Calorie Restriction, Exercise, And Longevity: Luigi Fontana, MD PhD

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Timestamps:
0:00 Human CR studies
6:00 IGF-1
16:52 Faster biological aging in people on extreme CR
21:00 What is the optimal amount of CR?
22:00 CR vs Exercise For Longevity
23:00 Exercise and anti-aging/longevity
27:00 Exercise and maximum lifespan
31:00 Using HRV, RHR to potentially limit overtraining
34:45 Visceral fat, waist circumference
36:00 Monitoring biomarkers to evaluate if CR, exercise approach is on the right track
38:00 Insulin, glucose
44:30 Albumin, CRP, creatinine as potential biomarkers of longevity vs glycemia and lipoproteins
45:20 Alcohol, Mediterranean diet
48:40 Olive oil
50:25 Is death unavoidable?
55:55 Maximum human lifespan
58:50 Climate Change
1:07:20 Luigi's start in aging research
1:10:40: Current/future studies
1:19:50 Nutrition education in primary schooling
1:25:30 Public science communication

[@conqueragingordietrying1797]

Timestamps: 0:00 Human CR studies 6:00 IGF-1 16:52 Faster biological aging in people on extreme CR 21:00 What is the optimal amount of CR? 22:00 CR vs Exercise For Longevity 23:00 Exercise and anti-aging/longevity 27:00 Exercise and maximum lifespan 31:00 Using HRV, RHR to potentially limit overtraining 34:45 Visceral fat, waist circumference 36:00 Monitoring biomarkers to evaluate if CR, exercise approach is on the right track 38:00 Insulin, glucose 44:30 Albumin, CRP, creatinine as potential biomarkers of longevity vs glycemia and lipoproteins 45:20 Alcohol, Mediterranean diet 48:40 Olive oil 50:25 Is death unavoidable? 55:55 Maximum human lifespan 58:50 Climate Change 1:07:20 Luigi's start in aging research 1:10:40: Current/future studies 1:19:50 Nutrition education in primary schooling 1:25:30 Public science communication

[@susymay7831]

Thank you for your fabulous timestamps!! ❤❤❤❤❤

[@michelangelobuonarroti916]

Great discussion. Since it is so long and wide ranging, the timestamps are very helpful. Thanks.

[@AladdinPersson]

Hey Michael, put these in the video description too so it’s embedded in the video:)

[@conqueragingordietrying1797]

@@AladdinPersson Thanks for that suggestion, now updated!

[@AnthonyPerea963]

If he's telling you to take igf-1 as a supplement he doesn't know what he's doing, period .

[@peterz53]

Thanks, Michael. Yes, Dr. Fontana has been on my radar for many years, and I agree he is very underrated. Hope you continue to occasionally bring on researchers who are distinguished in the field of aging, especially as you are positioned with your knowledge base to ask relevant questions.

[@conqueragingordietrying1797]

Thanks Peter. Who else do you think is underrated, as a potential channel interview?

[@TheBroSplit]

I agree, good interview.

[@waylonhastings]

Hi Michael, I wonder if you might have a presentation on the different classes of biological age measurement and the different mechanisms of aging they're purported to quantify. You already talk about this to a degree but it might be worthwhile to have an explicit video focusing on it. I'd be happy to do this myself, but Dan Belsky at Columbia, who is also published in CALERIE and is 1st author on several publications comparing TL, DNAm and biomarker-based biological aging measures, would probably be the bigger/more cited name to feature for this type of presentation.

[@DavidPodolsky]

@@conqueragingordietrying1797 I Like Dr. Kim Williams and Dr. Joel Kahn. Very sensible, fact-based Doctors. I think it is interesting to introduce specialty Doctors in the conversations, e.g., cardiologists, neurologists, etc.

