"What is Apoptosis?" The Apoptotic Pathways and the Caspase Cascade

This 3D medical animation explains the functioning of the extrinsic and intrinsic apoptotic pathways. We start off by taking a look at the important role apoptosis plays in growth and development as well as removing DNA damaged cells. Then we see how activation of the caspase cascade occurs in each external and internal signalling pathway. Lastly we get a glimpse of cancer cells and their ability to block apoptosis.
© Elvire Thouvenot-Nitzan, 2016
www.elvirethouv...
This resource is shared under Attribution-NonCommercial-NoDerivatives Creative Commons license (CC-BY-NC-ND 4.0). You are free to copy and reuse this for non-commercial purposes but we ask that you acknowledge “Elvire Thouvenot-Nitzan, created in collaboration with University of Dundee” when doing so. If you remix or modify this material, you may not distribute the modified material.
Medical Animator
Elvire Thouvenot-Nitzan BSc, MSc
Centre for Anatomy and Human Identification, University of Dundee
Medical Advisor and Pathology Instructor
Richard Oparka MBChB, FRCPath
Department of Histopathology, University of Dundee School of Medicine
MSc Medical Art Advisor
Caroline Erolin BA(Hons), PGCert, MPhil
Centre for Anatomy and Human Identification, University of Dundee
Technical Advisor
Annie Campbell BSc, MSc
Technology & Innovation Learning Team, University of Dundee School of Medicine
Attributions:
This animation features the track “Enrichment” by Podington Bear. The track is licensed under CC BY-NC 3.0 and has been edited to fit the animated short.
freemusicarchive.org/music/Podington_Bear/Backbeat/Enrichment
The animation features sound effects from freesfx.co.uk.

[@orhantokur7811]

How about a round of applause for the people made this?

[@Lotus-mz5wn]

How about a round of applause for the Who created this creativity?😊

[@mangiemuncheez3130]

Oh yes definitely 👏👏👏👏👏👏

[@saiyemiftekhar9993]

Definitely. Kudos to people who made this.

[@meorhakim7139]

Sir yess sir!!

[@mikecullinan2226]

I really liked the Fazballs and Fazbeans

[@YouToBeVP]

i LOVE that clicking noise when caspases activate one another 1:50

[@ramen4695]

SATISFYING

[@gabrielahimsa4387]

same im triggered

[@umamasiddiqa3205]

Haha same

[@arishaquazi964]

😂😂yes

[@vivavida6748]

Right with all those sounds I get the whole process. I love this video.

[@georgepartington1714]

this was oddly very soothing to watch

[@Ramora-hu2wb]

George Partington I KNOW omg so relaxing

[@Lotus-mz5wn]

Yaaaaah, I am truly influenced by the greatness of the Creator 🙆‍♀️

[@rubaabdulrahman7196]

You made apoptosis so cute ! The bubbles and the popping sounds Are 💘

[@naeemchaudhary4728]

Love U 💞🤩

[@huiguo4779]

the best video on apoptosis ever seen

[@aminaamii3237]

True

[@parkmicrosoft3638]

Are you from china

[@AxelZaore]

This is by far one of the best biochemistry videos I've ever seen! :) Literally didn't wanted it to end!

[@mitsunori222000]

Yes, round of applause. Excellent animation and animation.

[@whomstdve4409]

pretty sure this is the cutest, most satisfying and relaxing biochemistry video ive ever seen

[@Liboo52]

Whoever animated this deserves a Nobel Prize and a contract with every school in the world

[@nehap4769]

This is one the best biology videos I've ever seen. Highly appreciated. Thankyou.

[@kaylaknaperek8320]

still one of the best biology videos I've ever seen, and graphics have only gotten better since five years ago:')

[@robincraven6544]

Very easy to remember the difference between intrinsic and extrinsic after seeing this animation, thank you!

[@Mazen_alrady_MD]

I really want more of this .... This is evolutionary ✨✨ Respect and love for all who made this ! It's absolutely peaceful and amazing ❤️❤️❤️❤️❤️❤️❤️❤️

[@john.the.beloved]

I kept smiling while watching this video. It's so well-made! Thanks so much!

[@naeemchaudhary4728]

Same here chootye am also like this vodeo

[@lakhdeepsingh9132]

This video is amazing!! Great animations, sound effects, a clear script which is basic enough to follow along, and a great narrator! Well done

[@argent5795]

This the best video I’ve ever seen in my entire life! 1 hour lecture about apoptosis and not a single thing in my brain. But this!!!!!

