What Happens When CRISPR Backfires?

CRISPR is touted as a gene editing technology to change the world, but recent studies show that it might actually be doing more harm than good.
Your Body Could Be Immune to CRISPR! Is This the End of Gene Editing? - • Your Body Could Be Imm...
Read More:
CRISPR gene editing is not quite as precise and as safe as thought
www.newscientist.com/article/...
“But in studies of mice and human cells, Bradley’s team has found that in around a fifth of cells, CRISPR causes deletions or rearrangements more than 100 DNA letters long. These surprising changes are sometimes thousands of letters long.”
Doctors In China Lead Race To Treat Cancer By Editing Genes
www.npr.org/sections/health-s...
“Now he's back at the hospital to get an experimental treatment. It involves using cells from his own immune system, known as T cells, after they have been taken out of his body and genetically altered in a lab by the gene-editing tool called CRISPR.”
2 new CRISPR tools overcome the scariest parts of gene editing
www.vox.com/2017/10/25/165273...
“With CRISPR/Cas9, the changes to the genome, or the cell’s recipe book, are permanent. You can’t undo them. With REPAIR, since researchers can target single bits of ephemeral RNA, the changes they make are transient, even reversible.”
____________________
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[@sebastianelytron8450]

It would become SOFTR and CHEWR

[@SimonValmorya]

when will i laugh to that joke?

[@Finnstreams]

Simon Obiña LAUGHTR

[@kyrlics6515]

@@Finnstreams LAFTR

[@kyrlics6515]

SLAUGHTR

[@kodaspaws]

all of you...get out.

[@e4r281]

If you genetically edit the lettuce genome, you can make it CRISPR

[@theyoutubewizard1126]

Okay. That was actually pretty good XD

[@benjaminjordan2330]

These are hard to pull off, we are all getting better but this joke is a good start

[@kyrlics6515]

Im stupid help me.

[@thr2648]

CRISPR what does it sound like

[@waynedalegend67]

😂😂😂

[@eliannam.5700]

I can confirm this. I've put my kids in the crisper and now they're spoiled.

[@cjenner865]

Humor done the right way.

[@scientistsbaffled5730]

See people this is how you leave a comment

[@MonkeyspankO]

lower the humidity a bit

[@makismakiavelis5718]

@@cjenner865 not if you don't know what a crisper is, which I don't.

[@MrPumpplayer]

think fridge

[@asianlim3000]

When CRISPR fails, you get Devil's Breath...

[@bakaexmachina]

Poor Harry.

[@Red-rj7sr]

@@bakaexmachina rip

[@patrickbateman4541]

DLC time!

[@Red-rj7sr]

@@patrickbateman4541 when is it coming out

[@patrickbateman4541]

@@Red-rj7sr no idea but it is.

[@CanadianPrepper]

The why probably has something to do with giving big pharma time to prepare. Gene editing is like what Tesla is to big oil.

[@anthonycapitan5802]

No, I'm pretty sure this is actually dangerous.

[@jonz23m]

Hope you know there are is a difference between the complexity of batteries & electric cars and life🤦‍♂️

[@Quinnandfriends1]

'What happens when Crispr backfires'? Supervillains are born, that's what happens

[@Mustachioed_Mollusk]

Wrong universe unfortunately

[@The_Natsu.]

Real furries. /jk

[@scylla019]

Then you gotta call Spider-Man to stop the devil’s breath

[@Danny-jz9mj]

Omega or evil super soldiers

[@blackgriffinxx]

Think The Fly the 90s one . Warning don't crap your pants !!!!!!!! kzbin.info/www/bejne/hHmQaX9nnr-kaJI This make cancer look good

[@zefellowbud5970]

this is why i prefer Cybernetic Augmentation

[@gavinstarks2761]

Until your body rejects foreign objects. Ya no. I'm good.