[@peterz53]

@@conqueragingordietrying1797 I will have to think about the underrated part. Considering Luigi's comments on insulin, I recall a recent presentation at ARDD and NUS Medicine by Adam Antebi which appears to correlate low insulin with increased longevity in worms (and increased AKG and NMN). He runs an aging biology lab at the Max Plank Institute and I believe his focus in on identifying the key molecular/metabolic nodes which influence aging. I would like to know if it important to routinely check fasting insulin and try to dial it into particular value, say 2 to 3 mIU/l, or just use proxies such as glucose and HbA1c. Seems that maintaining low fasting insulin without huge transients may have broad positive effects.

[@berdi4berdi4]

Great conversation, and thanks as usual, for taking your time to answer the questions I made on other of your videos.

[@mathsfreak69]

Excellent talk, many thanks to both

[@lawnmower11]

Excellent information and interview with Dr Fontana, muchas gracias

[@jmc8076]

Dr Fontana is one of few I’ll watch. I prefer to read studies myself. There’s many dedicated researchers in the field who will never be on social media or have a following. They and Dr Fontana know science is never static. It always retesting and challenging itself. Diff views and opinions aren’t popular now but allow scientists to see various angles and holes. Thx. Edit: I’d only add it’s humans waste (personally/ commercially waste tonnes of food every yr and not efficiently grown using non chemical processes to feed not kill soil health. Farms that use natural cycles incl crop rotation, compost/manure for fertilizer etc yield far more with less cost and damage to ecosystems. Industrial age and post war mass consumerism incl processed food and our reliance on single use plastic continues to cause environmental damage. Not just climate.

[@SchaferBob1]

Great video and conversation, Michael! I really liked the point that you were getting at as to what is the optimal dose of exercise, calorie restriction, sleep, calories, etc. to impact your biomarkers based on what we know today? Your experiments are getting us closer and Luigi's work is great for long term thinking. Both of your work is outstanding and complements one another. And you both look young for your ages!

[@conqueragingordietrying1797]

Thanks @SchaferBob1!

[@JohnDoe-os3mc]

great talk, thanks for the insights!

[@DavidPodolsky]

Excellent content, thank you, Michael.

[@conqueragingordietrying1797]

Thanks David!

[@olyav5819]

Great conversation! Very informative about exercise, so far many longevity people are pushing exercise as #1 factor.

[@conqueragingordietrying1797]

Thanks Olya. Exercise is essential, but in animal studies, it doesn't beat CR for maximum longevity... Then, the question is, can we better titrate the exercise dose, to get the maximal benefits of exercise in terms of lifespan? That's what I'm after...

[@smedleyjefferson1450]

Yes, Peter Attia says VO2 max is the *most* important criterion for longevity!

[@conqueragingordietrying1797]

@@smedleyjefferson1450 For increasing average lifespan and healthspan, he's probably not wrong. No evidence for maximal lifespan, though.

[@jmc8076]

@@smedleyjefferson1450 Based on studies to date. Good science (as he knows and actual researchers in the field know) is never static and constantly testing and challenging itself.

[@leandrobecker123]

What a great talk! Congratulations to both! As a cardiologist here in Brazil I can understand very well the many aspects of health aging that you have discussed. Unfortunately our schools (basic and also medicine ones) have not gave yet the real importance to all that was adressed here . I will purchase Luigi's book and follow him in internet. And if he wants i can go to Australia to help him in the Longevity clinic! A friend of mine once said that Australia is the Brazil that worked.

[@Always-xl9db]

It started so tedious, hard to understand/follow but then really turned into a great discussion, excellent insights. He touched on a lot of questions that I always wanted to know answers for, but unless you have that broad view, lots of knowledge and experience, u simply can’t find answers anywhere. Obtaining more knowledge by living longer would not make much difference because we are so good in transferring knowledge to the next generation, it’s almost irrelevant to the issue…but I hope that it could shift that myopic, self-centered outlook because once u know with certainty you will be here in 100 years, may be you’ll start caring about the planet and nature instead of overconsumption…he is spot on on youth education, instead of trying to change adults or fight with them - he is so right, it’s been done exactly like that on the dangers of smoking, with great success. Thank you for the interesting guest, please do ask him about his views on your approach, I know you’ve already answered on that, but would be so good to hear from him, surely he has deep insights! 😊👍

