Renal Physiology: Reabsorption and Excretion

Physiology lecture on the reabsoption and excretion of electrolytes and waste products in the renal tubules.

[@hediehnazarian]

Shouldn't it be 3Na out, 2K in?

[@Dr.Nellah]

yeah!

[@HealthEdSolutions]

Good catch!

[@HealthEdSolutions]

Thanks for the feedback!

[@Ganesh224]

Mistakes in the video: 180 L not 48 L. Aminoacids are reabsorved by secondary active transporte not by pinocytosis. Creatinine is secreted in the proximal tubule not in the distal tubule. Great video :)

[@valerieethos2650]

proteins which may cross the filtration membrane (although not suppose to in normal circumstances) are reabsorbed via pinocytosis/endocytosis). The proteins are then broken down in cell into their constituent amino acids and then taken up into blood.

[@doctormwpepper]

Wouldn't the Na-K pump be pumping out 3 sodium in exchange for 2 potassium, instead of 3 potassium? 3:55

[@nellyhoffman6194]

Thanks Doctor :)

[@DanielHoffmanddhoffman]

The annotation is labeled incorrectly. It should be 3 Na+ and 2 K+.

[@HealthEdSolutions]

Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!

[@chuchibiris900119]

there is a little mistake... the exchange in the Na-K ATPase is 3Na+ going to the interstitial space and 2K+ going inside the cell :)

[@OneToughPickle]

Hi there, quick correction: I believe the Na+/K+ ATPase pump swaps 3Na+ for 2K+ (you say 3K+ in your video), otherwise very good and useful! *edit: just noticed this has already been said in the comments!*

[@Pav91011]

How did you come up with 48 lts?. If GFR is 120cc/min then total filtration per day will be : 120x60x24=172ltr

[@katrinabang7698]

Na+/K+ ATPase pump = 3Na+/2K+!!!!

[@HealthEdSolutions]

Thank you Katrina!

[@codmw280]

isnt the na/k Atp pumps in 2k and pumps out 3na ?

[@okimotor]

Pretty sure he said 48L/day because 180L is roughly 48 GALLONS.

[@zhicheng3804]

Thank you son much. :) You're really good

[@drasadkhan129]

sir v helpful video thank you sir

[@HealthEdSolutions]

Thank you for watching!

[@melieagle]

It's about 180L per day but enjoyed your video!

[@delsol7878]

Hum... I was hoping to hear about Mg excretion in kidney... but good video for sure!

[@HealthEdSolutions]

Thanks so much for the support!

[@alexconner930]

300mosm seems a little high. Are you rounding up from 285 for ease of memory? Your videos are incredibly helpful for our students.

[@olgatzareov6038]

Great video, thank you!

[@ned9819]

I thought aminoacids and protiens are transported with 2ry active transport with Na.

[@HealthEdSolutions]

Thanks for the question. We've passed it along to the Health Ed Solutions medical review board.

[@shimaagamal5889]

but this is the first time i hear about protein reabsorption by pinocytosis are you sure of this mechanism ? but seriously it is amazing video :)

[@HealthEdSolutions]

Thank you for the kind words!

[@sheenacoffey2608]

Thank you for this video!

[@HealthEdSolutions]

You're very welcome!

[@tiffanyschroer4645]

This is sooo helpful! ... you make it interesting and very, very visual and explain it in simple terms.Now when I read the textbook I'm not glossed over the entire time! :)

[@pinkishekhawat8312]

How much % of filtrate is reabsorbed back into the blood ?

[@HealthEdSolutions]

Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!

[@aishwaryars]

3 sodium efflux and 2 potassium influx is by Na-k atpase

[@HealthEdSolutions]

Thanks for watching!

[@blugranacule8260]

please also elaborate the reabsorbtion and excretion in loop of henle

[@HealthEdSolutions]

Thanks Ahmed for watching! Passed this along to the Health Ed Solutions team.

[@stevenbarker9841]

not 180L per day? (you say 48L/day...)

[@HealthEdSolutions]

Thanks for the question Steven. We've passed it along to the Health Ed Solutions medical review board.

[@gioalbuta1]

Super. Thnx a lot

[@hodag999]

It might be worthwhile mentioning how the K gets out of the cuboidal cells in the thick section of the loop. With Na/K ATPases pumping K into the cell from the basilar side, and Na/K/Cl co-transport doing the same from the luminal side, the K must have some way to exit.

[@devanmodi4753]

correction should be 2k+ not na+

[@HealthEdSolutions]

Thanks Devan for your input!

[@Lauraphoid]

My textbook says a small amount is secreted - but you can still use Clearance of creatinine as a measure of GFR, if you account for the small amount secreted.

[@bentao3352]

Should be 48 gallons, not liters

[@HealthEdSolutions]

Thanks Ben!

