COMT Gene Mutation and Estrogen Dominance

[@sebek12345]

🎯 Key Takeaways for quick navigation: [00:13] COMT gene alterations can lead to estrogen dominance, but not always. This video will discuss the connection. [01:09] COMT (catechol-O-methyltransferase) is an enzyme that breaks down catecholamines, including catechol estrogens. [01:37] ⚖️ Estrogen dominance is an imbalance of estrogen and progesterone, with too much estrogen and too little progesterone. [02:05] COMT dysfunction can lead to higher estrogen levels due to impaired breakdown of catechol estrogens. [03:39] Genetic testing can reveal COMT gene alterations that affect enzyme function. [04:18] Specific COMT gene polymorphism (rs4680) is linked to slower estrogen breakdown. [05:00] ❌ COMT mutations don't guarantee estrogen dominance; other elimination pathways exist. [05:15] ⚠️ Methylated estrogens, though easier to eliminate, can still exert estrogenic effects. [05:39] Examining estrogen dominance requires looking beyond COMT to assess other estrogen breakdown pathways. Made with HARPA AI

[@swintegrative]

Thank you

[@madlenj.4644]

it souds like you think we always have too less progsterone if w have too much estrogen. But thats not the case. if i ovulate and add bio P. n the second half of my cycle i get depressed.

[@Onebeautifulheart]

I’m COMT ++ who due to high stress is now estrogen dominate. I am also MTHFR heterozygous. I’m currently trying to detox my overload of epinephrine, norepinephrine, and estrogen right now. I’m taking magnesium flake baths, detoxing and supplementing with SAMe, Magnesium, Glutathione, folate and B12.

[@swintegrative]

Onebeautifulheart, good luck to you!

[@xakep4182]

My daughter(8) is the same - COMT rs4680 +/+ and COMT rs4633 +/+ and MTHFR rs1801131 +/- I am giving her zinc, molibdenum, manganese, magnesium (bisglycinate), potassium, B3(niacinamide), B6(P-5-P), B9(folinic acid not folic) B12 (non methylated), B2 , B5, B1 , D , C, taurine, choline, lysine, arginine, glycine, selenium, little bit of tryptophan for sleep, GABA, BACOPA, Theanine, BCAA, milk thistle, BUT still she is very unstable. She had a major psychosis a year ago, that's when we started our nutrition therapy. Looks like it could take years to stabilize such a severe condition as COMT +/+. I am wondering if it's even possible to be normal and act normal with COMT +/+ mutations.

[@swintegrative]

XAKEP, I can assure you it is possible.

[@humblehalfbreed740]

If you wanna clear excess estrogen, eat cruciferous vegetables. I'm also COMT homozygous. Honestly, you have to fix your circadian rhythm, gut health, diet. Throwing a bunch of supplements at it can just be confusing and counterproductive. I love my COMT mutations now that I am healthy, especially during the first half of my cycle. Use it to get kickass workouts out in upon waking!

[@GlebonCarnivore]

@@xakep4182 lithium and no methyls. Theanine and choline is methyl donors

[@ElizaFragmented]

It's all coming together...

[@swintegrative]

Good deal

[@snowps1]

If you have this mutation is it okay to take HRT for perimenopause symptoms

[@swintegrative]

Sure u just need to be more mindful to check your estrogen levels

[@snowps1]

@@swintegrative oh nice! Thank you

[@hayleythompson218]

What specifically can someone take for slow mthfr and slow comt?

[@swintegrative]

Have you seen this video? kzbin.info/www/bejne/q2Skp3-nZ6mWeqc

[@JuliusSP1]

What are the genes that control the other pathways for estrogen methylation?

[@swintegrative]

I think what you are looking for is estrogen detoxification which I don't have a detailed video on this one might help some though. COMT is the methylation detox of estrogen. kzbin.info/www/bejne/q4rPd42Qm9WXr6M

[@triciaknight6728]

I have huge fibroid huge, my mother died of cancer her brother and sister died of same. I am on an estrogen blocker at the moment zoladex, I am going to ask for content gene test?

[@swintegrative]

Hi Tricia, that's a good idea but your doctor probably won't order it.

[@shhh7762]

HI! I have Huge fibroids as well. Can you please tell me if Zoladex has helped you with yours? If you can give me any tips on if you've shrinks them I would appreciate it. Aslo, how did the gene test go for you?

[@MIlw55]

I have slow comt and it has caused breast cancer. 100% estrogen driven. What can I do?

[@amberkirkwood5621]

thank you for your comment, it applies to me directly. History of endometriosis, sister has had breast cancer plus lots of family history. ​@Sovereign Freedom

[@necessaryJustice_4all]

So, if I have four homozygous COMT ++ genes , plus a homozygous cyp1a1 gene, I'm basically going to have estrogen coming out the wazoo? All kidding aside, I've had what I perceive to be extra dominance, as a male, most of my life. Combating it has been very very difficult. I currently am 41 years old, have been on trt replacement for about a year now. I also take an aromatase inhibitor to keep too much of the testosterone from aromatizing. However, I'd like to stop taking the aromatase inhibitor - based on some of the negative cardiac correlations out there. Wish there was another way to combat this. Carbohydrates seem to also be my worst enemy.

[@swintegrative]

Insulin resistance also increases aromatase activity.

[@xakep4182]

Apart from other minerals and vitamins have you tried magnesium... a lot of it ? I am a completely different person when on magnesium - always calm. I mix malate, lactate, threonate and bisglycinate. From my experience, probably Zinc and Mg are the most important minerals for COMT +/+. I gave up all carbs totally, for 2 years now - no bread no potatoes no sweet juices or fruits. It really makes the difference.