[@jeanettespiteri7180]

This turned my frown upside down, thanks! I gleefully bobbed my head up and down as I made notes and consolidated my understanding after stumbling through pages upon pages of module text!

[@mohamadesaam3767]

i usually don't like to comment in youtube videos but after watching this i think you deserve a thank you from my heart one of the best videos in medical field that i have ever seen

[@mikefedorovsky2577]

ASMR: The educational version

[@charlihilton]

This has totally chilled me out during extreme exam stress - thank you!

[@zanygee]

Caspases are so cool

[@uchihapaulo]

You're gonna love apoptosis after watching this

[@savannahc7587]

one of the most explicit and simple to understand videos

[@knowledgedaily1173]

beautifully explained and visually stunning

[@afifezehrayurtsever6812]

There is no better way to describe the process! Splendid animation!

[@thecoreybrown]

Awesome! We (as in I) need more animated videos like this! This is how I learn the best.

[@interstellaa]

could not understand a single thing my teacher was talking about thank u sm for this video 🙏🏼🙏🏼

[@amonmeleki4647]

This is the best video I have watched an apoptosis so far, I am learning while enjoying the music in the background, this is awesome

[@gokcen636]

Im biology student in university. Tomorrow I have a molecular biology exam. This video is very helpfull for me thank you so much. Good luck.

[@weeeeeoow]

this was very interesting to watch and informative at the same time, thank you. No amount of words can express how grateful I am for coming across this masterpiece.

[@adronung1892]

This is the best scientific video I have ever seen

[@anikaa7064]

This is the most adorable explanation of apoptosis.

[@teensdoc]

This is awesome!!!! I, have never seen a more simplified yet conscised explanation of Apoptosis. My standing ovation🙌🙌🙌

[@thewaysofwildflowers]

i am so soothed by the clicking sounds of caspases ❤ omg, amazing video and explaining!

[@sqtheeta]

Cant get better than this! The best video on apoptosis I ever came across. Thanks a lot!

[@amnaabdullah1949]

The bestest video for apoptosis biochemical changes

[@fionnahallea8907]

WE NEED THIS IN OUR LIVES

[@elgeneralissimo-s9d]

The sound of the activation of caspase cascade is relaxing.

[@MsMurat7]

Thanks a lot for this wonderful video. I have understood the topic in just some minutes even I once did not understand it by reading book ....

[@stevecarter7612]

This was helpful thank you. Strangely it was really satisfying too! The noises of the cascade and fas ligand binding where particularly satisfying. Great job.

[@afnanalyasi2567]

The best video for apoptosis! thank you, whoever made this amazing video

[@arminap.2487]

Thank you so much for sharing this with us. This video makes it so clear and easy to understand a rather complex concept. Respect to the people who made this!

[@anormalperson1284]

👏👏👏👏 Thank you so much.. I highly appreciate the efforts of makers

[@naturalphilosophy9649]

Thank you so much, now I can put it all together in my head, before I was confused by the details. :)

[@aakashbhandari5689]

Best video on apoptosis ! Super easy explanation

[@illbeback111]

I am currently preparing for my PhD defense and this video has great value to me :D

[@mukunthannarayanasamy4773]

Very good illustration and clear voice. Thank you

[@arundhanasekaran8693]

I love this animation and clicking sound

[@sebastianm.6875]

Beautiful sound effects!

[@Just_rated]

Best video on apoptosis Nicely animated To be precise cutely done

[@taraeicher4241]

Amazing video! Great visuals!

[@sayanihazra5493]

From 2nd yr of my med school untill now in my pg prep days it's always been my 1st choice revise apoptosis.. thanx for making this incredibly concise yet high yielding vdo

[@let4be]

Fascinating! I just can't stop watching various videos about cellular machinery. Unbelievable, how complex and beautiful it is all created by nature thru countless cycles of evolution...

[@hassaineimene5965]

@sergey F nature cannot do this by itself.There is always a maker who does it. God does not know what God is. How can nature do this?Can you leave board, iron and some wires and put them on the sand? Can nature make you a ship like this or a plane or a car? No it needs a maker ,and so does the cell ,its maker . He is the Lord of the worlds and the creator of everything,Glory be to Him سبحانك اللهم 🙏

[@ShadesofViolet8]

@@hassaineimene5965 Imagine seeing something as complex and precise and finley tuned and purposed. Yet they claim that it was caused through randomness and time... As if these organelles and molecules keep records of lab notes.

