RESVERATROL MYSTERY #2: How It AFFECTS Senescent Cells + Fisetin & Quercetin

If you take resveratrol… did you know resveratrol works differently in your body depending on how much you take every day?
If you’re not careful about how you take resveratrol, you may achieve completely different benefits from the ones you intended! I couldn’t believe it either until I saw it too. And it is one of resveratrol’s biggest secrets.
And it’s kept within its polyphenol family. Which includes fisetin, quercetin, pterstilbene, and others.
Today, we’ll cover a hot topic in our longevity community: senescent cells.
What are senescent cells?
Are they so dangerous for longevity?
For that, we’ll hear Dr. David Sinclair, and Doctor James Kirkland, whom in my opinion, the world’s greatest experts on senescent cells.
Then, we’ll explore the impact of resveratrol in different doses on senescent cells.
We're also gonna cover fisetin and quercetin - what’s the correct way to take them to kill senescent cells?
And which dose current human studies are using them as senolytics?
And as a response to your requests today I will share what I do personally - my resveratrol dose, when....
....and my senolytics protocol - because of this investigation.
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Join with $1 & get access to the 10 resveratrol habits & earn an honorary mention in future videos.
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/ wellnessmessiah
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Previous videos of the investigation:
✅ Part 1: David Sinclair Study on Resveratrol: Fascinating Discovery
• David Sinclair Study o...
✅ Part 2: "How RESVERATROL affects your heart?"
• How RESVERATROL affect...
✅ Part 3: Could JUST 1mg of RESVERATROL Affect Your Longevity?
• Could JUST 1mg of RESV...
✅ Part 4: RESVERATROL Impact On Metabolism: 2021 Human Study
• RESVERATROL Impact On ...
✅ Part 5: RESVERATROL MYSTERY: Why Taking Too Much HURTS Your Longevity
• RESVERATROL MYSTERY: H...
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Chapters:
0:00 - Previously in our investigation
2:05 - What are senescent cells
8:25 - Low resveratrol and senescent cells
12:58 - High resveratrol and senescent cells
16:58 - Fisetin and Quercetin
21:14 - How much fisetin is used in ongoing studies
22:00 - What I do, how much I take
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Study References:
I'm working on a website to include each video with all links, with each page per video.
In the meantime, I ALWAYS show the exact study titles & years and read them aloud. Go to GoogleScholar.com, put the first 4 words only, and the study will come out as the top search, guaranteed. Please double-check me!
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The Wellness Messiah podcast is available on Spotify, Apple Podcasts, and Overcast.
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Credits: Scott Buckley
Disclaimer & Disclosure: The information in this video and/or at this channel is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge, educational and information from the research and experience of Rimon, who encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional.
Rimon is not a medical doctor. If there is a contradiction between the advice here to your doctor or local authorities, always go with the doctor and the authorities.
Statements made, or solutions suggested in this video and/or at this channel are not intended to diagnose, treat, cure, or prevent any disease.
The statements are not contradictory to first following authorities' guidelines of social distancing and hygiene.

[@veggiechefCD]

I increased resveratrol dosage to 1g based on your last video…. trying to kill leukemic cancer cells. I’m tired of being my own Guinea pig, but I don’t want to go down without a fight. Even a sliver of hope keeps me going.

[@WellnessMessiah]

Cross fingers for you Crystal 🤞Consult your doctor and please check Dr Nicholas Gonzalez too

[@01maggie]

Please read and do protocols by Anthony William Medical Medium. Sister had stage 4 metastatic cancer liver, breast and lymph. We did celery juice daily, heavy metal detox smoothie, complete plant based diet. Chemo ended 1.5 months early because all cancer was gone. Her doctor was shocked because he told her you have 2% survival. It's been 5 years clear. Book us called Cleanse to Heal by Anthony William. God Speed!!

[@ryantiltman260]

Hi Chrystal. I hope youre well. Also doing Resveratrol 1g p/d.. What do you recommend i take in terms of mg? Thank you.

[@dustinjohnson1047]

You're not a guinea pig, you're a warrior fighting a battle...stay strong.

[@marlenecampbell5439]

I read that a nurse working with children that had leukemia noticed that when they were given an anti fungal treatment that they went into remission. Then she got leukemia and used an anti fungal to cure it. You could at least use antifungal herbs ect

[@Chaotic313]

Definitely NOT boring! I'll be sixty within a few months and after embracing intermittent fasting several years ago, seeing and feeling wonderful results, I embarked on a longevity supplement journey this past summer. There is a lot of conflicting information out there and I find your videos extremely informative. I appreciate the work you put into researching studies and your delivery of the most current, available knowledge. Thank you! :)

[@WellnessMessiah]

Glad to meet you! your comment was really fun to read in this turbulent time in my life

[@semaaral2498]

Perfect 🙏🌟

[@pjaworek6793]

Are you kidding? This project is the least boring thing you could ever make a video about! Keep going and don't leave out anything. Thank you Rimon!