[@VariantAEC]

@@gavinstarks2761 This is a common musconception you're body doesn't often become allergic to non-bioreactive elements which is why we use them as implants. The only reason why some metal implants become toxic is due to the way they were handled or treated before implanting them. For example a corroded metal implant will react with your biology in a negative way but if the implant doesn't corrode because it was polished better or otherwise treated so that an oxidized layer isn't allowed to form inside of your body then the chances that you'll become allergic is so low that you actually just might be the first person with any kind of negative reaction at all! On top of all that augmented limbs don't need to be implanted at all they can exist as a totally independent part and may be allowed to interface with your brain activity in a slightly more passive manner through transdermal neuro stimuli detected by next generation of electrodes placed on the artificial limb. When the limb is touching your skin if can still act as if it was connected directly to your brain even though it's not actually physically attached to your body at all.

[@sf6555]

Resistance is futile

[@gavinstarks2761]

@@VariantAEC I'm talking about how organ transplants can go wrong and it's not about becoming allergic to it, its whether or not the body accepts the foreign (nonbiological) material in. A lot of people can get the controllable prosthetic arms because of 1. Injury 2. Some bodies straight up reject the object and due to it not being a biological material, it is worse. Yes some people are allergic to certain metals and its possible a metal can be handled wrong but in the end it's up to whether or not the body is ok with the transplant. I have a friend who unfortunately doesn't have much longer left due to a rejected liver.

[@ijusterik5384]

@@VariantAEC forgot allergies bud

[@michaelaltun]

I love this channel and their videos. Great production quality and love the hosts

[@afroninjaman1]

Recent undergraduate degree in Molecular Genetics chiming in. I began my degree around 2013 when CRISPR was starting to make a buzz, and by the time I hit my 4th year we were already working with it in laboratory courses. It's an incredible tool, and certainly not one to be viewed as some "Scientific Boogeyman" that causes cell death and cancer willy nilly, but as the video states it does come with its fair share of problems (may of which contribute to this behavior.) Even more so than are mentioned. For example it is exponentially more time intensive to work with than the previous standard for gene editing (restriction enzymes, same idea but they only cut at one specific sequence as opposed to being "programmable" and able to cut "anywhere".) That's because CRISPR/Cas9 requires you to make something called a small guide RNA, which is the template the enzyme uses to check the DNA sequence for the correct place to cut. In the lab, in a perfect setting, it took us 6-8 weeks of 4-8 hour days just to generate these RNAs. And that's if nothing went wrong in any of the various steps. In Molecular Genetics due to the incredibly small volumes, concentrations, and unknowable microscopic sources of error, you will have experiments fail, and frequently. So those set backs add even more time. And, once all that work is completed, the sgRNA you generated might not even WORK. And if you didn't choose a spot to cut carefully enough, or it wasn't specific enough, you could be left with something that cuts everywhere, or not at all. So in addition to off target effects and STAR activity (the enzyme cutting non-specifically due to design or experimental conditions) and the large deletions the video mentions, (likely caused by erroneous repair of off-target cuts from the enzyme), there is the aspect of inefficiency. If you are looking to do something highly specific that traditional enzymes just can't, CRISPR/Cas9 is awesome, but it's still a new technology and a pain in the ass at that. Personally I think the delays in human testing are justified, if for no other reason (i.e. morality and the whole designer babies debacle) than the fact that at the moment it would be like giving a surgeon a chef's knife instead of a scalpel to perform an operation. Sure it's sharp and it cuts potatoes and chicken like butter, and the surgeon might even be able to pull of the surgery with it, but is not the best solution and requires more refinement before it can be put to the test with a person's life and well being on the line.

[@afroninjaman1]

I should mention it was 4-6 weeks of meeting once a week, so if you were working on it 40 hours a week you'd be looking at 1-2 weeks if you did everything back to back. A lot of the time is waiting, so it's easy enough to slot other experiments into that time, but it is nowhere near as "plug and play" as traditional restriction enzymes.

[@illiterate.ink.]

