B has ApoB of 60 - B might still have more atherogenic ApoBs than A although his total ApoB count is lower (same was the case for LDL-C : some people had lower LDL-C but more ApoBs/Lp(a)s... ). Total ApoB is also a proxy. I heard Peter Attia say that ApoB is required BUT NOT SUFFICIENT condition for CV damage... isn't that part of the picture ? There should be a test to measure the "real atherogenic ApoBs". That would be THE number, not a proxy. Moreover, the enzyme statin blocks has many more products... What about their deficit ? Any long term complications due to their deficit? I am statin intolerant. I might try bempedoic acid when it arrives in my country. But I'm not sure. Although my ApoB is 90 and my LDLC is 200 - my family (uncles and grandparents) had always had high LDLC with no cardio-vascular issues - my grandpa lived to be 99 yo - and that's even without a good diet (he didn't eat junk food, but he didn't eat health food as well... just a normal traditional cuisine).

[@jp7357]

Actually that paper does say that the particles entering the artery wall is dependent on the number of apoB but the size plays a part on the retention of the particle. “Observations: Cholesterol can only enter the arterial wall within apoB particles. However, the mass of cholesterol per apoB particle is variable. Therefore, the mass of cholesterol that will be deposited within the arterial wall is determined by the number of apoB particles that are trapped within the arterial wall. The number of apoB particles that enter the arterial wall is determined primarily by the number of apoB particles within the arterial lumen. However, once within the arterial wall, smaller cholesterol-depleted apoB particles have a greater tendency to be trapped than larger cholesterol-enriched apoB particles because they bind more avidly to the glycosaminoglycans within the subintimal space of the arterial wall. “

[@zvikaso]

What I'm trying to clarify is - how do these researches explain all those healthy people with high LDLC and above average ApoB ? If these people are not insignificant in numbers, it means ApoB is indeed insufficient criteria to medicate. There is something else going on that causes ApoB to become atherogenic. I feel as if science is still far from understanding this issue. There is a lot of progress, and there is a lot of benefit for the masses who do not take care of themselves (millions of people with the metabolic syndrome : T2DM, hypertension, overweight etc.), but for those who do take care of themselves (healthy diet, exercise, normoglycemia, normotension. proper BMI, low LPa, no inflammtaion etc.) the long term side effects of medications can outweigh the assumed benefits. How can I trust a research without knowing whether those who took part in it had already had some metabolic syndrome issues, or whether they were all fit as a fiddle? It's important for drawing conclusions and making decisions.

[@aprilek6003]

@@zvikaso Excellent point. My thoughts and questions as well

[@ApoBeef]

Why not get on ezetimibe?

[@zvikaso]

@@ApoBeef Hi. Because the body knows - if you inhibit C form food intake, the body will up regulate internal production. If you inhibit internal production, the body will up regulate absorption from food intake. If you want to use a C-lowering drugs, you have to combine both body's own production and C food absorption. When benpedoic acid arrives in my country, I'll try the ezetimibe + bempedoic acid combination. Thanks for your suggestion.

[@conniealeck2142]

Dr. Malcolm Kendrick, it's clots

[@user-ss7ey1fd6n]

The Doc himself doesn’t look healthy 😂

[@welanduzfullo8496]

ldl cholesterol apob lipid @drlipid Dr Thomas Dayspring CVD treatment

[@Billy97ify]

He completely ignores diabetes and insulin resistance as risk factors. It looks like he is likely insulin resistant at least himself.

[@lf7065]

Wow... Never judge a book by its cover!

[@Billy97ify]

@@lf7065 How about his statements?

[@carmenross1077]

What I hear here is Drug,Drug Drug. History of statins, actions of the medication,cholesterol. LDL is the only focus because it got drugs on it. HOW ABOUT THE TRYGLYCERIDE / HDL RATIO.? This podcast sounds like focus on cholesterol, LDL, because this doctor promotes drugs, what it’s telling me is the ACTION of the medication he is promoting. Yup bye

[@doddsalfa]

Cholesterol is what blocks coronary arteries

[@ladagspa2008]

Go back to your supplement selling keto quack doctors

[@pilatesfitness8766]

Is this episode sponsored by statins manufacturers?

[@jamesherried9269]

It certainly seems oriented towards getting more people to take statins.

[@DrDemissieTadesse]

It looks like it

[@pilatesfitness8766]

@Feed_Bleed_Read So asking a question makes me a child? Grow up!