[@WellnessMessiah]

Ha ha you're awesome thank you for this!

[@gdok6088]

Your videos are not boring at all. It's hardly surprising that there are complexities at play here; the human body is awesomely complex. You do a really good job of using the data and studies available to put the appropriate questions under the microscope and give us cutting edge analysis of the best strategies to adopt. And please be reassured you very clearly and repeatedly stress that you are not giving medical advice. Keep up the good work Rimon :)

[@WellnessMessiah]

You're very kind Gary, it's very reassuring what you said! Ya' know it's much easier for content producers to say "why I don't take supplement X" because this way, they will not feel responsible or disappoint anyone. I remind myself, all too often, that it's irresponsible for me to not tell what's working if I know it does. P.S.I have a lovely patron with your name. Is this your youtube user (so I can recognize you)? I sent to my patron today my supplement routine document too.

[@JustVibingFullStop]

Great video! And I love the comment section. Such great conversations going on. I'm learning so much! I just recently started researching a longevity protocol for my parents. They are bort in their mid 70's and I've noticed some cognitive decline, especially in my father. It scared me and now I'm eager to try to help them as best I can.

[@imeldareza5180]

You’re NOT boring us at At ALL !!! You’re helping us !!! Gracias thanks gracias!!! Please keep the GREAT job,,?❤❤❤❤❤

[@graemeraynel8468]

Hi Rimon, my understanding from David Sinclair is that resveratrol needs to be taken with fat for better absorption - he takes his with yogurt. Also trans-resveratrol is supposed to have better absorption. So the 200+ studies you have read and commented on, have you taken this into account, as this will significantly impact the results of the studies? My understanding is that most studies that say resveratrol has no benefits, are those that are not taken with fat.

[@marylmarx]

Not boring! I've jumped on the Sinclair protocol and now am questioning how much I should be taking. Will stay tuned for more of your research!!

[@matzefritz]

It's not boring. It helps me adjust my longevity protocol.

[@WellnessMessiah]

Thank you matze, always great to read your positive comments

[@NTMihaila]

Wow, not what I expected! Thank you again for the excellent content.

[@siciliandefence1032]

Fascinating. This clears up some questions. Thanks for the careful research and presentation.

[@markanderson8146]

Definitely keep going! In 10 years this will probably be mainstream information but at the moment it is cutting edge. I suspect quite a few of us are running our own personal experiments on what to take and need the best information based on current knowledge. There are a lot of subtle nuances that need to be considered based on our personal situations.

[@WellnessMessiah]

Thank you Mark, you're very kind. The juice is in the nuance / devil in details

[@claudettesechler149]

Thank you for keeping us on this path of knowledge! Since things are forever changing, so happy to have someone like you to keep us informed.

[@semaaral2498]

Yes,Agree & Appreciate this work. Also wish a speedy recovery To Rimon's young wife🙏😞

[@user-q2Rftt8]

Thank you for this video. You're the only person that covers this much into details and the way you explain is always so easy to understand. I appreciate you so much!

[@WellnessMessiah]

Thank you H. ! The devil is in the details. Question: did you receive the impression that the end 22:00 that I provide medical advice? (which wasn't my intention!)

[@user-q2Rftt8]

@@WellnessMessiah Hi Rimon. The answer is, no, I didn't. I received the information that you've shared as your own conclusion from what you know, but if you are worried about sending the wrong message, you could say, " This video is not intended as a medical advice. Please consult with your doctor before you decide to start any supplementation " etc etc in the beginning of every video 😊 I do have a question for you as well. If I already take Fisetin 3 days a month in high dose to get rid of senescence cells, should I not take resvertol at all? Can they be combined? Thank you!

[@WellnessMessiah]

@@user-q2Rftt8 n. We know how it works per dosage, which I don't with fisetin quercetin. They are probably similar. 20mg/kg works to kill cells (resveratrol cancer, and they senescent and possibly cancer too) and 0.5mg-1mg/kg increases the longevity of cells. low dose resveratrol and high dose fisrtin, I think resveratrol can get in the way and help cells survive. They could have all synergetic effect in low doses, it hasn’t been studied so I don’t know. I do know that low dose resveratrol and olive oil do form a synergy, 100%.

[@user-q2Rftt8]

@@WellnessMessiah Thank you!

[@tom7471]

not at all boring! Great info!

[@tonymagnone7903]

Excellent information Thanks for your work

[@miriamsadof867]

Your videos are fantastic. Very practical and well presented. And… no.. NOT boring at all:)

[@researchersameet790]

Amazing video once again as always...cheers

[@Mary_QQQ]

We love this. So interesting, Dr Rimon ! ♥️🙏from Australia 🇦🇺

[@wardpreston1213]

Excellent. Please continue your work. Entertaining. In Depth. Factual. Focused.

[@pietbuizer1686]

very good to follow and understand how the different supplements work..

[@streambox1010]

Informative. Please continue.

[@phoenixgirl11]

Excellent,excellent video!!!