Then my dream of Eagle vision will get out of hand and I'll see the germs on everything and become a sanitary hermit

[@rwc1940]

"Genetic power is the most awesome force that this planet's ever witnessed, yet you wield it like a kid that's found his dad's gun."

[@craigcorson3036]

I was hoping this would be a Maren episode. You look great as always, Maren. Love the shirt!

[@MarenHunsberger]

Glad you liked the video, Craig. Thanks!

[@nano7586]

I really like how these videos are produced.. especially the sound engineer made the high end sound CRISPR af

[@BobMcCoy]

*CRISPRs are pretty good, I like BBQ flavour*

[@1337ofDiscreet1]

psh... salt and vinegar..... Ok both c:

[@benjaminjordan2330]

I like my BBQ CRISPR...Y than most people

[@kodaspaws]

smh....just stop.

[@landoc3761]

all dressed

[@immaforce-a-naturedaily9440]

Genes create forces-a-nature

I really like the way this channel explain science... And I love her glasses 👓🙂

[@angelic8632002]

Which is why we are already working on more modified versions of CRISPR that are much more accurate. You got to remember where CRISPR is coming from. Its a function of a virus(edit: its a bacteria. My bad) we have hijacked, but its still has largely the same functionality, and bacteria are a bit less caring about the damage they can cause than us, as it doesn't cut into their evolutionary fitness to a large degree. Simply put, there's been no strong(there still is) evolutionary pressure to make it better than it is. Which is why we need to step in and guide the process. All in due time folks. Be patient.

[@Manganization]

I'm having trouble understanding your post. Are you saying we should make this virus more potent to get what we want (because this sounds like a disaster in the making), or are we talking about guiding the virus into making more precise deletion?

[@Revan2662]

Wait, I thought the CRISPR method was derived from a type of immune response in bacteria that survive an attack from a virus. They take the injected DNA and implement it into their own in order to be able to identify it later and prevent it from taking over.

[@angelic8632002]

@@Revan2662 Oh darn, did I mix it up? Yea that sounds correct, I'll edit my post. A slip up on my part. The cells ability to do that though is from a virus.

[@angelic8632002]

@@Manganization No more accurate. And it has no other function and dies out with time.

[@Manganization]

+Simone, thanks for clarifying.

[@tiaanvdriel]

CAN WE PLEASE GET A LINK FOR THAT BACKGROUND

[@henrymonroy9533]

I am for progress in scientific knowledge and methods, so long as it's tempered with wisdom and prudence. Afterall , the goal is to better life, not harm it. RIGHT?

[@bangseto6847]

I need update information about research that oxford done for hiv cure. In the past it said that the result comes this year

[@anbumani6083]

I have been searching on various sites regarding the test result of lung cancer patient in china. But right now i know its not published anywhere. But if anyone finds what happened plz let me know.

[@hasher2265]

It will be interesting combining these tools with exponentially more powerful computer systems and more delicate sensors. You could accelerate evolution in a more regulated; controlled environment.

[@cmeyerowitz]

Other gene editing protocols using zinc finger proteins (ZFPs) have multiple ongoing trials (Sangamo), so not all gene editing trials are being halted

[@TommoCarroll]

*I'd love to hear what people think about the future use of genetic engineering technologies like CRISPR - does it worry you? Fascinate you? Would you want it to be used for something in particular? And what about genetic engineering on humans in general? Whatever really - what do you think?* 🤔

[@hansolo4017]

Uneducated people will hate it because of all the bad rep it's gotten in the media (films) like thry don't even know that we have been genetically engineering our food for thousands of years and yet there's all this stigma

[@genocidegrand2057]

it will happen sooner or later. human edited dna gonna ubiquitous in the future. morale not gonna help with the research. it's the same thing back when people started doing operation and sewing your skin. back then they are considered withcraft and evil. if china dare enough to do crispr on human they gonna lead the technology. but probably usa gonna try to steal it after there are some result, by saying china is doing immoral and horrendous thing. it's what happened with nazi and their human research. lot's of them are used nowadays and being patented by usa. slick huh?

