TWiV 1031: Death on the West Nile

TWiV notes the passing of virologist Michael BA Oldstone, a study to assess the performance of rapid antigen tests to detect symptomatic and asymptomatic SARS-CoV-2 infection, and the presence of antibodies to type I interferons in ~40% of patients with West Nile virus encephalitis.
Show notes at www.microbe.tv/twiv/twiv-1031/
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[@cynthialeech2507]

Belated Happy Birthday Dr. Condit! Best wishes for many more years. TWIV got me through the Pandemic. Forty-two years in health care and grateful for the updated science education.

[@garyfumeaux9226]

Hi Cynthia how about speeching the truth..... The PCR test was never designed to tell if someone is sick or not....

[@PifflePrattle]

@@garyfumeaux9226 The wheel was never designed with automobiles in mind.

[@leodikinis7390]

Thank you Vincent for chairing the program. Alan for the strong recommendation to see the Oppenheimer film and of course a Happy Birthday to Rich. May you have a fantastic upcoming year!

[@lesfaby8997]

KZbin timestamps by Les under construction 02:21 TWiV debunking Junior reception 03:56 New Offit episode debunking Junior 06:08 Job posting for Amy's lab for an additional assistant. 07:44 the passing of virologist Michael BA Oldstone 12:21 xkcd.com/2806/ 13:19 Ron DeSantis would consider Junior for CDC/FDA 17:28 assessing the performance of rapid antigen tests to detect symptomatic and asymptomatic SARS-CoV-2 infection . . . . 46:23 the presence of antibodies to type I interferons in ~40% of patients with West Nile virus encephalitis. 1:17:19 LETTERS 1:46:30 PICKS OF THE WEEK 1:46:37 Rich 1:48:07 Alan 1:57:53 Vincent 1:58:15 Richard Rhodes on Oppenheimer (Nature) Alan loves the movie Vincent relates it to contemporary vaccine hoo-haa, etc LISTENER PICK 2:04:01 Ryan PBS NewsHour Offit on Junior. kzbin.info/www/bejne/naHRZaaIps-mY9U Audio podcast timestamps by Jolene. Thanks.

[@actyrrel]

A study behind a paywall is not a study. It is commerce.

[@Virusesluna]

Wondering where from Vincent picks up the titles for the episodes. I am impressed

[@lesfaby8997]

Alan Dove supplies the most titles.

[@stormwalker321]

a memorable show for me - thank you -

[@marywhiteman3123]

Thanks, another great program. Happy birthday Rich.

[@sabine8419]

Thank you Alan for your great inputs.

[@luismatheu4226]

Great show... Must say Allan yo got Sars Cov2 or covid (mi 40) hope you are better now. Another question is Sars Cov2 nose first, lungs second or lungs first? Or both same. Time. For parctical. Approach does not matter

[@_c_y_p_3]

The person doing the covers lately have been on their A game!

[@boovan8902]

I also agree ! If your sick stay at home and quit saying I think it’s allergies!

[@terenzo50]

Bacterial quorum sensing is communication which demonstrates consciousness. Galvanic response of certain philodendrons identified a human murderer which demonstrates consciousness.

[@terenzo50]

My brain is experiencing some kind of flashback phenomenon: everytime I hear PCR, I immediately think Pulse Code Modulation. When the heck was I involved with that? 40 or 50 years ago? Sheesh!

[@jillrace401]

Many libraries provide a free daily online passcode to the New York times and other magazines. (Letters question)

[@maxheadrom3088]

We should do a test ... go back in time and make it so the Nile either stops existing or gets a new name; then we go back to the future and check if the disease is still called West Nile Fever! Am I being too mathematical?

[@tonaruch8623]

Thanks for not deleting the oopsy

[@aanderson2880]

What about a resurgence in covid or what ever they call it now…. all of the above. I need a 4 th shot. Dr. said so.

[@gratitudemodestyhonesty]

Not to be nitpicky Vincent but you are wrong that West Nile has nothing to do with the Nile river. The Nile river starts in Uganda... but you are right that it has nothing to do with Egypt

[@aanderson2880]

KEEP WASHING YOUR HANDS. aim for 6 or more times a day and a more as needed.

[@aanderson2880]

Ck out poor dr. Wachter. Fell down stairs. Broke neck, In a brace, Bad cuts 😅n face stitches,Black eye. Cards could go to Dept of Medicine, UCSF, to dr. Bob Wachter. He is home now I think.

[@kazoz3520]

1:42:00 But multiple countries did eliminate poliovirus from their populations by using only IPV (& as a consequence skipped the step of vaccine derived polio). So why do they not see polioviruses (including vaccine derived) in wastewater surveillance, unless from a recent international visitor? Making the mistake in assuming that only vaccination can eliminate an infectious pathogen from a population, forgetting that multiple public health measures combined are needed to reduce replication & transmissions to the point of elimination.

[@actyrrel]

From a cost benefit and/or strictly health outcome I wonder what is the best dollar spent. Sanitation? Environmental? Food quality? Exercise? BMI? Supplements? Drugs? Vaccines?

[@jckesinger]

Not a fan of NdGT, if you get him on I'll just skip that episode (like I skip the Mark Martin episodes of TWiM), but you'll more than make up for the loss of me on that one.

[@PifflePrattle]

What Alan says from around 42:30 is a conclusion I came to re colds and flu long before SARS 1 let alone SARS 2. Clever me! You're going to get a lot of push back on that one Alan! A lot of well paid non essential workers being told to stay at home during the early pre vaccine part of the pandemic aren't too happy at the nagging realisation that a load of poorly paid essential workers eg the unskilled labour that is employed to keep hospitals clean and without whom the greatest of surgeons are rendered useless. Or they are going to have to use a lot of their valuable time scrubbing the theatre before getting into their scrubs.

[@deborahhebblethwaite1865]

Do you guys have any idea what the state of our countries are in because people simply do not go to work? Businesses are failing because no one comes to work. Who is going to support all these people. Yes if you are very ill you stay home but for every sniffle?? In Texas with the extreme heat you had workers dying because they were afraid of losing pay and jobs if they took too many breaks. Now there they needed to stay home. Heat will kill even the healthy people. We went through hell when the powers that be just said oh just work from home. There are lots of people who cannot do this due to the nature of their jobs. Like you like getting your groceries? Guess what that won’t work. Shelves will be empty. And you will starve. That is 100 percent deadly. This attitude really bugs me🇨🇦

[@pedrosmith221]

Good luck with that... it has became political so many people won't put on a mask or stay at home even if they are dying.

[@sabine8419]

For a large part of humanity, who are intellectually or educationally not equipped to understand scientific topics, it cones down to deciding which information/informant to trust. I estimate, that this applies to the majority of humans. These types of people will not watch shows as these, or even become upset by them, for the simple reason, that they are unable to understand the content, and how it is presented. Because almost everyone thinks they are smart enough to understand everything and to have an informed opinion about everything, people will be suspicious of things they cannot understand. This is simply because they believe, if it were the truth, they should be able to intrinsically "undersrand" it.

[@tonaruch8623]

Francis Collins would be great guest; even better if he would be willing to sing “Dare to Dream.”

[@catherinecbeyer9199]

Becoming too political. Please stick to the science.

[@annihilator22]

No.

[@nancychandler3673]

Unfortunately, Politics entered Science. I am thankful that more professionals are addressing disinformation that is spread by Politicians.

[@dumbassloser]

Show starts at 17:21

[@hardtakeoff]

TWIV The podcast where we defend the zoonotic spread theory