[@stevecrawfordpianodreams5167]

Keep it up, it is not boring at all and I am making some changes to my protocol based on this information.

[@WellnessMessiah]

You're very kind Steve

[@CarlosCastro-ib1yn]

Not boring at all. Learning a lot making decisions. Thank you.

[@jillsierra8174]

Good information and please continue!

[@WellnessMessiah]

Thank you Jill, comments like yours def help! SO I guess I didn't bore you to death.

[@carlostrujillom]

Thank you for the great videos!!!

[@133397777]

I really like all the info you give us.

[@WellnessMessiah]

Thank you Donna you're extremely kind!

[@AboodCohen]

thanks for the video bro, keep it up!

[@WellnessMessiah]

Thank you Abood, you're very kind!

[@gospelofthomas77thpearl22]

Very interesting. Thank you 🙏🏼

[@destryevsquad4825]

thank you for this invaluable video and information. have a great day

[@WellnessMessiah]

Have a wonderful week, great to meet you 🙏

[@phaiklianng1672]

Thanks for the latest info. I have been taking low dosage of resveratrol, Fisetin & Quercetin 2 days per week.

[@WellnessMessiah]

Nice to meet you Phaik!

[@longevitylover6273]

Thanks for this video. I went back to the previous video about resveratrol and cancer and thet both complement each other nicely.

[@WellnessMessiah]

Thank you, yes it sounds you didn't miss it out!

[@matteopeluso7320]

keep going Rimon! Great content as always. It would be so useful to see you discuss your findings in depth with Sinclair to get his take on it!

[@WellnessMessiah]

Thank you Matteo, I want to have him one day :)

[@milesprice8363]

Excellent work keep it up

[@WellnessMessiah]

Thank you Miles. You've just made me stronger.

[@widgetty22]

Thanks for your time and efforts to educate and inform! My only feedback on your videos is if you could make them shorter if possible. Bite size content would encourage more viewers into your channel. Best of luck!

[@Always-xl9db]

This makes a lot of sense to me, and you know how picky I can be 😌👌 The only thing I would look into further is bioavailability and poor absorption of these compounds. Meaning, with low dosing it has to be so precise - and lipo forms do get absorbed so much better. So in that case should the dose be reduced even more? I would really like to know what Resveratrol are you taking yourself, what form/brand

[@WellnessMessiah]

Hey A T you're picky because you're smart. Yes, you're right about lipo. The problem is most studies just use regular resveratrol/fisetin/quercetin. If you see interesting studies on liposomal res/fis/que, maybe we can try to extrapolate the effect of the others 2, comparing lipo to non-liposomal. Their absorption is very similar. Resveratrol has the weakest solubility out of the three one less OH group) but for some reason, it's extremely potent nevertheless. Liposomal may even penetrate new tissues (e.g. hypothalamus, white blood cells). Feel free to provide me studies you see over times.

[@ryantiltman260]

Hi AT. Im taking 15mg p/d to boost bioavailability by 1544%. There are trials to show this. I hope this helps. Thank you.

[@markpappas9858]

Good Advice!

[@WellnessMessiah]

Thank you Mark, nice to meet you here!

[@revealanation7778]

Not boring at all!

[@vc983]

Yes keep going. Not boring to me

[@WellnessMessiah]

Thank you Vic, you're awesome

[@StancyInTheCity]

After listening to David Sinclair, this is a very good balancing video. I’m 57, although I’m disease-free I feel like I’m ageing like a freight train lol. I have enough weight to lose that I might use Fasting along with NMN prior to adding senolytics. What would you do personally if you were approaching 60 and had been experiencing rapid aging? For me that translates to abdominal weight gain, increase in wrinkles, insomnia, fatigue, increasing adiposity in general. Thank you

[@lesptitsoiseaux]

Thank you for the love and effort you put in your channel. It is very helpful and pleasant to watch honestly. I have a question on delivery that my son came up with as we were watching a tv show about a famous Columbian entrepreneur. After a good laugh, I wondered, not knowing much, what would be the best delivery mechanism for these substances like nmn, fisetin, et al. Pills? Seringes? Eye Drops? Under the tongue? Snorting (ha!). I think the worst way is probably the stomach however I'd love to hear the thought of someone who knows far more than me on the topic. Thank you for your videos! :)

[@rodelyanga6276]

Thanks for this , now i understand why my wounds haven't been healing as fast as it normally does. Usually my would will heal in 2 to 3 days , but in this case its been 1 week and it still looks fresh...

[@WellnessMessiah]

Interesting feedback. This whole senescent cells is a new world of science, really!

[@davidderidder2667]

Wow

[@carlor.s.4742]

Very interesting video. I'm 78 & I'm going to take trans-Resveratrol every second day now. Hey Rimon, I'm really interested in mushrooms like Turkey Tail, Cordyceps etc & their nutritional value & effect on the body. Have you done vids on this?