[@djentlover]

*Shut up with that bold text*

[@e4r281]

Like in-vitro fertilization and cloning before it, CRISPR won’t be without its ethical concerns and technical hurdles. But if we can move past that, Crispr has the potential to be a major game-changer for the health of the environment and we humans that occupy it.

[@tec-jones5445]

I love how this thread is starting out. I couldn't agree more!

[@wildbill3613]

I agree we need to move cautiously in manipulating dna in people. While we certainly know a lot about dna now there is still far more we don't know, the fact that they did not even see the collateral damage initially should scare the heck out of them. It is always hard to decide when it is ok to test on humans but in this case I agree that we need more time to ensure we really understand what is happening. As a programmer (of machines) I can tell you that minor edits on large programs can have all kinds of nasty impacts even in the hands of highly skilled programmers. My guess is dna is the same.

[@amphibiousone7972]

What do you mean could be used for editing crops? I think they already have been. Fact is they have been using many forms of gene editing on crops for quite awhile now. Yes we do need to take a step back and , proceed more carefully.

[@CosmicErrata]

Every time, I hear "I'm married, and thanks for watching Seeker."

[@ped2028221]

Not married

[@fuzzylumpkin8030]

Thanks for the update tell those dang scientists sort it out I got work to do they can keep there blue eyes I need gills and other cool stuff for exploration

[@filthyE]

At the end of the video, I thought she said: “I’m married. Thanks for watching seeker.” 😂😂

[@greenthizzle4]

filthy is she though? That's the real question

[@filthyE]

Jake Mitch 🤔

[@souravyadav4825]

I know 🤣

[@infoharvester]

Love this new presenter x

[@zodiacfml]

I agree. It is even more dangerous than nuclear technology. If one fancies zombies, this is the closest tech to get there

[@dnaann1867]

Aren't almost all the cells in the body supposed to have the same DNA,won't the body reject these targeted changes.

[@evaristegalois6282]

2:24 "The human trials have been delayed ... " I guess delays affect the gene editing world even more than the gaming community ... (shots fired at Persona 5)

[@terrysalava6981]

I have one game for this comment. Bannerlord

[@nh-wq6sw]

KH3 takes the cake

[@automaton4090]

FFXV basically got delayed for 10 years

[@twizzz2013]

If the human trials have been delayed how has there been “several new studies?” It’s funny too, because I bet in 5 years it’ll be leaked that rich people have been using it while everyone else has been waiting for the human trials to start.

[@nh-wq6sw]

Noah Sharp and military. They are half a century (at least) ahead of the general population

[@0r3os08]

How exactly do they cut the DNA, I don't think they make scissors that small.

[@greenthizzle4]

0r3os92 they do out of carbon nano tubes and graphene, you just snip snip snip.. baby got eagle wings and shit

[@TheGroundedCoffee]

Magnets.

[@hazardousmaterial5492]

they use a protein from the enzyme group, whose job it is in normal circumstances to make the atoms in a specific spot of DNA to seperate

[@jojibot9193]

It’s an enzyme

[@BuddyL]

Interesting development.🔬 What's the latest with stem cells?

[@theoriginaltroll4truth]

Goes far beyond cancer risk!

[@Arbulatov]

Where can I see a video of the actual process? I mean in real life, not a cartoon or an explanation. The work itself.

[@darkpokemon0426]

at 1:00 you listed taiwan as part of china :(

[@gibbyace5077]

Failure is always there, we Just need to try and Research more! PUSH ON LIKE A MAD SCIENTIST! ITS SO COOL SUNOVABICH

[@shawnl3151]

No undelete?

[@corbbing]

I just realised I was moving my head around trying to see through the glare in her glasses.

[@ssshukla26]

So basically it's equivalent to "git --reset hard " but without backup. Great.