[@caseyinutah]

great!

[@alcohen83]

great vid!

[@FarhanM2011]

sorry, but i heard that creatinine is excreted in distal tubule, is it added or just continuation of the filtration?

[@FarhanM2011]

nice video, but i still get stuck on pinocytosis... may i get more explanation about pinocytosis of protein?

[@WutLawl]

miliosmol not micro osmol right?

[@HealthEdSolutions]

Thanks for watching. We have passed your question along to the Health Ed Solutions medical review board.

[@onethirdlbofbeef]

thank you so much- in 14 min you explained everything more clearly than all 9 of my lectures

[@HealthEdSolutions]

Thanks John!

[@SuperDance4fun]

Where are the quick links to your video? Don't see them.Thank u for wonderful videos

[@priscilliakatambayi1124]

thank you so very much

[@HealthEdSolutions]

Thanks so much for watching!

[@juliamitchell9513]

im not sure if I missed it but what is an example of tertiary active transport?

[@Iminurse]

What about ions like K+ and Chloride? Are they constantly being reabsorbed as well? If so, then is that why the concentrations for sodium , chloride, and potassium stay basically the same in the proximal tubule while urea is increasing? Correct me if I am wrong but is the reason why Na+, K+, and Cl- concentration essentially the same in the proximal tubule because they are constantly reabsorbed and water continually follows where there is a higher concentration of solutes because of osmosis?

[@HealthEdSolutions]

Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!

[@maha1of6]

Great lectures

[@rivenshadowheart]

Hi! I always though that creatinine was part of the filtrate - it was neither absorbed nor secreted. :/ Are you sure it is secreted at the Distal tubule? Which one is correct? Either way, nice channel! Very helpful :)

[@HealthEdSolutions]

Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!

[@fiunipv9053]

I knew it was 125ml/min (approx 180L/day)... is it correct as well?

[@mohammedalsamani6846]

correction is wrong

[@HealthEdSolutions]

Thanks for the feedback!

[@zahraaalherz6907]

Thank you

[@sobster123]

thank you tho x

[@HealthEdSolutions]

Thanks for watching!

[@MrEvanston]

I would appreciate a full lecture on Nephology from you. I enjoyed this video. Thank You. Retired RN, continuing with education.

[@HealthEdSolutions]

Thanks for the feedback! We will be rolling out new lessons soon.

[@stonesafterdark]

i'm pretty sure he said Na by active transport. also i want to understand is it 48L/min or 180L/min?

[@calebsolomon6372]

Ugo Willis The video is wrong, it should be 125ml/min and 180L/day. He said 48L/day and if you think about it thats only 4800ml if we have 125ml/min of fluid filtering through the glomerulus, thats is going to be a lot more than 48L/day.

[@anushbudumyan2467]

+Caleb Solomon Yep, but only 48000ml not 4800ml.

[@HealthEdSolutions]

Thanks for the feedback!

[@HealthEdSolutions]

Thanks for the feedback!

[@HealthEdSolutions]

Thanks for your question Ugo. We have passed it along to the Health Ed Solutions medical review board. Thanks for watching!

[@basmed2000]

Super Good.

[@HealthEdSolutions]

Thanks so much!

[@jefubachs]

120ml/minute makes 172L a day. How do you get to 48?

[@Lauraphoid]

120 ml/min is 172 L/day ... not 48 : )

[@hudaqaddah4416]

What is the realation between K+ , H+ and acidosis or alkalinosis

[@HealthEdSolutions]

Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!

[@arodmitton]

Thanks so much for doing these videos and allowing us to view them for free... They are a great tool!

[@shimaagamal5889]

thanks doc

[@brianhernandez2726]

why does the concentration of urea increase in the proximal tubule?

[@philliplodico6811]

Fluid in the PCT is considered "filtrate" - this fluid is not considered urine until it passes thru the collecting tubule into the minor calyx. The osmolarity of the filtrate remains the same (11:30 in video) until it reaches the loop of Henle.

[@HealthEdSolutions]

Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!

[@judyelibri]

Thumbs up!!

[@zhicheng3804]

*So

[@mradadel1297]

was hoping to hear about the Hco3- :(

[@HealthEdSolutions]

Thanks so much for the feedback

[@sabahy7880]

Great video!

[@HealthEdSolutions]

Thank you Sabah!

[@sadafbenaf]

Thank you so much for the nice and easy explanation, the way learning should be. I would love to know a bit more about alpha and beta intercalated cells of the distal convoluted tubules functions. Much appreciated.

[@HealthEdSolutions]

Thanks for your feedback and thank you for watching.

[@dartosmuscle1592]

may i clarify about how many potassium pumped per 3 sodium in Na-K atpase

[@HealthEdSolutions]

Thank you for the question. We've passed it along to the Health Ed Solutions medical team.