[@azadehkhajeheian9430]

Great info ❤️

[@WellnessMessiah]

Great to meet you Azadeh! You're very kind!

[@x23w2]

very interesting channel. I would strongly recommend that you list the papers that you reference in the comments section. Thank you.

[@Earwaxfire909]

Take a look at the paper:"Grape Seed Oil Compounds: Biological and Chemical Actions for Health." It seems that grape seed extract might be worth investigating. It contains trans-resveratrol and other polyphenols.

[@woodypognon3961]

Hi There love the work you do, when you post a study can you post the source also?

[@TriangleDancing]

First of all, these are not boring, keep them coming! This was a very good video, and it confirms what I suspected, that resveratrol isn't a good senolytic. As I have said before, I take a total of 225mg daily, with 100mg being conventional resveratrol and 125mg being liposomal. This technically puts me in what you consider the medium range, but over half is liposomal, so presumably it reaches a lot more tissues and goes deeper into the cells. I also take quercetin every day, 250mg 3 times a day in phytosome form. Besides senescent cells there are benefits to quercetin like reduced inflammation. I know daily doses go as high as 1000mg, and I would guess that anything above that would put you in possible senolytic territory, which means I want to stay below that threshold. It also works as a zinc transporter which can boost your immune system if you're taking zinc (which I do). Recently I got some liposomal fisetin and began the Kirkland protocol, however I added liposomal 95% standardized OPC grape seed extract since pcc1 has shown evidence of being an excellent senolytic. I took these three days in a row, at 450mg fisetin and 600mg grape seed extract (I know the fisetin is below the Kirkland protocol, but my guess is liposomal delivery means you can go with less). However, after watching this video, I'm not sure how much benefit I can expect since I'm aged 45 and it looks like you need to be about 60 before you really need to kill off senescent cells. We definitely need more low dose fisetin studies. The liposomal pills I take are 150mg, so it would be nice to see what that dose would do. And we also need a LOT more studies looking at liposomal supplements. The few I've heard of show it makes them much more effective.

[@ilanta_sa]

Is the Kirkland protocol available online? I couldn’t find it. Thank you.

[@TriangleDancing]

@@ilanta_sa It's high dose fisetin for anywhere from 2-4 days in a row, then a month off, then repeat. Most folks go with 1200-1500mg doses a day.

[@ilanta_sa]

@@TriangleDancing thank you!

[@jxgardner]

Unique viewpoint on senolytics and Sirt activation.. These supplements should definitely be cycled , not taken every day. Dosage is another factor .. I assume David himself has ramped back the dosage of resveratrol a lot.. Re consulting a doctor…good luck! !

[@WellnessMessiah]

Def consulting a doctor! Thank you! I tried to stress this enough too, I hope I did

[@jxgardner]

Well, maybe someday they’ll prescribe Resveratrolabib, or Fiserinabib etc. etc. $$$$

[@rosesolis2306]

Not boring very very informative 👌

[@WellnessMessiah]

Great to meet you Rose! You're very kind!

[@craigr296]

Thank you for your awesome detailed videos , I'm still a little confused about dosage as I've seen other videos of yours and David Sinclair's mentioning taking 1G of Res every other day but I've also seen you mentioning taking low doses (I presume you cycle your doses)? I'm 52 and healthy and have been taking 1G every other day for a few weeks but sounds like I might have to lower my dose

[@ricodelta1]

Great video

[@WellnessMessiah]

Great to meet you Rico! You're very kind!

[@BlackLeg199]

Thank you for your effort, u r inspiring. So, what about fasting and resveratrol? Is it optimal to take resveratrol on fasting or non-fasting days? and should NMN should also be cycled with resveratrol?

[@dlbdlb3919]

good job

[@garygary7376]

Great video as always! Anyway, can you please explain how many mg per day would be considered as a low dose resveratrol?

[@vanessagregory8835]

Have ordered 100gm of Fisetin. Currently use 1gm NMN a day. Have ordered 100 gm Trans-Resveratrol. Plan to use it alternate days with lipid. Am now considering Fisetin dose and frequency. I have bought a Resveratrol mix for my son and brother. This may not be the way to go. They take 1gm of the mix daily. My GP has prescribed 1gm Metformin to lower my blood sugar and BP. My blood sugar has crept up to 6 ppm. I am 81 and am in good health. Gets complex. Thanks for the work you are analysing.

[@cheetahbrfc9016]

Thanks again for a great video! Sorry if asked before but what other supplements do you take in your protocol? Do you take nmn everyday? I take nmn 1g, resveratrol 500mg (might drop it to 250mg) every day though watching your videos I might take it 3x a week. 1225g quercetin twice a month. Vitamin d3 4000iu and k2 plus omega 3 every day(EPA 844mg, DHA 574mg. For my skin I wear a spf 50 every morning and take hyloronic acid and astaxanthin supplements. I am 33 white male in South Africa so skin care is important for me (being teased in my youth for acne didn't help). Oh and berberine for those unfortunate cheat meals 🙈 I want to start taking this every night and see how it makes me feel

[@01maggie]

I understand you in this video. I already cut back my Transreservatol to 200mg but will go lower now.

