Scientists Discuss Longevity Interventions & Optimisms | 45 - K-Lab Reunion

Subscribe to our channel: / @optispan
Related episode:
The Two New Highest Ranked Compounds For Lifespan Extension According to the ITP: • The Two New Highest Ra...
Matt, who ran the Kaeberlein lab at the University of Washington from 2006 to 2023, rounded up several former lab members for a chat at the recent 52nd annual meeting of the American Aging Association (AGE) in Madison, Wisconsin. The group included assistant and tenured professors at various institutions around the United States, startup founders, and prospective PhD students with geroscience research interests that span the microbiome, mitochondrial dysfunction, frailty, metabolism, sex differences in aging, and more.
In this episode, Matt and his former lab members pool their collective knowledge to engage in a lively conversation (and sometimes debate) about longevity interventions such as metformin, acarbose, and sauna use. In their discussion, they touch on hot-off-the-press positive results, unpublished data, and planned research from their respective research groups and labs. They also bring up nuances to recent published work, including results from the Interventions Testing Program on various interventions that Matt discussed in a previous podcast episode.
0:00 Introduction
1:07 Lab member introductions
10:49 Let's grade interventions: for, against, don't know
11:19 Methylene blue
12:31 Dasatinib and quercetin (D + Q)
13:51 Caffeine
14:04 Protein restriction
15:02 Branched-chain amino acid restriction
17:07 Hyperbaric oxygen therapy
19:04 Sauna
19:34 Cold plunges
21:48 Parabiosis
25:52 NAD+
26:52 AKG
29:55 Metformin
32:20 GLP-1 agonists
34:00 Resveratrol
35:02 Rapamycin
36:07 Acarbose
36:39 3-hydroxyanthranilic acid (3HAA)
37:05 ORB-1284
37:34 The weirdest thing you've ever done for your longevity
46:50 Wrapping up
Producers: Tara Mei, Nicholas Arapis
Video Editor: Jacob Keliikoa
DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.
More places to find us:
Twitter: / optispanpodcast
Twitter: / optispan
Twitter: / mkaeberlein
Linkedin: / optispan
www.optispan.life/
Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.
On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

[@bob-ss4wx]

Although I participated in Matt's rapamycin study, I never realized until now what a heavyweight he is in this field. And all your colleagues clearly have a lot of respect for you.

[@BarryBPruett]

Great show !!!! Surprised glycine, taurine, astaxanthin and NDGA weren't discussed.

[@sergey9986]

+somatropin

[@MusixPro4u]

Especially NAC + Glycine combo.

[@szghasem]

Loved seeing the human side of the Optispan team in this latest podcast. Your personal takes on intermittent fasting were really interesting. Despite the debates around Metformin, my own experience has been amazing: lost a lot of weight, yet got stronger, and as a prediabetic, it’s improved my life in every way. Just goes to show, one size doesn’t fit all, and context really matters

[@Icarianbrother]

Do you plan on testing rosmarinic acid? "Plant and fungal products that extend lifespan in Caenorhabditis elegans"- Rosmarinic acid, a substance in mint and lemon balm, among other things, increased the life span of the nematodes by 63 percent. Second and third come pomegranate and curcumin. These two substances extended the lifespan by 56 and 55 percent, respectively.

[@HvdHaghen]

I'm also interested in rosmarinic acid after I saw videos about many centenarians in Acciaroli who used a lot of raw Rosemary to chew on and put it in many dishes. A possible explanation is that it influences Angiogenesis (the growth of blood vessels from the existing vasculature)

[@Icarianbrother]

@@HvdHaghen I make rosemary tea with dried rosemary, stevia and lemon juice. I also add a small amount of black pepper for the piperine. It may potentially enhance the bioavailability of the rosmarinic acid. The tea tastes great!

[@ZoeyKs]

I think metformin (immediate release) causes diarrhea much more often than acarbose, and though acarbose does cause flatulence, if you increase it slowly, over time that side effect often stops. And yes, importantly, it does transform your pasta into a salad. lol

[@sticksstonesbuildmybones7837]

It's interesting, as a lay person and long time, avid, science podcast listener, to see how siloed research/ers can be. As an example, the first compound, MB. has been studied in this country by people like Dr. Francisco Gonzalez-Lima, for a long time. I get it though, these folks are doing deep dives into their particular areas of interest and asking questions outside of their areas of expertise can result in speculation and "deer in the headlights' scrambling for safety. That said, I'm really appreciative of this podcast and the rigor with which Matt K. approaches it.