[@AladdinPersson]

Awesome conversation, really enjoyed listening to it! I’ve listened to Elons thoughts on death where he sees it as a negative for society if people would live forever. The reasoning is bit different than Dr Fontana but same kind of conclusion, and then there’s other people who say death is what creates meaning etc. I don’t know what the right answer is to this, but if I could decide I’d like to live for as long as I want to. There’s too much to explore, too much to learn, too much to try in such a limited time. I also think scientific progress would be a lot faster, that the smartest people die and we have to reset knowledge and build it back into a new person seems like a huge bottleneck.. Wisdom often builds through time, and having more of that around would probably help solve a lot of other problems as well. If someone gave me a video game and I loved playing it, but they say you can only play it for a total of 24 hours. That would be kinda dumb. If I truly loved the game, I’d figure out how I could bypass the limit so I can play until I feel I have completed the game.

[@conqueragingordietrying1797]

Definitely, I agree 100%!

[@earx23]

Woah! Learning a lot here. I now understand that overdoing exercise is a bad thing.

[@beepbeepnj2658]

There was a longevity expert named Dr. Henry S. Lodge who knew more than these 2 people in the video. I am not sure what he has been doing lately but he was an expert in diet, health and had a specialty in Geriatrics. But Elizabeth Sullivan the HS math teacher who lived to age 106 owed much of her life to a very special doctor. Do you remember the name of the doctor?

[@casper98204]

Dr. Peper

[@beepbeepnj2658]

@@casper98204 Did Dr. Pepper come in a can after is wife died?

[@angeladavies]

Excellent information, the overdoing endurance exercise I am paying the price ( meniscus tear, bone death tibia & fibia), osteopenia. Education in early school is needed. No wonder health issues are problematic & youth on E cigarettes, alcohol, drugs, pre diabetes.... It has taken me 55 years to finally become better educated. I have bought all Prof Fontanas' books, the best buy I've made. Thankyou.

[@larsnystrom6698]

@angeladavies I consider it more likely that less than optimal nutrition causes that kind of problems, than that exercise does it. I noticed that the amount of protein that were fine when younger wasn't sufficient when older. I had to start supplementing with collagen. That and other things seems to work well for me, at an age where most people are getting frail. But I've held back some from excessive exercise. My rule has always been not to strain the same bodypart maximally two days in a row.

[@angeladavies]

@@larsnystrom6698 agree with your comment, 1980s & so on for women was diet, be thin, poor nutrition in reflection is paying a price. REDs in athletes. Your rule "not training same body part consecutively" is wise.

[@jpintero6330]

That was a fantastic interview. Dr. Fontana is so knowledgeable and has wisdom and common sense. He also looks very healthy and young. I think many people do not know about the potential danger of excess exercise regarding fibrosis of the heart.

[@jackbuaer3828]

We're still using combustion engines and can't even get one person to Mars. Yet, people are envisioning moving millions of people to some unknown planet that is much further away in the near future?

[@conqueragingordietrying1797]

Probably not millions in terms of making that trip...

[@tommyortiz6623]

Hi Micheal! Are you still consuming the crown prince brand? I heard they have prop 65 for heavy metals including lead.

[@conqueragingordietrying1797]

Hi Tommy, I am-can you post some links showing that?

[@rufisdodd4318]

I don't believe CR is a long term intervention. Even if you are just slightly below your BMR you will eventually starve to death. We have to balance what is best for longevity , healthspan and quality of life and food is a big part of living and quality of life. Also I got the not to subtle jab at Attia. I think Attia is saying exercise is the biggest lever you can pull in terms of healthspan not necessarily lifespan. I think you are right to monitor HRV and adjust your exercise volume accordingly, it's the best marker we have at this time.