[@WellnessMessiah]

Hey Maggie great to read again from you. Stay healthy & young!

[@jouan1]

I'm 73 and still in good health. Beginning my supplement journey. I wish you would address my age group in terms of resveratrol, fisetin and quercetin dosages

[@jeanbuckner515]

Yes, thank you I've been watching your videos and have a great deal of appreciation for what you have to say. I have a question though, an earlier videos you have stated that you had to move to London for your wife's pain treatments and now you are saying she has had a stroke and you need to help her with recovering from the stroke. I really like what you have to say, but I need to understand why you moved from Israel to London and then now or saying that her stroke requires treatments? I would so love for you to answer this question because I am just totally confused?

[@TriangleDancing]

A couple other things. You mention pterostilbene in this video. I think this would work best as a complement to resveratrol. From what I've read they activate different areas of SIRT1. So using both gives more benefits. Also, I seein future videos you mention olive oil and avocados. I'm guessing for oleic acid? This activates SIRT6 (as well as SIRT1) which needs more research! SIRT1 gets the fame for now but SIRT6 may be just as important or possibly moreso for longevity! Can't wait to see that episode! I've always tried to include olive oil in my cooking. Also love to eat avocados but man they go bad so quickly, it's much harder to incorporate them in to my diet.

[@tripleseven8361]

Costco sell small Guacamole packages, that are individually packaged, and I’m guessing, have enough avocado 🥑 in each package, to satisfy a healthy daily requirement, whilst avoiding, having to toss out the over-ripe avocados…

[@TriangleDancing]

@@tripleseven8361 That's a good option, although I don't have a Costco membership so I'll have to go another route. Chipotle makes great guacamole too, and I'm sure most grocery stores sell it too.

[@Jerry-du5yt]

Refrigerating avocados greatly extends shelf life.

[@isaacwhite7411]

good info

[@WellnessMessiah]

Good to meet you Isaac, you're very kind!

[@randomstuff5237]

Hi. Brilliant video thank you!! I am a 57 year old woman. I have been taking 500mg of good quality nmn and 500mg good quality trans resveratrol per day for about 2 years. As far as I am aware, I am healthy, but am feeling my age!! I am very interested in your information on resveratrol dosage and am now going to reduce my resveratrol dose down to 100mg per day. As at my age I am likely to have senesent cells, I am going to take 1.5 grams of Fisetin for 2 days per month. Many thanks for your wonderful information

[@JonnyLWarren1]

100 mg every other day or Mo We Fr, also Pro Healthy Longevity has a 30 g powder version for $40, so you should buy from them, because all other companies only have available 100 g powder version for more than a hundred bucks, and all these powders expire in less than two years so there will be a lot of waste if you go for the bigger container

[@GreatScottByJoe]

Did it work better at a lower dose

[@joeblow2183]

Not boring. Need to learn

[@WellnessMessiah]

Thank you Joe 🙏 comments like yours def help! I guess I didn't bore you to death haha

[@ryantiltman260]

Also doing 1g p/d.. What do you guys recommend? Thank you.

[@nutritionlifestyle]

Thank you.

[@WellnessMessiah]

Thank you for saying hi!

[@revealanation7778]

There are 2 great doctors that I love to listen to on dealing with cancer, Dr. Seyfried and Dr. Burzynski. Cancer survives on Glucose and Glutamine, get both completely out of your diet, especially if your dealing with cancer!

[@tamenewasiuk9845]

Is there any particular brand of resveratrol supplement you recommend? Thx!

[@GibaGouvea]

Hi, Maybe I know why Sinclair takes 1g of resveratrol. It is because the absorption of resveratrol. You need to multiply the resveratrol dose and the absorption rate. Please, what have you found about absorption rate of resveratrol together with fat?

[@jerrywest7068]

When doing the senescence purge I think it best to do while fasting.

[@cassopeia9]

Thank you so much, Rimon on this video. I did ask about Fisetin in light of dose dependency of Resveratrol. If I get you correctly, you think that 1.5g of fisetin in one day once per quarter for 70kg 55-60 year-old people? I know that nobody can tell until more solid studies emerge. I somehow feel that it’s too little. This strategy is acute stimulation instead of chronic which does make sense. However, why so different from Resveratrol of 100g every alternate day? 100g every other day also totalled up to 1.5g Resveratrol per month. Would like to understand why “chronic” intake of Resveratrol but acute intake for fisetin? And why not 1.5g in a day per month but per quarter? Could it because you’re being cautious in light of the Resveratrol surprise and that fisetin studies even more lacking? BTW, what do you think of spermidine?

[@WellnessMessiah]

Hey cassopeia - not a personal recommendation or medical advice: We know how it works per dosage, which I don't with fisetin quercetin. They are probably similar. 20mg/kg works to kill cells (resveratrol cancer, and they senescent and possibly cancer too) and 0.5mg-1mg/kg increases the longevity of cells.