[@jayh0086]

How are you doing Maren?

[@thatyougoon1785]

you can edit crisper-cas9. Increasing its accuracy is very plausible since crisper-cas9 was not designed to be very accurate (in a complicated way) since it was evolved to destroy viral DNA in bacteria and viral DNA evolves.

[@zegzeazon5682]

On the contrary, *CHINA* has been publicly *publishing* many of its *_breakthrough_* CRISPR studies in international peer-reviewed journals (e.g. *Nature* ); albeit caveat are included in the context of ethics and varying laws across different countries. Also, *Cas-9* is just the first paired version of *CRISPR.* Aside from the aforementioned in the video *MIT* & *Harvard's Broad Institute* also have *Cpft1,* which allows for greater specificity of edits. The issue of *p53* gene has long been *retracted* by its _investigators._ The said study originally appeared in the journal *Nature* and had since been rectified by the former considering that their were a lot of *faulty premises* and *wrong assumptions* to begin with. Nonetheless, *CRISPR* brings in both *promises* and *perils.* It will surely _transform_ our *society* and _redefine_ our *humanity.* An oversight and regulatory measures must be in-placed not just from the *government* but from *all pertinent sectors* in the society whose *well-being* and *general welfare* would stand to *benefit* (if all goes well) or *suffer injury* (if something goes berserk). Nonet

[@wemusthavechannelstocommen619]

I read *CHINA* in Trump's voice.

[@SeeMoreLevingthon]

Crispr needs a way to create backups before acting.

[@TheEmpireOfOne]

I'm interested in what will happen once these test subjects procreate and pass on their edited genes through a few generations. Perhaps serious abnormalities (or benefits) will only be seen generations later.

[@tahneethompson6012]

depends on whether the first gen gained benefits or abnormalities from the changes in their DNA

[@benitollan]

I love the smell of DNA in the morning

[@glockel4308]

@Zero Cool dumb joke. also dna isnt just in semen

[@glockel4308]

@Zero Cool i know, HOMIE. but cum still isnt the only thing that has dna

[@glockel4308]

@Zero Cool P.S. humour IS subjective but if the majority of people find your joke bad than its objectively bad

[@glockel4308]

@Zero Cool dude cmon, look at the joke and tell me its not bad

[@glockel4308]

@Zero Cool its 2 pm and you're right, i should.

[@Metacognition88]

So how long before i can be like deadpool?

[@belewyifru3624]

Good point!

[@lavaforevah5869]

Notification scientists

[@crownoforigin]

Is this Gundam SEED reference?

[@andrewharbit7449]

That's the sweet spot develope anti aging that targets RNA so once you stop getting the treatment your cells presume aging...that's where I see that going.

[@scenenuf]

What about affecting someone to the point that they can't reproduce when they grow up, like I have no idea how this works but I'm sure it only does to those that aren't born yet.. and predisposing them to other diseases and cancers and disabilities that we don't know are there before they are born and taking away there right to reproduce in fear of it mutating and doing more harm to overall humanity.. isn't that hitting a pretty large humanitarian right.. If that person were to break away and attempt procreating if they can, like will they be stopped by whoever owns them as the experiment, or will their life be payed for till they die as a an experiment. Haha I am all for it but this was the first thing that came to my mind..

[@pieflavr]

InconsistentlyConsistent Cauk this is why research is being done.

[@scenenuf]

@@pieflavr human trials have to go ahead before they know for sure.. hopefully Chinas human testing will be the research we need. But my concerns still stand as no other trials would be able to predict y concerns without actually testing it on a human first. So do those experiments if they make it to a certain age gets choice over their own life or are they just need experiment aga

[@mickelodiansurname9578]

Crispr and other techniques like Abe and so on work on any organism of any age. Its a genetic therapy that is not a germline modification. That means your genome would be affected but it will not be passed on to offspring. So any mods to the genome are not hereditary. It does this by basically infecting the host with a bacteria carrying the modified instruction set. Many people don't realise this but every bacterial and viral infection you ever went through altered your genome slightly. You really are different to when you were conceived and born. So these methods just infect you with a designer infection. Its obviously more complicated than my explanation there but as you pointed out you don't know a lot about genomics, so I apologise if it sounds like I'm talking down there. .