[@Battery-kf4vu]

Hi Michael, very interesting guest, thank you for the interview. It would have been interesting to know what Dr. Fontana thinks about your approach. Concerning the fact that food production will decrease in the future, perhaps paradoxally that will put people in CR and they will make them live longer. At some point for sure they may become undernourished and die.

[@conqueragingordietrying1797]

Thanks @Battery-kf4vu. In terms of Luigi critiquing my approach, I've seen other longevity YTers make the interview about themselves, rather than finding out more about the person that they were talking to. I tried to do that as little as possible...

[@jimdres7000]

Ask professor Valter Longo to assess his countryman’s update on IGF-1 and CR as this totally contradicts and dismisses his IGF-1 theory. I would also ask for Dr Peter Attias response about Luigi’s limited exercise impact remarks on overall longevity. If the so called science elite can’t agree on longevity factors then what hope do the masses have to follow ? Genetics and epigenetics to a certain degree must therefore be the only and by far the greatest and true longevity differentiator.

[@larsnystrom6698]

I'm looking for something else, other than calorie restriction. It's interesting that melathione restriction seems to do the same as calorie restriction does for lifespan, It's even more interesting that glycine seems to work like methionine restriction does. As if it wasn't really to much methionine, but a glycine deficency. That's interesting to explore, because protein restriction might not really be appropriate for older people. And that's a reason for avoiding calorie restriction too. I guess calorie restriction is something which might extend lifespan if you do it when young. But I think fraility is the main problem when older. In my opinion, we have to change our nutrition when older, to compensate for a less efficient system. That's why I'm trying to explore other ways. I'm still too young, at age 75, to know if this works out better than calorie restriction. But at least I'm not frail.

[@zhilahaghbin4766]

Thanks you both, enjoy listening to both of you. I agree the talk on lipids that is geared on needing meds to lower LDL, etc, I have listened to all of them. When it comes to taking fiber or drug like fibers, they emphasize so much on side of these and risks of getting into your blood and brain and being toxic, if you take phytosterols, but when it comes to Statins causing diabetes or elevated muscle enzyme, there is incredible minimization to the point of saying "let the liver enzyme go over 3 times normal then consider doing something else or what is the point of measuring CPK, don't do it, it will be high". I have even heard "statins don't prevent heart attacks but reduce "negative outcome of it", If any other doc said that they probably loose their license but these are docs clearly even to this day benefitting from money given to them by pharma for giving such talks and lectures. History will remember them as they are.

[@jaym9846]

You two could be brothers. Great discussion with a wide perspective. Is it possible to reduce Insulin, IGF1, mTOR via BCAA reduction?

[@conqueragingordietrying1797]

Thanks @jaym9846, and the only way to know (rather than speculate) is to measure those biomarkers after reducing (or even increasing) BCAAs

[@diamond_s]

CR mimetics have achieved 70% life extension in some organisms. In longer lived organisms it appears the aging related NAD+ depletion hinders the ability of some CR mimetics that work through sirtuins. Newer compounds that maintain NAD+ at high levels throughout life, and impede the aging decline of NAD+, might allow CR mimetics to similarly extend longer lived organisms.

[@Battery-kf4vu]

Yeah but Sinclair says that NAD activates hundreds of enzymes, and there is only 7 sirtuins and 17 PARPS. So what are the hundreds of other enzymes doing? Is it sure that overall increasing NAD is a positive thing? We know for instance that it strongly activates CD-38, which usually is considered a bad thing, that's why people take things like apigenin, to try and lower it.

[@diamond_s]

@@Battery-kf4vu cd-38 destroys NAD+ and it is believed age related increase in cd-38 may be behind NAD+ decline. Apigenin stops cd-38 and increases NAD+. iirc there have been long term NMN studies on rodents and no ill effects have been found so far. Even in short lived vertebrates up to 59% increase in lifespan has been observed with CR mimetics

[@runnerrn2247]

Would you pls clarify @45:06 ~ lower CRP, lower creatinine but higher albumin are associated with LOWER all cause mortality?