[@peterz53]

Agree, you're too young to treast SCs. I'm in my 60s and started taking Q and F monthly for 2 to 3 days at the doses used in Dr. Kirkland's trials. I'm not sure that Q and F are used togther so will recheck trial protocol. I alternate between F & Q (every 2 weeks) and divide into two doses per day. I am also not sure if doses are given as a bolus (all at once), or spread out over the day, and whether to use fat or black pepper to help with absorption. I take with a little fat (black olives or cocoa beans) I started donating plasma once a month (25% of plasma volume) at my local blood bank based Conboy studies, which among other things showed reduction of senescent cells in the brain. Very important topic, so hope ypu keep investigating and posting your findings. Thanks!

[@antonystringfellow5152]

One thing that will boost absorption dramatically (maybe too much) is Soya Lecithin. One study showed that ingesting these polyphenols with soya lecithin increased blood concentration levels as follows: Quercetin X20, Fisetin X24, Resveratrol X29 There seems to be 2 factors at play here. The first is that lecithin is a phospholipid emulsifier and so helps in the absorption of molecules that are hydrophobic, as these polyphenols are. This is probably the main factor. The other is that lecithin can also protect the polyphenols so they pass through more of the gut, giving them more opportuntuies to be absorbed. It also helps to have a high concentration of Vit C in the blood - this seems to increase the time it takes the body to metabolize them. I mixed 500mg Quercetin powder, 300mg of Trans-Resveratrol and 500mg Vit C (in paste form - from a capsule) with 1000mg of Soya Lecithin, on a slice of wholemeal bread (also said to help absorption). After watching this video, I realize may have overdone it a bit with this combination (understatement). Thankfully, I appear to be fine and my kidneys are still functioning normally. I'm not taking anything at the moment but I think I'll adopt the hit and run approach in the future, and with much, much lower doses. Btw, soya lecithin also has a few of its own health benefits and is used extensively in animal feeds. That includes food for dogs, cats, fish, turkeys, chickens, cattle, pigs, etc. It increases nutrient absoption, stress resistance, regulates the immune system, significantly reduces bad cholesterol, reduces fatty liver deposits, boost bile production, among a few other things (can't remember the full list) - odd that we give to all our animals but not to ourselves. For obvious reasons, this combination requires a LOT more study.

[@peterz53]

@@antonystringfellow5152 thanks for new rabbits holes to run down. Yes, don't want to overdose. .i recall that quercetin may have a lower threshold than fisetin for kidney toxicity. But can't seem to find a solid dose.

[@WellnessMessiah]

Hi Peter, an interesting protocol you're doing. I want to get Kirland in the future on this channel, to get the new juice on these trials. It will take 3-5 years until we see papers, better to ask him now! You're very kind with your compliment!

[@serge_stauffer]

Great insight. I wonder if your conclusions still are true, when Resveratrol is taken together with NMN.

[@pablogomez4959]

Crazy complexity. I think we will have true health optimization when some kind of technology in the future helps us monitor our bodies every day. Maybe some kind of nanorobot circulating the body and sending data through bluetooth or something like that.

[@sweeterasmus]

What if I exercise everyday? 5 times a week resistance training and 2 a week aerobic exercise. When would you take it? Right after exercise to be almost 24 from the next session? Or in the middle in between?

[@pkwan78]

Thanks for the useful insight! In the light of all this, could you share with us what might be considered as low dose resveratrol for humans? What dosage of resveratrol are you taking currently and are you taking it daily? Thanks and please keep up your good work!

[@WellnessMessiah]

Hi Pkwan, how are you? You're very kind to compliment like this. Simply go to the end of this video: 22:00 kzbin.info/www/bejne/pJyUnIh3lMSjb80

[@pkwan78]

Hi Rimon, thanks for sharing your personal protocol on resveratrol. I really appreciate your excellent work in connecting all the dots for us in the research literature. It has been so enlightening and beneficial! I have some difficulty finding a 50-120mg resveratrol as most brands I can find online have higher dosages. Would you be able to share with us a brand that has this dosage? Thanks once again!

[@WellnessMessiah]

@@pkwan78 I'm going to share that in the 10 habits video. Around I believe 27:00 I show the following episodes:)

[@pkwan78]

Thanks, Rimon. Looking forward to your next video :)

[@diamond_s]

@@pkwan78 I'm not Rimon but there are two low dose 98% resveratrol pure products using resvida on amazon. There's youth theory that has 25mg capsules and comes with 290 capsules, there's also 100mg resveragel from staywell that comes in 60 and 120 capsule forms. There are other products as well using resveratrol from other sources, what I'd say is avoid low purity as most resveratrol comes from japanese knotweed which has significant emodin and emodin is bad for telomeres and emodin is also a laxative, high purity 98% or 99% is better.