[@Mystical3030]

Awesome video...excellent explanation.. Thank u so much

[@autumnsellars]

ha, it makes so much sense now! Thank you! Very helpful.

[@EssienCharles-c2j]

I have never seen apoptosis made this easy. This is wonderful. Great job!!

[@EvaES97]

You know this is good when our Cellular Biology professor advices you to watch this. It is indeed incredible. Thank you. Cheers to all x

[@Th-th7sp]

I’m so lucky to have this video, many thanks 💕💕💕💕

[@caesarsmom]

this is the best explanation I've seen thank you so much

[@huyenkatepham4900]

This is one of the best videos I've ever seen in my life. Just wow! Thank you all so much for this remarkable creation.

[@abdorhman8883]

thank you very much ..Any person, no matter how much he reads and searches on the Internet, his brain will not be able to imagine as the video shows before us, because we only read and did not look with the electron microscope what is happening, and we do not know what each protein and receptor looks like!! now you be my reason after god to enhance my understanding apoptosis

[@hayaa.6545]

i can’t describe how great this is

[@geetarautela1]

Wonderful explanation

[@shubhamsanyal5459]

how beautifully explained by making such meaningful animation. Truly impressed by seeing caspases.

[@elvirethouvenot-nitzan1784]

Thank you for your comment! You might also enjoy some of the other University of Dundee biomedical animations available at vimeo.com/dundeetilt.

[@ChineloLucy]

I love the explanations, very smooth

[@kinzasajjad1148]

One of the best animation video. Thank you!

[@khaoula6658]

i have seen many videos about apoptosis but this one is by far the best one it was very simple and contains at the same time every thing you should know

[@livephysiology]

Interesting video. Makes one wonder of the pathways cancers use to avoid apoptosis.

[@MarieBai]

It would have been a crime for me not to like this amazing video. Thank you.

[@troy4272]

Really good animation on apoptosis ever seen in youtube Great man thank u ☺️😊

[@jemmawatkins9451]

I loved the animation - this was so easy to understand!

[@nurdaozturk2301]

thanks alot for this spectacular illustrative animation, it was very explanatory

[@pierfrancescosantin4325]

Thank you so much!!!!!!! this was so useful and well made

[@ra71.]

no video has even made understood a concept at one go like i did after watching this! and to think this was made 7 years ago??!

[@kainajones9393]

Love this visual approach

[@parkmicrosoft3638]

back again and still the best on you tube

[@michaelfries7969]

Wow that was so down to earth and well illustrated. nice vid!!

[@dusted11123]

Watching this for school but it’s still fascinating

[@jackedbyrohit3236]

This is so cute man! Literally saved me an hour

[@needy.00]

Um this is freaking amazing my sincerest respect n appreciation to the creators :((((

[@imsungjaesmelody.thesnorte5623]

Thank you. You explained in minutes what would have taken hours referring textbooks.

[@mamdoohal-nassirat1627]

LOL

[@drabhishekorthpaedics]

Wow so greatly explain,u cant forget even aftr ua Neet prep!! Round of applause to d presentor

[@manharsinhrajput2318]

SUPERB . ROUND OF APPLAUSE FOR YOU GUYS.

[@hitaisheejadab7414]

awesome video very much helpful

[@einsteingonzalez7897]

That was magnificant!!!

[@andieandbeatrice]

This video is mesmerizing. Beautiful biology TBH

[@TT-zu8ni]

my 1 hour lecture in less than 4 minutes. nice.

[@alirezafirouzi3343]

the best video that i saw on apoptosis

[@muhammadraza999]

The best description i have ever watched...❤❤❤ Want more vedios. 👍who like this.....

[@-273c3]

Best video about the cell dead mechanism

[@usmanahmad8846]

Great work we are students must appreciate such type of work its easy to get suitable knowledge in short time.... ❤

[@rigzinwangmo3113]

what a beautiful video on apoptosis

[@ThomastheCrak]

Excellent video, this is one of the best video biology i've ever seen, Thanks you👍

[@ghadeerbadr7242]

this is so beautiful :(

[@pkmt350]

Woww I thanked for whoever made this !!! It so easy to understand and helps a lot !!!

[@mannyadisa]

this is an incredible visual

[@abhibadboy95]

Simply Amazing Guys,keep up the good work.👍😊

[@cecilia1406]

THIS IS SO GOOD AND SOOTHING TO WATCH

[@apurvasachan8871]

Best video ever on apoptosis

[@RF-md3ey]

You’re a genius, thanks for making this video!

[@sudanvythis4786]

Awesome explanation