[@conqueragingordietrying1797]

That's right! A short video on that data is in the works, and in the same paper, HDL, LDL and HbA1c weren't associated with ACM risk within the 85 - 110y range.

[@caroldemas8019]

Regarding those people who had "too" low BMIs and faster biological aging--were they tall men (not mentioning any names) or short women? What were their BMIs? What specific metrics were used? If I gain just to get a BMI of 20 it's only going to be a bunch of adiposity around my midsection that I'm not convinced will be all that helpful.

[@jimking6484]

Lower CRP is a driver for cancer minute 45 makes no sense. Please elaborate.

[@conqueragingordietrying1797]

Lower CRP is not a driver of cancer at minute 45. Instead, relatively high albumin, low CRP and creatinine are better markers of longevity than HDL, LDL, or HbA1c, which comes from this paper: pubmed.ncbi.nlm.nih.gov/32732919/

[@KoiRun50]

You should interview this 95 year old on no meds Sidio Garatinni he mentioned. What’s his proper name anyway so perhaps I can look him up.

[@KoiRun50]

Got it Silvio Garattini😊.

[@alamond3318]

Could someone link the study which has to do with those with a BMI under 19 undergoing CR having an older epigenetic age?

[@conqueragingordietrying1797]

I think Luigi mentioned that they'll publish it soon?

[@alamond3318]

@@conqueragingordietrying1797 Oh I see. Thank you for answering!

[@orenhalperin2081]

About the comment regarding the mice in the CR study being fed every other day driving low IGF1 levels, could the fasting be the source of health benefits ?

[@conqueragingordietrying1797]

Yes, see this video: kzbin.info/www/bejne/p2a9f5KjiZKrmNk

[@orenhalperin2081]

Thanks - see my comments in that video

[@sooooooooDark]

from a logic standpoint the word "CR" kinda bugs me it doesnt make sense....if u restrict calories implies ur body "kinda needs more but u dont give it what it needs" imo it would be better to suggest to "stay in the 22+-1bmi range and eat 15% more calories over sedentary maintenance calories and exercise (say) 50+-15 min (including walking) daily without going outside that bmi range ever" (or something like this) to determine "what ur actual caloric needs" are (cuz if u go too low calories ur bmi will just inevitably tank and ull go ausschwitz-mode and life becomes hell, as the low appetite crowd can confirm 😐) not just from a CR maintenance perspective but from a slightly more wholistic/less reductionist point of view

[@sooooooooDark]

57:10 gotta love the sparkles in ur eyes when u talk about that stuff 🥺 the italiano guy too persimistic, true scientists know there is no (fundamenal) laws of nature, everything is possible (its usually just the thing of either not being away of a problem or not knowing how to solve the problem (yet)), never say never...etc :P (ok 1 line later he himself said "everything is possible" himself xD)

[@user-ex6wb8mu8i]

@conqueragingordietrying1797 Hi Michael, I've got one question for you and your audience: If fasting activates NAMPT and NAMPT signals to convert NAD precursors such as NMN or NR into NAD (salvage pathway) then it is clear that taking them during a prolonged fasting should increase NAD levels. Can this assumption be true? Has anyone checked it by chance?

[@conqueragingordietrying1797]

NAMPT converts niacinamide into NMN-there's still 1 step to convert NMN to NAD,. That makes sense-I don't know if there's published data, though.