[@meanderthalensis]

It is really great research, thank you for making this video. What does not make sense to me is that Sinclair continues to take 1g resveratrol per day. He would be aware of this bifurcation in response depending on dose, but he takes a high dose anyway. Perhaps he thinks the synergistic effect with NMN is of greater impact than the apoptosis promotion

[@WellnessMessiah]

Hi J Singh it's a speculation, and you had a very good one! Especially, it's interesting after the 2021 human study that included all known human data on resveratrol dose vs 3 aging parameters: kzbin.info/www/bejne/g3-yZYhrrMd5Zpo

[@sweeterasmus]

If antioxidants may not be wise to be taken in early ages, what's your take on green tea / EGCG supplements? May that be detrimental? Specially before exercise?

[@julianajuresic5574]

Hi Ramon, I didnt understand the part where you said that if you were 70 you would take Fisetin every quarter for one day. Did you mean every quarter of the year for one day?

[@jazzisback]

HELP! 60y you would only take 1 pill every 3 months? Sorry, I didn't understand it. Could you give us a regimen of how much of what we should take? I'm confused now.

[@dougnettles2308]

Rimon, please tell me your opinion on how much Fisetin to take as a "Hit & Run" dosage for a 65 Kg man 67 y/o. It's very confusing on dosage due to the new info on Resveratrol.

[@WellnessMessiah]

Hi Doug, not a personal recommendation/ medical advice. We don't know yet the best dosage, it seems that 20mg/kg works to kill cells (resveratrol cancer, and fisetin senescent and possibly cancer too) and 0.5mg-1mg/kg increases the longevity of cells. Kg of weight I mean, which is 1kg=2.2 pounds. I intend to share more on the discord for my patrons in October.

[@cosmospray]

I started fisetin with quercetin + resveratrol today and was flushing as hell immediatly after, what is happening. 300mg resveratrol and very low dose of fisetin and quercetin. Even scalp was itching. I took it with my habitual vit a+d pill NMN 250mg/ this morning 🤷‍♀️ I am a 39yo woman with very good health. But i had a long covid in 2020 completely healed since 2 years.

[@lungarotta]

May be I missed it but you did not say how much quercetin one should take and how long, is it the same as fisetin (I'm 72)?

[@rudieye6666]

Hi, thanks for great insights! I’m 60, a woman in great shape and a hectic life, that is, until 5 years ago when after a period of extreme workload collapsed and ended up with what is commonly known as ME. I’ve radically changed my lifestyle and doing “the right things”. Lately I’ve become very interested in the longevity aspect since longevity equals health. But I believe I may have reached an accumulation of senescent cell build-up due to that chronic stress I went through. My question is whether I should take Fisetin or Quercetin in a high dose for a short period of time and what would you consider to be a high dose (1g?) and for how long is a “short period”? I realise more studies are needed and coming up soon, but I would like to start before we have all the complete answers - at my own peril, as most of what I do is (conventional medicine has nothing for me). Would be so happy for any reply and this may be a question concerning a lot of people!

[@nikola_korneta]

From what I heard from one doctor he, in his 50, takes 1g of quercetin for 7 days then pauses for 21 day.

[@youtubeuser1105]

Hi Gertrude, how are you getting on? I've had M.E/CFS for 22 years (since age 15, but I think it gradually started from age 11). I'm very interested in all of this for the same reasons. I just tried a 3 day fisetin "flush" (1600mg/day for 3 days). Hasn't had any noticeable effect, unfortunately! I've also been on 1g of quercetin for a few years now (before information like this video came out! I might stop or reduce that one now!).

[@rudieye6666]

@@nikola_korneta Thank you!

[@rudieye6666]

@@youtubeuser1105 Thank you for your answer! I haven't started yet (still on my refrigerator shelf unopened, as is NMN). Still collecting answers to all my questions. I realize nobody knows the RIGHT answer, so I'll try to do something in between. I guess I'm afraid to start and get disappointed as you must feel,. I'm sorry to hear you feel no change as I'm really hoping this is it for us. It's so sad to hear you've been living with this debilitating condition for so long. We don't have time for this sh**! I imagine you've tried 'everything' over those years. Well, I hope the Covid long howl research (that's where the big money goes) will find a cure and that will trickle down on us. Hope is the last to die! Do you take Berberine, by the way? I wish you well!

[@gambit633]

Soo question... I should switch to high resveratrol while fasting? Low otherwise. I aim for apoptosis while fasting, because elsewhere I read that the body is intelligent and during apoptosis targets plaques (e.g. Alzheimer's) and early cancel cells. FYI I regularly fast (only water+vitamins+minerals) for a couple of weeks every 3 months and lose 20 lbs (which I regain on purpose over the next 3 months).

[@birgittadevlin4206]

Have I missed something? If low reservatrol stimulates cancer cells (besides repairing healty cells), why would anyone opt for that? Who knows if they do or do not have a tumor cell...?