[@savingsoulsforchrist6185]

Bruh not he convinced peoooe not to take statins, use pcski9, even he can’t tolerate statins lol

[@MyContestPix]

Tom says at 22:05, "statin side effects in really close trials are next to none, maybe 5% get muscle aches and nothing else". Are you kidding me? Tom just lost all credibility. He's been reading too many partisan studies that support his thesis that all statins are good. His crusade to push statins has rendered his once sharp analytical brain into mush. No legitimate doctor would say something so stupid. In the real world statins cause more than muscle aches and other imaginary problems like diabetes, dementia and a whole host of ailments. Just Google the nasty side effects and tell me they are "nothing".

[@MyContestPix]

​@Feed_Bleed_Read If you do any recent research (last 5 years), Tom is obsolete or ill informed on lipids and statins. What was convention is now stale as medicine advances. He's like a clock that is stuck at 12:00. Like anything in life we have newer science and technology as it relates to cholesterol. The fact that you still listening to Tom shows you are just as out of touch than he is. Sheesh!! Statins cause kidney disease, liver damage, muscle Atrophy/damage/fatigue, Type 2 diabetes, doubles the risk of dementia, osteoporosis, ER dysfunction (ED/Low testosterone), muscle destruction (myalgia, myopathy), joint inflammation, tendon disorders, hemorrhagic stroke, hepato-toxicity, neurological problems, loss of CoQ10 which allocates needed energy to the body Dr. Nadir Ali - 'Do statins prevent or cause heart disease? Should LDL be called "bad" Cholesterol? kzbin.info/www/bejne/pZC0lYGObsqneck&ab_channel=LowCarbDownUnder What causes heart disease? | Dr. William Cromwell kzbin.info/www/bejne/f6jdf6GLndaIsMU&ab_channel=NutritionMadeSimple%21 The dark history of statins - from causing cancer to billion dollar lawsuits kzbin.info/www/bejne/gYPQcniuaqiKf68&ab_channel=PaulMason

[@johnadair6108]

So cholesterol and lipids have been demonized since the 1950s. We have had drugs (statins) to reduce both since the 1970s. Dayspring has been practicing for forty years. Death from atherosclerosis has continued to rise worldwide. So what exactly is he an expert on? He's an expert on something that's getting into the walls of your arteries that shouldn't be. Not something that shouldn't be in your body. Diet, inflammation, and insulin resistance which directly correspond with our highly processed carbohydrate diet are the culprits. I only mention this because Dayspring continues to push statins.

[@lindapestridge3073]

I thought satins was bad nearly every dr says don't take them.

[@SET12DSP]

I'm not on a Statin even though my cardiologist wants me on one. But I have been able to reverse my CAC Score from 660 to 458 , if I can do that! Do you think I'd ever want to be on a Statin? Dr Thomas Levy has the answers 👌

[@yellowgames7]

Dan what did you do?

[@SET12DSP]

@Rog steam ally I'll get back to you in a few hrs. It's a shocking reversal, isn't it?

[@SET12DSP]

@Rog steam ally OK, I'm back. So what did I do? Have you ever heard of the Dr. Linus Pauling Heart Therapy? Pauling is a 2-time Nobel Prize winner. He came up with a way to reverse arteriosclerosis. It uses high dose vitamin C, Lysine, and Proline. The Lysine bonds with Lp-a, which is the very bad small cholesterol particle and neutralizes it. Proline enhances the effect further. Between Proline and Lysine, it can take the Lp-a particles count to zero. So when the particle count is low or zero vitamin C can come in and make collegan to repair the damaged artery walls exposed Lysine and Proline strands these are the girders of the artery wall. The RDA is not enough as the body requires much more C for its cells. First of the real issue with the artery is that though mechanical stress of a beating heart the arteries get depleted of Vitamin C which is called arterial scurvy. Vitamin C depleted can happen anywhere in the body. But those arteries next to the heart can take a real beating. An example is marathon runners or endurance athletes who experience a lot of heart damage. With Marathon runners, it can be as many as 40% of them. Another aspect of Vitamin C is that it can dissolve calcium if there is enough of it. Like at least 10-15 grams in divided doses per day. I myself take 18 grams. Lysine is 6 grams per day, and Proline 4 grams per day The success of this is dependent on your bodies toxicity level, especially oral. Because vitamin C can be all used up fighting dental issues. You can have bad root canals or bad implants and not even feel a thing. According to Dr. Thomas Levy you could have a river of C and not be effective for artery repairs. To combat the dental aspect I am on 2400mcg of K2-MK7 and 5000i.u of D3. From a dentist I heard K2-MK7 kills 95% of the bad bacteria. So besides making stronger teeth and having tough gums the high dose has to be enhancing my dental health as I do have an implant and several root canals that Dr. Levy says are typically found to still be infected contributing to one's heart disease. One other thing! I never have bad breath anymore. There are other supplements that I use to further enhance my chances of reversal.

[@antonbelsky]

So, does Tom take statins himself ?