[@ogeoge6000]

Changing my diet saved me from debilitating back pain, nerve pain, joint pain, muscle pain, digestive issues, raised blood pressure, 20kg over weight. It took around 8 months for all these problems to resolve. Since 2020 I've been completely pain free and never felt and looked healthier. I'm only eating fatty meats, seafood, eggs and dairy. Prior to that I was eating the mainstream version of a healthy diet (lots of veggies, fruit, whole grains, low fat, eating the rainbow etc) for decades and watching my health slowly decline. I learnt lots watching videos by Dr Ken Berry, Dr Shawn Baker, Dr Gary Fettke, Dr Benjamin Bikman, Dr. Malcolm Kendrick, Dr Anthony Chaffee, Dr Paul Mason etc. And these authors videos Diana Rodgers, Robb Wolf, Lierre Keith. I read this peer-reviewed scientific article, that shows how 2,029 people had amazing results on the diet I'm on it's called "Behavioral Characteristics and Self-Reported Health Status among 2029 Adults Consuming a Carnivore diet".

[@TheBroSplit]

Wait, so if I have a fasted glucose in the morning of 90, I am insulin resistant ?

[@conqueragingordietrying1797]

The best way to know would be to measure fasting insulin. My fasting glucose has been ~90mg/dL for a few years, but insulin is relatively low, 3 mU/mL. However, for most people on a SAD diet, a glucose of 90 probably is in conjunction with a fasting insulin of 8 or higher.

[@TheBroSplit]

@@conqueragingordietrying1797 thank you, I am considering the over excersizing. I'm 37 and putting on muscle. But maybe training too hard at times.

[@diamond_s]

if you're on keto it puts you in temporary insulin resistant state, also the artificial sweeteners present in many sugar free foods and drinks mess up insulin regulation. Apple cider vinegar dissolved in water helps improve insulin regulation, and I think certain forms of cinnamon also help improve insulin regulation.

[@conqueragingordietrying1797]

@@TheBroSplit I was overtrained for decades under the more is better philosophy. Once I started tracking HRV and RHR, I was better able to manage that.

[@TheBroSplit]

@diamond_s thank you I may keep doing ACV before some meals. I also tend to walk after eating. 10-20 minutes. Flex my muscles while doing so hahaha

[@jp7357]

The link to his YT channel doesn’t work and really doesn’t look right. Many t(ask for yet another excellent YT. I rewatching your nad+ YT’s thinking of switching from NMN to niacin.

[@conqueragingordietrying1797]

Thanks @jp7357 and apologies! I tagged him initially with a YT link, but for se reason it was the wrong link. Now corrected, and here's his page: www.youtube.com/@LuigiFontanaMDPhD Before you switch to niacin, in an upcoming video we'll see that it may have negatively affected my epigenetic aging rate. So higher NAD but a worse DunedinPACE. I didn't have that issue with NMN, though, and will will likely try a lower niacin dose (50-60 mg/d, not 600+) to try to get around it for upcoming tests.

[@diamond_s]

@@conqueragingordietrying1797 what will be interesting to see if the reduced nmn, nmnh is tested in humans and becomes available and how that would fare. Given preliminary results suggest it is even more effective than nmn and can reach more diverse set of organs.

[@jp7357]

@@conqueragingordietrying1797 it’s always something … I recently got a glycan age test .. it came back as 34 (I’m 65) .. now I’m nervous about changing anything … although I have just added apigenin …. I just couldn’t stomach (literally) the dried parsley.

[@viracocha2021]

Really interesting that CR didn't cause IGF-1 reductions in humans. This is really bad news! Is then the eating window as important as the CR in order to reach a fasting state? Would 16-8 IF be enough? OMAD has its own problems... Maybe OMAD + low insulin + good gut barrier? Each year this puzzle gets trickier and trickier...

[@diamond_s]

the animal experiments as mentioned by Fontana suggest the true comparable fasting time for humans is 2 to 3 days. That is pretty tough, but I think with a high fiber fasting mimicking diet during 2 to 3 days ala valter longo's fmd might confer the same benefits as actual fasting.

[@viracocha2021]

@@diamond_s so normal diet and eating window but with regular 2 day fast, right?

[@diamond_s]

@@viracocha2021 something like that, there's been talk of the 5 2 diet, 2 days of CR or Fasting and 5 days of regular eating. "The 5:2 diet is an intermittent fasting regime in which calorie intake is limited to 500-600 calories per day two times per week"-healthline Either very limited calories or full fast during 2 days.