[@scenenuf]

@@mickelodiansurname9578 no that does actually make some sense to me, thanks :)

[@coolworx]

What good is any of this, if we destroy the environment that sustains us?

[@wubforceone]

genetic edited could and already is beneficial in some ways to sustaining us. faster growing higher yield crops. modifying all the animals we farm. just think of all the implications this could have. they are already trying to modify some plants to get us a truly sustainable and cheap biofuel. which is the issue right now, like ethanol and algae they are insanely expensive to process, this could all go bad too, like everything else on the planet there is a good side and a bad side,

[@rajivarumugam6658]

Did she just say at the end of this video that she is married? Where did that come from?

[@sweiland75]

She said, "I'm Maren." because that's her name. Maren.

[@Yesica1993]

First time hearing the term. Sounds like a sci/fi/horror flick.

[@LungsOutJem]

Can you turn off that beeping in your background music? It's really distracting.

[@passengerprincesspodcast]

😬😬 this is way worse than I expected...

[@EXMachina.]

it get extra CRISPY

[@ethank5681]

The girls shirt makes it look like she drooled all over herself

[@isaiahdobesh5109]

1:12 I feel like this should be a no brainer. As well as 3:04

[@zegzeazon5682]

_Every _*_beacon_*_ should be _*_CRISPR!_*

[@BEYONDComfort]

Nice shirt!

[@cro9364]

What shirt? I don't see a shirt.

[@JLS_999]

@Jam it's a rocket..

[@xBigBean]

It looks like she sweats in really weird ways

[@filthyE]

Matty Man lmao idk why this made me laugh so much

[@naliniegunatilleke2279]

Notice that they said _when_ not _if_ ...

[@tyrgodofwarlawjustice213]

Why don't you guys talk about a Phenotype Revolution being an outcome with genetic editing especially adding AI into the situation

[@specialopsdave]

When it backfires, or IF it backfires?

[@mattk9708]

what about "MAGESTIC"?

[@tahneethompson6012]

oops i spelt it wrong

[@mattk9708]

huh?

[@anuragfreak]

we will get their eventually. no need to panic.

[@DeTrOiTXX12]

It can't apologize for being a new technology, like anything else, it will get better as we learn more.

[@sandipkumar322]

Dear maren, could you please reveal your fitness secrets.

[@TranscendingPolygons]

"...but why?..."

[@animex3183]

im 100% sure you alreaydy released this video a few weeks ago. or atleas a really similar one

[@ianstradian]

This technology is still leading edge, and leading edge in a way that has the potential to change humanity, history and our future as a species.

[@jinnensingh9391]

Nature is our (Human) Father So human can never became Father of Nature... It wud definitely lead to chaos

[@Baigle1]

needs to be done.

[@melchizedekpsj]

Safety first.

[@blitzkeir3750]

This just in! Cutting out barely-understood parts of your body *might not be safe!* I realize I’m a layman, that geneticists have a comprehension of their subject I could scarcely follow. But c’mon. This was progressing way too fast for major consequences to be anything but inevitable.

[@tahneethompson6012]

Technological progression is only going to get faster, and exponentially so at that

[@blitzkeir3750]

The general technological advancement of our species, certainly. But that acceleration should not apply to *specific* technologies. Reckless, hasty science-especially the medical variety-is unethical, and its consequences extremely well documented.

[@originalShorai]

I wonder how much the company behind those new editing techniques paid for a half-baked explanation of about half of what's done during a CRISPr treatment.

