Taurine Extends Lifespan The Lead Author Explains | Prof Vijay Yadav Ep2

We talk to Dr Vijay Yadav about some of the results in terms of lifespan and healthspan from the recent paper that he was the main author on.
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Dr Yadav leads the Systems Biology of Aging Laboratory, which aims to identify novel functional connections between organs and to unravel factors that underlie human metabolism and its disorders. The lab's expertise is in the development of a variety of technologies including mouse genetic (CRISPR/Cas, homologous recombination in embryonic stem cells, iPS cells), genomic (Nucleic acid sequencing), and proteomic (MS/NMR/HPLC). The ultimate aim is to identify novel therapeutic targets for genetic and metabolic disorders to manage these diseases in humans.
00:00 Headline observation
02:40 Taurine decline with age
05:30 Dosing
06:30 Human dosing
09:46 Major biochemical influence
11:53 Senescent cells/Hallmarks of aging
15:38 Systemic effect?
17:08 Inflammation
🌐Links in this video
Dr Yadav on Linkedin / drvijaykyadav
Taurine deficiency as a driver of aging www.science.org/doi/10.1126/s...
Taurine Caps, Jarrow Formulas 1g iherb.co/a3wg6tsV
Taurine Powder, Life Extension 300 g iherb.co/a3abpt4M
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Use SUBMHS when buying subscriptions for a continued discount of renewal orders.
DoNotAge 10% discount code MODERNHEALTHSPAN tinyurl.com/ycyn9vhn
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Evening
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Magnesium Breakthrough -
#taurine #lifespan #vijayyadav

[@ModernHealthspan]

Taurine Caps, Jarrow Formulas 1g iherb.co/a3wg6tsV Taurine Powder, Life Extension 300 g iherb.co/a3abpt4M Renue By Science 10% : tinyurl.com/4yrf4tv3 Use SUBMHS when buying subscriptions for a continued discount off renewal orders. DoNotAge 10% discount code MODERNHEALTHSPAN donotage.org/ref/modernhealthspan/products NOVOS Core & NOVOS Boost $5 off with code MODERNnow5 novoslabs.com/?ref=3957 ProHealth 10% discount code MODERN : prohealth.pxf.io/c/3176409/1541296/17976 Bulletproof 15% off with coupon code: HEALTHSPAN15: tinyurl.com/4npjk5vp

[@veeveemille8830]

Fantastic interview, Richard! I started taking 2-3 grams of taurine before bed. The quality of my rest has improved dramatically. I no longer feel tired in the morning and I think more clearly and have more energy during the day. Nothing else has helped my sleep this much, including melatonin. Taurine is super inexpensive, as well.

[@robertcullum2750]

These sessions with Yadav have been very informative! Please continue.

[@ModernHealthspan]

Hi Robert, thanks! I hope you find it helpful. Next episode is on the results in humans.

[@halfmoon26]

Thanks for all your videos and wonderful efforts

[@ModernHealthspan]

Hey, thank you for your kind comment!

[@nyhammer1]

6:30 dosing

[@ModernHealthspan]

Hi Thanks for your comment. I will add another chapter with human dosing at 6:30.

[@chidude]

I am confused by his dosing equivalents; at the higher dose of 1000mg per kg body weight, for a 70kg human that would be 70 grams, but he equated that to 6 grams. Since mice have so much less mass than humans, is there another conversion factor at play beyond mg of supplement per kg of body weight?

[@johnb9942]

@@chidude google "conversion rate for dosing in mice and humans". There's a mathematical formula to figure out the dose. The Dr in this video said 500mg per kg of body weight in the mouse is about 3 grams per day for a human and 6 grams for the 1000mg dose in mice. That's a loose estimate. It would depend on your weight.

[@talonjefe]

@@chidudethe metabolic rate of these tiny short-lived mammals is the second adjustment after weight. They consume more per kg of body weight.

[@mboiko]

Excellent video...thank you!

[@stevenblanca1]

I wonder what the top 3 substances are, that start diminishing in the body after 40. Is there any study on this besides the one on taurine?

[@StaffanOlsson-sw6tx]

Glutathione might by one if them. NAC + Glycine correct that deficiency. Search the net for NAC + Glycine. Very impressive research to. Even on humans.

[@pablogomez4959]

great questions

[@ModernHealthspan]

Hi Pablo, thanks!

[@ronm6585]

Thanks Richard.

[@ModernHealthspan]

Hey Ron, thanks!

[@houndofzoltan]

In mice... did you read the Peter Attia piece suggesting why it's unlikely to be the same in humans?

[@Battery-kf4vu]

I have seen studies where they speculate that the healthspan and lifespan of the Japanese may be due to the taurine they get from the fish they eat. Same for the okinawan diet. Also one of the special things in the okinawan diet is their very protein intake ( I think around 9% of calories). So wouldn't one secret in the okinawan diet be a very low protein intake while keeping taurine at a good level?

[@KenOtwell]

Hard to say - fish protein is very high quality, plus fish oil is highly cell-protective as well as improves muscle uptake of protein. There's more to sarcopenia than simply raw protein intake.

[@Battery-kf4vu]

@@KenOtwell Their taurine intake probably helps, not just for sarcopenia, but it is not the only positive thing in their diet. Higher omega 3s intake also must be a factor.

[@KasKade7]

Japanese do alot more things right then just a diet high in taurine. Tofu/tempeh is high in spermidine and quality protein. Seaweed has Sirt6 activator Fucoidan. High omega3 intake and low omega6. High glycine intake and low methionine. Also simply being a smaller human being helps with longevity.

[@Battery-kf4vu]

@@KasKade7 For sure there are a lot of other positive things they do. There must be a synergistic effect.

[@KenOtwell]

@@Battery-kf4vu Omega 3 is a major ingredient in fish oil.

[@javadivawithdog]

Glad to know I should keep going as not really experiencing much improvement yet at 1 month.

[@ModernHealthspan]

Thanks for sharing.

[@michael-qp9xd]

How much are u taking? Thanks

[@ScottSummerill]

Probably true for every amino acid deficiency. So would addressing the deficiency be sufficient or is he recommending mega dosing?

[@ModernHealthspan]

Hi Scott, thanks for your question. We got into dosing a bit in this episode and we also talk about it later in the interview. The message I got from Dr Yadav (which Dr Baur agreed with) was that at this point we don't know and clinical trials are needed. As Dr Yadav alluded to, the European Food Safety has said that they do not have concern over taurine safety, (tinyurl.com/2x37knup)

[@jimdandy8996]

1g/Kg dosing? Good God!