Is This The Best Time to Exercise? | 36 - Longevity This Week #6

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In this episode, we discuss three findings that have made the rounds in the geroscience and healthspan spaces in recent months. They relate to three universally-relevant topics: pregnancy, exercise, and diet.
The first study suggested that women who have been pregnant at least once age faster than women who had never been pregnant, controlling for social, environmental, and genetic variation and measuring aging rate via six epigenetic clocks.
The second study found a connection between workout timing and cardiovascular disease, microvascular disease, and all-cause mortality risk in adults with obesity. Evening workouts appeared to lead to the greatest morbidity and mortality benefits.
The third study, which researchers presented at a recent American Heart Association meeting, demonstrated a positive relationship between time-restricted eating-that is, eating all daily meals in a short time window rather than throughout the day-and risk of dying from heart disease.
It's been an interesting time for geroscience-related findings. Matt and Nick chat about the three studies, discussing their potential limitations, possible mechanisms underlying the observed longevity effects, and further work that would provide greater depth to our understanding of healthspan and longevity.
0:00 Trailer
0:48 Introduction
1:28 The Washington Post article: How pregnancy may speed in the aging process
3:13 What the study did
6:55 Potential confounders in the study
7:41 Does pregnancy accelerate biological aging?
11:59 Theories about the tradeoff between reproduction and longevity
14:25 Mechanisms that might be involved in a relationship between reproduction and longevity
15:32 Differences in results between epigenetic clocks
19:33 What Matt would want to see in studies examining reproduction and longevity
20:33 The New York Times article: When Is the Best Time to Work Out?
22:01 What the study did
27:35 Mechanisms that might be involved in a relationship between workout time and longevity
30:30 What Matt would want to see in studies examining workout time and longevity
32:25 Factors to consider in choosing a workout time
33:03 The Washington Post article: The intermittent fasting trend may pose risks to your heart
34:46 What the study did
38:55 Limitations of the study
47:23 Advice for people doing intermittent fasting
49:51 Dietary recall surveys
50:43 Matt's thoughts on media headlines describing the three studies
53:40 Summing up
Producers: Tara Mei, Nicholas Arapis
Video Editor: Jacob Keliikoa
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Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.
On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

[@Oblonsky-cr6pb]

Hey I just discoverd the channel, great job!

[@SilverFan21k]

Based longevity video. You're on the way to 10k!

[@felipearbustopotd]

32:40 when it gets answered. Factors to consider in choosing a workout time 32:26 what we already talked about which is work the best time for you like whenever you can make it a habit are there other sort of factors you'd want to take into play 32:32 when someone's choosing a workout time or does it not really matter to you I mean again I'm not convinced that that 32:38 there is a big difference in time of day so number one just make sure you can get 32:44 the workout in right and if you feel like you get better workouts in the 32:49 morning and you can fit that into your schedule maybe that makes more sense or vice versa

[@Pepeekeo808]

The Best Time to Work Out? When one will actually do it. If some study comes out and says the "best time" to workout is X, and an individual, for whatever reason, can not do it then, they can use this as just another excuse not to work out. There may very well be an optimum time, but working out ANYTIME is far, far better than not working at at all.

[@hoffmancapote]

I have ran for years both morning, midday and night. I find night running is more difficult because after having eaten most of my food in the day I am heavier at night. Concerning night running causing sleep problems it never has for me in fact generally the opposite. When I have time and energy I prefer morning running. Just feels easier and I generally run farther

[@szghasem]

Very fascinating as always! Thanks for another great educational episode !

[@HvdHaghen]

Could it be that when you are reducing the arterial plaque your chances of having a heart attack or a stroke increases (temporarily), because the formerly stabilized plaque starts to move?

[@kamanashisroy]

On top of what is discussed, consider that most people move during the day by default, this is why we see the effect of workout in the evening amplified.

[@kamanashisroy]

Is it good to have ampk activated while at sleep ?

[@christopherbrand5360]

Go ask any activity tracking vendor to analyze their data according to your design. Garmin, Coros, Whoop, Oura, etc. all have large datasets that can be used to address the question about exercise timing and sleep quality/recovery.

[@jgray3171]

Do we know if the individuals chronotype was factored in? Would be great to talk to PHD Michael Breus about this study.

[@SuperAmazingAnt]

Study proved you would about double your gains of not dying(like 14%vs 28% or something like that) if you workout later at night, but you guys think that is not enought to change your routine. LOL. That is f huge diffrence that you definetly should concider tranining later at day.