[@erdemy2702]

Really appreciate this talk! I'm surprised that so many experts are unsure about so many interventions. Funny that almost everbodies 'weird' longevity intervention is the same. It was probably a joke but the assumption that people are lazy (cold water plunge) excludes a lot of people who do like to work on their longevity and excercise regularly (I assume the type of people that watch this channel).

[@optispan]

Yes, there's still a lot of uncertainty around most longevity interventions. It's important for experts not to overstate what they know! - Tara

[@peterz53]

Seems a bit odd to favor rapamycin but not BCAA restriction as they both affect mTOR1. Would be good to parse. Yes, more work needs to be done. Interesting work from Lamming lab pointing at isoleucine. Downside of HBOT is cost. Hypoxia can be done at no cost.

[@lumanliu8457]

I think Matt mentioned that high protein (including high BCAA) will likely only activate mTOR transiently especially if you are not having an protein focused energy surplus. I think quantity is the key. Also Dr Sinclair （he is a proponent of inhibiting mTOR as well)mentioned similar opinion on this. After all, we know we need some BCAA. We also know protein, carbs and fats can be interconverted. If you maintain yourself on a slight calorie deficit, the harm from high protein should be very minimal.

[@akashnagarajan6719]

This along with the R files are my fav Optispan videos so far!

[@Lizditz]

I loooove this brilliant format. I wish that you and your panel rated the supplements and methods for daily health as well as the longevity angle I could tell there were some on the fence because they knew the benefits but were measuring for their longevity capabilities. Maybe you could think about doing that. I don’t wanna live long. I just wanna live great. ❤

[@adjusted-bunny]

Apart from Matt almost nobody has aged well. So I hope this will spur progress in this field.

[@anirecapped.]

Lack of exercise, poor dietary habits and all around lack of discipline. I see this exact same thing among many physicians as well.

[@glennthorn367]

hair piece helps

[@anirecapped.]

@@glennthorn367 I don't think Matt's wearing a hairpiece.

[@lucycooper55]

This is fantastic!! Relaxed conversation and such a bonus to discuss a variety of supplements / meds. Thanks ❤

[@JCramer121]

Biological clocks (circadian rhythms) need to be further explored.

[@bob-ss4wx]

Excellent podcast! Learned the lot from these folks different perspectives!

[@kittypopcorn2347]

This is my favorite channel

[@bethaustin1884]

I am not clear if they think the Longo’s FMD (or even pure fast) is potentially effective for health.

[@peterz53]

On parabiosis, why not skip straight to exchanging out old plasma with saline as the Conboy lab did. See their 2020 and 2022 papers. Anyone can donate plasma at local blood bank and loose 25% of there old plasma in one go. This needs more study but seems to positively affect many markers including DNA damage. Maybe a good easy therapy for older people along with exercise.

[@SilverFan21k]

Dang super cool reunion haha

[@jonathonmills3563]

It wasn’t mentioned but should be noted when talking about BCAA restriction, that in the NIH ITP mouse trials, Leucine didn’t extend or more importantly reduce mouse lifespan

[@bob-ss4wx]

Matt believes that Rapamycin is the gold standard at this point. Perhaps your organization could acknowledge Dr. Blagosklonny and Dr Alan Green contribution with Rapamycin.

[@lumanliu8457]

Hi Matt, I know this is not your primary focus. But can you make a comment about the gene therapy (activating the Yamanaka factors), led by Juan Carlos Izpisua Belmonte and frequently mentioned by David Sinclair. I am fully aware that this type of technology is likely decades away from practices if it will ever be. But let’s also be honest, life extension from simple drugs and lifestyle can only be very modest even if possible. Age reversal will probably rely on something fundamental like in vivo gene editing.

[@johannchagot1405]

Glad to see that all efforts are invested on longevity and not hair regrowth 😉

[@y.g.1313]

wow.. not even an attempt to think about extending maximum human lifespan/healthspan.. astonishing.. the modern 'longevity science' is a huge nonsensical pile of quasi-scientific nonsense.

[@glennthorn367]

what a clueless crew