[@loganladue2]

I agree. At the same time, the FDA hasn't really been looking out for the people lately and more for Big Pharma so if lets say CRISPR did what it was suppose to do, would Big Pharma want it to be available asap?

[@sandm4n]

The Orchid happens

[@bjarnes.4423]

1:03 Tiny Alaska

[@R34L157]

The potential for greatness is unlimited. The potential for a children of men scenario is also massive. You cannot predict that which is inherently unpredictable. The Asgard (sg1) reaped the benefit and then the destruction of their civilization through DNA manipulation. We cannot rush blindly into this future, we need to see with both eyes what is before us.

[@Mark-uk8wz]

I hope it doesn’t go *Stale*

[@DEXEvolution]

In Deus Ex, electromechanical augmentations make you dependent on Neuropozyne, in REAL LIFE biochemical augmentations make you dependent on codeine So much for being ‘pure organic’ 😄 But seriously though, I am extremely itchy for the augmentation revolution to begin. Sacrifices must be made. No pain no gain 🤘

[@Delosian]

Or Warfarin, a blood thinner to stop clotting upon the mechanical parts.

[@djfirewolf]

The vocal fry is strong with this one

[@kartik0016]

I thought she said: "I'm MARRIED. Thanks for watching Seeker." :P

[@theguythatcoment]

What do you mean by taking a step back from the hype? the tech is out there, better and new methodologies to accomplish a successful mutation pour out of universities every single month. There's no step back from nowhere, only moving forward.

[@yeosyahzuan]

0:41 I bet this is from stock video. People working in lab aren't usually this hot.

[@andrewvirtue5048]

Yeah I can 50/50 vouch for this. When I delivered appliances at Lowes, I delivered a refrigerator to a genetics lab. From the areas I saw 60% of the workers were women. Some of those women were sexy.

[@BothHands1]

Many are, in my experience in S FL labs anyway

[@andrewvirtue5048]

@@BothHands1 new friend?! :D

[@Crispr00]

I love CRISPR!!

[@Mark-uk8wz]

Editing DNA is the best way to augment humans

[@DuckDad26]

I’m sorry but I couldn’t help but notice how gorgeous you looked Mary!!

[@mr.g-sez]

what did you think when you saw the rocket in between🤔😂 funny funny funny funny life

[@JesbaamSanchez]

Why would I ever want to change the color of my child, whatever color eye, hair, skin, (anything that isn't a mutation that can kill my child) I love him/her just the way they are

[@cjenner865]

Is anyone else admiring her glasses or am I the only one?

[@cryingwater]

At the end of the video, "I'm married thanks for watching seeker.". Me: I'm single, could you fucking stop stabbing my wound!

[@fb150185]

Of course it's of utmost importance to study this tech as deep as possible before moving to human trials too fast or to just assume it works as we want it.

[@tahneethompson6012]

you can't study a tech that's used for humans in-depth without testing it on humans

[@fb150185]

@@tahneethompson6012 actually you can. Just like they do with all other developments applied on humans. There are stages that make test it in many ways before testing on a complete live human.

[@rodigoduterte9192]

Imma be young forever and rule Brita.... Phillipines

[@infinite-sadness]

how's the purge of drug dealers going.

[@SimonValmorya]

@@infinite-sadness that ain't the official accnt. my answer to ur q, its still going. a lot of cities have changed for good because of that. more safer, more peaceful and etc.

[@SimonValmorya]

when will i laugh to that joke?

[@infinite-sadness]

@@SimonValmorya how many of them were thrown out of helicopters

[@BothHands1]

Half of them weren't even drug dealers, people have taken the opportunity to kill political rivals, calling them drug dealers. However, i had an uber driver from the Philippines who seemed to have a totally different take on what's going on over there, and basically wanted to suck Duterte off. So take that for what its worth. I guess a lot of citizens are into it. Or some of them, anyway

[@matthewzuelke6721]

The thumbnail is completely inaccurate

[@baronblackdragon9078]

CRISPR CRME 2018