[@nootri]

you need to read up on IGF-1. You want more, not less.

[@espinosalexis]

It's a shame you went into the end of the world rabbit hole. I hope you can create a list of anti-exercise research discussing all those papers that you and Luigi said exists vs top athletes.

[@bgrobbins]

so many things are restricted during calorie restriction, the idea that it is the restriction of calories that gives the benefit seems narrow minded, especially when restriction of other things like methionine have shown longevity benefit. also no mention of the negative effects of polyunsaturated fats or endotoxin? no mention of the benefits of sugar and how fructose acts like insulin. really no mention about how to improve metabolism. no mention of beneficial hormones like thyroid, pregnenolone, progesterone, dhea ? calorie restriction shows minimal benefit. the nia study on monkeys showed that. the other monkey study showed that calorie restriction shows benefit vs a very poor diet.

[@monnoo8221]

well, first thank you very much, very interesting interview. Yet, Mr. Fontana may have a lot more citations, but answering the precise questions i not his thing, so those more citations simply can mean that he is a better politician than you :) I also wonder WHY it should be amazing (@11:40) that if you restrict calories BELOW maintenance, the body adapts all the hypothalamic hormonal systems??? What I want is reduced IGF-1 but of course not increased cortisol. What about circadian rhythms? what about people with a good BMI etc of 21, feeding at maintenance. == in a NORMAL body? I feel underrepresented hehehehe... And occasionally he just utters the opposite: @10:54 the cortisol increases, and @11:52 cortisol decreases ... eehhhmmm, what? will continue to watch later if at all

[@conqueragingordietrying1797]

I don't offer praise often, but Luigi's career success is not because he's a politician, but because he's a great academic scientist.

[@Aryeh-o]

Imho high median age (5000+) and overpopulation don't come together but low median age (30~) and overpopulation always come together. basic exponents math say so!!

[@claudecamire5913]

Mr Fontana is a good man and has a critical mind. However his comments on Italian diet ressemble those of Blue zones and totLly inaccurate. If you are poor you cant buy wine,cheese, fish and meat. Most people love meat and wine. When we go every year we have meat at lunch and dinner plus wine plus cheese. Fish is expensive so less frequent. Food choices are money driven not driven by health choices

[@conqueragingordietrying1797]

Luigi is Italian by birth, and lived there for about half of his life. If anyone knows what the real Mediterranean diet is, it's Luigi...

[@ccamire]

Interesting discussion. In conclusion, i will continue my current regimen of high protein meat and wine, zero UPF and very low sugar, fair amount of resistance and cardio exercise, living in the country far from noise and pollution, optimizing sleep, so that i can live drug free and healthy to ~100. While people continue to debate what might be optimal to live beyond 122, we have many other societal challenges that may prevent us to achieve this.

[@TheJasonHowarth]

[@dancurran7669]

Couldn't hear it needs to be louder

[@conqueragingordietrying1797]

Are you watching on a mobile device? On PC, the volume is ok

[@dancurran7669]

Mobile KZbin

[@dancurran7669]

Google pixel pro 7

[@sooooooooDark]

olives might be better than olive oil but olive leaves r the true unknown star of polyphenols ;P 50-100 times the amount per gram compared to the best olive oils out there and absolutely impossible to like taste-wise! 😂

[@davidfullhouse]

Olives are a whole food, but the salt! One disadvantage compared to EVOO!

[@sooooooooDark]

@@davidfullhouse u can put lots of olives in big glass jar and soak them in regular water for 1 day and discard that water once a day to slowly remove the salt a bit tedious but possible it wont remove 100% tho and the olives will taste rather bland in the end but it works!

