Putting it all together - Pathophysiology of Parkinson's disease | NCLEX-RN | Khan Academy

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[@faash8964]

watched this as a student. now watching this as a doctor. your work is my favorite!

[@amnatahir4059]

Numbering their videos would be appreciated! This helps to keep track of order in which they are supposed to be watched. Thanks

[@irazani97]

Amna Tahir Agree

[@georgemoussa9225]

agree

[@michaelmifsud4763]

Very well explained.

[@debbiechristianson363]

Great explanation! I could follow along without previous education on this topic

[@user-px7qo8wu4f]

What in insanely simple and accurate explaination. Saved by time ❤

[@Theresamanaswi]

well said

[@jimmytovar2844]

I love the dog analogy ! Thank you

[@nizamkilliyas6845]

Wonderful

[@divyakhubdikar5129]

The explanation was Just wow😍❤️

[@miguelangeljaimescruz5305]

thanks editors for theirs most nices chapters online througt these w.w.w. I woul'd like to know much more abaut this developed and expert knowledge I hadn't saw in this environment thanks for send me theirs paragraphs

[@leenahmed147]

She explained it so well ! Thank you

[@rakshitasingh6574]

ikr, the example she used was so good it made this easier to understand.

[@ahmedassadi9227]

after watching both basal ganglia videos I come across this and I fucking love this gurll

[@Ventus2077]

What's the difference between Caudate Circuits and the Nigral Stratium pathway? Cuz I thought that Stratium is what stimulates the Substintia Nigra to release Dopamine into the Thalamus...

[@priyad5899]

just wow!!!!!!!!!!!!!

[@joereid2610]

interesting

[@aishatlawal1774]

How do I cite this video in text APA format

[@fatimabukhari5478]

omg moood

[@louisagupta9758]

F guy if its

[@MedicalNemesis]

These videos were great, but a big problem for me is that there is no explanation as to the origin of tremors. If dopaminergic neurons always aim to inhibit the GPI and by doing so increase the activity of the thalamus -> more movement, then why does damaging these neurons cause tremors? In that case there should be a pathway with dopamine that aims to inhibit unwanted movement. You've said that the indirect pathway aims to decrease unwanted movement, but dopaminergic neurons in this pathway still aims to lessen the effects of this pathway, i.e. increase movement. So I'm still not understanding why a loss of dopamin neurons would cause tremors (unwanted movements).

[@kessacornel4323]

It's actually because of the side effects of levodopa

[@MedicalNemesis]

kessa cornel Tremors are one of the earliest symptoms of Parkinson's, dyskinesias are side effects, not the same thing

[@claudiomaniero645]

From what I learnt there are different hypothesis on the exact origin of resting tremors in Parkinson and although they are necessary related to the death of dopamine neurons this process of cell death is not the direct cause of tremors since the direct effect caused by death of dopaminergic neurons is a difficulty in moving. And among the different hypothesis this is the best one I have found www.ncbi.nlm.nih.gov/pmc/articles/PMC3407214/

[@er8017]

Same!!

[@vaibhavi1dec]

slow sound

[@ullianove151]

Still ....no way to overcome or prevent this state....not even able to find the exact cause..is this really do to decrease in neural activity or due to lose in ability of stayatum to sense the dopomine..

[@FinancialConsultdotcodotza]

You can also see additional treatments and studies for PD here:www.maxwellmagneticmeds.co.za/blog/category/parkinsons-disease/

[@leostack8495]

I got parkinson now ill be 65 april.1 my syptons are getting harder to deal with quickly i have 3 children and devorced question what do you know about turning glieal cells of the brain into neurons human trials i was into cbs in my 4yr honorably dis charged duty at a young age 17 yrs

[@er8017]

Dopamine acts as inhibitory neurotransmitter for indirect pathway. This means that nigrostriatal pathway always amplifies movements. I do not think that what you mentioned is right.

[@pradhumansharma9770]

Thankyou❤

[@monaiannucci7831]

Dr Kahn? Hey

[@kummarakluxter8027]

very very very slow sound

[@tomreynolds792]

My friend was diagnosed with PD(Parkinson’s Disease) in the summer of 2012 and I was diagnosed 5 years ago. Her initial symptoms were quite noticeable so was mine. She first experienced weakness in her right arm and her speech and swallowing abilities were profoundly affected. She did so much to seek help for this disease, as she had been her brother's caregiver a few years earlier for the same disease. Early this year she started on organic/natural PD treatment from Best Dr Madida on KZbin which she introduced to me too. The treatment worked very effectively and all her symptoms and mine simply disappeared completely after 7 weeks of usage.

[@user-qm9wd3pg1t]

So Dopamine turns the direct pathway on, and that excites the cortex. Dopamine turns the indirect pathway down, and that also excites the cortex.

[@monaiannucci7831]

Dr Huntleman lol

[@monaiannucci7831]

Con artist

[@YogaJunky12]

Great video, just a little less emphasis on the dog, I feel like a preschooler lol

[@billkuo1]

Too much analogy, too little how it actually works, so confusing

[@gnsstan13]

Can u talk just a little bit slower :/

[@radhikadmr863]

Plz add some pitch sound to ur teaching...we r nt clearly understanding ur voice

[@TheHeyDood]

I love these videos, but the volume is very low. Also....I can only take the Canadian accent for so long...Like nails on a chalkboard.

[@Vincisomething]

I didn't know people complained about Canadian accents lol. It's not that noticeable to be.