[@WellnessMessiah]

Hi Brigitta it does not. What it does, it helps cells survive to live longer. This will not increase nor decrease cancer development. However, once a tumor is formed, it can use resveratrol to survive. I explained it here (check minute 18): kzbin.info/www/bejne/mXW3mGWoeNGfg5o&ab_channel=WellnessMessiahwithRimon

[@ElK.-qv4ol]

so then wouldn't taking low doses help the tutor to survive@@WellnessMessiah

[@babatarot]

My RDW is low and MCHC is high , can it be a side affect from takingNMN 600mg with resverortal 400 mg with Quercetin at 800mg and also 100 mg chlorophyll!, NAC ! Milk thistle Am I inducing cancer in my blood ? If so how do I reverse these affects and bring my bood levels back to normal I'm 51 with autoimmune disease 😢 and calcium score of 174😢

[@thomasrebotier1741]

Should senolytics preferably be taken during a long term water fast ?

[@KJ-um1gq]

So what is the optimal dose, Rimon?

[@oneinabillionfun4284]

Good job mate. But honestly have you seen Sinclair last year? He looks younger than before. He looks like 30 now. So I think all he does make sense, even though I agree with you low doses of resveretrol and quercetin and fisetina are not needed in our 30s. By the way have you found anything for combatting grey hair?

[@WellnessMessiah]

I agree he looks young. It could be his genes, his height (smaller people age slower, he's I think 5'6. Dwarf humans live commonly till 90 ), or the fact he has been cutting sugar in the last 20 years. I find it difficult to believe that high-dose resveratrol did it, although he could have genetic variation, which I hope I have too since I used to take his dose.

[@oneinabillionfun4284]

@@WellnessMessiah so if I am correct you take 1 gram NMN everyday and resveretrol less than 200 g every other day? Also, do you take metformin (or berberine) as well before sleep?

[@elainecharette8202]

How much then for resveratrol? What is a low amount?

[@kimmynordahl6406]

I got sick from resveratrol making my blood pressure extremely high and I had to visist the ER several times before I understood that it was the resveratrol which made me sick. I took resveratrol every night with a high fat meal for a long peiod of time in doses between 600 - 1200mg and I've never been so sick in my life. My heart really worked hard and I got hypertension headaches & muscle weakness. I'm not a sensitive person at all and I've worked with supplements and taken alot for 10 years and never before got sick by supplements. I'm 31 and I'm a fully healthy individual who has never had high blood pressure before. I took resveratrol because nothing helped my tinnitus better than resveratrol for some reason. I'm not saying I believe it's necessarly bad just because I got side effects but definitly alot we dont know yet. Maybe Its better to take lower doses and less often as said in the video. This all happened 6 months ago and now when I took resveratrol 600mg just 5 days in a row again. I started to get some degree of the exact same symptoms back, which is scary, heavy chest, pounding heart, unregular heartbeats, diarrhea, weakness and terrible insomnia

[@diamond_s]

You should also check company that provided the resveratrol. There is rampant fraud in supplement industry and many companies even put dangerous and illegal drugs into the supplements they sell while containing none of the actual supplement.

[@TerriblePerfection]

Have you tried a carnivore diet for your tinnitus? Many people have been helped by it.

[@DT-lf2up]

Rimon, why then Sinclair takes high dose of Resveratrol according to his protocol even in his most recent interviews he is referring to high dosage reference of Resveratrol? And thanks for the update 😊

[@WellnessMessiah]

Hi DT it's a speculation. He has been taking high dose since 2004. Many of these studies are 2020-2022. I do have the last chapter in this series "speculation on why Dr. Sinclair does X". pretty disgusting content, but entertaining nevertheless.

[@DT-lf2up]

@@WellnessMessiah Makes sense. Then waiting for your next video 😉

[@ronaldpark87]

So may I ask whats the standard of low and high dosage for Resveratrol? Im taking 2G (1G Separately) daily

[@WellnessMessiah]

Hi Ronald, The standard of low and high dosages for Resveratrol is a lot of extrapolation. My extrapolation is as such: 0.5-1.5 mg/ kg of body weight. High: 20mg/kg.

[@rmh3657]

The comments about Resveratrol & exercise are not clear to me - Can you please clarify?

[@jenxsj3902]

Can someone tell me how much Resveratrol I can take daily to achieve a positive effect?

[@KuumbaOnline]

What is considered high dose resveratrol? How much and frequency... What are the numbers?

[@WellnessMessiah]

Hey there - not a personal recommendation or medical advice: We know how it works per dosage, which I don't with fisetin quercetin. They are probably similar. 20mg/kg works to kill cells (resveratrol cancer, and they senescent and possibly cancer too) and 0.5mg-1mg/kg increases the longevity of cells. Check minute 22:00

[@zer0nix]

Sinclair mentioned some peptide discovered by Chinese researchers that reverses senescence rather than killing those cells,but he kind of garbled the pronunciation and I can't find anything on Google that resembles what Sinclair mentioned. Does anyone know what I'm talking about and can mention the peptide / molecule?

[@gloriagolemboski4515]

So what is low resveratrol dose.