[@k14pc]

Interesting and helpful analysis in general. Still confused how so many smart people are so pessimistic about our ability to adapt to different environments. We will grow more food, we haven't even tried vertical farms yet really and there's plenty of land. We adapted to literal ice ages, I think we can adapt to some warming with modern technology. Also, there isn't even clear evidence right now that more disasters are occurring, it's too soon to tell.

[@TheBroSplit]

How much protein does this guy get a day?

[@Moonlightfire88]

Stopped listening when he started with all the Malthusian pseudoscience

[@yourbrain8700]

His coping around death being fine was highly unfortunate. Still a worthwhile interview otherwise.

[@yourbrain8700]

Even the fact that he thinks we'd spend most of our day in the real world by the time he himself is 90 is pretty comical.

[@BarryBPruett]

Should stick with their expertise. Too much discussion, mostly speculation about things they are at est, only casually knowledgeable of....and in some cases, wrong.

[@michelangelobuonarroti916]

LOL

[@artelc]

Or maybe he and others like him can spare us the lecturing and check out at 95-120 and let the rest deal with the consequences of aging beyond that.

[@sarpsomer]

I would question why you are here on this channel; just saving the day ?

[@Thomas-wz2nu]

Interesting but shame it had to veer into political stuff

[@madpower2000]

Sorry Michael, but I didn't like this interview. Zero useful information and a lot of speculation.

[@conqueragingordietrying1797]

Sorry to hear that @madpower2000! Who would you suggest instead?

[@madpower2000]

​@@conqueragingordietrying1797 Morgan Levine, PhD and Dr Nichola Conlon (nuchido.com/blogs/news/meet-dr-nichola-conlon-the-founder-of-nuchido) my top choices!

[@paulpellico3797]

ok. stop. you had me going until you started on the 130-year life-span followed by the greenie eco crap and under-water cities. no, they are NOT under water and this discussion ends, NOW..scientifically

[@diamond_s]

De Grey thinks the longer lived an organism the harder it is to extend lifespan, but the opposite may be true, and the longer lived an organism the fewer mutations away it is from biological immortality. It may be that small interventions perhaps even the combination of some nutraceuticals and drugs, may bring humans to such state and allow for multicentury lifespan.

[@michelangelobuonarroti916]

Head in the sand, huh?

[@jackbuaer3828]

Scientist believe that the environment is directly related to all of our lifespans. Air Pollution is almost certainly shortening your life and mine. " Air pollution, which is primarily the result of burning fossil fuels, takes 2.2 years of the global life expectancy for each person, according to a new report out Tuesday from the Energy Policy Institute at the University of Chicago" Are there any well respected scientists that believe that air pollution is harmless?

[@paulpellico3797]

@@jackbuaer3828 are you kidding me? you answer my comment about cities being under water with pollution now being tha cuse of shortened life spans? i mean...what causes air polution? what causes quality of life but the manufacturing, washing machine production and other qulity of life improvements. it seems we can never stop hurting what others have done to make our lives better. do we always have to live with guilt and beg for yesterday????? yes, perhgaps you can have your cake and eat it to, but i am betting in the yin yang of life you cannot. and you WILL die. Remember, you can build airplanes and cut the distance of travel, but you will fill the sky with smoke. you can create electric lights but you lose the magic of darkness and find night pollution. what will you have, the middle ages or today? and the most humorus grasp of the obvious, you say "Scientist believe that the environment is directly related to all of our lifespans." no shit sherlock! everything IS environment. bacteria and disease are environment. love and hate? didn't "god" plan it this way?????? EVERYTHING is environment! actually, everything is natural. if a bee can make honey, man can make plastics. one isn't more natural than another. and besides, after losing my son at age 24 to CIC DUX4 sarcoma, don't give me this bullshit longevity thing. everything dies. i wasn't here for the black plague and i will not mind NOT being here when man once again faces WW3.

[@paulpellico3797]

@@michelangelobuonarroti916 perhaps, but at least it ain't up my ass.

[@wmp3346]

Not exactly up lifting, you may as well drink and smoke